检索结果-南通市图书馆

Early proactive monitoring of DNA-thioguanine in patients with Crohn’s disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers

引用

World Journal of Gastroenterology 2024年第12期30卷 1751-1763页

作者： Ting Yang kang Chao Xia Zhu Xue-ding Wang Sumyuet Chan Yan-Ping Guan Jing Mao Pan Li Shao-Xing Guan Wen Xie Xiang Gao Min Huang school of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Institute of Clinical Pharmacology Sun Yat-sen UniversityGuangzhou 510006Guangdong ProvinceChina Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655Guangdong ProvinceChina Department of Pharmacy The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080Guangdong ProvinceChina Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261United States

BACKGROUND Thiopurine-induced leucopenia significantly hinders the wide application of *** optimization guided by nudix hydrolase 15(NUDT15)has significantly reduced the early leucopenia rate,but there are no definitive biomarkers for late risk leucopenia *** To determine the predictive value of early monitoring of DNA-thioguanine(DNATG)or 6-thioguanine nucleotides(6TGN)for late leucopenia under a NUDT15-guided thiopurine dosing strategy in patients with Crohn’s disease(CD).METHODS Blood samples were collected within two months after thiopurine initiation for detection of metabolite *** leucopenia was defined as a leukocyte count<3.5×10^(9)/L over two *** Of 148 patients studied,late leucopenia was observed in 15.6%(17/109)of NUDT15/thiopurine methyltransferase(TPMT)normal and 64.1%(25/39)of intermediate *** patients suffering late leucopenia,early DNATG levels were significantly higher than in those who did not develop late leucopenia(P=4.9×10^(-13)).The DNATG threshold of 319.43 fmol/μg DNA could predict late leucopenia in the entire sample with an area under the curve(AUC)of 0.855(sensitivity 83%,specificity 81%),and in NUDT15/TPMT normal metabolizers,the predictive performance of a threshold of 315.72 fmol/μg DNA was much more remarkable with an AUC of 0.902(sensitivity 88%,specificity 85%).6TGN had a relatively poor correlation with late leucopenia whether in the entire sample(P=0.021)or NUDT15/TPMT normal or intermediate metabolizers(P=0.018,P=0.55,respectively).CONCLUSION Proactive therapeutic drug monitoring of DNATG could be an effective strategy to prevent late leucopenia in both NUDT15/TPMT normal and intermediate metabolizers with CD,especially the former.

关键词： Thiopurine-induced late leucopenia DNA-thioguanine 6-thioguanine nucleotide Proactive therapeutic drug monitoring Crohn’s disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arc erosion behavior of a nanocomposite W-Cu electrical contact material

引用

Rare Metals 2006年第1期25卷 37-42页

作者： CHEN Wenge kang Zhanying SHEN Hongfang ding Bingjun school of Materials Science and Engineering Xi＇an University of Technology Xi＇an 710048 China Department of Materials Physics Xi＇an Jiaotong University Xi＇an 710049 China

The erosion behavior of a nanocomposite W-Cu material under arc breakdown was investigated. The arc erosion rates of the material were determined, and the eroded surfaces and arc erosion mechanisms were studied by scanning eleclion microscopy. It is concluded that the nanocomposite W-Cu electrical contact material shows a characteristic of spreading arcs. The arc breakdown of a commercially used W-Cu alloy was limited in a few areas, and its average arc erosion rate is twice as large as that of the former. Furthermore, it is also proved that the arc extinction ability and arc stability of the nanocomposite W-Cu material are excellent, and melting is the major failure modality in the make-and-break operation of arcs.

