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Performance of Cardiovascular Risk Equations versus Vascular Ultrasound in Systemic Lupus Erythematosus in a Black African Population

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World Journal of Cardiovascular Diseases 2021年第11期11卷 523-532页

作者： Sow Maïmouna Kane Baïdy Sy diouf marguerite téning Aw Fatou Ndao Awa Cheikh Samba Abdourahmane Ndiaye Mouhamadou Bamba Ndongo Souhaibou Diao Maboury Pouye Abdoulaye Internal Medecine Department of Aristide Le Dantec teaching Hospital of Dakar Senegal Cardiology Department of Aristide Le Dantec teaching Hospital of Dakar Senegal Biochemial Department of Aristide Le Dantec teaching Hospital of Dakar Senegal Internal Medecine Department of Dalal Jamm Hospital of Dakar Senegal

Introduction: Cardiovascular risk is increased in systemic lupus erythematosus. Cardiovascular events are the first cause of death in lupus after five years duration. Prevention of cardiovascular events needs a good e... 详细信息

trong>Introduction:trong> Cardiovascular risk is increased in systemic lupus erythematosus. Cardiovascular events are the first cause of death in lupus after five years duration. Prevention of cardiovascular events needs a good evaluation of the risk. In this work, we tried to evaluate the performance of conventional and adjusted forms of cardiovascular risk equations to predict high risk in lupus patients, in comparison with carotid ultrasound. Method: We realized a cross-sectional study during the period from 24 August 2017 to 22 November 2018. Consenting patient meeting the 1997 American college of Rheumatology criteria of systemic lupus erythematosus were recruited. The clinical characteristics and the treatment data were informed. Traditional cardiovascular risk factors were also investigated, and the assessment of cardiovascular risk was performed by Framingham and SCORE equations and their modified forms (multiplication by a factor of 1.5). Carotid ultrasound was used to detect atherosclerosis by measuring intima media thickness and searching for carotid plaques. In last, we compared cardiovascular risk levelstyle="white-space:normal;font-family:;" "=""> by equations to results of carotid ultrasound. Statistical analysis and data collection were performed using SPSS 23.0 software. Results: Forty-nine patients with a sex ratio of 0.13 and a mean age of 33.5 (±11.3) years were enrolled. More than half of patients had dyslipidemia. More than 80% of the population were at lo

关键词： Cardiovascular Risk Equations Carotid Ultrasound Systemic Lupus Erythematosus

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totally Occluded Coarctation of the Aorta in a Young Adult

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World Journal of Cardiovascular Diseases 2024年第4期14卷 282-287页

作者： marguerite téning diouf Mohamed Leye Joseph Salvator Mingou Aw Fatou Ndeye Faye Sy Aimé Mbaye Malick Bodian Aliou Alassane Ngaidé Abdoul Kane Cardiology Dalal Jamm Hospital Dakar Senegal training and Research in Health Sciences Unit University of Thi&#232s Thi&#232s Senegal Cardiology Department Hospital Aristide Le Dantec Dakar Senegal

We report the case of a 20-year-old female patient presenting with a totally occluded coarctation of the aorta. the patient was admitted for the evaluation of resistant grade III high blood pressure. the physical examination revealed a blood pressure gradient between the upper and lower limbs, absent femoral pulses, a diffuse continuous murmur over the chest, and hyperpulsatility of the carotid arteries and sternal notch. A transthoracic echocardiography outlined a narrowing in the caliber of the isthmic aorta without acceleration of flow or gradient. thoracic Ct angiography revealed a complete aortic coarctation with interruption of continuity between segment 3 and the descending aorta.

