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芍药苷通过STAT3抑制IL-13诱导的BEAS-2B细胞氧化应激和自噬

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中国医院药学杂志 2024年第13期44卷 1535-1540页

作者：何芳丁敏甄海宁陈亚隽薛欣欣武汉市第三医院呼吸与危重症医学科湖北武汉430060

目的:评估芍药苷通过信号转导与转录激活子3(signal transducer and activator of transcriptions 3,STAT3)对白细胞介素-13(interleukin-13,IL-13)诱导的BEAS-2B哮喘细胞模型的炎症、氧化应激和自噬的改善作用。方法:用1、10和30μmol·L^(-1)的芍药苷干预IL-13诱导前后的BEAS-2B细胞,CCK-8检测细胞增殖活力,筛选芍药苷最佳作用条件。然后利用芍药苷和STAT3激活剂干预IL-13诱导的细胞模型,将细胞分为对照组、模型组、STAT3激活剂组、芍药苷组和STAT3激活剂+芍药苷共处理组。CCK-8检测各组细胞增殖活力,ELISA试剂盒检测各组细胞上清中IL-4、IFN-γ的含量,及细胞中MDA、CAT、SOD水平,Western blot检测各组细胞LC3Ⅱ、LC3Ⅰ、P62、p-STAT3和STAT3的蛋白表达。结果:CCK-8检测结果显示,10μmol·L^(-1)的芍药苷作用24 h为最佳干预条件。与对照组相比,模型组细胞增殖能力下降(P<0.05),IFN-γ、SOD和CAT含量下降(P<0.05),IL-4和MDA含量增加(P<0.05),LC3Ⅱ/Ⅰ蛋白表达比值和p-STAT3/STAT3蛋白表达比值增加(P<0.05),P62蛋白表达下降(P<0.05)。与模型组相比,STAT3激动剂组细胞增殖能力下降(P<0.05),IFN-γ、SOD和CAT含量下降(P<0.05),IL-4和MDA含量增加(P<0.05),LC3Ⅱ/Ⅰ蛋白表达比值和p-STAT3/STAT3蛋白表达比值增加(P<0.05),P62蛋白表达下降(P<0.05);芍药苷组细胞增殖能力增加(P<0.05),IFN-γ、SOD和CAT含量增加(P<0.05),IL-4和MDA含量下降(P<0.05),LC3Ⅱ/Ⅰ蛋白表达比值和p-STAT3/STAT3蛋白表达比值下降(P<0.05),P62蛋白表达增加(P<0.05)。与STAT3激动剂组相比,STAT3激动剂+芍药苷组共处理逆转了STAT3激动剂的作用。结论:芍药苷通过抑制STAT3蛋白磷酸化,抑制炎症反应,从而改善哮喘中细胞氧化应激和自噬。

关键词：哮喘芍药苷信号转导与转录激活子3 氧化应激自噬

Magnetic and Optical Properties of the TiO_2-Co-TiO_2 Composite Films Grown by Magnetron Sputtering

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Chinese Journal of Aeronautics 2007年第2期20卷 162-167页

作者： LIU Fa-min ding Peng SHI Wei-mei WANG Tian-min Department of Physics School of Sciences Beijing University of Aeronautics and Astronautics Beijing 100083 China

The TiO2-Co-TiO2 sandwich films were successfully grown on glass and silicon substrata making alternate use of radio frequency reactive magnetron sputtering and direct current magnetron sputtering. The structures and properties of these films were identified with X-ray diffraction （XRD）, Raman spectra and X-ray photoemission spectra （XPS）. It is shown that the sandwich film consists of two anatase TiO2 films with an embedded Co nano-film. The fact that, when the Co nano-film thickens, varied red shifts appear in optical absorption spectra may well be explained by the quantum confinement and tunnel effects. As for magnetic properties, the saturation magnetization, remnant magnetic induction and coercivity vary with the thickness of the Co nano-films. Moreover, the Co nano-film has a critical thickness of about 8.6 mn, which makes the coercivity of the composite film reach the maximum of about 1413 Oe.

