检索结果-南通市图书馆

Light-driven sextuple theranostics:nanomedicine involving second near-infrared AIE-active Ir(Ⅲ)complex for prominent cancer treatment

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第7期67卷 2314-2324页

作者： Xue Liu Jiangao Li Fei Zhang dingyuan yan Lei Wang Dong Wang Ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Material Science and EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Light-driven cancer theranostics has shown inexhaustible and vigorous vitality by virtue of its high efficacy,prominent controllability and *** of an all-round theranostic material simultaneously affording both multimodal diagnosis imaging and synergistic phototherapy would be an appealing yet significantly challenging ***,a novel nanomedicine Ir@PPEG-MeEPO was ingeniously constructed by integrating beforehand1O2-charged amphiphilic polymer and well-tailored Ir(Ⅲ)complex IrDPTP,which was featured by second near-infrared(NIR-Ⅱ)aggregation-induced emission(AIE)tendency,efficient reactive oxygen species(ROS)generation,good photothermal conversion efficiency and high-performance hydrogen gas *** the best of our knowledge,IrDPTP held the longest emission wavelength among all reported AIE Ir(Ⅲ)***,Ir@PPEG-MeEPO was capable of controllably releasing ROS via triggered photothermal effect upon NIR irradiation,making it well-adapted to hypoxic environment of *** distinctive characteristics of Ir@PPEG-MeEPO endowed it with unprecedented performance on sextuple theranostics comprised of NIR-Ⅱfluorescence-photoacoustic-photothermal trimodal imaging and photodynamic-photothermal-hydrogen trimodal therapy,witnessed by the precise tumor diagnosis and complete tumor *** study would open up new perspectives for the exploration of superior nanomedicine for practical cancer theranostics.

关键词： aggregation-induced emission NIR-II emission cancer theranostics multimodal diagnosis imaging multimodal therapy

在线全文

学校读者我要写书评

暂无评论

聚集诱导发光材料用于肿瘤光学诊疗

有机化学 2024年第8期44卷 2413-2424页

作者：黄伟庚高翼亭孙妍燕鼎元王东唐本忠深圳大学材料学院聚集诱导发光(AIE)研究中心东北师范大学化学学院吉林省高校纳米生物传感与纳米生物分析重点实验室香港中文大学(深圳)理工学院深圳分子聚集体科学与工程研究院

近年来,聚集诱导发光(AIE)材料因其优异的聚集态增强诊疗特性在肿瘤诊疗领域备受关注.激发后的AIE材料可以通过不同的能量弛豫途径耗散激发态能量,产生活性氧或光热,用于成像导航下的肿瘤一体化诊疗.根据激发方式的不同,系统地总结了AI... 详细信息

近年来,聚集诱导发光(AIE)材料因其优异的聚集态增强诊疗特性在肿瘤诊疗领域备受关注.激发后的AIE材料可以通过不同的能量弛豫途径耗散激发态能量,产生活性氧或光热,用于成像导航下的肿瘤一体化诊疗.根据激发方式的不同,系统地总结了AIE材料用于肿瘤诊疗的研究进展,具体包括光致激发(包含使用白光、660、808、980或1064nm激光器)、化学激发、超声激发和X射线激发.此外,简要讨论了每种激发方式的优势和局限性.

关键词：聚集诱导发光激发源肿瘤诊疗

Near-infrared emissive AIE nanoparticles for biomedical applications:From the perspective of different nanocarriers

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Particuology 2023年第3期74卷 103-118页

作者： dingyuan yan Yi Qin Saisai yan Panpan Sun Yuanwei Wang Dong Wang Ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhen518060GuangdongChina School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen518172GuangdongChina

Fluorescent imaging based on near-infrared(NIR)fluorophores has revolutionized the techniques employed for detecting biological events in depth owing to their advantages referring to diminished photon scattering,high signal-to-noise ratio and better light transparence through *** for conventional luminogens,the nanofabrication of those innately hydrophobicπ-conjugated architectures into water-dispersible nanoparticles(NPs)may result in attenuated fluorescent intensity deriving from the detrimental distribution ofπ-πinteractions in the confined ***,chromophores possessing aggregation-induced emission(AIE)characteristics emit boosted brightness at aggregate level according to the mechanism of restriction of intramolecular motion(RIM).In this review,we summarize the recent progresses of NIR emissive AIE NPs for multifarious biomedical applications from the viewpoint of different fabricated manners,mainly covering self-assembly and matrices assisted ***,the current challenges and future research directions of NIR AIE NPs are briefly discussed.

