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Asian pacific Journal of Reproduction 2017年第5期6卷 212-216页

作者： Irfan Yunianto nurul Ain Kamar Bashah Mahanem Mat Noor School of Biosciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 Bangi SelangorMalaysia

Objective:To investigate the antifertility properties ofCentella asiatica L. ethanolic extract and identify the sperm proteomic changes in treated male ***: A total of 32 male Sprague-Dawley rats were divided into two groups: control group (n=16) received distilled water and treatment group (n=16) which received 300 mg/kg ofCentella asiatica L. extract for 42 d. After the treatment period, the number of implantation sites was recorded and the sperm proteomic changes were analysed by 2D gel electrophoresis. In addition, the expression of protein spots was quantified by MALDI-TOF ***:Centella asiatica L. extract resulted in low number of implantation sites in the treatment group (100.00±2.82) compared to the control group (183.00±2.14). The percentage of infertile male rats in the treatment group was higher (43.75%) compared to the control group (18.75%). Proteomic analysis showed the expression of protein spots identified in the treatment group decreased with 234 spots compared to the control group with 282 ***:The results revealed that there was antifertility activity in the male rats with the administration ofCentella asiatica L. ethanol extract and the identified proteins could provide understanding on the adverse effect ofCentella asiaticain male reproductive system.

关键词： Centella asiatica L Antifertility MALDI-TOF Sperm proteomic

Biological and Functional Properties of Wedelolactone in Human Chronic Diseases

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Phyton-International Journal of Experimental Botany 2021年第1期90卷 1-15页

作者： Ramachandran Vinyagam Pradeep Kumar Kyung Eun Lee Baojun Xu Muhammad nurul Matin Sang Gu Kang Department of Biotechnology Institute of BiotechnologyCollege of Life and Applied ScienceYeungnam UniversityGyeongsanGyeongbuk38541Korea Department of Forestry North Eastern Regional Institute of Science and TechnologyNirjuli791109India Stemforce 313 Institute of Industrial TechnologyYeungnam UniversityGyeongsanGyeongbuk38541Korea Food Science and Technology Program Beijing Normal University-Hong Kong Baptist UniversityUnited International CollegeZhuhai519000China Department of Genetic Engineering and Biotechnology University of RajshahiRajshahi6205Bangladesh

Medicinal herbs are well known and studied over the past millennia in most of the developing countries as a rational means of treatment against various diseases and ***(WDL),a major bioactive compound in Eclipta prostrata L(Eclipta alba L),has been reported with potential benefits in human health against chronic ***,a comprehensive study on WDL pharmacological benefits in various ailments,to the best of our knowledge,is not yet ***,the present review provides the recent therapeutic applications in reference to biological and functional activities against major human chronic diseases,including cardiovascular,cancer,diabetes mellitus,liver disease,Alzheimer’s disease,and androgenetic *** this study,we collected all the relevant experimental information on WDL from Scientific databases such as PubMed,Web of Science,Science Direct,and Google ***,WDL is recognized as a key anti-oxidant with both specific regulator and inhibitor of major drug targetable proteins in human chronic diseases and ***,WDL as a novel therapeutic bioactive molecule is advised to explore further for relevant pharmacological activities.

关键词： Wedelolactone Eclipta alba L Ecliptaprostrata L bioactivity bioavailability

MELex: The Construction of Malay-English Sentiment Lexicon

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Computers, Materials & Continua 2022年第4期71卷 1789-1805页

作者： nurul Husna Mahadzir Mohd Faizal Omar Mohd Nasrun Mohd Nawi Anas ASalameh Kasmaruddin Che Hussin Abid Sohail Faculty of Computer and Mathematical Sciences Universiti Teknologi MARA(UiTM)Kedah08400MerbokKedahMalaysia Department of Decision Sciences School of Quantitative SciencesUniversiti Utara Malaysia06010KedahMalaysia Disaster Management of Institute School of Technology Management and LogisticUniversiti Utara Malaysia06010KedahMalaysia Department of Management Information System College of Business AdministrationPrince Sattam Bin Abdulaziz University165Al-KharjSaudi Arabia Faculty of Entrepreneurship and Business Universiti Malaysia KelantanMalaysia Department of Computer Science COMSATS University IslamabadLahorePakistan

