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Contribution of functional KIR3DL1 to ankylosing spondylitis

Cellular & molecular Immunology 2010年第6期7卷 471-476页

作者： Ivan V Zvyagin Ilgar Z mamedov Olga V Britanova dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev dmitriy m chudakov Shemiakin-Ovchinnikov Institute of Bioorganic Chemistry RASMoscowRussia Institute of Rheumatology RAMSMoscowRussia DNA-Technology JSC MoscowRussia Vavilov Institute of General Genetics MoscowRussia

Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune *** particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several ***,none of the studies analyzed these associations in the context of functionality of polymorphic *** better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)*** genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 *** the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low ***3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1**** finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating ***,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1**** activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective ***,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS.

关键词： ankylosing spondylitis autoimmune disease HLA-B27 KIR KIR3DL1 KIR3DS1 KIR3DL1*004 NK cell T cell

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Polariton lasing in mie-resonant perovskite nanocavity

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Opto-Electronic Advances 2024年第4期7卷 27-42页

作者： mikhail A.masharin Daria Khmelevskaia Valeriy I.Kondratiev Daria I.markina Anton D.Utyushev dmitriy m.Dolgintsev Alexey D.Dmitriev Vanik A.Shahnazaryan Anatoly P.Pushkarev Furkan Isik Ivan V.Iorsh Ivan A.Shelykh Hilmi V.Demir Anton K.Samusev Sergey V.makarov UNAm-Institute of materials Science and Nanotechnology National Nanotechnology Research CenterDepartment of Electrical and Electronics EngineeringDepartment of PhysicsBilkent UniversityAnkara 06800Turkey ITmO University School of Physics and EngineeringSt.Petersburg 197101Russia Abrikosov Center for Theoretical Physics MIPTDolgoprudnyiMoscow Region 141701Russia LUmINOUS!Center of Excellence for Semiconductor Lighting and Displays School of Electrical and Electronic EngineeringSchool of Physical and Mathematical SciencesSchool of Materials Science and EngineeringNanyang Technological UniversitySingapore 639798Singapore Department of Physics Engineering Physics and AstronomyQueen’s UniversityKingstonOntario K7L 3N6Canada Science Institute University of IcelandDunhagi 3IS-107ReykjavikIceland Experimentelle Physik 2 Technische Universität DortmundDortmund 44227Germany Qingdao Innovation and Development Center Harbin Engineering UniversityQingdao 266000China

Deeply subwavelength lasers(or nanolasers)are highly demanded for compact on-chip bioimaging and sensing at the *** of the main obstacles for the development of single-particle nanolasers with all three dimensions shorter than the emitting wavelength in the visible range is the high lasing thresholds and the resulting *** we ex-ploit exciton-polariton condensation and mirror-image mie modes in a cuboid CsPbBr3 nanoparticle to achieve coherent emission at the visible wavelength of around 0.53μm from its ultra-small(≈0.007μm3 or≈λ3/20)semiconductor *** polaritonic nature of the emission from the nanocavity localized in all three dimensions is proven by direct com-parison with corresponding one-dimensional and two-dimensional waveguiding systems with similar material *** a deeply subwavelength nanolaser is enabled not only by the high values for exciton binding energy(≈35 meV),re-fractive index(>2.5 at low temperature),and luminescence quantum yield of CsPbBr3,but also by the optimization of po-laritons condensation on the mie resonances with quality factors improved by the metallic ***,the key parameters for optimal lasing conditions are intermode free spectral range and phonons spectrum in CsPbBr3,which govern polaritons condensation *** chemically synthesized colloidal CsPbBr3 nanolasers can be potentially de-posited on arbitrary surfaces,which makes them a versatile tool for integration with various on-chip systems.

关键词： nanolaser perovskite polariton mie resonance exciton-polariton

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Exploring van der Waals materials with high anisotropy:geometrical and optical approaches

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Light(Science & Applications) 2024年第4期13卷 645-653页

作者： Aleksandr S.Slavich Georgy A.Ermolaev mikhail K.Tatmyshevskiy Adilet N.Toksumakov Olga G.matveeva dmitriy V.Grudinin Kirill V.Voronin Arslan mazitov Konstantin V.Kravtsov Alexander V.Syuy Dmitry m.Tsymbarenko mikhail S.mironov Sergey m.Novikov Ivan Kruglov Davit A.Ghazaryan Andrey A.Vyshnevyy Aleksey V.Arsenin Valentyn S.Volkov Kostya S.Novoselov moscow Center for Advanced Studies Kulakova str.20Moscow 123592Russia. Emerging Technologies Research Center XPANCEOInternet CityEmmay TowerDubaiUnited Arab Emirates. Donostia International Physics Center(DIPC) Donostia/San-Sebastián 20018Spain. Institute of materials Ecole Polytechnique Federale de Lausanne1015 LausanneSwitzerland. Department of Chemistry Lomonosov Moscow State UniversityMoscow 119991Russia. Laboratory of Advanced Functional materials Yerevan State UniversityYerevan 0025Armenia. National Graphene Institute(NGI) University of ManchesterManchester M139PLUK. Department of materials Science and Engineering National University of SingaporeSingapore 03-09 EASingapore. Institute for Functional Intelligent materials National University of Singapore117544 SingaporeSingapore

