检索结果-南通市图书馆

Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan ding xiaoming Liu Haiqin Chen Jianxin Zhao R.Paul Ross Catherine Stanton Shilong jiang Wei Chen Bo Yang Nutrition and Metabolism Research Division， Innovation Center， Heilongjiang Feihe Dairy Co.， Ltd. National Engineering Research Center for Functional Food， jiangnan University State Key Laboratory of Food Science and Technology， jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development APC Microbiome Ireland， University College Cork School of Food Science and Technology， jiangnan University International Joint Research Center for Probiotics & Gut Health， jiangnan University Teagasc Food Research Centre

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

关键词：

Behavioral responses of blue sheep(Pseudois nayaur) to nonlethal human recreational disturbance

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2013年第17期58卷 2237-2247页

作者： jiang TianYi WANG xiaoming ding YouZhong LIU ZhenSheng WANG ZhengHuan School of Life Science East China Normal University Shanghai Science and Technology Museum College of Wildlife Resources Northeast Forestry University Shanghai Key Laboratory of Urbanization and Ecological Restoration East China Normal University

Nonlethal human recreational activities have been confirmed to have negative effect on wild animals in a number of ways,including changes in behaviors,avoidance of suitable habitats and declines in breeding *** on the anti-disturbance mechanism of wild animals to human disturbance can provide valuable knowledge to the management of wild animals and the evolutionary mechanisms of behavioral adaptation to their *** evaluate how blue sheep(Pseudois nayaur) would react to nonlethal human recreational disturbance,we studied their anti-disturbance strategy towards human disturbance in Suyukou National Forest Park(SNFP),Helan Mountains,Yinchuan of Ningxia Hui Autonomous *** multinomial logistic regression models(MLRMs),we sought to answer two questions:(1) which kind of human recreational behavior would evoke the most serious anti-disturbance behaviors in blue sheep;and(2) how would various ecological factors influence the anti-disturbance strategy of blue sheep to human recreational disturbance? We collected 10 habitat and population variables and evaluated three kinds of reaction of blue sheep-no response,vigilance and flight.A total of 921 observations qualified to enter *** found that habitat type(HT),gender(GEN),head direction(HD),visibility index(VI),and disturbance source(DS) were the five variables that significantly influenced the intensity of reactions of blue *** sheep were more alert to tourists than to vehicles,and roads were the habitat type that caused the most intensive reaction of alertness where human disturbance was the *** were more vigilant than *** sheep might feel safer when staying in open habitat,and taking a front head direction provided them with the highest *** on these results,we present suggestions to SNFP for the management of ecotourism and blue sheep conservation.

关键词：行为反应人类干扰休闲活动非致命性干扰机制岩羊 logistic回归模型宁夏回族自治区

Efficient Splitting of Trans-/Cis-Olefins Using an Anion-Pillared Ultramicroporous Metal-Organic Framework with Guest-Adaptive Pore Channels

在线全文

学校读者我要写书评

暂无评论

Engineering 2022年第4期8卷 80-86页

作者： Zhaoqiang Zhang Xili Cui xiaoming jiang Qi ding Jiyu Cui Yuanbin Zhang Youssef Belmabkhout Karim Adil Mohamed Eddaoudi Huabin Xing Key Laboratory of Biomass Chemical Engineering of Ministry of Education College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China Advanced Membranes and Porous Materials Center King Abdullah University of Science and TechnologyThuwal 23955Saudi Arabia

Trans-/cis-olefin isomers play a vital role in the petrochemical *** paucity of energy-efficient technologies for their splitting is mainly due to the similarities of their physicochemical ***,two new tailor-made anion-pillared ultramicroporous metal–organic frameworks(MOFs),ZU-36-Ni and ZU-36-Fe(GeFSIX-3-Ni and GeFSIX-3-Fe)are reported for the first time for the efficient trans-/cis-2-butene(trans-/cis-C_(4)H_(8))mixture splitting by enhanced molecular ***,ZU-36-Ni unexpectedly exhibited smart guest-adaptive pore channels for trapping trans-C_(4)H_(8)with a remarkable adsorption capacity(2.45 mmol∙g^(−1))while effectively rejecting cis-C_(4)H_(8)with a high purity of 99.99%.The dispersion-corrected density functional theory(DFT-D)calculation suggested that the guest-adaptive behavior of ZU-36-Ni in response to trans-C_(4)H_(8)is derived from the organic linker rotation and the optimal pore dimensions,which not only improve the favorable adsorption/diffusion of trans-C_(4)H_(8)with optimal host–guest interactions,but also enhance the size-exclusion of cis-C_(4)H_(8).This work opens a new avenue for pore engineering in advanced smart or adaptive porous materials for specific applications involving guest molecular recognition.

