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Percutaneous interventions in elderly patients with atrial fibrillation： leftatrial ablation and left atrial appendage occlusion

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Journal of Geriatric Cardiology 2017年第9期14卷 541-546页

作者： Evgeny N Mikhaylov Tamas Szili-Torok dmitry S lebedev Arrhythmia Department Almazov National Medical Research Centre Saint-Petersburg Russia Neuromodulation Laboratory Almazov National Medical Research Centre Saint-Petersburg Russia Electrophysiology Unit Cardiology Department Erasmus Medical Center Rotterdam the Netherlands

Heart rhythm disturbances become of special importancewhen patients reach a senior age. Atrial fibrillation （AF） isthe most prevalent arrhythmia among the old age groups,and its impact on morbidity and mortality becomes of para-mount significance. In this population, AF is responsible forsignificant amount of thromboembolic cerebrovascularevents, especially for disabling and fatal strokes, Follow-ing announcement of the special issue of the Journal of Geri-atric Cardiology devoted to heart rhythm disorders in theelderly, a number of submissions have been received withAF as the major topic of authors＇ researches.

关键词： Atrial fibrillation Ablation Efficacy Left atrial appendage Occlusion Safety The elderly

Discrimination of ventricular tachycardia and localization of its exit site using surface electrocardiography

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Journal of Geriatric Cardiology 2019年第4期16卷 362-377页

作者： Heber Ivan Condori Leandro dmitry S lebedev Evgeny N Mikhaylov Lang G.F. department of Internal Medicine Pavlov First Saint Petersburg State Medical UniversitySaint-PetersburgRussia Almazov National Medical Research Centre Saint-PetersburgRussia Department of Medical and Biotechnology Systems First Electrotechnical UniversitySaint-PetersburgRussia

Differential diagnosis of supraventricular tachycardia (SVT) and ventricular tachycardia (VT) is of paramount importance for appropriate patient management. Several diagnostic algorithms for discrimination of VT and SVT based on surface electrocardiogram (ECG) analysis have been proposed. Following established diagnosis of VT,a specific origination tachycardia site can be supposed according to QRS complex characteristics. This review aims to cover comprehensive and comparative description of the main VT diagnostic algorithms and to present ECG characteristics which permit to suggest the most common VT origination sites.

关键词： Arrhythmias Electrocardiogram Supraventricular Tachycardia Ventricular

Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants

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Journal of Geriatric Cardiology 2016年第9期13卷 807-810页

作者： Svetlana V Garkina Tatiana V Vavilova dmitry S lebedev Evgeny N Mikhaylov Arrhythmia Department Almazov Federal North-West Medical Research Centre Saint-Petersburg Russian Federation Nearomodulation unit Almazov Federal North-West Medical Research Centre Saint-Petersburg Russian Federation Department of Clinical Laboratory Diagnostics and Genetics Almazov Federal North-West Medical Research Centre Saint-Petersburg Russian Federation

Thromboembolic complications represent a substantial problem in patients with atrial fibrillation （AF）. The prevalence of AF burden and associated arterial and venous thrombosis progressively increases with age. At ... 详细信息

关键词： Adherence Anticoagulation Atrial fibrillation Compliance Direct anticoagulants Elderly Novel oral anticoagulants

Renal artery denervation suppresses intractable ventricular arrhythmia in patients with left heart thrombosis

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Journal of Geriatric Cardiology 2017年第9期14卷 587-589页

作者： Marianna A Vander Petr A Fedotov Tamara A Lyubimtseva Maria A Bortsova Maria Yu Simikova dmitry S lebedev Evgeny N Mikhaylov Neuromodulation Unit Almazov National Medical Research Centre Saint-Petersburg Russia Arrhythmia Department Almazov National Medical Research Centre Saint-Petersburg Russia Heart Failure Department Almazov National Medical Research Centre Saint-Petersburg Russia

Transcutaneous renal artery denervation （RND） has beeninitially developed for destruction of efferent nerve fireswith luminal delivery of radiofrequency or ultrasonic energyaiming blood pressure reduction in patients with refractoryhypertension. However, other positive results of RNDwere described afterwards, and they include suppression ofatrial fibrillation and ventricular tachycardia （VT） storm.

关键词： Renal nerve denervation Sympathetic nerve activity Ventricular tachyarrhythmias

Serological diagnostics of myocardium diseases based on multivariate analysis of cardiotrophic autoantibodies’ profiles

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Open Journal of Immunology 2012年第1期2卷 49-58页

作者： Olga Moiseeva Lubov Mitrofanova Elena Karelkina dmitry Zverev dmitry lebedev Serge Skurydin Alexander Poletaev Medical Research Center “Immunculus” Moscow Russia V.A. Almazov’s Federal Center for Heart Blood and Endocrinology St. Petersburg Russia

We analyzed profiles of IgG autoantibodies to 16 cardiac specific proteins and their main immunogenic region B-epitopes, in the groups of already verified cardiac pathology: acute and chronic lymphocytic myocarditis, ST elevation myocardial infarction, postinfarction remodeling of myocardium, dilated cardiomyopathy and in healthy controls along with patients, suffered from gastritis (to evaluate immune response against cross-reactive B-epitopes). AAB specific patterns allowed us to distinguish cases among themselves by means of multiparametrical canonical discriminant analysis in approximately 95% of cases. Positive predictive value in the group of MYO reached 95%, in the STEMI—89%, in the PIR—99%, in the DCM—99%, in the group of gastritis—88%. Principal component analysis of mentioned cardiac pathologies extended current clinical knowledge of their immunopathogenesis. Obtained data markedly proved a usability of serum AAB profiling for non invasive screening, differential diagnostics and working hypothesis composition.

