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Bridging therapy and direct mechanical thrombectomy in the treatment of cardiogenic cerebral infarction with anterior circulation macrovascular occlusion

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World Journal of Clinical Cases 2021年第27期9卷 8051-8060页

作者： Hong-Ju ding Cong Ma fu-Ping Ye Ji-fang Zhang Department of Emergency Qingdao Jiaozhou Central HospitalQingdao 266300Shandong ProvinceChina Department of Neurology Qingdao Jiaozhou Central HospitalQingdao 266300Shandong ProvinceChina Department of Gastrointestinal Surgery Qingdao Jiaozhou Central HospitalQingdao 266300Shandong ProvinceChina Department of Neurosurgery Qingdao Municipal HospitalSchool of MedicineQingdao UniversityQingdao 266071Shandong ProvinceChina

BACKGROUND Intravenous thrombolysis is an important treatment for cerebral ***,it is difficult to achieve good results if the patient is complicated with anterior circulation macrovascular *** addition,the vascular recanalization rate is low,so mechanical thrombectomy,that is,bridging therapy,is needed AIM To investigate the efficacy and safety of bridging therapy and direct mechanical thrombectomy in the treatment of cardiogenic cerebral infarction with anterior circulation macrovascular *** Ninety-six patients in our hospital with cardiogenic cerebral infarction with anterior circulation macrovascular occlusion from January 2017 to July 2020 were divided into a direct thrombectomy group(n=48)and a bridging group(n=48).Direct mechanical thrombectomy was performed in the direct thrombectomy group,and bridging therapy was used in the bridging treatment *** were performed for the treatment data of the two groups(from admission to imaging examination,from admission to arterial puncture,from arterial puncture to vascular recanalization,and from admission to vascular recanalization),vascular recanalization rate,National Institutes of Health Stroke Scale(NIHSS)and Glasgow Coma Scale(GCS)scores before and after treatment,prognosis and incidence of adverse *** In the direct thrombectomy group,the time from admission to imaging examination was 24.32±8.61 min,from admission to arterial puncture was 95.56±37.55 min,from arterial puncture to vascular recanalization was 54.29±21.38 min,and from admission to revascularization was 156.88±45.51 min,and the corresponding times in the bridging treatment group were 25.38±9.33 min,100.45±39.30 min,58.14±25.56 min,and 161.23±51.15 min;there were no significant differences between groups(P=0.564,0.535,0.426,and 0.661,respectively).There was no significant difference in the recanalization rate between the direct thrombectomy group(79.17%)and the bridging group(75.00%)(P=0.627)

关键词： Bridging therapy Direct mechanical thrombectomy Cardiogenic cerebral infarction Anterior circulation macrovascular occlusion

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Twin and twin intersection phenomena in a creep deformed microalloyed directionally solidified high Nb containing TiAl alloy

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Journal of Materials Science & Technology 2022年第32期127卷 115-123页

作者： Xuesong Xu Hongsheng ding Haitao Huang He Liang Hao Guo Ruirun Chen Jingjie Guo Hengzhi fu National Key Laboratory for Precision Hot Processing of Metals School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China

The creep behavior of a directionally solidified TiAl alloy with a high Nb content after microalloying by the addition of small amounts of W,Cr,and B elements was investigated by scanning electron microscopy and transmission electron *** means of directional solidification and microalloying,a TiAl alloy with a fine and uniform microstructure and continuous columnar crystals was ***-density dislocations,deformation nanotwins,and twin intersections were observed inγ*** results show that,in comparison with the ternary TiAl alloy,the microalloyed high Nb containing TiAl alloy exhibited better creep properties at 760℃and 275 *** decrease in stacking fault energy can promote dislocation dissociation and the formation of deformation twins,and the twin intersections can hinder the movement of dislocation to enhance the creep performance of the TiAl alloy.

