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IL-1α、Bax、Bcl-2等基因mRNA在帕金森病小鼠模型中的表达

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汕头大学医学院学报 2003年第1期16卷 5-8,15页

作者：申延琴李康生 j.Arsaut E.Moze p.j.Neveu 汕头大学医学院微生物学与免疫学教研室广东汕头515031 InsERMU394 NeurobiologieIntegrative InstitutFranoisMagendie1RueCamilleSaintSens

目的 :探讨细胞因子IL 1α和IL 10与凋亡相关基因Bcl 2家族中Bax和Bcl 2在 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶(MpTp)致C5 7BL6j.鼠帕金森病模型中黑质和纹状体内的表达意义及关系。方法 :利用RT pCR的方法检测对照组 (ns组 )C5 7BL6... 详细信息

目的 :探讨细胞因子IL 1α和IL 10与凋亡相关基因Bcl 2家族中Bax和Bcl 2在 1 甲基 4 苯基 1,2 ,3,6 四氢吡啶(MpTp)致C5 7BL6j.鼠帕金森病模型中黑质和纹状体内的表达意义及关系。方法 :利用RT pCR的方法检测对照组 (ns组 )C5 7BL6j.鼠及皮下注射MpTp后第 6天C5 7BL6j.鼠的左右侧脑内黑质、纹状体、下丘脑内的IL 1α ,IL 10 ,Bax和Bcl 2的mRNA的表达。结果 :与对照组相比 ,IL 1αmRNA在帕金森小鼠模型纹状体内表达显著增加 ;除对照组 1只外 ,对照组和MpTp组均未检测到IL 10mRNA的表达 ;BaxmRNA和Bcl 2mRNA在黑质内的表达均显著低于对照组。结论 :黑质和纹状体在MpTp所致的小鼠帕金森病中受累 ,表现为有不同基因的消长。促进炎症发生的细胞因子IL

关键词： IL-1α Bax Bcl-2 基因mRNA 帕金森病小鼠模型表达

遗传性大疱性表皮松解症的眼部表现:美国本土大疱性表皮松解症登记处的结果

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 13-14页

作者：赵炜 Fine j.-D j.hnson L.B Weiner M Natl.Epidermolysis Bullosa R eg -istry Lexing tonKYUnited States.Dr.

purpose To determine the frequency o f ocular manifesta-tions in inherited epidermolysis bullosa(EB)within the continental United States and to define the estimated cu-mulative risks of developing nonscarring(blisters or ero-sions)and scarring corneal manifestation s within each maj.r EB subtype over *** Observational(cross-sectional and longitudinal).Methods Up to 16years of longitudinal follow-up was conducted on 3,280consec-utively enrolled patients in the National EB Registry,an epidemiologic study funded by the Na tional Institutes of *** were stratified by maj. r EB type and *** of occurrence were dete rmined for eight vari-ables(corneal erosions or blistering;corneal scarring;symblepharons;blepharitis;ectro pions;lacrimal duct ob-struction;impaired vision;blindn ess)by contingency ta-bles,and cumulative risks were generated by life table analysis *** The most common ocular manifestations were corneal erosio ns and ***-quencies mirrored relative severity of skin disease,with74.10%of all patients with recessiv e dystrophic EB,Hallopeau-Siemens(RDEB-HS )and 47.50%of all pa-tients with j.nctional EB,Herlitz(j.B-H)experiencing at least one *** frequencie s were noted for corneal *** and ectrop ions were most com-monly seen in inversa RDEB and j.B-H,*** was reported in 6.47%of RD EB-HS *** cumulative risks of nonscarring and scarring corneal lesions in j.B-H at age 5are 83.18%an d 27.08%and at age 25are 83.18%and 72.22%.With tim e,the cumu-lative risk of each in RDEB-HS approached that reported in j.B-H *** Ocular d isease activity,par-ticularly corneal,is common in some EB *** ophthalmologic examination should become an integral part of the management of all patients wit h inherited EB.