关键词： Autoantibody Autoimmunity B-Epitope Autoantibody Profiling Cardiology Principal component Analysis

Suppressing filamentation instability due to laser beam self-filtering

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High Power Laser Science and Engineering 2024年第3期12卷 51-61页

作者： dmitry Silin Efim Khazanov A.V.Gaponov-Grekhov Institute of Applied Physics of the Russian Academy of Sciences Nizhny NovgorodRussia

The development of small-scale self-focusing in a nonlinear Kerr medium after preliminary self-filtering of a laser beam propagating in free space is studied *** is shown that,under definite conditions,due to self-filtering,filamentation instability(beam splitting into filaments)either occurs at significantly larger values of the B-integral,or does not occur at *** the latter case,there develops the honeycomb instability revealed in this *** instability is the formation of a random honeycomb structure in the beam *** is shown that self-filtering can significantly increase the permissible values of the B-integral,at which the beam quality remains acceptable.

关键词： filamentation instability honeycomb instability self-filtering small-scale self-focusing

Formation of diffuse and spark discharges between two needle electrodes with the scattering of particles

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Plasma Science and Technology 2024年第9期26卷 32-39页

作者： Victor F TARASENKO dmitry V BELOPLOTOV Alexei N PANCHENKO dmitry A SOROKIN Institute of High Current Electronics Siberian BranchRussian Academy of SciencesTomsk 634055Russia National Research Tomsk State University Tomsk 634050Russia

The development of a nanosecond discharge in a pin-to-pin gap filled with air at atmospheric pressure has been studied with high temporal and spatial resolutions from a breakdown start to the spark *** and negative nanosecond voltage pulses with an amplitude of tens of kilovolts were ***-resolved images of the discharge development were taken with a fourchannel Intensified Charge Coupled Device(ICCD)*** minimum delay between the camera channels could be as short as≈0.1 *** made it possible to study the gap breakdown process with subnanosecond *** was observed that a wide-diameter streamer develops from the high-voltage pointed *** ionization processes near the grounded pin electrode started when the streamer crossed half of the *** bridging the gap by the streamer,a diffuse discharge was *** development of spark leaders from bright spots on the surface of the pointed electrodes was observed at the next *** was found that the rate of development of the spark leader is an order of magnitude lower than that of the wide-diameter *** thin luminous tracks were observed against the background of a discharge plasma *** has been established that the tracks are adjacent to brightly glowing spots on the electrodes and are associated with the flight of small particles.

关键词： needle electrodes short voltage pulses atmospheric air streamer breakdown diffuse and spark discharges scattering metal particles

A New Generation of Rules-based Approach:Mivar-based Intelligent Planning of Robot Actions(MIPRA)and Brains for Autonomous Robots

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Machine Intelligence Research 2024年第5期21卷 919-940页

作者： Oleg Varlamov dmitry Aladin Department of Information Processing and Management Systems RI MIVARBauman Moscow State Tchnical University(BMSTU)Moscow105005Russian Federation

To create autonomous robots,both hardware and software are *** enormous progress has already been made in the field of equipment,then robot software depends on the development of artificial *** article proposes a solution for creating“logical”brains for autonomous robots,namely,an approach for creating an intelligent robot action planner based on Mivar expert *** application of this approach provides opportunities to reduce the computational complexity of solving planning problems and the requirements for the computational characteristics of hardware platforms on which intelligent planning systems are *** theoretically and practically justify the expediency of using logically solving systems,in particular Mivar expert systems,to create intelligent planners,the MIPRA(Mivar-based Intelligent Planning of Robot Actions)planner was created to solve problems such as STRIPS for permutation cubes in the Blocks World *** planner is based on the platform for creating expert systems of the *** a result,the Mivar planner can process information about the state of the subject area based on the analysis of cause-effect relationships and an algorithm for automatically constructing logical inference(finding a solution from“Given”to“Find”).Moreover,an important feature of the MIPRA is that the system is built on the principles of a“white box”,due to which the system can explain any of its decisions and provide justification for the actions performed in the form of a retrospective of the stages of the decision-making *** preparing a set of robot actions aimed at changing control objects,expert knowledge is used,which is the basis for the functioning algorithms of the *** approach makes it possible to include an expert in the process of organizing the work of the intelligent planner and use existing knowledge about the subject *** experiments of this study have shown that instead of many hours and powerfu

关键词： Autonomous robot blocks world decision-making system expert systems intelligent planning

Source localization based on field signatures:Laboratory ultrasonic validation

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Journal of Electronic Science and Technology 2024年第3期22卷 47-56页

作者： Mahmoud Eissa dmitry Sukhanov Department of Radiophysics Tomsk State UniversityTomsk634050Russia Higher Institute for Applied Sciences and Technology(HIAST) Damascus31983Syria

Location awareness in wireless networks is essential for emergency services,navigation,gaming,and many other *** article presents a method for source localization based on measuring the amplitude-phase distribution of the field at the base *** existing scatterers in the target area create unique scattered field interference at each source *** unique field interference at each source location results in a unique field signature at the base station which is used for source *** the proposed method,the target area is divided into a grid with a step of less than half the *** grid node is characterized by its field signature at the base *** signatures corresponding to all nodes are normalized and stored in the base station as fingerprints for source *** normalization of the field signatures avoids the need for time synchronization between the base station and the *** a source transmits signals,the generated field signature at the base station is normalized and then correlated with the stored *** maximum correlation value is given by the node to which the source is the *** simulations and results of experiments on ultrasonic waves in the air show that the ultrasonic source is correctly localized using broadband field signatures with one base station and without time *** proposed method is potentially applicable for indoor localization and navigation of mobile robots.

关键词： Base station Field signature Fingerprints Localization Ultrasonic frequencies