关键词： arc erosion W-Cu alloy contact materials nanocomposite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

引用

Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan Shi Chunyan Cao Yiheng Zeng Yuanliang ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang Jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of climate and human activity on NDVI of various vegetation types in the Three-River Source Region, china

引用

Journal of Arid Land 2024年第8期16卷 1080-1097页

作者： LU Qing kang Haili ZHANG Fuqing XIA Yuanping YAN Bing Research Center of Resource and Environment Economics East China University of TechnologyNanchang 330013China Jiangxi Key Laboratory of Watershed Ecological Process and Information East China University of TechnologyNanchang 330013China school of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China Nanchang Key Laboratory of Landscape Process and Territorial Spatial Ecological Restoration East China University of TechnologyNanchang 330013China Institute of Energy Research Jiangxi Academy of SciencesNanchang 330096China

The Three-River Source Region(TRSR)in china holds a vital position and exhibits an irreplaceable strategic importance in ecological preservation at the national *** the basis of an in-depth study of the vegetation evolution in the TRSR from 2000 to 2022,we conducted a detailed analysis of the feedback mechanism of vegetation growth to climate change and human activity for different vegetation *** the growing season,the spatiotemporal variations of normalized difference vegetation index(NDVI)for different vegetation types in the TRSR were analyzed using the Moderate Resolution Imaging Spectroradiometer(MODIS)-NDVI data and meteorological data from 2000 to *** addition,the response characteristics of vegetation to temperature,precipitation,and human activity were assessed using trend analysis,partial correlation analysis,and residual *** indicated that,after in-depth research,from 2000 to 2022,the TRSR's average NDVI during the growing season was *** preliminary ranking of the average NDVI for different vegetation types was as follows:shrubland(0.5762)>forest(0.5443)>meadow(0.4219)>highland vegetation(0.2223)>steppe(0.2159).The NDVI during the growing season exhibited a fluctuating growth trend,with an average growth rate of 0.0018/10a(P<0.01).Notably,forests displayed a significant development trend throughout the growing season,possessing the fastest rate of change in NDVI(0.0028/10a).Moreover,the upward trends in NDVI for forests and steppes exhibited extensive spatial distributions,with significant increases accounting for 95.23%and 93.80%,*** sensitivity to precipitation was significantly enhanced in other vegetation types other than highland *** contrast,steppes,meadows,and highland vegetation demonstrated relatively high vulnerability to temperature fluctuations.A further detailed analysis revealed that climate change had a significant positive impact on the TRSR from 2000 to 2022,particularly in its

关键词： growing season normalized difference vegetation index(NDVI) highland vegetation trend analysis partial correlation analysis residual analysis contribution rate

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Social network learning efficiency in the principal-agent relationship

引用

Journal of Management Science and Engineering 2024年第2期9卷 193-219页

作者： Chuan ding Yilin Hong Yang Li Peng Liu school of Mathematics Southwestern University of Finance and EconomicsChengdu611130China S.C.Johnson College of Business Cornell UniversityIthacaNY14853USA

Under the bounded rationality assumption,a principal rarely provides an optimal contract to an *** from others is one way to improve such a *** paper studies the efficiency of social network learning(SNL)in the principal–agent *** first introduce the Cobb-Douglas production function into the classic Holmstrom and Milgrom(1987)model with a constant relative risk-averse agent and work out the theoretically optimal *** are then designed to model the SNL process based on profit gaps between contracts in a network of *** the uncertainty of the agent's labor output,we find that the principals can reach a consensus that tends to result in overcompensation compared to the optimal ***,this study examines how network attributes and model parameters impact learning efficiency and posits several summative *** simulation results validate these hypotheses,and we discuss the relevant economic implications of the observed changes in SNL efficiency.

关键词： Simulation Social network learning Principaleagent Reaching consensus Learning efficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中国数字经济与企业集聚空间格局重塑

引用

科学学研究 2024年第3期42卷 528-540页

作者：邢丁徐康宁东南大学经济管理学院江苏南京211189

数字经济已成为重塑社会经济空间组织的重要力量。基于2011-2020年中国285个城市面板数据,使用GIS空间分析、空间杜宾模型和地理加权回归模型,分析数字经济空间格局演变及其对企业空间集聚的重塑效应。结果表明:(1)2011-2020年中国数字... 详细信息