关键词： TiO2-Co-TiO2 sandwich films surface structure and properties optical and magnetic properties

TIG-MIG间接电弧窄坡口焊侧壁未熔合缺陷数值分析及电场辅助抑制措施

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焊接技术 2024年第7期53卷 17-21,115页

作者：卢文轩丁敏陈杰太原理工大学材料科学与工程学院山西太原030024

文中用FLOW-3D软件模拟了TIG-MIG间接电弧焊接窄坡口厚4 mm 443铁素体不锈钢板对接侧壁未熔合缺陷的产生机理,提出一种电场辅助的抑制缺陷产生措施。研究结果表明:较窄的焊缝阻碍熔滴传热传质过程,在侧壁出现一个相比对侧低600℃的局部... 详细信息

文中用FLOW-3D软件模拟了TIG-MIG间接电弧焊接窄坡口厚4 mm 443铁素体不锈钢板对接侧壁未熔合缺陷的产生机理,提出一种电场辅助的抑制缺陷产生措施。研究结果表明:较窄的焊缝阻碍熔滴传热传质过程,在侧壁出现一个相比对侧低600℃的局部低温区域,进一步阻碍流体在此区域内与侧壁的熔合,因此产生侧壁未熔合缺陷。辅助电场的加入改善流体在焊缝侧壁的流动性,抑制未熔合缺陷的产生;焊缝内流体温度更高;侧壁熔合线距焊缝中心距离增加0.09 mm。

关键词： TIG-MIG间接电弧 443铁素体不锈钢侧壁未熔合电场辅助数值模拟

基于乡土树种利用的龙丽温高速公路生态廊道改造

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绿色科技 2024年第11期26卷 54-59,95页

作者：潘建林毛朝明丁敏浙江省松阳县自然资源和规划局浙江松阳323400 浙江省丽水市森林资源保护管理总站浙江丽水323000

为提升高速公路生态廊道森林景观效果,建立了美丽生态廊道森林群落评价指标,调查了龙丽温高速公路廊道植被状况后发现,多年的人工经营改变了森林原有的自然植被特征,各种纯林脆弱与不稳定的缺陷,给森林可持续经营带来风险。根据森林演... 详细信息

为提升高速公路生态廊道森林景观效果,建立了美丽生态廊道森林群落评价指标,调查了龙丽温高速公路廊道植被状况后发现,多年的人工经营改变了森林原有的自然植被特征,各种纯林脆弱与不稳定的缺陷,给森林可持续经营带来风险。根据森林演替规律,提出充分利用乡土树种,对不同群落使用间伐改造、补植、定向抚育等措施,增加森林群落内具有明显层次、叶色、花色和果色的乡土阔叶树种品种和数量;对容易发生森林火灾区域,种植耐火阔叶树种;清除外来有害生物、保护生物多样性的建设目标。通过改造,构造不同的景观斑块,形成具有空间和时间变化的异质景观,各种景观彼此镶嵌,季相变化明显,形成丰富多彩、美学价值高、生态功能强的美丽生态廊道景观。

关键词：乡土树种生态廊道森林健康森林景观植物群落生态美学森林演替

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基于SWAP模型分析青铜峡灌区春小麦播期优化及其对灌溉需水量的影响

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中国农业气象 2024年第6期45卷 594-608页

作者：孙风朝赵翠平张杰丁一民山西水利职业技术学院运城044004 中国电建集团北京勘测设计研究院有限公司北京100024 宁夏大学土木与水利工程学院银川750021

以宁夏青铜峡灌区春小麦为研究对象,基于2a田间观测试验和率定后的SWAP模型,构建旱作区春小麦模型参数集,以偏差校正后的7个大气环流模式(General Circulation Models,GCMs)数据驱动模型,评估未来不同气候情景下(SSP2-45和SSP5-85)春小... 详细信息

以宁夏青铜峡灌区春小麦为研究对象,基于2a田间观测试验和率定后的SWAP模型,构建旱作区春小麦模型参数集,以偏差校正后的7个大气环流模式(General Circulation Models,GCMs)数据驱动模型,评估未来不同气候情景下(SSP2-45和SSP5-85)春小麦产量和灌溉需水量变化,定量分析播期调整对青铜峡灌区春小麦生长和耗水过程的影响。结果表明:参数校正后的SWAP模型能有效模拟青铜峡灌区春小麦生长过程;SSP2-45情景下未来两个时期(2021-2050年和2051-2080年)青铜峡灌区多模式平均最高温度相对于历史基准期(1991-2020年)分别增加1.6℃和2.6℃,两个时期SSP5-85情景下最高温度将分别增加1.8℃和3.6℃。在不改变播期和品种条件下,未来春小麦全生育期长度将随温度升高而缩短,最大缩短天数达14.2d,出现在SSP5-85情景下2051-2080年。SSP2-45情景下未来两个时期春小麦多模式平均产量将分别下降9.6%和12.9%,SSP5-85情景下则分别下降12.1%和17.2%;不同情景不同时期春小麦灌溉需水量变化幅度相对较小,均不超过3.5%;提前播种可有效减少青铜峡灌区春小麦产量损失,但不能完全抵消气候变化的负面影响,其中,SSP2-45情景下未来两个时期分别提前23d和33d播种,产量损失可控制在1.5%和5.3%,在SSP5-85情景下分别提前30d和42d播种,产量损失可分别控制在2.9%和5.4%。优化播种日期后,青铜峡灌区春小麦收获日期平均提前5d左右。未来不同情景不同时期下春小麦灌溉需水量增加明显,增加比例在4.0%~8.0%。