关键词： Aggregation-induced emission Nanoparticles Biomedical applications Near-infrared emission Nanocarriers

Aggregation-Induced Emission:A Rising Star in Chemistry and Materials Science

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2021年第3期39卷 677-689页

作者： Ting Han dingyuan yan Qian Wu Nan Song Haoke Zhang Dong Wang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Materials Science and EngineeringShenzhen UniversityShenzhenGuangdong 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhenGuangdong 518060China Department of Chemistry The Hong Kong University of Science and TechnologyClear Water BayKowloonHong KongChina

Aggregation-induced emission(AIE)refers to a photophysical effect that the luminescence of aggregates is stronger than that of the dispersed *** the concept of AIE was coined by Professor Ben Zhong Tang and co-workers in 2001,AIE has evolved from a simple luminescent phenomenon to a multidisciplinary research field with a widespread *** has changed people's way of thinking about chromophore aggregation and greatly promoted the development of advanced luminescent *** the 20-year development,diverse AIE luminogens(AlEgens)with attractive functionalities have been developed and remarkable achievements have been made in the mechanistic study and high-tech applications of *** this review,we provide an overview of the historical development and representative achievements of AIE *** on the application of AIE in aggregate science are also briefly discussed to guide the future development in this field.

关键词： Aggregation-induced emission Fluorescence Materials science Structures Mechanisms

Strategies for Improving the Brightness of Aggregation-Induced Emission Materials at Aggregate Level

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Chemistry 2023年第10期41卷 1249-1259页

作者： Yixiong Gui Keyao Chen yan Sun Yonghong Tan Wenshuai Luo Dongxia Zhu Yu Xiong dingyuan yan Dong Wang Ben Zhong Tang Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhenGuangdong 518060China School of Science and Engineering Shenzhen Institute of Molecular Aggregate Science and EngineeringThe Chinese University of Hong KongShenzhenGuangdong 518172China Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province Department of ChemistryNortheast Normal UniversityChangchunJilin 130024China

The brightness of fluorescent agents directly determines the imaging performance as *** various fluorophores,small organic species are promising given its exact purity/composition and excellent ***,chromophores with planar geometry may suffer from the undesirable aggregation-caused quenching(ACQ)***,luminogens showing aggregation-induced emission(AIE)features are preferable as the aggregates which are the most common used *** this review,we mainly focus on the strategies employed for boosting the brightness of AIE-active luminogens(AIEgens).From molecule to mor-phology levels,approaches that regulate electronic transition processes of the molecule or the packing extent of aggregates in order to confine molecular motion,reduceπ-πstacking,disrupt fluorophore-water interactions,etc.,are *** the end,the current challenges and perspectives are briefly *** anticipate that this review will stimulate new insights and more efforts for the advancement of ultrabright AIEgens.

关键词： Aggregation-induced emission Fluorescence brightness Restriction of molecular motion Radiative energy decay Electron transfer π-πstacking

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高速公路隧道廊道厅堂式溶洞处治技术研究

公路工程 2015年第3期40卷 185-191页

作者：鄢定媛傅鹤林湖南省永吉高速公路建设开发有限公司湖南吉首416000 中南大学湖南长沙410076

那丘隧道为长隧道,位于湖南省永吉高速第4合同段。左线K12＋060～K14＋935,长2 875 m,右线K12＋060～YK14＋920,长2 860 m。左线主洞掌子面施工至K14＋513处,发现本次K14＋350～520段大型溶洞,是一廊道厅堂式大型岩溶。从回填、改桥及... 详细信息