关键词： Coarctation of Aorta Complete Aortic Occlusion High Blood Pressure Adult

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thrombolysis in Pulmonary Embolia at the Cardiology Department of Aristide le Dantec Cardiology Department

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World Journal of Cardiovascular Diseases 2024年第9期14卷 521-538页

作者： Joseph Salvador Mingou marguerite téning diouf Fatou Aw Simon Antoine Sarr Khadim Rassoul Diop Malick Bodian Mouhamadou Bamba Ndiaye Maboury Diao Abdoul Kane Cardiology Department Aristide le Dantec Hospital Dakar Senegal Cardiology Department Dalal Jam Hospital Dakar Senegal

Introduction: Venous thromboembolic disease is the 3rd most common cardiovascular pathology. Acute pulmonary embolism constitutes its most serious presentation and a major cause of mortality, morbidity and hospitalization in Africa and Senegal. the objectives of this work were to study the epidemiological profile of pulmonary embolisms and to evaluate the practice of thrombolysis in patients in a cardiological setting. Methodology: A retrospective, descriptive study was carried out in the Cardiology department of the Aristide le Dantec Hospital (HALD) over the period from August 2011 to December 2019 in patients hospitalized in the cardiology department for pulmonary embolism confirmed by Ct angiography and/or with thrombi on cardiac ultrasound and who had also benefited from thrombolysis. Results: thirty-one patients with pulmonary embolism were thrombolyzed. there was a predominance of the female gender with an average age of 45.97 years. Risk factors were dominated by age (61.29%) followed by obesity (32.26%) and prolonged immobilization (22.5%). the functional signs were dominated by dyspnea (77.42%) followed by chest pain (51.62%) and cough (35.48%). the physical signs were dominated by right heart failure in 22.5% of cases, pulmonary condensation syndrome in 19.35%, and inflammatory large leg in 12.9% of cases. Echocardiography and chest Ct angiography were the means of diagnosis. Nine of our patients presented with an intracardiac mass. thrombotic treatment was administered in all patients. the average length of hospitalization was 12.32 days and in-hospital mortality was 32.26%. Conclusion: Pulmonary embolism does exist in our regions and is responsible for heavy mortality. Rapid and efficient support is essential. Prevention remains the corner-stone in the fight against this pathology.

关键词： Pulmonary Embolism thrombolysis Senegal

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Deep Vein thrombosis of the Upper Limb: About 6 Cases Collected in Dakar

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World Journal of Cardiovascular Diseases 2020年第2期10卷 57-66页

作者： Mouhamadou Bamba Ndiaye Fatou Aw marguerite téning diouf Joseph Salvador Mingou Simon Antoine Sarr Malick Bodiian Aliou Alassane Ngaidé Alassane Mbaye Adama Kane Maboury Diao Abdoul Kane Department of Cardiology Aristide Le Dantec Hospital University Dakar Senegal Department of Cardiology HOGGY Dakar Senegal Departement of Cardiology Regional Hospital of Saint Louis Saint Louis Senegal Departement of Cardiology Dalal Jamm Hospital Dakar Senegal

Deep vein thrombosis of the upper limb is a rare location of venous thromboembolic disease. Data on this form of thrombosis are limited. We report six cases collected in Dakar. the sex ratio was 0.5 and the average age was 27.6 years with extremes of 17 and 39. Painful limb edema was the most constant sign and involved the non-dominant limb in almost all patients. thrombosis occurred in a field of peripartum cardiomyopathy in two patients and SS sickle cell disease in one patient taking oral contraception. there was neither cancer nor venous catheter in medical history. the diagnosis was made by venous Doppler ultrasound in all patients. Subclavian involvement was the most common. the thrombophilia assessment, done for two patients, was normal. It was about exertion thrombosis on three (3) patients. All the patients had received antivitamin K treatment relaying a low molecular weight heparin. Venous limb compression was associated with anticoagulation for all patients. the treatment duration was six (6) months. there were no reports of pulmonary embolism or death. One patient presented a post-thrombotic syndrome.

关键词： Deep Vein thrombosis Upper Limb Dakar

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Screening of Myocardial Cardiotoxicity Induced by Anticancer Chemotherapy and the Importance of Global Longitudinal Strain

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World Journal of Cardiovascular Diseases 2024年第6期14卷 381-391页

作者： marguerite téning diouf Fatou Aw Hussein Khadra Sophie Ba Doudou diouf Michel Ngonar Sarr Joseph Salvador Mingou Malick Ndiaye Simon Antoine Sarr Momar Dioum Aliou Alassane Ngaide Serigne Mor Beye Simon Manga Alain Affangla Youssou diouf Khadimu Rassoul Diop Malick Bodian Mohamed Leye Mouhamadou Bamba Ndiaye Alassane Mbaye Adama Kane Maboury Diao Abdoul Kane Cardiology Department of the Dalal Jamm Hospital Dakar Senegal Cardiology Department Hospital Aristide Le Dantec Dakar Senegal Cardiology Department Hospital Fann Dakar Senegal UFR2S Saint Louis Saint Louis Senegal UFR Ziguinchor Ziguinchor Senegal training and Research in Health Sciences Unit University of Thies Thies Senegal Cardiology Department Hospital General Idrissa Pouye Dakar Senegal