The emergence of van der Waals(vdW)materials resulted in the discovery of their high optical,mechanical,and electronic anisotropic properties,immediately enabling countless novel phenomena and *** success inspired an intensive search for the highest possible anisotropic properties among vdW ***,the identification of the most promising among the huge family of vdW materials is a challenging quest requiring innovative ***,we suggest an easy-to-use method for such a survey based on the crystallographic geometrical perspective of vdW materials followed by their optical *** our approach,we found As2S3 as a highly anisotropic vdW *** demonstrates high in-plane optical anisotropy that is~20%larger than for rutile and over two times as large as calcite,high refractive index,and transparency in the visible range,overcoming the century-long record set by *** these benefits,As2S3 opens a pathway towards nextgeneration nanophotonics as demonstrated by an ultrathin true zero-order quarter-wave plate that combines classical and the Fabry–Pérot optical phase ***,our approach provides an effective and easy-to-use method to find vdW materials with the utmost anisotropic properties.

关键词： anisotropy anisotropic high

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Single and multi domain buckled germanene phases on Al(111)surface

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Nano Research 2019年第12期12卷 2988-2996页

作者： dmitriy A.muzychenko Sergey I.Oreshkin Vladimir I.Panov Chris Van Haesendonck Andrey I.Oreshkin Faculty of Physics Lomonosov Moscow State University119991 MoscowRussia Sternberg Astronomical Institute Lomonosov Moscow State University119234 MoscowRussia Solid-State Physics and magnetism Section KU LeuvenBE-3001 LeuvenBelgium

The simultaneous formati on of single domain(3×3)and multi domai n(√7×√7)R(±19.1°)germa nene phases on Al(111)surface in thesub-monolayer range was studied using seanning tunneling microscopy(STm)and density functional theory(DFT)based *** results revealed that both germa nene phases nu cleate and grow in dependently from each other and regardless of Al substratetemperature within significantly expanded range Ts=27-200℃.Our results unambiguously showed that STm images with hexagonalcontrast yield correct-resolved structure for both germanene phases,while honeycomb contrast is a result of an artificial tip-induced STm ***-principles calculations suggested atomic models with strongly buckled germanene(2×2)/Al(111)(3×3)and(√3×√3)R30°/Al(111)(√7×√7)R(±19.1°)with one of eight and one of six Ge atoms protruding upward respectively,that consistently describe the experimentally observed STm images both for single and multi domai n surface *** to the DFT based simulati ons both germa nene(2×2)and(√3×√3)R30°superstructures have a stretched lattice strain with respect to the ideal free-standing germa nene by 6.2%and 13.9%,***,numerous small domains separated by domain boundaries in the(√3×√3)R30°/Al(111)(√7×√7)R(±19.1°)germanenephase tend to reduce the surface energy and prevent the formation of extended single domains,in contrast to the(2×2)/Al(111)(3×3)***,our experimental results showed that the nucleation and growth of germa nene on Al(111)surface yield strong modifications of Alsurface even at room temperature(RT),which may be contributed to the formation of Al-Ge alloy due to Ge surface solid-states reactivitythat was ignored in recent *** is already evident from our present findings that the role of Al atoms in the formation of(3×3)and(√7×√7)R(±19.1°)germa nene phases is worthy to be carefully studied in the future,which could be an important knowledge for large-quantityfabrication of germane

关键词： germanene two-dimensional(2D)materials scanning tunneling microscopy density functional theory aluminum

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Pharmacogenetic-Guided Warfarin Dosing in Russian Patients： A meta-analysis

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Journal of Pharmacy and Pharmacology 2014年第5期2卷 313-321页

作者： dmitriy Sychev dmitriy Ivashchenko Ilya Rusin Department of Therapeutics and Clinical Pharmacology Russian State Medical Academy of Postgraduate Education Moscow123995 Russian Federation Department of Clinical Pharmacology I.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation Department of Biological Therapy of mental Disorders SaintPetersburg V.M. Bekhterev Psychoneurological Research InstituteSaintPetersburg192019 Russian Federation medical Faculty I.M. Sechenov First Moscow State Medical University Moscow 119991 Russian Federation