数字经济已成为重塑社会经济空间组织的重要力量。基于2011-2020年中国285个城市面板数据,使用GIS空间分析、空间杜宾模型和地理加权回归模型,分析数字经济空间格局演变及其对企业空间集聚的重塑效应。结果表明:(1)2011-2020年中国数字经济发展水平的空间分布呈现出东高西低的分布特征,高值区主要集聚在东部沿海地区以及部分省会城市。(2)2011-2020年规模以上工业企业的空间集聚格局始终呈现出“东高西低”型的分布特征,并逐渐向中西部地区扩散。(3)总体来说,数字经济对企业集聚起分散作用,且相比于小城市,数字经济对大城市企业空间集聚的分散力更强。(4)数字经济对企业空间集聚的影响存在空间异质性,数字经济对东部地区和沿海地区的企业集聚有更大的分散力。

关键词：数字经济企业集聚空间分布空间异质性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Decision and Coordination of an E-commerce Supply Chain Considering Returns and Network Externalities

引用

Journal of Systems Science and Systems Engineering 2024年第5期33卷 552-575页

作者： Liang Shen Fei Lin Yuyan Wang Luping ding T.C.E.Cheng Dexia Wang school of Public finance and Taxation Shandong University of Finance and Economicsjinan 250014China bschool of Management Science and Engineering Shandong University of Finance and EconomicsJinan 250014China PolyU Business school The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong 999077China

Considering the large number of returns in online sales and the network externalities of e-platforms,we develop a decentralized model and a centralized model to explore the impacts of returns and network externalities on e-commerce supply chain(ECSC)*** show that in the decentralized model,the service level,price,market demand,and ECSC members’profits increase with the network externality ***,the service level and price increase,while the market demand and ECSC members’profits decrease with the product return *** centralized model is the optimal operating mode when it is properly *** design the“commission and return cost-sharing”contract to optimize ECSC,in which the proportion of the e-platform’s sharing of the return handling cost is exactly equal to the proportion of the system profit after *** on the decentralized model,we develop two extended models in which we endogenize the impacts of the service level and return rate on the network externality *** comparisons between the extended and decentralized models,we show that high-quality service can improve ECSC’s profitability,while a high return rate hurts its economic performance.

关键词： E-commerce supply chain coordination mechanism network externalities return products

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

学龄前儿童家长对口腔不良习惯的认知调查

引用

上海口腔医学 2024年第1期33卷 101-105页

作者：康莹丁琴汪隼上海交通大学医学院附属第九人民医院儿童口腔科上海交通大学口腔医学院国家口腔医学中心国家口腔疾病临床研究中心上海市口腔医学重点实验室上海市口腔医学研究所上海200011

目的:通过问卷调查,了解家长对学龄前儿童口腔不良习惯的认知情况及其相关影响因素,为科普宣教提供参考依据。方法:使用自行设计的调查问卷,对247名初诊患儿家长进行基本信息和口腔不良习惯相关问题调查,采用SPSS 26.0软件包对计数资料... 详细信息

目的:通过问卷调查,了解家长对学龄前儿童口腔不良习惯的认知情况及其相关影响因素,为科普宣教提供参考依据。方法:使用自行设计的调查问卷,对247名初诊患儿家长进行基本信息和口腔不良习惯相关问题调查,采用SPSS 26.0软件包对计数资料采用描述性统计,影响儿童家长对口腔不良习惯认知情况的相关因素采用logistic回归分析。结果:在247名学龄前儿童家长中,家长带孩子去医院就诊的原因中,因口腔不良习惯就诊占17.4%,口腔不良习惯发生率为44%。家长对口腔不良习惯的认知不高,不到一半的家长(46.6%)知晓口腔不良习惯,其中82.6%的家长认为不良习惯影响孩子牙、颌、面发育以及心理健康,影响面形(62.1%)、牙列整齐(34.7%)、咀嚼功能(48.4%)、心理健康(21.1%)。78.3%的家长认为口腔不良习惯需要纠正,69.6%认为需要去医院治疗,30.4%认为只要孩子停止放弃口腔不良习惯就可以;61.7%的家长发现孩子有不良习惯会及时就医。家长获取口腔不良习惯相关知识的途径,医院宣教占61.5%。不同特征的家长对口腔不良习惯认知有所不同,logistic回归分析结果显示,家长学历是影响家长对口腔不良习惯认知情况的危险因素(P=0.009)。结论:家长对儿童口腔不良习惯的认知不高,家长学历是影响家长对口腔不良习惯认知情况的危险因素,需要提升家长对口腔习惯的认知,加强口腔不良习惯的卫生健康教育,尤其对特殊体征家长进行口腔健康宣教,提高对口腔保健的重视程度,做到早发现、早预防、早治疗和及时治疗,以预防错畸形的发生、发展。

