检索结果-南通市图书馆

Lentivirus-mediated Persephin overexpression in Parkinson's disease rats

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Neural Regeneration Research 2015年第11期10卷 1814-1818页

作者： Xiao-feng Yin Hua-min Xu Yun-xia Jiang Yun-lai Zhi Yu-xiu Liu Heng-wei Xiang Kai Liu Xiao-dong ding Peng Sun Department of Neurosurgery the Second Affiliated Hospital of Shanxi Medical University Department of Physiology Qingdao University Nursing College of Qingdao University Department of Pediatric Surgery Affiliated Hospital of Qingdao University Department of Nursing Affiliated Hospital of Qingdao University Department of Neurosurgery Affiliated Hospital of Medical College Qingdao University

Persephin, together with glial cell line-derived neurotrophic factor and neurturin, has a neurotrophic effect and promotes the survival of motor neurons cultured in vitro. In this study, dopaminergic neurons in the substantia nigra of rats were transfected with the Persephin gene. One week later 6-hydroxydopamine was injected into the anterior medial bundle to establish a Parkinson＇s disease model in the rats. Results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with Persephin gene. In addition, the rotating effect of the induced Parkinson＇s disease rats was much less in the group pretreated with the Persephin gene. Persephin has a neuroprotective effect on the 6-hydroxydopamine-induced Parkinson＇s disease through protecting dopaminergic neurons.

关键词： nerve regeneration Persephin lentivirus Parkinson's disease dopaminergic neurons gene therapy over-expression transfection striatum neural regeneration

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试论高校图书馆员的印象管理

图书馆工作与研究 2011年第6期 51-53页

作者：丁冬东南大学图书馆

印象管理是一种人们试图控制他人对自己形成某种印象的过程。印象管理是协调人际关系,进行组织管理的重要手段。高校图书馆员的印象管理有着历史原因和现实需要,高校图书馆员印象构建必须与数字化图书馆的发展、队伍建设和服务工作创新... 详细信息

印象管理是一种人们试图控制他人对自己形成某种印象的过程。印象管理是协调人际关系,进行组织管理的重要手段。高校图书馆员的印象管理有着历史原因和现实需要,高校图书馆员印象构建必须与数字化图书馆的发展、队伍建设和服务工作创新结合起来。

关键词：高校图书馆员印象管理

Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice

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World Journal of Gastroenterology 2015年第36期21卷 10375-10384页

作者： Wan-Qin Liao Ya-Lei Qi Lin Wang Xiao-Ming dong Tao Xu Chao-dong ding Rui Liu Wei-Cheng Liang Li-Ting Lu He Li Wen-feng Li Guang-bin Luo Xin-Cheng Lu School of Basic Medical Science Wenzhou Medical UniversityChashan CampusChashan University Town First Affiliated Hospital of Wenzhou Medical University Departments of Genetics and Genome Sciences Case Western Reserve University

AIM: To investigate the effects of Recql5 deficiency on liver injury induced by lipopolysaccharide/D-galactosamine(LPS/D-Gal).METHODS: Liver injury was induced in wild type(WT) or Recql5-deficient mice using LPS/D-Gal,and assessed by histological,serum transaminases,and mortality analyses. Hepatocellular apoptosis was quantified by transferase d UTP nick end labeling assay and Westernblot analysis of cleaved caspase-3. Liver inflammatory chemokine and cytochrome P450 expression was analyzed by quantitative reverse transcription-PCR. Neutrophil infiltration was evaluated by myeloperoxidase activity. Expression and phosphorylation of ERK,JNK,p65,and H2 A.X was determined by Western blot. Oxidative stress was evaluated by measuring malondialdehyde production and nitric oxide synthase,superoxide dismutase,glutathione peroxidase,catalase,and glutathione reductase ***: following LPS/D-Gal exposure,Recql5-deficient mice exhibited enhanced liver injury,as evidenced by more severe hepatic hemorrhage,higher serum aspartate transaminase and alanine transaminase levels,and lower survival rate. As compared to WT mice,Recql5-deficient mice showed an increased number of apoptotic hepatocytes and higher cleaved caspase-3 levels. Recql5-deficient mice exhibited increased DNA damage,as evidenced by increased γ-H2 A.X levels. Inflammatory cytokine levels,neutrophil infiltration,and ERK phosphorylation were also significantly increased in the knockout mice. Additionally,Recql5-deficicent mice exhibited increased malondialdehyde production and elevated inducible nitric oxide synthase,superoxide dismutase,glutathione peroxidase,catalase,and glutathione reductase activity,indicative of enhanced oxidative stress. Moreover,CYP450 expression was significantly downregulated in Recql5-deficient mice after LPS/D-Gal ***: Recql5 protects the liver against LPS/D-Gal-induced injury through suppression of hepatocyte apoptosis and oxidative stress and modulation of CYP4