We performed the first meta-analysis of Russian prospective studies and compared a dose-selection strategy that used pharmacogenetic information to one that did not. We searched Pubmed and eLibrary through September 30, 2013. We included seven Russians prospective studies that compared pharmacogenetic-guided warfarin dosing group, using polymorphisms of CYP2C9, VKORC1 and CYP4F2, to a dosing algorithm that did not incorporate genetic testing. Clinical outcomes were both the major and minor bleedings and the cases of elevated INR. Quantitative data synthesis was performed using mIX Pro 2.0. 6 studies compared the cases of bleedings between two groups. There was no evidence of statistical heterogeneity, so patient＇s characteristics could not impact on results. Genetic-based warfarin dosing decreases the risk of bleeding. Pooled odds ratio was significant for＂major＂（OR = 0.07, 95% CI 0.008-0.54; P = 0.01） and both ＂minor＂ and ＂major＂ bleedings （OR = 0.49; 95% CI 0.31-0.78; P = 0.002）. Six studies evaluated the cases of elevated INR. There was no evidence of statistical heterogeneity （Q-test P = 0.13, 12 = 40%）. Four studies were powered to show a difference in elevated INR （P 〈 0.05）. Pooled odds ratio was significant （OR = 0.21, 95% CI 0.15-0.3; P 〈 0.01）. The intervention groups contained the fewer cases of elevated INR compared to the control groups. Genotype-based warfarin dosing reduces the risk ofbleedings （especially major bleedings） and cases of elevated INR. Results of meta-analysis depend on the quality of included studies and should be interpreted with caution.

关键词： Warfarin pharmacogenomics bleeding INR meta-analysis Russian.

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Reperfusion injury after critical intestinal ischemia and its correction with perfluorochemical emulsion "perftoran"

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World Journal of Gastroenterology 2005年第45期11卷 7084-7090页

作者： Vyacheslav Leontjevich Kozhura dmitriy Alexeevich Basarab marina Innokentievna Timkina Arkadiy mikhailivich Golubev Vasiliy Ivanovich Reshetnyak Viktor Vasiljevich moroz Research Institute of General Reanimatology

AIm： To investigate the anti-ischemic properties of perfluorochemical emulsion ＂perftoran＂ in mesenteric region. mETHODS： Experiments were conducted on 146 nonlinear white male rats weighing 200-350 g. Partial critical intestinal ischemia was induced by thorough atraumatic strangulation of 5-6 cm jejunal loop with its mesentery for 90 rain. Global critical intestinal ischemia was made by atraumatic occlusion of the cranial mesenteric artery （CmA） for 90 rain also. Perftoran （PF, 0.8-1.0 mL per 100 g） in experimental groups or 0.9% sodium chloride in control groups was injected at 75 rain of ischemic period. mean systemic arterial blood pressure （BPm） registration, intravital microscopy and morphological examination of ischemic intestine and its mesentery were performed in both groups. RESULTS： During 90 min of reperfusion, BPm progressively decreased to 27.3±7.4% after PF administration vs 38.6±8.0% in the control group of rats with partial intestinal ischemia （NS） and to 50.3±6.9% vs 53.1±5.8% in rats after global ischemia （NS）. During the reperfusion period, full restoration of microcirculation was never registered; parts with restored blood flow had leukocyte and erythrocyte stasis and intra-vascular clotting, a typical ＂non-reflow＂phenomenon. The reduction of mesenteric 50-400 μm feeding artery diameter was significantly less in the PF group than in the control group （24±5.5% vs 45.2±3.6%, P〈0.05） 5 min after partial intestinal ischemia. This decrease progressed but differences between groups minimized at the 90th min of reperfusion （41.5±4.2% and 50.3±2.8%, respectively）. In reperfusion of rat＇s intestine, a significant mucosal alteration was registered. Villous height decreased 2.5-3 times and the quantity of crypts decreased more than twice. In the group of rats administered PF, intestinal mucosal layer was protected from irreversible post-ischemic derangement during reperfusion. Saved cryptal epithelial cells were the source of regeneration of the epithelium

关键词： Rats Ischemia-reperfusion injury Gut Intestine Perfluorocarbon emulsions

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Static loading and vertical displacement at southern Siberia

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Geodesy and Geodynamics 2017年第3期8卷 160-168页

作者： Anton V.Timofeev dmitriy G.Ardyukov Vladimir Yu.Timofeev trofimuk Institute of Petroleum Geology and Geophysics of Siberian Branch Russian Academy of Sciences 630090 Russia