关键词： Adsorption and separation Trans-/cis-butene Ultramicroporous metal-organic frameworks Pore engineering Guest-adaptive

Fish Assemblage Responses to a Low-head Dam Removal in the Lancang River

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical Science 2019年第1期29卷 26-36页

作者： ding Chengzhi jiang xiaoming WANG Lieen FAN Hui CHEN Liqiang HU Jinming WANG Hailong CHEN Yifeng SHI Xiaotao CHEN Hao PAN Bohui ding Liuyong ZHANG Chao HE Daming Yunnan Key Laboratory of International Rivers and Transboundary Eco-security Yunnan University State Key Laboratory of Eco-hydraulic in Northwest Arid Region of China Xi'an University of Technology Huaneng Lancang River Hydropower Co. Ltd Laboratory of Biological Invasion and Adaptive Evolution Institute of Hydrobiology Chinese Academy of Sciences Engineering Research Center of Eco-environment in Three Gorges Reservoir Region Ministry of Education China Three Gorges University

Dam removal is becoming an effective approach for aquatic biodiversity restoration in damming river in order to balance the aquatic ecosystem conservation with large-scale cascade damming. However, the effects of dam removal on fish communities in Asian mountainous rivers, which are dominated by Cypriniformes fishes, are still not well known. To determine whether dam removal on a mountainous river benefit restoration of fish diversity, we investigated the response of fish assemblage to dam removal using a before-after-control-impact design in two tributaries of the Lancang River(dam removal river: the Jidu River, and control river: the Fengdian River). Fish surveys were conducted one year prior to dam removal(2012) and three years(2013–2015) following dam removal. We observed rapidly and notably spatio-temporal changes in fish biodiversity metrics and assemblage structure, occurring in the Jidu River within the first year after dam removal. Overall, fish species richness, density and Shannon-Wiener diversity all increased immediately in above-and below-dam sites, and maintained a stable level in subsequent years, compared to unchanged situation in the control river. All sites in the Jidu River experienced shifts in fish composition after dam removal, with the greatest temporal changes occurred in sites below-and above-the former dam, resulting in a temporal homogenization tendency in the dam removed river. These findings suggest that dam removal can benefit the recovery of habitat conditions and fish community in Asian mountainous rivers, but the results should be further evaluated when apply to other dammed rivers since the dam age, fluvial geomorphology and situation of source populations could all affect the responses of fish assemblages.

关键词： fish diversity dam demolition habitat recovery Cypriniformes international rivers

Linsitinib (OSI‑906) modulates brain energy metabolism and seizure activity in the lithium‑pilocarpine rat model

在线全文

学校读者我要写书评

暂无评论

Acta Epileptologica 2021年第1期3卷 114-125页

作者： Guohui jiang Shenglin Wang Mingyue Chen Xiaomi ding Weiwei He Li Wang Shunxian Wang Juming Yu xiaoming Wang Department of Neurology Affiliated Hospital of North Sichuan Medical CollegeInstitute of Neurological DiseasesNorth Sichuan Medical CollegeNanchongChina

Background:Epileptic seizure is a process of energy accumulation,bursting,and depletion accompanied by the production,spread,and termination of epileptic *** energy required for a seizure is mainly provided through mitochondrial production of *** diseases often lead to epileptic seizures,and energy depletion caused by seizures can lead to mitochondrial *** energy metabolism has become a key target for treatment of epileptic ***:The effect of OSI-906,an insulin receptor(IR)/insulin-like growth factor 1 receptor(IGF-1R)inhibitor,on behaviors and electroencephalographic activity in the lithium-pilocarpine rats were tested.18F-FDG positron emission tomography(PET)/computed tomography(CT)was performed to detect the relative whole-brain glucose uptake *** microscopy was performed to observe the ultrastructure of neuronal and mitochondrial *** changes in blood glucose at different time points before and after the intervention were tested and the effects of OSI-906 on IR/IGF-1R and downstream Akt signaling in the context of seizures were ***:The OSI-906 treatment applied 3 days before the pilocarpine-induced seizures significantly reduced the seizure severity,prolonged the seizure latency and decreased the EEG energy ***/CT revealed that 50 mg/kg of OSI-906 inhibited the 18F-FDG glucose uptake after epileptic seizures,suggesting that OSI-906,through inhibiting IR/IGF-1R and the downstream AKT signaling,may regulate the excessive energy consumption of the epileptic *** OSI-906 treatment also reduced the mitochondrial damage caused by epileptic ***:The IR/IGF-1R inhibitor OSI-906 can significantly reduce the sensitivity and severity of pilocarpineinduced seizures by inhibiting the IR/IGF-1R and the downstream Akt signaling pathway.

关键词： Epilepsy Mitochondria Energy metabolism Insulin receptor IGF-1 receptor Akt signaling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ge量级大满阱容量脉冲频率调制电路设计

红外技术 2019年第7期41卷 666-671页

作者：蒋大钊丁瑞军中国科学院上海技术物理研究所中国科学院红外成像材料与器件重点实验室上海200083 中国科学院大学北京100049

本文对一种提高红外焦平面读出电路满阱电荷容量的方法进行了研究。采用了基于脉冲频率调制结构的单元电路,与传统电路相比满阱电荷容量提高了1~2个量级。本文对该像元的电路结构、工作原理与信号误差进行了分析。单元电路前端的调制器... 详细信息