关键词： CMIP6 气候变化春小麦适应性调控播期调整

Fulvic acid degradation using nanoparticle TiO_2 in a submerged membrane photocatalysis reactor

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Journal of Environmental Sciences 2005年第6期17卷 942-945页

作者： FU Jian-feng JI min AN ding-nian School of Environmental Science and Engineering Tianjin University Tianjin 300072 China

The degradation of fulvic acid（FA） by nanoparticle TiO2 in a submerged membrane photocatalysis（SMPC） reactor was studied. In this reactor, photocatalytic oxidation and membrane separation co-occured. The continuous air supplier provided O2 for the photocatalytical reaction and mixed the solution through an airflow controller. The particle TiO2 could automatically settle due to gravity without particle agglomeration so it could be easily separated by microfiltration（MF） membrane. It was efficient to maintain high flux of membranes. The effects of operational parameters on the photocatalytic oxidation rate of FA were investigated. Results indicated that photocatalyst at 0.5 g/L and airflow at 0.06 m^3/h were the optimum condition for the removal of fulvic acid, the removal efficiency was higher in acid media than that in alkaline media. The effects of different filtration duration on permeate flux rate of MF with P25 powder and with nanoparticle TiO2 were compared. Experimental results indicated that the permeate flux rate of MF was improved and the membrane fouling phenomenon was reduced with the addition of nanoparticle TiO2 catalyst compared with conventional P25 powder. Therefore, this submerged membrane photocatalysis reactor can faciliate potential application of photocatalytic oxidation process in drinking water treatment.

关键词： fulvic acid microfiltration membrane nanoparticle TiO2 photocatalytic oxidation reactor

Frankel Ⅲ型矫治器联合口唇肌训练治疗替牙期错[牙合]畸形的疗效评价

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上海口腔医学 2024年第4期33卷 432-437页

作者：丁敏林张海亮张吉敏杭州绿城口腔医院正畸科浙江杭州310012 杭州绿城口腔医院儿童口腔科浙江杭州310012 中国人民解放军联勤保障部队第903医院口腔科浙江杭州310013

目的:探讨口唇肌训练配合FrankelⅢ型矫治器矫治替牙期Ⅲ类错[牙合]畸形的临床疗效。方法:选择杭州绿城口腔医院2018年6月-2022年12月收治的100例替牙期Ⅲ类错[牙合]畸形儿童,采用随机数字表法将患儿分为联合组(采用口唇肌训练配合Fran... 详细信息

目的:探讨口唇肌训练配合FrankelⅢ型矫治器矫治替牙期Ⅲ类错[牙合]畸形的临床疗效。方法:选择杭州绿城口腔医院2018年6月-2022年12月收治的100例替牙期Ⅲ类错[牙合]畸形儿童,采用随机数字表法将患儿分为联合组(采用口唇肌训练配合FrankelⅢ型矫治器矫治)和对照组各50例(采用FrankelⅢ型矫治器矫治)。比较2组患儿治疗前后X线头影测量指标、颞下颌关节参数、上气道测量值参数及12个月后的随访情况。采用SPSS 21.0软件包对数据进行统计学分析。结果:治疗前,联合组和对照组SNA、SNB、ANB、U1-NA、L1-NB、ANS-Ptm、S-Ptm、Co-Po、CoS、MP-SN、MP-FH和NP-FH相比,差异无统计学意义(P>0.05);治疗后,联合组ANB、U1-NA、L1-NB和MP-SN大于对照组,NP-FH小于对照组,差异有统计学意义(P0.05);治疗后,联合组关节上间隙、后间隙大于对照组,差异有统计学意义(P0.05);治疗后,联合组Ad2-PNS大于对照组,差异有统计学意义(P<0.05)。随访12个月,联合组复发率为2.00%,显著低于对照组的16.00%(P<0.05)。结论:口唇肌训练配合FrankelⅢ型矫治器矫治替牙期Ⅲ类错[牙合]畸形,更有利于纠正畸形,改善上气道形态,降低治疗后复发率。