关键词： TiAl alloy Directional solidification Deformation nanotwins Twin intersections Creep Stacking fault

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High temperature oxidation and ablation behaviors of HfB_(2)-SiC/SiC coatings for carbon/carbon composites fabricated by dipping-carbonization assisted pack cementation

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Journal of Materials Science & Technology 2022年第16期111卷 88-98页

作者： Lei Zhou Jiaping Zhang Dou Hu Qiangang fu Wuqing ding Jiaqi Hou Bing Liu Mingde Tong State Key Laboratory of Solidification Processing Shaanxi Key Laboratory of Fiber Reinforced Light Composite MaterialsNorthwestern PolytechnicalUniversityXi’an 710072China

To improve the uniformity and the content of HfBin Hf B-Si-based ceramic coating and alleviate the damage of substrate,and then enhance the high-temperature(1700°C)oxidation and cyclic ablation resistances of carbon/carbon composites,a close-knit double layer HfB_(2)-SiC/SiC coatings with a mosaic structure and high content of HfBwere prepared by a novel dipping-carbonization assisted pack cementation methods(DPC–HS/S).In contrast,a HfB_(2)-SiC/SiC coatings were also fabricated by pack cementation(PC–HS/S).Results revealed that the oxidation and ablation protective performances of the DPC–HS/S coatings were superior to those of PC–HS/S *** 30 thermal cycles between 1500°C and room temperature,the mass gain of the coated sample was 0.78%,and the mass loss was 1.65%after oxidation at 1700°C for 156 ***,under an oxyacetylene torch ablation for 180 s(3 cycles),the linear ablation rate of the DPC–HS/S coated specimen was 1.62μm/s,which was much lower than that of PC–HS/S coated specimen(3.08μm/s).

关键词： C/C composites HfB2 Oxidation resistance Cyclic ablation resistance

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Text Difficulty Study:Do Machines Behave the Same as Humans Regarding Text Difficulty?

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Machine Intelligence Research 2024年第2期21卷 283-293页

作者： Bowen Chen Xiao ding Yi Zhao Bo fu Tingmao Lin Bing Qin Ting Liu Research Center for Social Computing and Information Retrieval Harbin Institute of TechnologyHarbin 150001China fundamental Technology Center China Construction Bank Financial Technology Co.Ltd.Beijing 100033China

With the emergence of pre-trained models,current neural networks are able to give task performance that is comparable to ***,we know little about the fundamental working mechanism of pre-trained models in which we do not know how they approach such performance and how the task is solved by the *** example,given a task,human learns from easy to hard,whereas the model learns ***,difficulty-insensitive learning leads to great success in natural language processing(NLP),but little attention has been paid to the effect of text difficulty in *** propose a human learning matching index(HLM Index)to investigate the effect of text *** results show:1)LSTM gives more human-like learning behavior than ***,UID-SuperLinear gives the best evaluation of text difficulty among four text difficulty *** nine tasks,some tasks’performance is related to text difficulty,whereas others are not.2)Model trained on easy data performs best in both easy and medium test data,whereas trained on hard data only performs well on hard test data.3)Train the model from easy to hard,leading to quicker convergence.

关键词： Cognition inspired natural language processing psycholinguistics explainability text difficulty curriculum learning

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Transcriptomic profile of human erythroleukemia cells in response to Sargassum fusiforme polysaccharide and its structure analysis

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Chinese Journal of Natural Medicines 2021年第10期19卷 784-795页

作者： ding Hao-Miao fu Rui-Jie XIE Ce WANG Cai-Sheng QIAN Guo-Ying College of Biological and Environmental Sciences Zhejiang Wanli UniversityNingbo 315100China School of Marine Sciences Ningbo UniversityNingbo 315211China

