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Chinese Journal of Natural Medicines 2014年第11期12卷 819-826页

作者： Hiren M.Chawda divyesh r.mandavia Pravin H.Parmar Seema N.Baxi Chandrabhanu r.Tripathi Pacific Medical College & Hospital Udaipur Rajasthan India Government Medical College Bhavnagar-364001 Gujarat India Analytical Chemistry Division Department of Chemistry Maharaja Krishnakumarsinhji Bhavnagar University Bhavnagar 364002 India

Lipid-lowering and antioxidant activities of a hydroalcoholic extract of Cyperus scariosus Linn. root(HCS) were evaluated in guinea pigs fed with a high cholesterol diet. Serum lipid profile(total cholesterol, triglycerides, LDL-C, VLDL-C, and HDL-C), atherogenic indices and serum enzymes(ALT, AST, ALP, LDH, and CK-MB) were performed in each group at 0 days and at the end of 60 days. Histological study of liver and kidney was done in groups 1, 2, 5, 6 and 7. The total phenolic and flavonoid content in HCS and its antioxidant activity were evaluated by the DPPH assay. Both doses of HCS decreased serum lipid profile and atherogenic indices(P ring, immunosuppressive and antioxidant properties, and mays have value in atherosclerosis prevention. The higher dose of HCS also reduced serum AST, ALP, and LDH levels and rosuvastatin increased AST and ALP levels(P r showed decreased lipid accumulation and improvement in hepatocytes in HCStreated animals. The antioxidant activity of HCS may be responsible for its lipid lowering and cytoprotective action. HCS had significant lipid lowering and antioxidant activity, which; may be due to the phenolic compounds. HCS may be a safe and cost effective alternative to current statin therapy for patients with dyslipidaemia.

关键词： Antioxidant activity Cyperus scariosus Dyslipidemia Statin

Dry/wet snow mapping based on the synergistic use of dual polarimetric SAr and multispectral data

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Journal of Mountain Science 2019年第6期16卷 1435-1451页

作者： divyesh VArADE Onkar DIKSHIT Surendar MANICKAM Geoinformatics Department of Civil EngineeringIndian Institute of Technology KanpurKalyanpurKanpur-208016India Department of Civil and Environmental Engineering Duke UniversityDurhamNC-27708-028USA

We propose a multi-sensor multi-spectral and bi-temporal dual-polarimetric Synthetic Aperture radar(SAr) data integration scheme for dry/wet snow mapping using Sentinel-2 and Sentinel-1 data which are freely available to the research community. The integration is carried out by incorporating the information retrieved from ratio images of the conventional method for wet snow mapping and the multispectral data in two different frameworks. Firstly, a simple differencing scheme is employed for dry/wet snow mapping, where the snow cover area is derived using the Normalized Differenced Snow Index(NDSI). In the second framework, the ratio images are stacked with the multispectral bands and this stack is used for supervised and unsupervised classification using support vector machines for dry/wet snow mapping. We also investigate the potential of a state of the art backscatter model for the identification of dry/wet snow using Sentinel-1 data. The results are validated using a reference map derived from rADArSAT-2 full polarimetric SAr data. A good agreement was observed between the results and the reference data with an overall accuracy greater than 0.78 for the different blending techniques examined. For all the proposed frameworks, the wet snow was better identified. The coefficient of determination between the snow wetness derived from the backscatter model and the reference based on rADArSAT-2 data was observed to be 0.58 with a significantly higher root mean square error of 1.03 % by volume.

关键词： Snow mapping ratio method Normalized Differenced Snow Index Classification Polarimetric synthetic-aperture radar

Synthesis and in vitro antimicrobial screening of new pyrano[4,3-b]pyrane derivatives of 1H-pyrazole

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Chinese Chemical Letters 2012年第1期23卷 57-60页

作者： Chetan B.Sangani divyesh C.Mungra Manish P.Patel ranjan G.Patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

A new series of pyrano[4,3-b]pyrane 4a-l bearing 1H-pyrazole has been synthesized by one pot base catalyzed cyclocondensation reaction of 1H-pyrazole-4-carbaldehyde la-1,malononitrile 2 and 4-hydroxy-6-methylpyrone *** the synthesized compounds were screened against six bacterial pathogens,namely ***,***,***,***,***, *** and antifungal activity against,two fungal pathogens,*** and *** using broth microdilution MIC method. Some of the compounds are found to be equipotent or more potent than that of commercial drugs,against most of employed strains.

