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Integrated multi-omics reveals the relationship between growth performance,rumen microbes and metabolic status of Hu sheep with different residual feed intakes

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Animal Nutrition 2024年第3期18卷 284-295页

作者： Yanzhen Zhang Xiaowei Zhang dingren cao Jinyong Yang Huiling Mao Lingling Sun Chong Wang College of Animal Science and Technology College of Veterinary MedicineZhejiang A&F UniversityHangzhou 311300China Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province Hangzhou 311300China Zhejiang Provincial Animal Husbandry Technology Promotion and Monitoring Station of Breeding Livestock and Poultry Hangzhou 310021China Department of Animal Science Shandong Vocational Animal Science and Veterinary CollegeWeifang 261061China

Residual feed intake(RFI)is a metric that provides a more accurate measure of feed *** lower the RFI,the higher the feed *** changes in the host microbiome and metabolome contribute to the greater feed efficiency of low RFI(LRFI)*** aim of this study was to explore the differences in rumen microorganisms,rumen metabolites and plasma metabolites of Hu sheep with differing RFI through the microbiome and metabolome.A total of 80 Hu sheep were *** experiment consisted of a 15-d pretrial period and a 128-d experimental *** RFI in the experimental period was calculated for all sheep,and the sheep were screened into high RFI(HRFI,n=8)and LRFI(n=8)*** HRFI and LRFI sheep did not differ in their initial and final body weights,average daily gain and body measurements,but the dry matter intake of LRFI sheep was significantly decreased(28.4%,P<0.001).The sheep with LRFI had higher digestibility of crude protein(P=0.010)and ether extract(P=0.010)compared to HRFI *** concentrations of acetate(P=0.036),propionate(P=0.010),valerate(P=0.027)and total volatile fatty acids(P=0.048)in rumen of LRFI group were higher compared to HRFI *** results of 16S rDNA sequencing indicated that the sheep with LRFI had higher proportions of Prevotella genus in rumen liquid(P=0.031).The rumen metabolome and plasma metabolome results showed that the citrate cycle,pyruvate metabolism and alanine,aspartate and glutamate metabolism processes were more active for sheep in LRFI group,which provided more energy substrate such as malic acid,oxoglutaric acid and citric *** conclusion,sheep with LRFI can utilize feed more efficiently,and the more active energy metabolism pathway and the production of energy substances may account for the higher feed efficiency.

关键词： Feed efficiency Residual feed intake Rumen microbiome and metabolome Plasma metabolome

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Piezo1 channel exaggerates ferroptosis of nucleus pulposus cells by mediating mechanical stress-induced iron influx

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Bone Research 2024年第2期12卷 334-348页

作者： Ziqian Xiang Pengfei Zhang Chunwang Jia Rongkun Xu dingren cao Zhaoning Xu Tingting Lu Jingwei Liu Xiaoxiong Wang Cheng Qiu Wenyang Fu Weiwei Li Lei Cheng Qiang Yang Shiqing Feng Lianlei Wang Yunpeng Zhao Xinyu Liu Department of Orthopaedics Qilu Hospital of Shandong UniversityJinan 250012China University of Health and Rehabilitation Sciences Qingdao 226000China Xiangya School of Medicine Central South UniversityChangsha 410013China School of Nursing and Rehabilitation Shandong UniversityJinan 250012China Department of Pediatrics Cangzhou Central HospitalCangzhou 061011China Department of Pediatric Surgery Qilu Hospital of Shandong UniversityJinan 250012China Department of Pathology Qilu Hospital of Shandong UniversityJinan 250012China Department of Spine Surgery Tianjin HospitalTianjin UniversityTianjin 30021China The Second Hospital of Shandong University Cheeloo College of MedicineShandong UniversityJinan 250012China