关键词： Recql5 Liver injury Apoptosis Oxidative stress CYP

弘扬民族音乐发展民族声乐——由原生态歌手引发的思考

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人民音乐 2007年第7期 52-53页

作者：丁冬安徽省铜陵学院艺术系

加强对民族声乐理论的建设与学习是我们深入理解和掌握民族声乐演唱的基础，也是促进我国民族声乐演唱风格由“单一化”向“多元化”转变的核心举措。近年来，从自然科学领域借鉴而来的“原生态”一词，成了音乐领域描述“原汁原味”民... 详细信息

加强对民族声乐理论的建设与学习是我们深入理解和掌握民族声乐演唱的基础，也是促进我国民族声乐演唱风格由“单一化”向“多元化”转变的核心举措。近年来，从自然科学领域借鉴而来的“原生态”一词，成了音乐领域描述“原汁原味”民歌的时髦词汇，随着一批来自民间的歌手，如陕北民歌王王向荣、山西羊倌歌手石占明等登上大雅之堂，尽管带着浓厚的乡音，尽管穿着“土得掉渣”的服饰，

关键词：民族声乐演唱民族音乐原生态歌手陕北民歌声乐理论演唱风格科学领域

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严寒地区高速铁路冰雪飞溅特性及防治研究

铁道工程学报 2017年第9期34卷 29-34页

作者：井国庆丁东北京交通大学北京100044

研究目的:冰雪飞溅是严寒地区高速铁路有砟轨道面临的重要问题之一,列车结构和道床断面形式都是其重要影响因素。本文基于k-ε Realizable湍流模型,采用滑移网格技术,建立CRH3型高速列车-有砟道床模型,对列车绕流特性和道床空气动力学... 详细信息

研究目的:冰雪飞溅是严寒地区高速铁路有砟轨道面临的重要问题之一,列车结构和道床断面形式都是其重要影响因素。本文基于k-ε Realizable湍流模型,采用滑移网格技术,建立CRH3型高速列车-有砟道床模型,对列车绕流特性和道床空气动力学特性进行研究,揭示冰雪飞溅机理,以期为优化道床断面和防治冰雪灾害提供理论基础。研究结论:(1)车头、车尾和转向架区域,风速和风压出现大幅度波动,冰雪飞溅几率较高;(2)道床中心风压较大,风速较高,冰雪块极易发生飞溅现象,道床表面风压由内向外递减,轨枕槽内易出现冰雪块移动和堆积;(3)列车速度是影响冰雪飞溅的关键因素,随着车速增加,风压值随之变大,列车速度在250 km/h以上时,车速每增加100 km/h,风压峰值增加约1倍,冰雪飞溅几率明显增加;(4)风压随着砟肩堆高的增大而增大,在列车速度为350 km/h条件下,砟肩堆高由0 mm到150 mm,负压峰值增幅达9.0%,因此在保证道床横向阻力基础上宜降低砟肩堆高;(5)本研究结论可为冰雪飞溅防治提供工程依据及指导作用。

关键词：严寒线路冰雪飞溅空气动力学道床断面形式防治措施

Singular integral on bounded strictly pseudoconvex domain

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Applied Mathematics(A Journal of Chinese Universities) 2008年第3期23卷 273-278页

作者： GONG ding-dong Dept.of Math.,Zhejiang Univ.,Hangzhou 310027,China Dept.of Math.Sci.,Zhejiang Sci-Tech Univ.,Hangzhou 310018,China. Dept. of Math. Zhejiang Univ. Hangzhou China Dept. of Math. Sci. Zhejiang Sci-Tech Univ. Hangzhou China

Kytmanov and Myslivets gave a special Cauchy principal value of the singular integral on the bounded strictly pseudoconvex domain with smooth boundary. By means of this Cauchy integral principal value, the corresponding singular integral and a composition formula are obtained. This composition formula is quite different from usual ones in form. As an application, the corresponding singular integral equation and the system of singular integral equations are discussed as well.