Introduction: the improvement of survival in patients with cancer and the expansion of therapeutic options have led to the emergence of a new profile of cardiotoxicity, specifically associated with antimitotic agents. Our study aimed to assess the incidence of chemotherapy-induced myocardial toxicity in patients with cancer. Patients and Methods: We conducted a looking-forward longitudinal cohort study including all patients admitted to the Cardiology departments of Aristide le Dantec Hospital and Dalal Jamm National Hospital Centre for apre-chemotherapy check-up. the included patients did not undergo any pre-existing cardiopathy. Results: Over a period of two years ranging from January 2019 to December 2021, a total of 37 patients were included in the study. Notably, there was a female predominance (92%) with an average age of 49.7 years ± 13.69. Breast cancer accounted for 70% of the neoplasms. Laboratory findings revealed moderate anemia in 19 patients (51%). At inclusion, the left ventricle (LV) was of normal size (LV diastole at 44.46 ± 4.97 mm). the systolic function of the left ventricle was normal in all patients, with an average ejection fraction (EF) of 63.1% ± 5.80 and a mean global longitudinal strain (GLS) of −20.4% ± 2.58. the most commonly used agents were anthracyclines. During follow-up, 3 patients (8.1%) developed clinical symptoms of left heart failure, and LV dysfunction on echocardiography was observed in 5 (13.5%) patients, with a significant decrease in EF Conclusion: the incidence of cardiac toxicity is not negligible, hence the importance of early screening. Strain imaging is an essential tool that should be performed as part of the assessment before chemotherapy and re-evaluated during treatment.

关键词： Cancer Chemotherapy Global Longitudinal Strain Cardiotoxicity

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St-Segment Elevation Myocardial Infarction with Multiple Complications: A Case Report

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World Journal of Cardiovascular Diseases 2023年第3期13卷 124-129页

作者： Khadimu Rassoul Diop Mame Awa Sene Serigne Mor Beye Joseph Salvador Mingou Aliou Alassane Ngaïdé Youssou diouf Papa Guirane Ndiaye Cheikh Mouhamadou Bamba Diop marguerite tening diouf Adama Kane Maboury Diao Abdoul Kane Department of Cardiology CHU Aristide Le Dantec Dakar Senegal Department of Cardiology Dalal Jamm Hospital Dakar Senegal Department of Cardiology Saint Louis Regional Hospital Saint Louis Senegal Department of Cardiology Idrissa Pouye General Hospital Dakar Senegal

Introduction: St-Segment Elevation Myocardial Infarction (StEMI) usually involves complete thrombotic occlusion of a coronary artery and require urgent reperfusion;it is one of the leading cause of global mortality and morbidity worldwide. A variety of mechanical, rhythmic, conductive, embolic or hemodynamic complications can occur following StEMI, especially when the treatment is delayed or inadequate. Clinical presentation: A 58-year-old patient with hypertension was admitted to our department for a circumferential StEMI complicated by an ischemic stroke;received 24 hours after the onset of pain. His blood pressure was 100/60 mmHg, heart rate was 55 beats/min. the examination revealed right central facial paralysis and a slight motor deficit of the right upper limb (muscle strength 4/5). the first electrocardiogram (ECG) showed a significant circumferential St-segment elevation with Q waves in the same territory, as well as a Luchiani Wenckebach atrio-ven- tricular block. the first echocardiography performed showed apical akinesia along with the presence of an apical thrombus. Coronarography was not performed because it was not available and the patient was given curative low molecular weight heparin combined with dual antiplatelet therapy, an angiotensin converting enzyme inhibitor and high dose statins. Seventy-two hours later, the ECG showed a complete atrioventricular block with narrow QRS and the average ventricular rate was 51 beats/min. the patient was asymptomatic. Another echocardiography was performed to assess new complications and showed a rupture of the left ventricular wall and a moderate amount of circumferential pericardial effusion, without any sign of cavity compression. No particular therapeutic attitude was adopted apart from close monitoring with daily ECG and echocardiography. ten days later, spontaneous regression of the AV Bloc was noted. Conclusion: St-Segment Elevation Myocardial Infarction is a major cause of morbidity and mortality worl