本文对一种提高红外焦平面读出电路满阱电荷容量的方法进行了研究。采用了基于脉冲频率调制结构的单元电路,与传统电路相比满阱电荷容量提高了1~2个量级。本文对该像元的电路结构、工作原理与信号误差进行了分析。单元电路前端的调制器将光电流信号调制成一系列固定频率的脉冲信号,计数器记录脉冲个数,脉冲个数与输入的光电流信号成正比,通过脉冲个数来表征光电流的信号量。使用0.35.m2P4M工艺进行了电路设计与验证。通过测试结果表明,最大电荷容量达到了3.5Ge,每个电荷包的电荷量为5.46ke,该方法的电荷容量提高了2个量级。

关键词：大电荷容量脉冲频率调制读出电路

Efficient emission of InGaN-based light-emitting diodes:toward orange and red

在线全文

学校读者我要写书评

暂无评论

Photonics Research 2020年第11期8卷 1671-1675页

作者： Shengnan Zhang Jianli Zhang jiangdong Gao Xiaolan Wang Changda Zheng Meng Zhang xiaoming Wu Longquan Xu Jie ding Zhijue Quan Fengyi jiang National Institute of LED on Silicon Substrate Nanchang UniversityNanchang 330096China

Indium gallium nitride(InGaN)-based light-emitting diodes(LEDs)are considered a promising candidate for red-green-blue(RGB)micro ***,the blue and green LEDs are efficient,while the red ones are inefficient for such *** paper reports our work of creating efficient InGaN-based orange and red LEDs on silicon(111)substrates at low current *** on the structure of InGaN yellow LEDs,by simply reducing the growth temperature of all the yellow quantum wells(QWs),we obtained 599 nm orange LEDs with peak wall-plug efficiency(WPE)of 18.1%at 2 A/cm^*** optimized QW structure was proposed that changed two of the nine yellow QWs to orange *** with the sample containing nine orange QWs,the sample with two orange QWs and seven yellow QWs showed similar emission spectra but a much higher peak WPE up to 24.0%at 0.8 A/cm^2 with a wavelength of 608 *** improvement of peak WPE can be attributed to the improved QW quality and the reduced active recombination ***,a series of efficient InGaN-based orange and red LEDs was *** further development,the InGaN-based red LEDs are believed to be attainable and can be used in micro LED displays.

关键词： diodes orange yellow

基于分时共享方案的640×512红外读出电路设计

在线全文

学校读者我要写书评

暂无评论

红外与激光工程 2017年第10期46卷 239-246页

作者：梁清华蒋大钊陈洪雷丁瑞军中国科学院上海技术物理研究所中国科学院红外成像材料与器件重点实验室上海200083 中国科学院大学北京100049

大规模、高集成度的红外焦平面器件是实现高空间分辨率红外成像的核心。针对高集成度的红外焦平面技术发展,文中设计了一款15μm中心距640×512的红外焦平面读出电路。为提升器件信噪比和积分时间,提出了一种2×2四个像元分时复用积分... 详细信息

大规模、高集成度的红外焦平面器件是实现高空间分辨率红外成像的核心。针对高集成度的红外焦平面技术发展,文中设计了一款15μm中心距640×512的红外焦平面读出电路。为提升器件信噪比和积分时间,提出了一种2×2四个像元分时复用积分电容共享技术方案,单元采用直接注入(DI)结构作为输入级,使得读出电路最大电荷容量可达20 Me-/像元。电路有两档电荷容量可选,可满足不同光电流信号的读出要求。为了减小噪声的注入及提高缓冲器偏置电流的精度,为信号传输链路设计了相应的偏置电路。电路仿真结果表明,电路帧频108 Hz,功耗低于110 m W,线性度可高达99.99%。电路采用了CSMC 0.18μm 1P4M 3.3 V工艺加工流片,常温测试结果显示电路工作电流正常,偏置开关可控,功能正常。

关键词：红外焦平面读出电路电容共享电荷容量偏置电路

在线全文

学校读者我要写书评

暂无评论

一种深低温环境LVDS驱动电路

微电子学 2019年第5期49卷 648-652页

作者：蒋大钊丁瑞军中国科学院上海技术物理研究所中国科学院红外成像材料与器件重点实验室上海200083 中国科学院大学北京100049

研究了深低温环境下MOS管与LVDS驱动电路的工作特性。与常温环境相比,LVDS电路在77K环境下的输出电流更大,导致输出差分信号幅值增大。MOS管在77K低温环境下的载流子迁移率为常温下的3倍,导致器件电流增大。根据低温条件下器件变化特性... 详细信息

研究了深低温环境下MOS管与LVDS驱动电路的工作特性。与常温环境相比,LVDS电路在77K环境下的输出电流更大,导致输出差分信号幅值增大。MOS管在77K低温环境下的载流子迁移率为常温下的3倍,导致器件电流增大。根据低温条件下器件变化特性的数据分析结果,调节电路结构与器件参数,设置多档可调参考电流,并调节LVDS输出信号于标准范围内。采用标准0.35μm CMOS工艺进行流片验证。结果表明,LVDS驱动电路在77K环境下工作时,共模电平为1.2V,电压摆幅为400mV。

关键词：焦平面阵列读出电路低温特性数字接口