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NeCAB family of neuronal calcium-binding proteins in health and disease

Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno Michael K.e.Schafer Sudena Wang Michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal eF-hand calcium-binding proteins 1–3(NeCAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one eF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NeCAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NeCAB2 interacts with predominantly striatal G-protein-coupled receptors, while NeCAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NeCAB proteins exhibit distinct subcellular localizations: NeCAB1 is found in the nucleus and cytosol, NeCAB2 resides in endosomes and the plasma membrane, and NeCAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NeCAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NeCAB proteins by controlling the availability of protein–protein interaction domains situated between the eF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium eF hand mitochondria nervous system signal transduction

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Smoking prevalence in the area of responsibility of the German Ministry of Defense——results of the employee survey in the context of occupational health management

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Military Medical Research 2020年第3期7卷 343-349页

作者： Stefan Sammito Annika Claus dirk-Matthias Rose Department I 3 Research&Development Air Force Centre of Aerospace MedicineCologneGermany Occupational Medicine Faculty of MedicineOtto-von-Guericke-University of MagdeburgMagdeburgGermany Institute for Teachers’Health Institute of OccupationalSocial and Environmental Medicine of the Johannes-Gutenberg University MainzMainzGermany

Background:Tobacco use,correlated with reduced physical fitness,is one of the leading causes of avoidable death *** increases the risk of dementia and can shorten the lifespan by 10 *** the German Armed Forces(Bundeswehr),figures on smoking behavior have not been comprehensively *** study analyzes current data in a large sample from this ***:Based on an employee survey as part of the Occupational Health Management System,data on smoking behavior from 13,326 participants were analyzed in relation to age,gender,professional status,education level and membership in military operational units versus other ***:Smoking behavior varied significantly(Pe group(younger>older),gender,professional status,military agency membership status,and education level(the lower the education level,the higher the smoking rates).With the exception of the downward trend in smoking behavior with increasing age among civilian employees,these results were all significant(Pevalence among personnel in the area of responsibility of the Federal Ministry of Defense is comparable to the current data from corresponding surveys of the German *** on gender,they generally show values that are slightly above those of the German *** well-known trend in the general population of decreasing smoking prevalence with increasing age is also seen in this ***,there are considerable differences in the smoking prevalence among individual subgroups(professional status,agency,gender,education level).The data show that particular young soldiers in the armed forces should be the target group for further preventive measures.

关键词： Prevention Smoking Military Health promotion

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Tuning thermal release kinetics of soy oil from organic nanoparticles using variable synthesis conditions

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Particuology 2016年第3期14卷 54-65页

作者： Pieter Samyn Dieter Van Nieuwkerke Vibhore Rastogi dirk Stanssens University of Freiburg Freiburg Research Institute for Advances Studies (FRIAS) Faculty for Environment and Natural Resources Chair of Bio-based Materials Engineering Werthmannstrasse 6 D-79085 Freiburg Germany Ghent University Department of Textiles Technologiepark 907 B-9052 Zwijnaarde Belgium Topehim N.K Nijverheidsstraat 98 B-2160 Wommelgem Belgium

The thermal release properties of soy oil from poly（styrene-co-maleimide） nanoparticles containing 50 wt% encapsulated oil have been quantified as a function of temperature and time. The effects of dif- ferent synthesis conditions on the thermal stability of the nanoparticles and their oil release have been evaluated, i.e., by gradually increasing the amount of ammonium hydroxide used for the imidization of poly（styrene-co-maleic anhydride）. First, the intrinsic thermal properties of the oil-filled nanoparti- cles were analysed by differential scanning calorimetry, which revealed an exothermal reaction related to the oil release and a suppression of the glass transition that may be masked owing to the complex structure of the hybrid nanoparticles. The isothermal scans showed different rates of oil release after a post-imidization reaction. The oil release was better followed by dynamic mechanical analysis, which illustrated changes in visco-elastic properties expressed by the maximum in the loss factor that related to the amount of released oil. Depending on the amount of ammonium hydroxide, the oil started to release below the glass transition temperature at various rates. Thermal release profiles of the oil we re quantified by infrared and Raman spectrocopy after heating for 2 min to 6 h at 125 to 250 ℃, based on variations in oil-related and imide-related absorption bands. The oil release increased below and above the glass transition temperature, following a parabolic trend, and progressively decreased at higher ammonium hydroxide concentrations, in parallel with higher imide content and changes in imide conformation. The kinetics and mechanism of the oil release can be described by the Korsmeyer-Peppas model, suggesting a dominating diffusion mechanism that is influenced by further imidization of the polymer matrix during heating.