关键词： Pyranopyrane MCr Pyrazole-4-carbaldehyde Antimicrobial activity

Microwave assisted synthesis of novel Hantzsch 1,4-dihydropyridines,acridine-1,8-diones and polyhydroquinolines bearing the tetrazolo[1,5-α]quinoline moiety and their antimicrobial activity assess

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Chinese Chemical Letters 2011年第12期22卷 1407-1410页

作者： Niraj K.Ladani divyesh C.Mungra Manish P.Patel ranjan G.Patel Department of Chemistry Sardar Patel UniversityVallabh Vidyanagar 388120GujaratIndia

Microwave assisted efficient Hantzsch reaction via four-component coupling reactions of tetrazolo[1,5-α]quinoline-4-carbal-dehyde, dimedone/cyclohexane-1,3-dione,ethyl/methyl acetoacetate and ammonium acetate was described as the preparation of tetrazolo[1,5-α]quinoline based 1,4-dihydropyridines,acridine-1,8-diones and *** process presented here is simple,rapid,environmentally welcoming and high *** the derivatives were subjected to an in vitro antimicrobial screening against a representative panel of bacteria and fungi and results worth further investigations.

关键词： Microwave assisted Tetrazolo[1 5-α]quinoline 1 4-Dihydropyridine Acridine-1 8-dione Polyhydroquinoline Antimicrobial activity

Molecular iodine catalyzed synthesis of tetrazolo[1,5-a]-quinoline based imidazoles as a new class of antimicrobial and antituberculosis agents

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Chinese Chemical Letters 2012年第12期23卷 1367-1370页

作者： divyesh C.Mungra Harshad G.Kathrotiya Niraj K.Ladani Manish P.Patel ranjan G.Patel Department of Chemistry Sardar Patel University

A series of some new tetrazolo[1,5-a]quinoline based tetrasubstituted imidazole derivatives 6a-i have been synthesized by a reaction of tetrazolo[ 1,5-a]quinoline-4-carbaldehyde 3a-d, benzil 4, aromatic amine 5a--c and ammonium acetate in the presence of iodine through one-pot multi-component reaction （MCr） approach. All the derivatives were screened for antimicrobial and antituberculosis activities and results worth further investigations.

关键词： Tetrazolo[1,5-a]quinoline Imidazole MCr Iodine Antimicrobial activity Antituberculosis activity

Laparoscopic Hemi-Hysterectomy-retrospective Study of Case Series of over 9 Years

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 845-866页

作者： divyesh V. Shukla Shilpi D. Shukla Amit Shah Isha Hospital Sarabhai Campus Vadodara India

Background: Word hemi-hysterectomy and removal of rudimentary functional horn may be used interchangeably in published data. The same term may be used when a non-obstructive hemi-uterus is removed when there is an associated pathology. The article tries to standardise classification of Mullerian dysgenesis where this procedure is required according to ESHrE ESGE classification, preoperative diagnosis and discuss the operative details. Objective: The objective was to study the demographic profile, symptoms, association of endometriosis, variation in the anatomy, accuracy of preoperative diagnosis, to classify according to ESHrE ESGE classification and to standardize the laparoscopic surgical steps of hemi-hysterectomy. Study Design: This is a retrospective case series of cases of Mullerian dysgenesis with obstructive hemi-uterus or non-obstructive hemi-uterus with pathology treated by laparoscopic hemi-hysterectomy. (Canadian task force classification III). Methods: Data from hospital electronic records of all cases tagged with word laparoscopic hemi-hysterectomy were collected for 9 years from Jan 2009 to Dec 2018. results: Total 19 patients of hemi-hysterectomy were analysed. Pre-operative diagnosis was made in 100% of patients. 100% patients with obstructive horn had dysmenorrhoea. ESHrE ESGE class U4aC3V0 was more frequently seen followed by U5aC4V4 and U3bC3V2 as obstructive and U4bC3V0, as non-obstructive. Associated endometriosis along with other pathology was seen in 74% of the patients. 3 patients with HWWS had ipsilateral renal agenesis. Laparoscopic hemi-hysterectomy was offered to all such patients. The operative steps & variants were studied. Post-operative outcome was uneventful in all. Conclusion: An experienced surgeon should deal with these problems of Mullerian dysgenesis discussed in this study. The other variants diagnosed also must be treated by an experienced surgeon only. Laparoscopic hemi-hysterectomy is almost the most standard surgical metho

关键词： Hemi-Hysterectomy Mullerian Dysgenesis rudimentary Non-Communicating Horns ESHrE ESGE Unicornuate Uterus

Can Incarceration of Uterus between 14 - 17 Wks. Be Managed by General Anaesthesia Only? A Second reported Case

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Open Journal of Obstetrics and Gynecology 2018年第8期8卷 720-727页

作者： divyesh V. Shukla Shilpi D. Shukla Amit Shah Yesha Choksi Isha Hospital Sarabhai Campus Vadodara India

This is a case of primigravida of 35 years of age having spontaneous conception & 14.5 wks. pregnancy with retention of urine and pain in lower abdomen for 5 days. There was history of unsuccessful attempt of correction of retroversion one day prior. Transabdominal USG (ultrasonography) confirmed 14.5 wks. live pregnancy with incarceration of uterus. In this case, only GA (general anaesthesia) corrected retroversion & incarceration.