Sargassum fusiforme(***)has been used as an ingredient in Chinese herbal medicine for thousands of ***,there are a limited number of studies concerning its therapeutic *** performance gel permeation chromatography(HPGPC)analysis showed that the average molecular weight of the *** polysaccharide,SFPS 191212,is 43 *** 191212 is composed of mannose,rhamnose,galactose,xylose,glucose,and fucose(at a molar ratio:2.1:2.9:1.8:15.5:4.6:62.5)withα-andβ-*** present research evaluated the anti-tumor potential of the *** polysaccharide in human erythroleukemia(HEL)cells in *** explore the SFPS 191212’s apoptosis mechanism in HEL cells,transcriptome analysis was performed on HEL cells that were incubated with SFPS *** inhibitory effect of SFPS 191212 on HEL cell growth was also *** was found that SFPS 191212 inhibited HEL cell proliferation,reduced cell viability in a concentration-dependent manner,and induced an insignificant toxic effect on normal human embryonic lung(MRC-5)*** with the control group,transcriptome analysis identified a total of 598 differentially expressed genes(DEGs),including 243 up-regulated genes and 355 downregulated *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analyses were performed on all DEGs,and 900 GO terms and 52 pathways were found to be significantly ***,23 DEGs were randomly selected and confirmed by quantitative real-time polymerase chain reaction(qRT-PCR).Moreover,SFPS 191212 down-regulated the PI3K/Akt signal transduction *** results provide a framework for understanding the effect of SFPS 191212 on cancer cells and can serve as a resource for delineating the anti-tumor mechanisms of ***.

关键词： Human erythroleukemia Polysaccharide Sargassum fusiforme Transcriptome

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Catalytic effect of a novel MgC0.5Co3 compound on the dehydrogenation of MgH2

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Progress in Natural Science:Materials International 2021年第2期31卷 264-269页

作者： Yaokun fu Zhenmin ding Lu Zhang Hongming Zhang Wenfeng Wang Yuan Li Shumin Han Hebei Key Laboratory of Applied Chemistry School of Environmental and Chemical Engineering Yanshan University State Key Laboratory of Metastable Materials Science and Technology Yanshan University

The application of magnesium hydride(MgH) is limited due to the high reaction temperature and slow kinetics during dehydrogenation. In order to ameliorate the dehydrogenation property of MgH, MgCCocompound with induction and catalytic effects was introduced into the Mg/MgHsystem via ball-milling and hydriding combustion methods in present study. Compared to the pure MgH,the initial hydrogen desorption temperature of MgH–MgCCocomposite lowered to 237°C, decreasing by 141°C. At 325°C the MgH–MgCCocomposite could release 4.38 wt% Hwithin 60 min, which is 4.5 times the capacity of hydrogen released by as milled-MgH. Besides, the hydrogen desorption activation energy of the MgH–MgCCocomposite was dramatically reduced to 126.7 ± 1.4 k J/mol. It was observed that MgCCowas chemically stable and no chemical transformation occurred after cycling, which not only inhibited the nucleation and growth of composite particles, but also had a positive effect on the hydrogen desorption reaction of MgHdue to its catalytic *** study may provide references for designing and synthesizing Mg–C–Co alloy compound for the Mg-based hydrogen storage area.

关键词： Hydrogen storage materials Magnesium hydride Dehydrogenation performance MgC0.5Co3 alloy compound

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Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini

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Chinese Journal of Integrative Medicine 2024年第4期30卷 366-378页

作者： ZUO Qian XU ding-qiao YUE Shi-jun fu Rui-jia TANG Yu-ping Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility Shaanxi University of Chinese MedicineXi'an(712046)China

Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor,with active ingredients of bufadienolides and indole *** further research and clinical applications,it is found that cinobufacini alone or in combination with other therapeutic methods can play an anti-tumor role by controlling proliferation of tumor cells,promoting apoptosis,inhibiting formation of tumor neovascularization,reversing multidrug resistance,and regulating immune response;it also has the functions of relieving cancer pain and regulating immune *** this paper,the chemical composition,pharmacological effects,clinical applications,and adverse reactions of cinobufacini are ***,the extraction of monomer components of cinobufacini,the relationship between different mechanisms,and the causes of adverse reactions need to be further ***,high-quality clinical studies should be conducted.