关键词： Soy oil Nanoparticle encapsulation Release

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(english edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-TALOOKOLAeI H.GHANDVAR e.JUMAeV S.KHATIR T.CUONG-Le School of Mechanical engineering Babol Noshirvani University of Technology Department of Mechanical engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for engineering Application and Technology Solutions Ho Chi Minh City Open University

This paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. The strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. The curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. The accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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Statistical landslide susceptibility assessment in a dynamic environment:A case study for Lanzhou City,Gansu Province,NW China

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Journal of Mountain Science 2018年第6期15卷 1299-1318页

作者： TORIZIN Jewgenij WANG Li-chao FUCHS Michael TONG Bin BALZeR dirk WAN Li-qin KUHN dirk LI Ang CHeN Liang Federal Institute for Geosciences and Natural Resources （BGR） Hannover 30655 Germany China Institute of Geo-environment Monitoring （CIGeM） Beijing 100081 China

This study presents a statistical landslide susceptibility assessment(LSA) in a dynamic environment. The study area is located in the eastern part of Lanzhou, NW China. The Lanzhou area has.exhibited rapid urbanization rates over the past decade associated with greening, continuous land use change, and geomorphic reshaping activities. To consider the dynamics of the environment in the LSA, multitemporal data for landslide inventories and the corresponding causal factors were collected. The weights of evidence(Wof e) method was used to perform the LSA. Three time stamps, i.e., 2000, 2012, and 2016, were selected to assess the state of landslide susceptibility over time. The results show a clear evolution of the landslide susceptibility patterns that was mainly governed by anthropogenic activities directed toward generating safer building grounds for civil infrastructure. The low and very low susceptibility areas increased by approximately 10% between 2000 and 2016. At the same time, areas of medium, high and very high susceptibility zones decreased proportionally. Based on the results, an approach to design the statistical LSA under dynamic conditions is proposed, the issues and limitations of this approach are also discussed. The study shows that under dynamic conditions, the requirements for data quantity and quality increase significantly. A dynamic environment requires greater effort to estimate the causal relations between the landslides and controlling factors as well as for model validation.

关键词： Landslide susceptibility assessment Dynamic environment Weights of evidence method Validation Urbanization Lanzhou City

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Multi-criteria decision making methods to address rural land allocation problems:A systematic review

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International Soil and Water Conservation Research 2021年第4期9卷 490-501页

作者： Sintayehu Legesse Gebre dirk Cattrysse esayas Alemayehu Jos Van Orshoven Department of Mechanical engineering Center for Industrial ManagementTraffic&InfrastructureKU Leuven(University of Leuven)Celestijnenlaan 3003001LeuvenBelgium Department of earth and environmental Sciences Division of ForestNature and LandscapeKU Leuven(University of Leuven)Celestijnenlaan 200E3001LeuvenBelgium Department of Natural Resource Management Jimma UniversityJimmaEthiopia Department of Civil and environmental engineering JITJimma UniversityJimmaEthiopia

Land allocation has been an important issue in land use planning research *** allocation involves different multifunctional activities of maximizing environmental,economic and social ***-criteria decision making(MCDM)method is the most popular tool to optimize land allocation problems by considering decision variables,conflicting objectives,and ***,decision-makers face problems on how to optimize the land allocation while minimizing the conflicting trade-offs existing in the decision *** this review study,we aim at identifying and extracting information on MCDM methods to solve land allocation problems from english language articles published between 2000 and 2019 and indexed by four scientific literature databases(Web of Science,Science Direct,Scopus,Google scholar).To this end,we applied a systematic literature review approach,*** Preferred Reporting Items for Systematic Reviews and Meta-Analysis procedure(Moher et al.,2009),with a structured database search expression.120 articles were selected of which,after careful screening of title,keywords and abstract,69 were retained for detailed *** review study report compiles comprehensive information by classifying the papers into application area,optimization objectives,criteria used,decision techniques,publication year and study *** summary,we found that in the last two decades,the use of the MCDM method has increased,particularly in europe and ***(analytical hierarchal process)is frequently used for multi-attribute land allocation problems with reference to ecotourism and ecosystem ***(linear programming)and SA(simulating annealing)methods are predominantly used to optimize multi-objectives complex agricultural and forest land allocation problems respectively.