Currently,the sentiment analysis research in the Malaysian context lacks in terms of the availability of the sentiment ***,this issue is addressed in this paper in order to enhance the accuracy of sentiment *** this study,a new lexicon for sentiment analysis is constructed.A detailed review of existing approaches has been conducted,and a new bilingual sentiment lexicon known as MELex(Malay-English Lexicon)has been *** MELex involves three activities:seed words selection,polarity assignment,and synonym *** approach differs from previous works in that MELex can analyze text for the two most widely used languages in Malaysia,Malay,and English,with the accuracy achieved,is 90%.It is evaluated based on the experimentation and case study approaches where the affordable housing projects in Malaysia are selected as case *** finding has given an implication on the ability of MELex to analyze public sentiments in the Malaysian *** novel aspects of this paper are ***,it introduces the new technique in assigning the polarity score,and second,it improves the performance over the classification of mixed language content.

关键词： Machine learning data sciences artificial intelligence opinion mining sentiment analysis sentiment lexicon lexicon-based bilingual lexicon

Metabolomics for characterization of gender differences in patients infected with dengue virus

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Asian Pacific Journal of Tropical Medicine 2015年第6期8卷 452-457页

作者： nurul Shahfiza Hasnah Osman Tang T.Hock Khozirah Shaari Abdel-Hamid Z Abdel-Hamid Advanced Medical and Dental Institute University Science Malaysia School of Chemical Sciences University Science Malaysia Laboratory of Natural Products Institute of BioscienceUniversiti Putra Malaysia National Research Centre CairoEgypt

Objective:To determine the metabolic response associate with dengue infection based on human gender metabolic differences by means of ~1H ***:The mid-stream urine collected from both male and female patients diagnosed with dengue fever at Penang General Hospital and fourty-three healthy individuals were analyzed with^1H NMR spectroscopy,followed by chemometric multivariate *** signals which highlighted in the OPLS-DA S-plot were further selected and identified using Human Metabolome Database,Chenonix ***:The results pointed out that NMR urine profiling was able to capture human gender metabolic differences that are important for the distinction of classes of individuals of similar physiological conditions;infected with *** differences between dengue infected patients versus healthy individuals and subtle differences in male versus female infected with dengue were found to be related to the metabolism of amino acid and tricarboxylic acid intermediates ***:The ~1H NMR metabolomic investigation combined with appropriate algorithms and pattern recognition procedures,gave an evidence for the existence of distinct metabolic differentiation of individuals,according to their gender,modulates with the infection risk.

关键词： Metabolomics Dengue infection NMR-Spectroscopy

Mechanical characteristics of oil palm fiber reinforced thermoplastics as filament for fused deposition modeling(FDM)

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Advances in Manufacturing 2020年第1期8卷 72-81页

作者： Mohd Nazri Ahmad Mohammad Khalid Wahid nurul Ain Maidin Mohd Hidayat Ab Rahman Mohd Hairizal Osman Izzati Fatin Alis@Elias Faculty of Mechanical and Manufacturing Engineering Technology Universiti Teknikal Malaysia Melaka.Hang Tuah JayaDurian Tunggal 76100MelakaMalaysia Centre for Smart System and Innovative Design Universiti Teknikal Malaysia MelakaHang Tuah JayaDurian Tunggal 76100MelakaMalaysia