关键词： cinobufacini chemical composition Chinese medicine pharmacological effect clinical application adverse effect

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Multi-component system maintenance optimization of a rail transit train based on opportunistic correlations

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Transportation Safety and Environment 2023年第4期5卷 182-191页

作者： Jisheng Dai Rongjun ding Yong fu Yong Qin College of Mechanical and Vechicle Engineering Hunan UniversityYuelu DistrictChangshaHunan 410082China Zhuzhou CRRC Times Electric Co. Ltd.Shifeng DistrictZhuzhouHunan 412001China State Key Lab of Rail Traffic Control&Safety Beijing Jiaotong UniversityHaidian DistrictBeijing 100044China

ln order to deal with the problems of insufficient or excessive maintenance in the current maintenance activities of China transit trains,this paper develops a novel multi-component system maintenance optimization approach based on an opportunistic correlation *** on the minimal reliability and failure rate change rule of each train component,the novel proposed maintenance optimization benefits from an improved opportunistic maintenance model with system structure correlation,fault correlation and reliability correlation under imperfect ***,different maintenance modes can be determined by a proposed mainte-nance factor under the different conditions of ***,the reliability threshold of each component is also considered to optimize the maintenance cost by the system reliability and operational availability of the ***,as the mentioned problem belongs to the NP-Hard optimization problems,a modified particle swarm optimization(PSO)with the improvement of inertia weight is proposed to cope with the optimization *** on a specific case under the practical recorded failure data,the analysis shows that the proposed model and approach can effectively cut the maintenance cost.

关键词： multi-component system maintenance optimization rail transit train opportunistic correlation modified particle swarm optimization(PSO)

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Magneto-Impedance in Fe_(73.5)Cu_(1)Mo_(3)Si_(13.5)B_(9) Alloy Ribbons

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Chinese Physics Letters 1997年第4期14卷 310-313页

作者： KU Wan-jun GE fu-ding YAN Ge ZHU Jing Central Iron and Steel Research Institute Beijing 100081 Department of materials Science and Engineering Tsinghua UniversityBeijing 100084

Giant magneto-impedance(GMI)effects in Fe_(73.5)Cu_(1)Mo_(3)Si_(13.5)B_(9) alloy ribbons have been measured under different external magnetic fields and different ac driving current *** results show that the longitudinal and the transverse GMI change with the annealing *** on the classical electromagnetic theory,the difference between the longitudinal and the transverse GMI(R,X,Z)has been discussed in this letter.

关键词： temperature alloy transverse

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Permian tectonic evolution and continental accretion in the eastern Central Asian Orogenic Belt:A perspective from the intrusive rocks

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Geoscience Frontiers 2024年第2期15卷 433-451页

作者： Anzong fu Hongyan Geng Changzhou Deng Chenglu Li Jishuang ding Bizheng Yang Wenpeng Yang Heilongjiang Institute of Natural Resources Survey Harbin 150036China State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550002China Science Unit Lingnan UniversityHong KongChina College of Earth Sciences Jilin UniversityChangchun 130061China

The tectonic evolution and history of continental accretion of the eastern Central Asian Orogenic Belt(CAOB)are not yet fully *** this study,we investigate Permian intrusive rocks from the Jiamusi Block of the eastern CAOB to constrain the tectonic evolution and continental accretion of this region during the late-stage evolution of the Paleo-Asian *** new data show that Early Permian gabbro-diorites were derived from the partial melting of depleted mantle metasomatized by oceanic-slab-released *** Permian adakitic granites have low Na2O and MgO and high K2O contents,indicating a thickened-lower-crust *** Permian S-type granites were derived from the partial melting of continental crust.A compilation of the available geochronological data for Permian intrusive rocks(including adakitic and A-,S-,and I-type granites and mafic rocks)from the eastern CAOB reveals that the A-type granites formed mainly during the Early–Middle Permian,S-type and adakitic granites mostly during the Middle–Late Permian,and I-type granites and mantle-derived mafic rocks throughout the *** A-type granites,which are proposed to have been sourced from thinned continental crust,indicate an extensional setting in the eastern CAOB during the Early *** Middle–Late Permian adakitic granites imply a thickened continental crust,which indicates a compressional ***,the eastern CAOB underwent a transition from extension to compression during the Middle Permian,which was probably triggered by the late-stage subduction of Paleo-Asian oceanic *** the petrogenesis of the intrusive rocks and inferred regional tectonic evolution of the eastern CAOB,we propose that vertical underplating of mantle-and oceanic-slabderived magmas contributed the materials for continental crust accretion.

关键词： Permian Intrusive rocks Eastern Central Asian Orogenic Belt Paleo-Asian Ocean Tectonic evolution

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