Seismic method is usually used for elastic parametric estimation. This is why this method presents dynamic parameters of Earth. Frequency seismic range changes greatly from geodynamic modelling time. Now we have opportunity to use geodesy result for some years for elastic parameters estimation. Static solution from elastic theory may be used for the interpretation of long term results. It presents static elastic parameter. The inverse problem for different types of vertical surface loading on one year period is calculated. Two cases of loading with maximal and minimal area are presented. Results are determined by space geodesy and leveling methods. Current relation between atmospheric pressure and vertical displacements was estimated at the center of Siberian Anti Cyclone with size varied from 2000 km to 3000 kin. Pressure-displacement coefficients （PDC） can be achieved by three years obser- vation （0.997 mm/mbar for NVSK GPS station）. It is used for elastic module study of geology medium with maximum thickness up to 600 km. In the context of elastic model, the modulus of rigidity is estimated to be 113 GPa. Vast expanse of anti-cyclone may relate with rheology of crust and upper mantle. Smaller size of surface loading - local loading is seasonal variation of water reservoir. Annual vertical changes were obtained by leveling near the dam of the reservoir. PDC ratio was 1.15 mm/bar for these places. In elastic theory, the Young modulus E = 80 GPa （Poisson ratio = 0.25, the modulus of rigidity - 32 GPa） was calculated by sixteen years of leveling measurements. This result can effectively be represented for upper crust. Our results were checked by solution for coseismic displacement of Chyia- Altai earthquake （Sep. 27, 2003, m = 7.3）. Coseismic results calculated by static modules agree with experimental coseismic GPS data at 10% level.

关键词： Static loading Vertical annual subsidence Space geodesy and leveling method Barometry Elastic modules Earthquake

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Investigation of mechanism and Kinetics of magnesium Oxide Chlorination Based on the ＂method of Separated Reagents＂

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材料科学与工程（中英文A版） 2012年第3期2卷 367-371页

作者： Sergey m. Lupinos dmitriy V. Prutskov State Titanium Research and Design Institute 180 Lenin av. Zaporozhye 69035 Ukraine

For express analysis of mechanism and kinetics of heterogeneous processes involving the interaction of two or more solid reagents, the "method of separated reagents" has been developed. Based on this method a process of magnesite (magnesium oxide) chlorination has been analyzed. It was found that the chlorination processes can be conducted with various rates in several stages and maximum rate of the chlorination process can be attained at the initial stage of the solid reductant gasification in the reactor and subsequent using of carbon oxide as oxygen acceptor. The resulting information on the mechanism and kinetics of the chlorination process enabled the upgrading of the process, its intensification and improvement of reactor productivity by 3 times.

关键词：动力学分析氯化过程氧化镁试剂分离机制相互作用消毒过程

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CATALYTIC PROPERTIES OF NANOFIBROUS CARBON IN SELECTIVE OXIDATION OF HYDROGEN SULPHIDE

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China Particuology 2006年第2期4卷 70-72页

作者： Gennady G. Kuvshinov Vasiliy V. Shinkarev Alexey m. Glushenkov maxim N. Boyko dmitriy G. Kuvshinov Department of Chemical Engineering Novosibirsk State Technical University Pr.Karla Marksa 20 Novosibirsk Russia Group of catalytic technologies of carbon materials synthesis Boreskov Institute of Catalysis Pr.Akademika Lavrentieva 5 Novosibirsk Russia

Nanofibrous carbonaceous materials （NFC） as a new class of materials having many applications, can catalyze the selective oxidation of H2S to sulfur. The correlation between NFC structure and its activity and selectivity in H2S oxidation was determined. It is demonstrated that selectivity can be improved if NFC with more ordered structure be synthesized and the portion of the original catalyst in carbon be reduced by increasing the carbon accumulated in the catalyst.

关键词： nanostructure carbon nanofiber carbon nanotubes carbon yield selective oxidation of the hydrogen sulfide oxygen excess

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The Detection of Partial Albinism at Three Species of Bats (mammalia: Chiroptera) in European Part of Russia

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Open Journal of Animal Sciences 2014年第5期4卷 291-296页

作者： dmitriy G. Smirnov Vladimir P. Vekhnik Nailya m. Kurmaeva Farid Z. Baishev Department of Zoology and Ecology Penza State University Penza Russia Zhiguli Preserve p/o Bakhilova Polyana Samara Region Russia

The first time for the territory of European Russia describes the cases of catching bats with signs of albinism. This article describes the detection of three species of bats with partial albinism in European part of Russia. There are four animal units of Eptesicus serotinus turcomanus that are stored in Penza State University. They were procured in Astrahan region in 1992 and in 1996. One more animal was found in Volgograd region in 2004. All these animals have white spots of different size and shape on their abdominal part of body. In 2012 it was caught a young female of Pipistrellus nathusii in Samarskaya Luka (Samara region) and in 2013 the scientists found a mature female of myotis mystacinus. Both animals had a light-colored fur, red eyes and with almost white ears. moreover, they had pale-pink noses and extremities.

关键词： Partial Albinism Eptesicus serotinus Pipistrellus nathusii myotis mystacinus

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