Fibers are increasingly in demand for a wide range of polymer composite *** study^purpose was the development of oil palm fiber(OPF)mixed with the thermoplastic material acrylonitrile butadiene styrene(ABS)as a composite filament for fused deposition modeling(FDM).The mechanical properties of this composite filament were then *** is a fiber extracted from empty fruit bunches,which has proved to be an excellent raw material for *** cellulose content of OPF is 43%-65%,and the lignin content is 13%-25%.The composite lilament consists of OPF(5%,mass fraction)in the ABS *** fabrication procedure included alkalinizing,drying,and crushing the OPF to develop the *** OPF/ABS materials were prepared and completely blended to acquire a mix of 250 g of the material for the ***,the FLD25 filament extrusion machine was used to form the OPF/ABS composite into a *** composite filament then was used in an FDM-based 3D printer to print the ***,the printed specimens were tested for mechanical properties such as tensile and flexural *** results show that the presence of OPF had increased the tensile strength and modulus elasticity by approximately 1.9%and 1.05%,***,the flexural strength of the OPF/ABS composite had decreased by 90.6%compared with the virgin ***,the most significant outcome of the OPF/ABS composite was its suitability for printing using the FDM method.

关键词： Natural fibers Oil palm fiber(OPF) Fused deposition modeling(FDM) 3D printer Composite filament

Antimicrobial effect of Malaysian vegetables against enteric bacteria

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Asian Pacific Journal of Tropical Biomedicine 2016年第3期6卷 211-215页

作者： Hassanain Al-Talib Norliana Dalila Mohamad Ali Mohamed Harreez Suhaimi Siti Shafika Nabila Rosli nurul Huda Othman Nur Ain Sakinah Mansor Amira Kartini Sulaiman Shah nurul Syuhada Ariffin Alyaa Al-Khateeb Laboratory Medical Science Cluster Faculty of Medicine Universiti Teknologi MARA (UiTM) Faculty of Medicine Universiti Teknologi MARA (UiTM)

Objective: To investigate the antibacterial activities of green vegetables(pennywort,mint, garlic, parsley and celery) against four common enteric bacteria [Salmonella enterica(ATCC 25957)(S. enterica), Shigella flexneri(ATCC 12022)(S. flexneri),Escherichia coli(ATCC 43889)(E. coli) and Enterobacter cloacae(ATCC 13047)(E. cloacae)] as an alternative medicine for controlling food borne diarrhea disease and the synergistic effect of green vegetables against those ***: Five common vegetables(pennywort, mint, garlic, parsley and celery) were purchased and extracted. The antimicrobial activities of these extracts were tested against four common enteric bacteria(S. enterica, S. flexneri, E. coli and E. cloacae). Ten different concentrations of the extracts(from 640 to 1.25 mg/m L) were prepared and used for the study. The minimal inhibitory concentration(MIC) was determined by the broth dilution method. The antimicrobial activities were assessed by using both well diffusion and disc diffusion ***: Garlic extract showed excellent inhibitory effects on all enteric bacteria. Other plants(parsley, celery, mint and pennywort) were not effective against enteric *** MIC of garlic against S. flexneri and E. cloacae was 40 mg/m L. The MIC of S. enterica and E. coli were 20 and 10 mg/m L, respectively. The performance of the well diffusion method was better than that of the disc diffusion method with clear and sharp inhibition zones of tested bacteria against plant ***: Garlic had excellent antimicrobial effects against enteric bacteria and was recommended to be given to patients with gastroenteritis. The other vegetables(pennywort, mint, parsley and celery) showed no inhibitory effects on enteric bacteria but still can be used for its richness in vitamins and fibers. The performance of the well diffusion method was better than that of the disc diffusion method in detecting the antibacterial effects of green vegetables.