关键词： Incarceration USG GA retention of Urine 14 - 20 Wks. Pregnancy

Prospective Assessment of Direction of Cervical Canal in routine Hysteroscopy

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Open Journal of Obstetrics and Gynecology 2021年第6期11卷 660-673页

作者： divyesh V. Shukla Shilpi D. Shukla Sangita Patel Amit Shah Department of Obg/Gyn and Minimal Access Surgery Isha Hospital Sarabhai Campus Opposite Atlantis Mall Vadodara India Department of PSM Govt Medical College Baroda Vadodara India Isha Hospital Vadodara India

Introduction: If the direction of the cervical canal is known, the commonly performed procedures as sono salpingography, embryo transfer, IUD insertion, cervical dilation etc. will be easier. The reported resultant trauma to the cervical canal and uterus during these procedures also can be avoided. As we know the cervical canal is tortuous in majority of cases, but the exact course is not yet reported or known. Objective: The objective of the present study was to try to identify the various directions of cervical canal while performing routine hysteroscopic surgeries. Methods:rdana;">rdana;">rdana;"> Four-point cervical canal direction was assessed while performing routine hysteroscopic procedures using 5fr Bettocchi operative assembly with 2.9 mm 12-degree telescope (Karl-Storz). The study group was patients with infertility who required

关键词： Cervical Canal Direction 5 fr Bettocchi Hysteroscope Down right Up Straight

Changing Trends in rate of Cervical Dilation in First Stage of Labor: Prospective Longitudinal Study

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Open Journal of Obstetrics and Gynecology 2020年第9期10卷 1176-1186页

作者： divyesh V. Shukla Shilpi D. Shukla Sangita Patel Amit Shah Isha Hospital Vadodara India Department of PSM Medical College Baroda Vadodara India

Introduction: Knowledge of change in the duration of stages of labour would be an essential step to reduce the increasing rates of cesarean section reported worldwide. Objective: To study the rate of cervical dilation in the 1st stage of labour in spontaneous and induced labour and in primigravida and multigravida with singleton pregnancy. Methods: A prospective observational study conducted at a multispeciality hospital was carried out for a period of 3 years from Jan 2017 to Dec 2019. A total of 640 patients who were admitted with spontaneous and induced labour having singleton pregnancy with cephalic presentation and intact membranes after 34 weeks who delivered vaginally were included for analysis. Progression of labor in the 1st stage of labour was measured by the rdana;">rate of cervical dilation as noted by serial per vaginal examination and findings were plotted in part

关键词： Cervical Dilatation Spontaneous Labour Induced Labour Active Phase of Labour

Prospective Interventional Study to Quantify Barbed Suture Exposure at Vaginal Vault and Assess Post-Operative risk

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Open Journal of Obstetrics and Gynecology 2020年第7期10卷 855-865页

作者： divyesh V. Shukla Shilpi D. Shukla Amit Shah Sangita Patel Vaidehi Nene Isha Hospital Vadodara India Department of PSM Medical College Baroda Vadodara India

Background: The use of barbed suture in laparoscopic surgery is increasing ever since 2008. Published reports of use of unidirectional barbed suture for vaginal vault closure following total laparoscopic hysterectomy ... 详细信息

rong>Background:rong> The use of barbed suture in laparoscopic surgery is increasing ever since 2008. Published reports of use of unidirectional barbed suture for vaginal vault closure following total laparoscopic hysterectomy (TLH), indicates it is safe. Despite of this many reports of adhesions and bowel obstruction are reported. This complication was never assessed in relation to amount of suture exposure at vaginal vault. We thought of quantifying the barbed suture exposure at vaginal vault and assess the risk of post-operative complications. Objective: The objective was to quantify the exposure of barbed suture at vaginal vault by adopting a uniform technique of vault suturing and assessing postoperative risk related to adhesions at vaginal vault. Method: In 30 patients who underwent TLH, a uniform new technique of vaginal vault closure using barbed suture was used and the portion of suture exposed at vaginal vault was quantified. The patients were followed up for a period of 6 months to assess post-operative risk of adhesions at vault and sequalae. Result: Mean length of suture exposed was 2.64 ± 1.65 mm only. Suture exposure at vaginal vault was seen in 23 (76.67%) out of 30 patients. The suture was exposed on average at 1.57 ± 1.20 places at vaginal vault. Conclusion and Recommendations:

关键词： Barbed Suture DS Suturing Technique Suture Exposure TLH Vaginal Vault Closure