关键词： Myocardial Infarction Delayed Reperfusion Complication

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Mitral Valve Abnormalities during Hypertrophic Cardiomyopathy: Study on a Cohort in Dakar

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World Journal of Cardiovascular Diseases 2023年第11期13卷 710-717页

作者： Simon Antoine Sarr Hicham Fassi-Fehri marguerite tening diouf Youssou diouf Fatou Aw Joseph Salvador Mingou Khadimu Rassoul Diop Serigne Mor Beye Aliou Alassane Ngaidé Malick Bodian Mouhamadou Bamba Ndiaye Alassane Mbaye Adama Kane Maboury Diao Abdoul Kane Cardiology Unit Aristide Le Dantec Hospital Dakar Senegal Cardiology Unit Dalal Jamm Hospital Dakar Senegal UFR2S Saint Louis Saint-Louis Senegal Cardiology Unit Idrissa Pouye General Hospital Dakar Senegal

INtRODUCtION: Mitral valve abnormalities in hypertrophic cardiomyopathy (HCM) are becoming increasingly well defined, and their role in intra-ventricular obstruction is well defined. the aim of this study was to evaluate mitral valve abnormalities in patients with HCM. PAtIENtS AND MEtHODS: We conducted a descriptive cross-sectional study from May 1 to July 1, 2022 in the Cardiology Department of Aristide Le Dantec Hospital. All patients with HCM aged at least 18 years old were included. the parameters studied concerned mainly the mitral valvular apparatus (papillary muscles abnormalities, leaflet length, mitral insufficiency). RESULtS: A total of 10 patients were included. Mean age was 58.3. On Doppler echocardiography, mean interventricular septal thickness was 20.6 mm. the mean maximum intra-ventricular gradient was 21.06 mmHg. two patients had significant intraventricular obstruction. the mean length of the anterior mitral valve leaflet was 28.7 ± 3.55 mm, with extremes of 22 and 33 mm. the posterior mitral leaflet averaged 14.8 ± 3.16 mm. Nine (9) out of 10 patients had an elongated anterior valve leaflet. Elongation of the posterior leaflet was noted in 6 patients. With regard to papillary muscle position, 6 patients had an anterolateral ascending pillary muscle. these patients had a mean intra-ventricular gradient of 25 mmHg, compared with 16.5 mmHg in the others cases. We found no direct insertion on the mitral valve. Mitral insufficiency was noted in 9 patients, including 5 with mild insufficiency and 4 with moderate one. CONCLUSION: Mitral valve abnormalities in HCM appear to be frequent. they should be analyzed for a better diagnostic and therapeutic approach.

关键词： Hypertrophic Cardiomyopathy Mitral Valve Obstruction

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therapeutic Education of Heart Failure: Prospective Study in the Cardiology Department of the Dalal Jamm National Hospital Center in Dakar

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World Journal of Cardiovascular Diseases 2023年第7期13卷 415-432页

作者： Mamadou Barry marguerite tening diouf Mamadou Bassirou Bah Aimé Mbaye Sy Ibrahima Sory Sylla Hassatou Diallo Aissatou tiguidanké Balde Elhadj Yaya Balde Abdoul Kane Mamadou Dadhi Balde Cardiology Department of the Ignace Deen National Hospital Conakry Guinea Cardiology Department of the Dalal Jamm National Hospital Center Dakar Senegal