To date,several molecules have been found to facilitate iron influx,while the types of iron influx channels remain to be ***,Piezo1 channel was identified as a key iron transporter in response to mechanical ***1-mediated iron overload disturbed iron metabolism and exaggerated ferroptosis in nucleus pulposus cells(NPCs).Importantly,Piezo1-induced iron influx was independent of the transferrin receptor(TFRC),a well-recognized iron ***,pharmacological inactivation of Piezo1 profoundly reduced iron accumulation,alleviated mitochondrial ROS,and suppressed ferroptotic alterations in stimulation of mechanical ***,conditional knockout of Piezo1(Col2a1-CreERT Piezo1^(flox/flox))attenuated the mechanical injury-induced intervertebral disc degeneration(IVDD).Notably,the protective effect of Piezo1 deficiency in IVDD was dampened in Piezo1/Gpx4 conditional double knockout(cDKO)mice(Col2a1-CreERT Piezo1^(flox/flox)/Gpx4^(flox/flox)).These findings suggest that Piezo1 is a potential determinant of iron influx,indicating that the Piezo1-iron-ferroptosis axis might shed light on the treatment of mechanical stress-induced diseases.

关键词： stress overload channel

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冷冻稀释液和抗氧化剂对金华猪精液冷冻效果的影响

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黑龙江畜牧兽医 2023年第4期 41-44,49页

作者：邢之宁曹丁壬章晓炜王争光浙江大学动物科学学院杭州310058 浙江省畜牧技术推广与种畜禽监测总站杭州310021

为了探究不同冷冻稀释液及抗氧化剂对金华猪精液冷冻效果的影响,试验通过手握法采集健康的20月龄纯种金华猪公猪精液,采用两种常用的商品冷冻稀释液(A、B)稀释精液,然后液氮冻存1 d,解冻后测定精液精子活力、顶体完整率和质膜完整率指标... 详细信息

为了探究不同冷冻稀释液及抗氧化剂对金华猪精液冷冻效果的影响,试验通过手握法采集健康的20月龄纯种金华猪公猪精液,采用两种常用的商品冷冻稀释液(A、B)稀释精液,然后液氮冻存1 d,解冻后测定精液精子活力、顶体完整率和质膜完整率指标,筛选最适金华猪精液冷冻保存的稀释液;在最适冷冻稀释液中添加20,30,40,50μmol/L表没食子儿茶素没食子酸酯(epigallocatechin gallate,EGCG),以未添加EGCG和上述添加EGCG的冷冻稀释液稀释金华猪精液,然后液氮冷冻保存精液1 d,解冻后测定精液精子活力、顶体完整率、质膜完整率及抗氧化指标[包括活性氧(reactive oxygen species,ROS)、丙二醛(malondialdehyde,MDA)含量及超氧化物歧化酶(superoxide dismutase,SOD)和过氧化氢酶(catalase,CAT)活性],筛选EGCG的最适添加量。结果表明:两种商品冷冻稀释液的精子活力、顶体完整率、质膜完整率差异不显著(P>0.05),但考虑到价格成本,选择B冷冻稀释液作为后续试验的冷冻稀释液。随着EGCG添加量的增加,金华猪精子的抗氧化能力大致呈现先增加后减少的趋势,其中当EGCG添加量为40μmol/L时,精子活力和顶体完整率显著高于未添加和其他添加量(P0.05);ROS和MDA含量最低,除MDA含量与30μmol/L差异不显著外(P>0.05),均显著低于未添加和其他添加量(P0.05)。说明在兼顾冷冻效果与成本的基础上,选用加入40μmol/L抗氧化剂EGCG的B冷冻稀释液可以有效改善金华猪冷冻后精液品质,并提高了精子的抗氧化能力。

关键词：金华猪精液冷冻稀释液抗氧化剂精液品质抗氧化能力

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全基因组水平湖羊不同保种方式的可行性探究

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黑龙江畜牧兽医 2021年第13期 54-57,145,146页