那丘隧道为长隧道,位于湖南省永吉高速第4合同段。左线K12＋060～K14＋935,长2 875 m,右线K12＋060～YK14＋920,长2 860 m。左线主洞掌子面施工至K14＋513处,发现本次K14＋350～520段大型溶洞,是一廊道厅堂式大型岩溶。从回填、改桥及改线及施工难度等角度对此岩溶的处治技术进行了研究,力求为工程及技术支持,并为类似工程提供参考。

关键词：岩溶隧道厅堂式岩溶溶洞回填溶洞内架桥改线方案比较

在线全文

学校读者我要写书评

暂无评论

风化砂质板岩水理特性研究

公路工程 2013年第6期38卷 10-12,78页

作者：吴平傅鹤林鄢定媛湖南省怀通高速公路建设开发有限公司湖南怀化418116 中南大学土木工程学院湖南长沙410075

砂质板岩在怀通高速公路分布极为广泛。砂质板岩在水的作用下,极易发生崩解和软化,进而出现强度降低。针以怀通高速公路24标边坡全、强、中和弱风化砂质板岩为研究对象,进行了崩解特性、软化、无侧限压缩、剪切渗透性的系列试验,揭示了... 详细信息

砂质板岩在怀通高速公路分布极为广泛。砂质板岩在水的作用下,极易发生崩解和软化,进而出现强度降低。针以怀通高速公路24标边坡全、强、中和弱风化砂质板岩为研究对象,进行了崩解特性、软化、无侧限压缩、剪切渗透性的系列试验,揭示了砂质板岩受的水理特性。研究表明:①砂质板岩具备强烈崩解特性。砂质板岩揭露遇水后,快速发生氧化反应,进而发生崩解。风化程度越高,崩解越强烈;②砂质板岩水理性能由弱到强排序为:全风化砂质板岩<强风化砂质板岩<中风化砂质板岩<弱风化砂质板岩;③砂质板岩越干燥,崩解效应越明显,大旱后突降雨,会导致板岩的强烈崩解,很容易诱发潜在滑坡。

关键词：砂质板岩水理特性试验

阳洞滩Ⅱ号隧道左线施工突涌水与塌方的风险评价及控制

在线全文

学校读者我要写书评

暂无评论

公路工程 2013年第6期38卷 24-27页

作者：韩红桂傅鹤林鄢定媛湖南省怀通高速公路建设开发有限公司湖南怀化418116 中南大学土木工程学院湖南长沙410075

在不良地质隧道隧道施工过程中,突水涌水、塌方是最常见、危害最大的风险事故。怀通高速公路阳洞滩II号江隧道,洞口段埋深浅,且多为强风化砂质板岩,为国内外隧道施工难度之最。建立的模糊综合层次评估模型,评价料阳洞滩II号江隧道突水... 详细信息

在不良地质隧道隧道施工过程中,突水涌水、塌方是最常见、危害最大的风险事故。怀通高速公路阳洞滩II号江隧道,洞口段埋深浅,且多为强风化砂质板岩,为国内外隧道施工难度之最。建立的模糊综合层次评估模型,评价料阳洞滩II号江隧道突水涌水、塌方风险,得出了洞口段的突水涌水、塌方风险等级。在此基础上,提出了风险控制技术措施,为隧道的安全施工提供了技术保障。

关键词：水下隧道突涌水塌方风险评价

在线全文

学校读者我要写书评

暂无评论

阳洞滩2号隧道特大涌泥塌方处治方案研究

公路工程 2013年第6期38卷 17-19,42页

作者：吴平鄢定媛易鑫文浩光湖南省怀通高速公路建设开发有限公司湖南怀化418116

阳洞滩2号隧道为双洞单向交通隧道。隧道施工过程中出现了隧道塌方。借助数值分析技术,结合数值模拟,仿真分析隧道塌方抢险的力学效应,进而形成阳洞滩2号隧道右洞YK194+040-YK194+085段处理方案。为隧道的安全施工提供了技术保障。

关键词：隧道塌方数值模拟抢险方案技术支持