Lentivirus-mediated Persephin overexpression in Parkinson's disease rats

作     者：Xiao-feng Yin Hua-min Xu Yun-xia Jiang Yun-lai Zhi Yu-xiu Liu Heng-wei Xiang Kai Liu Xiao-dong Ding Peng Sun 

作者机构：Department of Neurosurgery the Second Affiliated Hospital of Shanxi Medical University Department of Physiology Qingdao University Nursing College of Qingdao University Department of Pediatric Surgery Affiliated Hospital of Qingdao University Department of Nursing Affiliated Hospital of Qingdao University Department of Neurosurgery Affiliated Hospital of Medical College Qingdao University 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2015年第10卷第11期

页      面：1814-1818页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China No.81171208 the Natural Science Foundation of Shandong Province of China No.Z2008C06 

主　　题：nerve regeneration Persephin lentivirus Parkinson's disease dopaminergic neurons gene therapy over-expression transfection striatum neural regeneration 

摘      要：Persephin, together with glial cell line-derived neurotrophic factor and neurturin, has a neurotrophic effect and promotes the survival of motor neurons cultured in vitro. In this study, dopaminergic neurons in the substantia nigra of rats were transfected with the Persephin gene. One week later 6-hydroxydopamine was injected into the anterior medial bundle to establish a Parkinson＇s disease model in the rats. Results found that the number of dopaminergic neurons in the substantia nigra increased, tyrosine hydroxylase expression was upregulated and concentrations of dopamine and its metabolites in corpus striatum were increased after pretreatment with Persephin gene. In addition, the rotating effect of the induced Parkinson＇s disease rats was much less in the group pretreated with the Persephin gene. Persephin has a neuroprotective effect on the 6-hydroxydopamine-induced Parkinson＇s disease through protecting dopaminergic neurons.