作者：章晓炜刘莉君马敏彪曹丁壬王争光浙江省畜牧技术推广与种畜禽检测总站杭州310021 浙江大学动物科学学院杭州310058

为了在全基因组水平上探究冷冻胚胎和冷冻精液技术对湖羊种群多样性的保护效果,试验采用简化基因组测序方法对冷冻精液(1988年和1998年制备)湖羊群体、冷冻胚胎(1998年制备)湖羊群体及浙江省两个种羊湖羊保种场湖羊群体[即种群A(Asub1、... 详细信息

为了在全基因组水平上探究冷冻胚胎和冷冻精液技术对湖羊种群多样性的保护效果,试验采用简化基因组测序方法对冷冻精液(1988年和1998年制备)湖羊群体、冷冻胚胎(1998年制备)湖羊群体及浙江省两个种羊湖羊保种场湖羊群体[即种群A(Asub1、Asub2群体)、种群B(Bsub1、Bsub2、Bsub3群体)、种群C(popC群体)和种群D(popD群体)]的共90只湖羊的遗传多样性及保种效果进行了研究,利用布鲁斯惠勒校准工具、GCTA软件、FastTree软件的ML算法以及Structure软件对不同群体的单核苷酸多态性(SNP)、群体遗传多样性与分化指数、个体间亲缘关系和群体遗传结构进行分析。结果表明:90只不同种群湖羊共存在3 353 529个SNP差异位点;所有群体均处于中度核苷酸多样性水平(0.273~0.325),通过GCTA软件能够将popC和popD群体基本划分开,但Asub1、Asub2、Bsub1、Bsub2、Bsub3群体互相汇集;除Bsub1群体样本基本相似度较高外,其他个体的分化关系相对不明显;湖羊群体的基因信息来源于3个祖先,其中Bsub1群体中的冷冻胚胎湖羊几乎遗失了祖先的信息,遗传多态性相对较低,而popD群体的遗传多态性最高。说明湖羊遗传多样性不高,种质资源较贫瘠,亟需进行种质资源保护;冷冻精液保种能有效维持群体核苷酸的多样性,对于种质资源的保护起到了一定效果;现有的活体保种与冷冻胚胎和冷冻精液相比,同样能够很好地保存生物体的遗传多样性。

关键词：湖羊冷冻胚胎冻精保种效果活体保种遗传多样性

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei Zheng Tingwei cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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基于SNP分子标记的湖羊群体遗传结构分析

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畜牧与兽医 2024年第6期56卷 1-8页

作者：马敏彪武利恒丁琳金慧佳赵丽莉曹丁壬王争光浙江省畜牧技术推广与种畜禽监测总站浙江杭州310021 浙江华欣牧业有限公司浙江江山324100 浙江大学动物科学学院浙江杭州310058 衢州市畜牧业发展中心浙江衢州324000

旨在运用现代生物信息学技术,评估湖羊群体的遗传结构,构建详细的系谱记录。通过对40只湖羊种公羊进行单核苷酸多态性(SNP)位点检测,基于检测结果进行遗传结构分析、主成分分析和进化树构建。结果:在40只种公羊中,共检测得到952214个SN... 详细信息

旨在运用现代生物信息学技术,评估湖羊群体的遗传结构,构建详细的系谱记录。通过对40只湖羊种公羊进行单核苷酸多态性(SNP)位点检测,基于检测结果进行遗传结构分析、主成分分析和进化树构建。结果:在40只种公羊中,共检测得到952214个SNPs;平均核苷酸多样性在0.2129~0.2425之间,平均观测杂合度大于平均期望杂合度,遗传分化程度值在0.3702~0.4524之间;状态同源(IBS)遗传距离在0.1739~0.2280之间,平均为0.2209;主成分分析和系统进化树的结果一致,最终可以将40只种公羊分为14个家系,湖羊群体中大部分个体间的亲缘关系较远,具有较高的遗传多样性和选择潜力。本研究在全基因组水平上,分析了湖羊种公羊的遗传结构和亲缘关系,完善了系谱记录,为湖羊场后续育种、配种等提供了科学依据。