关键词：瘢痕化睑球粘连睑外翻角膜糜烂角膜病变泪小管累积危险度角膜瘢痕眼部病变瘢痕性

体外受精移植前应用预防性抗生素疗法(阿莫西林+克拉维酸)无益:随机研究结果

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世界核心医学期刊文摘（妇产科学分册） 2005年第5期1卷 61-62页

作者： peikrishvili R Evrard B pouly j.-L j.nny L 侯巍 Centre de Fecondation In-Vitro Polyclinique Philippe-Marcombes 13 boulevard Charles-de-G aulle 63033 Clermont-Ferrand France

Obj.ctives. We studied the implantation rate during IVF cycles according to th e prescription or not of antibiotics. Materials and methods. During a 5-month p eriod all the patients aged less than 38 years were randomized into two groups a ccording to an independent personal variable. In group 1 amoxicilline +clavuian ic acid 1g/125mg were administrated from the ovum pick-up day for 6 days. In th e group 2 no antibiotic treatment was administered. Results. The two groups were identical for all the criteria (type of stimulation, IVF/ICSI report, indicatio ns, average age). The average number of collected oocytes, obtained embryos and transferred embryos was similar in the two groups. The implantation rate per tra nsfer was similar in the two groups (36.9%versus 36.5%; p>0.95). The pregnancy loss rate (biological pregnancy, early and late miscarriages or extra uterine p regnancy) was increased in a non significant manner (p=0.15) in the group with a ntibiotic: 33.3%(16/48) versus 20.8%(11/53) in the group without antibiotic. C onclusion. This prospective randomised study leads us not to recommend this anti biotic prescription at the time of the embryo transfer during in vitro fertilisation attempt.

关键词：预防性抗生素体外受精随机研究克拉维酸着床率取卵卵母细胞显微注射流产率晚期流产

串联光伏电池非晶硅薄膜的Nd^(3+):YAG激光辅助掺杂与同时毛化(英文)

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光学精密工程 2011年第9期19卷 2263-2270页

作者： VASA N j.pALANI I A SINGApERUMAL OKADA Department of Engineering Design Indian Institute of Technology Madras Department of Mechanical Engineering Indian Institute of Technology Madras Graduate School of Information Science and Electrical Engineering Kyushu University

对结合激光辅助掺杂和毛化方法合成的光伏电池用Sb掺杂非晶硅薄膜进行了研究。首先,用阈值通量为460mj.cm2的激光照射镀有200～300nm厚Sb的非晶硅薄膜进行施主扩散。为激活施主,样品用230mj.cm2的低激光通量再一次进行处理。进行施主激... 详细信息

对结合激光辅助掺杂和毛化方法合成的光伏电池用Sb掺杂非晶硅薄膜进行了研究。首先,用阈值通量为460mj.cm2的激光照射镀有200～300nm厚Sb的非晶硅薄膜进行施主扩散。为激活施主,样品用230mj.cm2的低激光通量再一次进行处理。进行施主激光扩散和活化时,激光光斑的重叠度达到光斑大小的90%,因此随后诱发了薄膜表面的毛化。多晶毛化峰由扫描电子显微镜、喇曼光谱、原子力显微镜等多种表征手段进行了验证,处理后的样品其正面和背面的拉曼光谱均出现了521cm-1的晶体峰值。样品的n型特征得到了Hall效应测试的证实,同时证明了掺杂的有效性。表面毛化粗糙度达到450nm,并且观测到了光电导和吸收光谱的增强,这些均证实了样品光伏性质的改善。

关键词：激光辅助掺杂掺杂毛化 Sb 光伏电池 Nd3+∶YAG纳秒激光

在亚利桑那州西班牙裔人群中进行老年性黄斑变性的患病率调查:VER计划

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世界核心医学期刊文摘(眼科学分册) 2006年第3期 24-25页

作者： Muoz B Klein R Rodriguez j. 王海燕 Wilmer Eye Institute Johns Hopkins University 600 N Wolfe St BaltimoreMD21287 United States

Obj.ctive: To report the prevalence of age-related macular degeneration (AMD) in a population-based sample of Hispanic individuals aged 50 years and older. Methods: proyecto VER (Vision and E ye Research) is a population-based study of blindness and visual impairment of Hispanic people in Arizona. participants underwent complete ophthalmic evaluation, including stereoscopic fundus photography of fields 1, 2, and 4. All photographs for participants aged 50 years and older were graded using the Wisconsin Age-Related Maculopathy Grading system. The following signs were graded: drusen size, drusen type, and the area covered by drusen; pigmentary abnormalities; geographic atrophy; and exudative AMD. Results: Sixty-seven percent (3178) of the original 4774 participants were 50 years of age or older. Of those, 92%(2928) had fundus photographs in at least 1 eye, and 95%(2780) of the photographs were of sufficient quality to grade early and late AMD. Outcome Measures: The overall prevalence of late AMD was 0.5%. The prevalence increased from 0.1%in the 50 to 59 year age group to 4.3%in the group aged 80 years and older. Likewise, early AMD was strongly associated with age with a prevalence of 20%in the 50-to 59-year age group, increasing to 54%in the group aged 80 years and *** prevalence of early AMD in Hispanic people was significantly higher than the reported prevalence in the white population. However, the prevalence of late AMD was lower than the estimates for the white population of the United States. Conclusio ns: Although early macular changes were very common among Hispanic people, the prevalence of late AMD was infrequent. Further work is necessary to understand the underlying reasons for the different patterns of presentation of early and late signs of AMD among racial/ethnic groups and to characterize early AMD based on predictive value for severe disease in different populations.