关键词： strictly pseudoconvex domain singulax integral composition formula singular integral equation

An experimental analysis on the turnover time of railway freight transportation based on the impact strength of factors

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Journal of Chongqing University 2017年第3期16卷 113-123页

作者：张光远 ding Xiao-dong 鲁工圆于洋 School of Transportation and Logistics Southwest Jiaotong UniversityChengdu 610031.P.R.China Nation and Region Combined Engineering Lab of Intelligentizing Integrated Transportation Chengdu 610031 P. R. China Transportation & Economics Research Institute China Academy of Railway Sciences Beijing 100089 P. R. China School of Architecture and Design Southwest Jiaotong UniversityChengdu 610031 P. R. China

Based on the factors impact strength model(FISM), we studied on calculation formulas of influence strength and key elements of FISM, and analyzed the turnover time of railway freight transportation of China. The results show that wagon transfer time is the most critical factor among the three subjective factors of wagons turnover time. The FISM based analysis of wagon transfer time show that the wagon turnover time is significantly correlated with transit time with resorting. Among the seven factors of detention time of transit time with resorting, the time of waiting to departing, converging, and waiting to break-up are key factors, while the time of make-up, break-up, arrival and departure are general factors. We carried out one empirical research based on the data of Baoji East Railway Station in 2015. The results of empirical research and FISM are consistent completely.

关键词： railway transportation wagon turnover time impact strength wagon transfer time correlation coefficient method

Serum microRNA-204 levels are associated with long-term cardiovascular disease risk based on the Framingham risk score in patients with type 2 diabetes: results from an observational study

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Journal of Geriatric Cardiology 2020年第6期17卷 330-337页

作者： Rui WANG Yao-dong ding Wen GAO Yu-Qiang PEI Jia-Xin YANG Ying-Xin ZHAO Xiao-Li LIU Hua SHEN Shuo ZHANG Lei YU Hai-Long GE Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Cardiology Bayannaoer City HospitalInner MongoliaChina Department of Gynecology and Obstetrics Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Cardiology the Third Hospital of JinanShandongChina

Background Previous studies have demonstrated that micro RNA-204(mi R-204) is involved in atherosclerosis and vascular calcification. However, the value of mi R-204 as the predictive biomarker for cardiovascular disease(CVD) remains unclear. We aimed to evaluate the association between the circulating mi R-204 level and ten-year CVD risk based on the Framingham risk score(FRS). Methods In this retrospective study, we enrolled 194 consecutive patients with type 2 diabetes mellitus(T2DM) without CVD in Beijing Anzhen Hospital between January 2015 and September 2016. We used the FRS to evaluate the risk of CVD for each patient. Circulating mi R-204 levels were measured by quantitative real-time polymerase chain reaction. Results Circulating mi R-204 levels were significantly lower in the group of patients(0.49 ± 0.13) at high risk of CVD(FRS > 20%) than in the low(FRS ding to multivariate logistic analyses, reduced mi R-204 level was independently associated with an increased risk of CVD after adjusting for conventional risk factors(OR = 0.876, 95% CI: 0.807–0.950, P = 0.001). Receiver-operating characteristic curve analysis showed that the circulating mi R-204 level can predict the high risk of CVD with higher specificity than the traditional risk factor of high systolic blood pressure or the protective factor of high-density lipoprotein cholesterol. Conclusions Our study demonstrated that patients with lower circulating mi R-204 levels were at high risk for CVD. After adjustment for potential confounders, mi R-204 was independently associated with CVD in patients with T2DM.

关键词： Cardiovascular disease Framingham risk score MicroRNA-204 Type 2 diabetes mellitus

Test of Cu base alloy Huadong sintering model

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中国有色金属学会会刊：英文版 2001年第2期11卷 192-195页

作者：丁华东方宁象遇元宏 Department of Materials Science and Engineering Armored Force Engineering Institute PLA Zhejiang Institute of Metallurgy

Through modular pressing and sintering, the Cu C powder metallurgy samples were made and the process was investigated. The results show that there exist expanding mechanism and shrinking mechanism in sintering process, and whether the sintering body is shrinking or expanding depends on the interacting between the two mechanisms, and the HD sintering model is in keeping with the actual sintering process. [

关键词： powder metallurgy sintering mechanism sintering model Cu-C material