关键词： Antibacterial activities Green vegetables Enteric bacteria Inhibitory effects

Visual efficiency among teenaged athletes and non-athletes

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International Journal of Ophthalmology(English edition) 2017年第9期10卷 1460-1464页

作者： Rokiah Omar Yau Meng Kuan nurul Atikah Zuhairi Faudziah Abd Manan Victor Feizal Knight Optometry&Vision Science Program School of HealthcareSciencesFaculty of Health SciencesUniversity Kebangsaan MalaysiaJalan Raja Muda Abdul AzizKuala Lurnpur 50300Malaysia Department of Optometry&Vision Science Kulliyyah of Allied Health SciencesInternational Islamic University MalaysiaBandar Indera MahkotaKuantan 25200PahangMalaysia Faculty of Medicine and Defence Health National Defence University of MalaysiaSungai Besi CampKuala Lumpur 57000Malaysia

AIM：To compare visual efficiency,specifically accommodation,vergence,and oculomotor functions among athletes and ***：A cross-sectional study on sports vision screening was used to evaluate the visual skills of 214elementary students（107 athletes,107 non-athletes）,aged between 13 and *** visual screening assessed visual parameters such as ocular motor alignment,accommodation,and vergence ***：Mean visual parameters were compared between age-group matched athletes（mean age14.82±0.98y）and non-athletes（mean age 15.00±1.04y）.The refractive errors of all participants were corrected to maximal attainable best corrected visual acuity of log *** function assessment evaluated amplitude of accommodation and accommodation *** functions measured the near point of convergence,vergence facility,and distance fusional vergence at break and recovery *** motor alignment was not statistically significant between both *** had a statistically significant amplitude of accommodation for both the right eye（t=2.30,P=0.02）and the left eye（t=1.99,P=0.05）.Conversely,non-athletes had better accommodation facility（t=-2.54,P=0.01）and nearpoint of convergence（t=4.39,P〈0.001）when compared to *** facility was found to be better among athletes（t=2.47,P=0.01）.Nevertheless,non-athletes were significantly better for both distance negative and positive fusional ***：Although the findings are still inconclusive as to whether athletes had superior visual skills as compared to non-athletes,it remains important to identify and elucidate the key visual skills needed by athletes in order for them to achieve higher performance in their sports.

关键词： accommodation phoria vergence athletes non-athletes sports

The coastal medicinal plant Vitex rotundifolia: a mini-review on its bioactive compounds and pharmacological activity

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Traditional Medicine Research 2021年第2期6卷 1-10页

作者： nurul Husna Azizul Wan Amir Nizam Wan Ahmad nurul Laili Rosli Muhammad Aniq Hamzah Mohd Azmi Choo En Liang Noor Wini Mazlan Suvik Assaw Biomedicine Program School of Health SciencesUniversiti Sains MalaysiaKubang Kerian 16150KelantanMalaysia Faculty of Science and Marine Environment Universiti Malaysia TerengganuKuala Nerus 21030TerengganuMalaysia

Humans have long used natural remedies like plants and herbs to treat ***,research has been ongoing to find alternative pharmaceutical drugs based on traditionally used plants,as natural products show fewer side effects compared to synthetic *** plants have long been targeted in drug development due to their bioactive compounds like alkaloids,flavonoids,and *** is not only the case for terrestrial plants,but marine environments also provide a larger diversity of flora and fauna with medicinal bioactive *** rotundifolia,also known as Beach Vitex,is a coastal plant that has been traditionally used to treat a variety of diseases including premenstrual syndrome,headaches,migraines,colds,and eye *** have been many review papers on ***,emphasizing its taxonomy,distribution,and biological *** current mini-review not only summarizes the pharmacology and bioactivity of ***,but it also provides new information on the main bioactive compounds of *** such as flavonoids,phenolic acid,and terpenes and their current pharmacological activity in vitro and in vivo *** information can be useful for developing new pharmaceutical and nutraceutical agents to treat and manage disease.