关键词：黄斑变性患病率 VER 亚利桑那州老年性西班牙南欧

Sex-specific differences in white matter microvascular integrity after ischaemic stroke

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Stroke & Vascular Neurology 2019年第4期4卷 198-205页

作者： Mark R Etherton Ona Wu pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark j.R j.Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost Department of Neurology Massachusetts General Hospital and Harvard Medical SchoolBostonMassachusettsUSA Martinos Center for Biomedical Imaging Massachusetts General HospitalCharlestownMAUnited States Department of Radiology Massachusetts General Hospital and Harvard Medical SchoolBostonMAUnited States Medical School of Ribeirao preto University of Sao PauloSao PauloBrazil Department of Human Neurosciences Sapienza University of RomeRomeItaly Institute of psychology Leiden UniversityLeidenNetherlands Department of Neuroradiology Goethe-Universitat Frankfurt am MainFrankfurtGermany Department of Neurology Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUnited States Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRhode IslandUSA

background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adj.sting for differences in comorbidities and treatment *** matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic *** aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic *** A retrospective analysis of subj.cts with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was *** the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)*** analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)scorep=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) *** multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not *** In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural *** studies investigating sex-specific differences in white matter microvascular integrity are needed.

关键词： microvascular white coefficient

113例乳腺癌游离腹部皮瓣乳房重建术机会性内乳淋巴结活检情况及其影响因素

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中华肿瘤杂志 2016年第10期38卷 769-773页

作者：全晨莲黄乃思杨犇龙王研曹阿勇张莹莹黄晓燕陈嘉健沈镇宙邵志敏吴炅复旦大学附属肿瘤医院乳腺外科复旦大学上海医学院肿瘤学系 200032

目的分析游离腹部皮瓣乳房重建术中机会性内乳淋巴结活检的情况，探讨内乳淋巴结检出及转移的相关因素。方法收集2006年11月至2015年12月，以内乳血管作为受区血管的游离腹部皮瓣乳房重建术乳腺癌患者的临床资料，分析内乳淋巴结的检出... 详细信息

目的分析游离腹部皮瓣乳房重建术中机会性内乳淋巴结活检的情况，探讨内乳淋巴结检出及转移的相关因素。方法收集2006年11月至2015年12月，以内乳血管作为受区血管的游离腹部皮瓣乳房重建术乳腺癌患者的临床资料，分析内乳淋巴结的检出率和阳性率，分析影响内乳淋巴结检出和转移的相关因素。结果113例游离腹部皮瓣乳房重建术中，共有53例乳腺癌检出内乳淋巴结，内乳淋巴结检出率为46．9％。即刻重建患者中，内乳淋巴结转移4例。检出内乳淋巴结的患者中，内乳淋巴结转移阳性率为7．5％（4／53））。Logistic多因素分析显示，肿瘤最大径、肿瘤位置和腋窝淋巴结状态与内乳淋巴结转移均无关（均p〉0．05）。结论乳腺癌患者腹部游离皮瓣重建术中，可以通过机会性内乳淋巴结活检的方法评估内乳淋巴结转移状态，检出率较高，且无需额外手术操作。腋窝淋巴结转移和肿瘤最大径可能为内乳淋巴结转移的高危因素。

关键词：乳腺肿瘤活组织检查针吸淋巴结乳房成形术

phase imaging of irradiated foils at the OMEGA Ep facility using phase-stepping X-ray Talbot–Lau deflectometry

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High power Laser Science and Engineering 2023年第4期11卷 45-54页