关键词： Database Allocation Decision techniques PRISMA

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Hydrogen-based direct reduction of iron oxide at 700℃:Heterogeneity at pellet and microstructure scales

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International Journal of Minerals,Metallurgy and Materials 2022年第10期29卷 1901-1907页

作者： Yan Ma Isnaldi R.Souza Filho Xue Zhang Supriya Nandy Pere Barriobero-Vila Guillermo Requena dirk Vogel Michael Rohwerder dirk Ponge Hauke Springer Dierk Raabe Max-Planck-Institut für eisenforschung Max-Planck-Straße 140237 DüsseldorfGermany Corrosion Center Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Institute of Materials Research German Aerospace Center(DLR)Linder Höhe51147 CologneGermany Lehr-und Forschungsgebiet Metallische Strukturen und Werkstoffsysteme für die Luft-und Raumfahrt RWTH Aachen University52062 AachenGermany Institut für Bildsame Formgebung RWTH Aachen UniversityIntzestraße 1052072 AachenGermany

Steel production causes a third of all industrial CO_(2) emissions due to the use of carbon-based substances as reductants for iron ores,making it a key driver of global ***,research efforts aim to replace these reductants with sustainably produced ***-based direct reduction(HyDR)is an attractive processing technology,given that direct reduction(DR)furnaces are routinely operated in the steel industry but with CH_(4) or CO as *** diffuses considerably faster through shaft-furnace pellet agglomerates than carbon-based ***,the net reduction kinetics in HyDR remains extremely sluggish for high-quantity steel production,and the hydrogen consumption exceeds the stoichiometrically required amount ***,the present study focused on the improved understanding of the influence of spatial gradients,morphology,and internal microstructures of ore pellets on reduction efficiency and metallization during *** this purpose,commercial DR pellets were investigated using synchrotron high-energy X-ray diffraction and electron microscopy in conjunction with electron backscatter diffraction and chemical *** the interplay of different phases with internal interfaces,free surfaces,and associated nucleation and growth mechanisms provides a basis for developing tailored ore pellets that are highly suited for a fast and efficient HyDR.

关键词： hydrogen-based direct reduction iron oxide microstructure spatial gradient metallization

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Current Challenges and Opportunities Toward Understanding Hydrogen embrittlement Mechanisms in Advanced High-Strength Steels: A Review

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Acta Metallurgica Sinica(english Letters) 2021年第6期34卷 741-754页

作者： Binhan Sun Dong Wang Xu Lu Di Wan dirk Ponge Xiancheng Zhang Max-Planck-Institut flir eisenforschung GmbH Max-Planck-StraBe 140237 DlisseldorfGermany Department of Mechanical and Industrial engineering Norwegian University of Science and TechnologyRichard Birkelands vei 2B7491 TrondheimNorway Key Laboratory of Pressure Systems and Safety Ministry of EducationSchool of Mechanical and Power EngineeringEast China University of Science and TechnologyShanghai 200237China

Hydrogen embrittlement(He)is one of the most dangerous yet most elusive embrittlement problems in metallic *** high-strength steels(AHSS)are particularly prone to He,as evidenced by the serious degradation of their load-bearing capacity with the presence of typically only a few parts-per-million *** strongly impedes their further development and application and could set an abrupt halt for the weight reduction strategies pursued globally in the automotive *** is thus important to understand the He mechanisms in this material class,in order to develop effective H-resistant ***,we review the related research in this field,with the purpose to highlight the recent progress,and more importantly,the current challenges toward understanding the fundamental He mechanisms in modern *** review starts with a brief introduction of current He models,followed by an overview of the state-of-the-art micromechanical testing techniques dedicated for He ***,the reported He phenomena in different types of AHSS are critically *** are particularly placed on two representative multiphase steels,i.e.,ferrite–martensite dual-phase steels and ferrite–austenite medium-Mn steels,with the aim to highlight the multiple dimensions of complexity of He mechanisms in complex *** on this,open scientific questions and the critical challenges in this field are discussed to guide future research efforts.