关键词：口腔不良习惯家长认知调查

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

借用规模视角下中国城市收缩时空特征及其空间溢出效应

引用

经济地理 2024年第3期44卷 66-75页

作者：陈姝兴丁登龙吴康西南财经大学经济学院四川成都611130 西南财经大学经济与管理研究院四川成都611130 首都经济贸易大学城市经济与公共管理学院北京100070

近年来中国城市收缩现象日益突出,客观准确识别城市收缩现象并探究其影响因素,对于新型城镇化建设具有重要意义。文章以2011—2018年中国286个地级及以上城市为研究对象,通过构建城市收缩指数测度指标体系,从功能规模借用和绩效规模借... 详细信息

近年来中国城市收缩现象日益突出,客观准确识别城市收缩现象并探究其影响因素,对于新型城镇化建设具有重要意义。文章以2011—2018年中国286个地级及以上城市为研究对象,通过构建城市收缩指数测度指标体系,从功能规模借用和绩效规模借用的视角,对城市面板数据采用双固定效应模型、空间杜宾模型和面板门限模型等方法,实证检验了城市收缩的影响因素。研究发现:(1)中国城市在时间维度和空间维度上都出现增长与收缩并存现象,不同类型收缩城市数量、收缩程度和区域分布都存在显著差异。(2)功能规模借用和绩效规模借用2种效应在城市群和非城市群中均表现出异质性,并存在“空间溢出效应”现象。功能层面以规模借用形式存在,在全国范围内效应都显著;绩效层面则以集聚阴影形式存在,在非城市群中效应不显著。(3)借用规模因城市规模不同对城市收缩呈现非线性影响,功能规模借用水平表现为大城市>小城市>中型城市,而在绩效层面中小城市表现为集聚阴影,大城市则表现为绩效规模借用。

关键词：城市收缩借用规模城市群功能规模借用绩效规模借用集聚阴影

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

MiR-107-3p/Atp6v0e1 contributes to protective effects of two selenium-containing peptides,TSeMMM and SeMDPGQQ on lead-induced neurotoxicity

引用

Food Science and Human Wellness 2024年第4期13卷 2060-2067页

作者： Yong Fang Tianhang Huang Jian Wu Xieqi Luo Fengjiao Fan Peng Li Jian ding Xinyang Sun College of Food Science and Engineering Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and SafetyNanjing 210023China Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi School of MedicineJiangnan UniversityWuxi 214122China

Two selenium(Se)-containing peptides from Se-enriched rice,TSeMMM and SeMDPGQQ,possess neuroprotective potency against lead(Pb2+)-induced ***,the crosstalk between mRNA and microRNAs(miRNA)involved in the neuroprotection mechanism remains to be *** this study,RNA-sequencing and miRNA-sequencing were used to independently identify differentially expressed mRNAs and small RNAs profiles in Pb^(2+)-treated primary fetal rat cortical neurons and then the correlated miRNA-mRNA target pairs were *** was found that 34 mRNAs related to oxidative phosphorylation could be reversed by pretreatment of TSeMMM and *** protective effect of TSeMMM and SeMDPGQQ was mediated by upregulation of miR-107-3p,which downregulates the ATPase H+transporting V0 subunit e1(Atp6v0e1)mRNA level.A zebrafish model was applied to verify the relevance between the targeted mRNA and miRNA by real-time quantitative *** results indicated that miR-107-3p was a potential therapeutic target to achieve neuroprotection of Se-containing peptides via stimulation of Atp6v0e1.

关键词： Lead Se-containing peptides Neuroprotection miRNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：