作者： G.pérez-Callej. V.Bouffetier L.Ceurvorst T.Goudal S.R.Klein D.Svyatskiy M.Holec p.perez-Martin K.Falk A.Casner T.E.Weber G.Kagan M.p.Valdivia Departamento de Física Teórica Atómica yÓptica Universidad de ValladolidValladolidSpain Universitéde Bordeaux-CNRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance European XFEL GmbH SchenefeldGermany Laboratory for Laser Energetics RochesterNew YorkUSA CEA-DAM DIFArpajonFrance University of Michigan Ann ArborMichiganUSA Los Alamos National Laboratory Los AlamosNew MexicoUSA Lawrence Livermore National Laboratory LivermoreCaliforniaUSA Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany Technische Universität Dresden DresdenGermany Institute of physics of the ASCR PragueCzech Republic CEA-CESTA CS 60001Le Barp CedexFrance Blackett Laboratory Imperial College LondonLondonUK Department of Astrophysics and Astronomy The Johns Hopkins UniversityBaltimoreMarylandUSA Center for Energy Research University of California San DiegoSan DiegoCaliforniaUSA

Diagnosing the evolution of laser-generated high energy density(HED)systems is fundamental to develop a correct understanding of the behavior of matter under extreme ***–Lau interferometry constitutes a promising tool,since it permits simultaneous single-shot X-ray radiography and phase-contrast imaging of dense *** present the results of an experiment at OMEGA Ep that aims to probe the ablation front of a laser-irradiated foil using a Talbot–Lau X-ray interferometer.A polystyrene(CH)foil was irradiated by a laser of 133 j.1 ns and probed with 8 keV laser-produced backlighter radiation from Cu foils driven by a short-pulse laser(153 j.11 ps).The ablation front interferograms were processed in combination with a set of reference images obtained ex situ using *** managed to obtain attenuation and phase-shift images of a laser-irradiated foil for electron densities above 1022 cm−*** results showcase the capabilities of Talbot–Lau X-ray diagnostic methods to diagnose HED laser-generated plasmas through high-resolution imaging.

关键词： deflectometry OMEGA Ep phase-contrast imaging Talbot-Lau X-ray interferometry

Machine-learning-based head impact subtyping based on the spectral densities of the measurable head kinematics

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j.urnal of Sport and Health Science 2023年第5期12卷 619-629,F0003页

作者： Xianghao Zhan Yiheng Li Yuzhe Liu Nicholas j.Cecchi Samuel j.Raymond Zhou Zhou Hossein Vahid Alizadeh j.sse Ruan Saeed Barbat Stephen Tiernan Olivier Gevaert Michael M.Zeineh Gerald A.Grant David B.Camarillo Department of Bioengineering Stanford UniversityStanfordCA 94305USA Department of Biomedical Data Science Stanford UniversityStanfordCA 94305USA Ford Motor Company 3001 Miller RdDearbornMI 48120USA Technological University Dublin DublinD07 EWV4Ireland Department of Radiology Stanford UniversityStanfordCA 94305USA Department of Neurosurgery Stanford UniversityStanfordCA 94305USA

Background:Traumatic brain inj.ry can be caused by head impacts,but many brain inj.ry risk estimation models are not equally accurate across the variety of impacts that patients may undergo,and the characteristics of different types of impacts are not well *** investigated the spectral characteristics of different head impact types with kinematics ***:Data were analyzed from 3262 head impacts from lab reconstruction,American football,mixed martial arts,and publicly available car crash data.A random forest classifier with spectral densities of linear acceleration and angular velocity was built to classify head impact types(e.g.,football,car crash,mixed martial arts).To test the classifier robustness,another 271 lab-reconstructed impacts were obtained from 5 other instrumented ***,with the classifier,type-specific,nearest-neighbor regression models were built for brain ***:The classifier reached a median accuracy of 96% over 1000 random partitions of training and test *** most important features in the classification included both low-and high-frequency features,both linear acceleration features and angular velocity *** head impact types had different distributions of spectral densities in low-and high-frequency ranges(e.g.,the spectral densities of mixed martial arts impacts were higher in the high-frequency range than in the low-frequency range).The type-specific regression showed a generally higher R2value than baseline models without ***:The machine-learning-based classifier enables a better understanding of the impact kinematics spectral density in different sports,and it can be applied to evaluate the quality of impact-simulation systems and on-field data augmentation.

关键词： Classification Contact sports Head impacts Impact kinematics Traumatic brain inj.ryTagedApTARAEnd