Context: Heart failure (HF) is a common pathology requiring many types of treatments, including therapeutic education, which has demonstrated a major benefit in terms of reducing re-hospitalization and mortality from HF or all other causes. Objective: the aim of this study was to evaluate the contribution of therapeutic education (tPE) in patients with heart failure. Methodology: this was a single-centre, interventional, non-randomized, before-and-after type study. It focused on hospitalized heart failure patients aged 18 and over. We evaluated the effect of tPE on therapeutic compliance, knowledge, practical attitudes, patient perceptions and quality of life. Results: Our study included 41 patients prior to therapeutic education: 17 men (41%) and 24 women (59%). the mean age was 54.7 ± 16.2 years. After the tPE sessions we evaluated 32 patients: the patients with good compliance increased from 75% to 90.63%, and patients with a low level of compliance (90.6%) decreased to 34.4%. An increase in the number of patients who had an attitude adapted to not exceeding the recommended amount of salt (6 before tPE and 22 after tPE), as well as in the number of patients who had an attitude adapted to physical activity (12 before tPE and 16 after tPE). there was also an increase in the number of patients who were confident about the outcome of their disease (12 before tPE and 16 after tPE), and a decrease in those who were hopeless (8 before tPE and 5 after tPE), an improvement in the quality of life score (45.03 before tPE and 15.78 after tPE). Conclusion: this study shows the beneficial effect of therapeutic education in patients hospitalized for heart failure in improving their level of knowledge, compliance with treatment, lifestyle habits and quality of life.

关键词： therapeutic Education Heart Failure Quality of Life

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Cardiac Rehabilitation in the Elderly

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World Journal of Cardiovascular Diseases 2023年第12期13卷 854-869页

作者： Aw Fatou Wiam Akif Mame Madjiguene Ka Aimee Mbaye Sy Waly Niang Mboup Aliou Aalassane Ngaide Ccherif Mboup Simon Antoine Sarr Josep Salvadou Mingou marguerite tening diouf Khadim Rassoul Diop Momar Dioum Malick Bodian Mohamed Leye Alain Désiré Affangla Mouhammadou Bamba Ndiaye Alassane Mbaye Serigne Mor Beye Adama Kane Maboury Diao Abdoul Kane Department of Cardiology University Hospital Center Aristide Le Dantec Dakar Senegal Hopital Principal Dakar Senegal Hopital Dalal Jamm Dakar Senegal Hopital général Idrissa Pouye Dakar Senegal University Hospital Center Fann Dakar Senegal UFR de thies Dakar Senegal UFR de Saint Louis Dakar Senegal Medical Department Cheikh Anta Diop University Dakar Senegal

Introduction: the purpose of cardiac rehabilitation is to improve the effects of aging and maintain a good quality of life for older individuals. this study aims to assess how cardiac rehabilitation affects the autonomy and quality of life of older adults. Patients and Method: this was a longitudinal, descriptive and comparative before-and-after cardiovascular rehabilitation study conducted over a two-year period from January 2019 to December 2021. this study was conducted at four cardiac rehabilitation units in Dakar: the Aristide Le Dantec Hospital (HALD), National Dalal Jamm Hospital, and the General Idrissa Pouye Hospital (HOGIP). We compared the degree of autonomy, dependence and quality of life of subjects aged over 65 before and after the cardiac rehabilitation program using the Katz index, the Lowton index and the SF12 quality-of-life questionnaire. Results: Over a two-year period, a total of 345 patients had benefited from a complete cardiovascular rehabilitation program in the four cardiovascular rehabilitation units in Dakar, and 86 patients, or 24.92% of the population, were at least 65 years old. the patients were predominantly male (sex ratio M/F = 4.73). the mean age was 70.35 ± 4.55 years for men and 69.27 ± 4.59 years for women. the main pathology motivating cardiac rehabilitation was ischemic heart disease, which was found in 73 patients (84.88%). Initial assessment revealed exertional dyspnea in 35 patients (40.69%), followed by residual exertional angina in 21 patients (4.41%). Mean functional capacity increased from 5.81 ± 2.38 Mets in pre-cardiac rehabilitation to 8.68 ± 2.28 Mets in post-cardiac rehabilitation (p the mean distance covered in the 6-minute walk test increased from 330.42 ± 170.50 m in pre-cardiac rehabilitation to 524 ± 98.54 m in post-cardiac rehabilitation (p = 0.119). the Lowton dependency index in pre-cardiac rehabilitation was 44.18% versus 36.04% in post-cardiac rehabilitation (p = 0.0156). the mental quality of

关键词： Cardiac Rehabilitation Elderly Dakar

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