关键词： Vitex rotundifolia Fructus viticis Marine plants Anti-inflammation Anti-nociception Antioxidant

Assessment of the stiffened panel performance in the OTEC seawater tank design:Parametric study and sensitivity analysis

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Theoretical & Applied Mechanics Letters 2023年第4期13卷 261-271页

作者： Yogie Muhammad Lutfi Ristiyanto Adiputra Aditya Rio Prabowo Tomoaki Utsunomiya Erwandi Erwandi nurul Muhayat Department of Mechanical Engineering Universitas Sebelas MaretSurakarta 57126Indonesia Research Center for Hydrodynamics Technology National Research and Innovation Agency(BRIN)Surabaya 60117Indonesia Department of Marine Systems Engineering Kyushu UniversityFukuoka 819-0395Japan

Ocean thermal energy conversion(OTEC)is a process of generating electricity by exploiting the temperature difference between warm surface seawater and cold deep *** to the high static and dynamic pressures that are caused by seawater circulation,the stiffened panel that constitutes a seawater tank may undergo a reduction in ultimate *** current paper investigates the design of stiffening systems for OTEC seawater tanks by examining the effects of stiffening parameters such as stiffener sizes and span-over-bay ratio for the applied combined loadings of lateral and transverse pressure by fluid motion and axial compression due to global bending *** ultimate strength calculation was conducted by using the non-linear finite element method via the commercial software known as *** stress and deformation distribution due to pressure loads was computed in the first step and then brought to the second step,in which the axial compression was *** effects of pressure on the ultimate strength of the stiffener were investigated for representative stiffened panels,and the significance of the stiffener parameters was assessed by using the sensitivity analysis *** a result,the ultimate strength was reduced by approximately 1.5%for the span-over-bay ratio of 3 and by 7%for the span-over-bay ratio of 6.

关键词： Ocean thermal energy conversion(OTEC) Seawater tank Stiffened panels Numerical analysis Combined loadings

Keladi candik(Alocasia longiloba Miq.) petiole extracts promote wound healing in a full thickness excision wound model in rats

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Asian Pacific Journal of Tropical Biomedicine 2019年第4期9卷 140-149页

作者： nurul Hazirah Che Hamzah Arifullah Mohammed KNS Sirajudeen Mohd Asnizam Asari Zulhazman Hamzah Ibrahim Khalivulla Shaik Faculty of Agro-Based Industry Universiti Malaysia Kelantan Department of Chemical Pathology School of Medical Sciences Universiti Sains Malaysia Department of Anatomy School of Medical Sciences Universiti Sains Malaysia Faculty of Sains Bumi Universiti Malaysia Kelantan Faculty of Pharmaceutical Sciences UCSI University

Objective: To investigate the wound-healing effect of Alocasia longiloba(A. longiloba) petiole extract on wounds in ***: Twenty-two male Sprague-dawley rats were randomly assigned to receive 10% solcoseryl gel, phosphate buffer saline, 50% ethanol, 95% ethanol and hexane extracts of A. longiloba at 1.5%, 3% and 6% doses, respectively. A full thicknesses wound(6 mm) was created on the dorsal of the rat; and all rats were applied with the extract solutions, 10% solcoseryl gel and phosphate buffer saline once a day topically until day 12. The wound was photographed on day 1, 6 and 12, and the percentage of wound contraction was calculated. On day 12, rats were sacrificed and histological examination of granulation tissue was carried out using haematoxylin & eosin and Masson's Trichrome stain to determine the wound healing ***: In this study, 6% of 50% and 95% ethanol extracts of A. longiloba showed 82.50% and 82.32% wound contraction, respectively, and were comparable with 10% solcoseryl gel(82.30%). Meanwhile, phosphate buffer saline treated group showed the lowest wound contraction(69.86%). Histological assessment of wound treated with 6% of 95% ethanol extract of A. longiloba showed distinct epidermal and dermal layer, higher proliferation of fibroblast and more angiogenesis with collagen compared to other wound treated ***: A. longiloba petiole extracts have a wound healing potential and 6% of 95% ethanol extract of A. longiloba is more effective. Further studies are required to understand the wound healing mechanism of action of the extract.

关键词： Full thickness excision wound Rat model Sprague-dawley rat Alocasia longiloba petiole extract