关键词： Hydrogen embrittlement Advanced high-strength steels(AHSS) Damage mechanisms Multiphase steels

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The pseudo-homogeneous flow regime in large-scale bubble columns:experimental benchmark and computational fluid dynamics modeling

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Petroleum 2019年第2期5卷 141-160页

作者： Giorgio Besagni Fabio Inzoli Thomas Ziegenhein dirk Lucas Department of energy Politecnico di MilanoVia Lambruschini 4a20156MilanItaly Helmholtz-Zentrum Dresden-Rossendorf e.V.Institute of Fluid Dynamics 01314 DresdenGermany

A precise prediction of the fluid dynamics in bubble columns is of fundamental importance to correctly design“industrial-scale”*** is known that the fluid dynamics in bubble columns is related to the prevailing bubble size distribution existing in the *** this respect,multiphase computational fluid dynamic simulations,in the eulerian multi-fluid framework,are able to predict the local bubble size distributions and,thus,the global fluid dynamics from the fluid flow conditions and by applying modeling *** particular,in in“industrial-scale”reactors,owing to the large gas sparger openings,the“pseudo-homogeneous”flow regimedcharacterized by a wide spectrum of bubble sizesdis typically ***,reliable predictions of the“pseudo-homogeneous”flow regime are limited up to now:one important drawback concerns the selection of appropriate models for the coalescence and break-up.A set of closure relations was collected at the Helmholtz-Zentrum Dresden-Rossendorf that represents the best available ***,the authors have extended the validation of this set of closure relations to the“pseudo-homogeneous”flow regime,by comparing the numerical predictions to a comprehensive experimental dataset(gas holdup,bubble size distributions and local flow measurements).Unfortunately,the previous study suffers from some limitations;in particular,in the previous experimental dataset,the bubble size distributions concerned only one axial position and a detailed characterization of the gas sparger was *** study contributes to the existing discussion and proposed a step ahead in the study of the“pseudo-homogenous”flow *** this end,we propose an experimental study,to improve the comprehensive dataset previously *** novel datasetdobtained for two gas velocitiesdconcerns bubble size distributions at different axial and radial positions and a precise characterization of the gas *** comprehensive bubble size distribution

关键词： CFD Bubble column Large-scale Bubble size distribution Coalescence and break-up Validation

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Mechanical characterization of rose bengal and green light crosslinked collagen scaffolds for regenerative medicine

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Regenerative Biomaterials 2021年第6期8卷 185-198页

作者： Joy Braun Stefanie eckes Michelle Fiona Kilb dirk Fischer Claudia eßbach Pol Maria Rommens Philipp Drees Katja Schmitz Daniela Nickel Ulrike Ritz Department of Orthopedics and Traumatology BiomaTiCSUniversity Medical CenterJohannes Gutenberg UniversityLangenbeckstraße 1Mainz 55131Germany Clemens-Schopf-Institute of Organic Chemistry and Biochemistry Technical University of DarmstadtAlarich-Weiss-Straße 4Darmstadt 64287Germany Berufsakademie Sachsen—Staatliche Studienakademie Glauchau University of Cooperative EducationKopernikusstraße 51Glauchau 08371Germany

Collagen is one of the most important biomaterials for tissue engineering *** its excellent biocompatibility,it shows the non-negligible disadvantage of poor mechanical *** crosslinking with rose bengal and green light(RGX)is an appropriate method to improve this *** development of collagen laminates is helpful for further adjustment of the mechanical properties as well as the controlled release of incorporated *** this study,we investigate the impact of crosslinking and layering of two different collagen scaffolds on the swelling behavior andmechanical behavior inmicro tensile tests to obtain information on its wearing comfort(stiffness,strength and ductility).The mechanical stability of the collagen material after degradation due to cell contact is examined using thickness *** is no linear increase or decrease due to layering homologous ***,a decrease in elongation at break,Young’s modulus and ultimate tensile strength are measured when the untreated monolayer is compared to the crosslinked ***,we can detect a connection between stability and cell *** results show that with variation in number and type of layers,collagen scaffolds with tailored mechanical properties can be *** a multi-layered structure enables the release of biomolecules into inner or outer layers for biomedical applications.

关键词： collagen type I collagen laminates rose bengal and green light crosslinking thickness analysis micro tensile testing cell-collagen interactions

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