关键词：湖羊单核苷酸多态性遗传多样性遗传结构亲缘关系

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基于SSR标记的2个鹅群体品种鉴定

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中国家禽 2022年第10期44卷 14-18页

作者：章晓炜许文武曾涛崔鸣曹丁壬施金虎杨金勇浙江省畜牧技术推广与种畜禽监测总站浙江杭州310021 浙江省农业科学院浙江杭州310058

为对2个养殖场的2个未知鹅品种(群体1、群体2)进行群体类别鉴定,研究使用浙江省6个鹅品种(磐石灰鹅、江山白鹅、永康灰鹅、浙东白鹅、太湖鹅、朗德鹅)为参考,利用16对高度多态的微卫星引物对8个鹅品种进行遗传距离(DA)计算、进化树构建... 详细信息

为对2个养殖场的2个未知鹅品种(群体1、群体2)进行群体类别鉴定,研究使用浙江省6个鹅品种(磐石灰鹅、江山白鹅、永康灰鹅、浙东白鹅、太湖鹅、朗德鹅)为参考,利用16对高度多态的微卫星引物对8个鹅品种进行遗传距离(DA)计算、进化树构建,对有效等位基因数(Ne)、期望杂合度(He)、多态信息含量(PIC)三个遗传多样性参数估计。结果显示:群体1和群体2与江山白鹅的遗传距离分别为0.051和0.046,进一步的系统发生树结果显示群体2和群体1聚为1类,且与江山白鹅聚为一起;群体1与群体2和6个已知群体的Ne、He和PIC指标比较,发现它们与江山白鹅在这三个指标上呈极显著正相关(P0.05)。研究表明群体1和群体2极有可能是江山白鹅品种,研究为未知遗传资源品种鉴定提供借鉴,为江山白鹅的保种、遗传资源保护提供重要依据。

关键词：微卫星分子鉴定江山白鹅遗传多样性

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Unraveling post-growth mechanisms of monolayer CsPbBr3 nanocubes:Laser-enhanced transformations and cathodoluminescence-electron microscopy correlations

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Journal of Energy Chemistry 2025年第1期100卷 146-156页

作者： Mingxing Li Xiaoge Wang Xiaofan cao Zhiqun He Chunjun Liang Mingxing Chen Jing Ju Fangtian You Key Laboratory of Luminescence and Optical Information Ministry of Education Institute of Optoelectronic Technology Beijing Jiaotong University Beijing National Laboratory for Molecular Sciences (BNLMS) College of Chemistry and Molecular Engineering Peking University

Lead-halide perovskite nanoparticles（LHP NPs） are highly promising materials for next-generation displays and solid-state lighting due to their exceptional optical properties. However, their inherent instability presents a significant challenge. Recent advances have demonstrated that optoelectronic devices based on monolayer nanoparticle films exhibit both high luminescence efficiency and long-term *** research demonstrates that mobility limitations and anisotropic alignments in CsPbBr3nanocube monolayer films are key to their stabilization, hindering spontaneous growth through face-to-face fusion and resulting in the formation of connecting necks in a diagonal direction. Introducing laser irradiation confirmed this by significantly accelerating nanocubes growth, increasing mobility, and enhancing local structural ordering, leading to larger and more regularly shaped nanosheets. Fourier transform infrared spectroscopy and energy dispersive spectroscopy line-scan analyses indicated that laser irradiation did not disrupt the ligand structure. Transmission electron microscopy and correlative cathodoluminescence electron microscopy revealed the effects of post-growth and heterogeneous structures, including enhanced luminescence and inhomogeneous intensity in the nanosheets. These findings deepen the understanding of the post-growth mechanism of monolayer nanoparticles and the structure-emission correlation and highlight the unique role of laser irradiation in directing the formation of well-defined and regular nanostructures.

关键词： Post-growth mechanism Heterogeneous structure Single-particle spectroscopy Laser irradiation

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao Xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong cao Ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

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