关键词：口唇肌训练 FrankelⅢ型矫治器替牙期错[牙合]畸形

Endoscopic resection of bronchial mucoepidermoid carcinoma in a young adult man: A case report and review of literature

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World Journal of Clinical Cases 2022年第32期10卷 11921-11928页

作者： Yong-min ding Qing Wang Department of Respiratory and Critical Care Medicine Shengzhou People’s HospitalShengzhou 312499Zhejiang ProvinceChina Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Primary tracheobronchial mucoepidermoid carcinoma(MEC),derived from salivary mucus glands,is an uncommon neoplasm in *** present,surgery is still the preferred treatment for adult bronchial MEC,although it may cause significant trauma and loss of lung ***,we report a patient with endobronchial MEC who received the interventional bronchoscopic therapy to remove the neoplasm and no recurrence occurred during *** SUMMARY A 28-year-old man was admitted to our unit with mild hemoptysis for 3 *** examination did not show any abnormal signs,and the serological indexes were all in the normal *** computed tomography(CT)indicated an intraluminal nodule in the bronchus intermedius with homogeneous density and a well-defined *** fiberoptic bronchoscopy,an endobronchial pedunculated polypoid was discovered without submucosal *** the neoplasm was confined to the bronchus,interventional bronchoscopy was performed to remove the mass by high-frequency electric knife and laser *** was sampled and histopathological examination confirmed the diagnosis of low-grade *** the proliferation index was low,no further treatment was *** 2 years of follow-up,the patient’s condition was good and no relapse was discovered under fluorescence bronchoscopy or CT *** Interventional bronchoscopy can be considered for treatment of low-grade bronchial MEC,with few complications and preserved lung function.

关键词： Mucoepidermoid carcinoma Interventional bronchoscopic therapy Intraluminal nodule Airway tumor Bronchoscopy Case report

Groove formation on Phobos from reimpacting orbital ejecta of the Stickney crater

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Earth and Planetary Physics 2022年第3期6卷 294-303页

作者： XiangYu Xi min ding MengHua Zhu State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacaoChina China National Space Administration Macao Center for Space Exploration and ScienceMacaoChina

Numerous linear grooves have long been recognized as covering the surface of Phobos, but the mechanisms of their formation are still unclear. One possible mechanism is related to the largest crater on Phobos, the Stickney crater, whose impact ejecta may slide,roll, bounce, and engrave groove-like features on Phobos. When the launch velocity is higher than the escape velocity, the impact ejecta can escape Phobos. A portion of these high-velocity ejecta are dragged by the gravitational force of Mars, fall back, and reimpact *** this research, we numerically test the hypothesis that the orbital ejecta of the Stickney crater that reimpact Phobos could be responsible for a particular subset of the observed grooves on Phobos. We adopt impact hydrocode i SALE-2 D(impact-Simplified Arbitrary Lagrangian Eulerian, two-dimensional) to simulate the formation of the Stickney crater and track its impact ejecta, with a focus on orbital ejecta with launch velocities greater than the escape velocity of Phobos. The launch velocity distribution of the ejecta particles is then used to calculate their trajectories in space and determine their fates. For orbital ejecta reimpacting Phobos, we then apply the sliding boulder model to calculate the ejecta paths, which are compared with the observed groove distribution and length to search for causal relationships. Our ejecta trajectory calculations suggest that only ~1% of the orbital ejecta from the Stickney crater can reimpact Phobos. Applying the sliding boulder model, we predict ejecta sliding paths of 9-20 km in a westward direction to the east of the zone of avoidance, closely matching the observed grooves in that region. The best-fit model assumes an ejecta radius of ~150 m and a speed restitution coefficient of 0.3, consistent with the expected ejecta and regolith properties. Our calculations thus suggest the groove class located to the east of the zone of avoidance may have been caused by reimpact orbital ejecta from the Stick

关键词： Phobos groove formation Stickney crater reimpact ejecta