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Integrated sensing and delivery of oxygen for next- generation smart wound dressings

Microsystems & Nanoengineering 2020年第1期6卷 991-1006页

作者： Manuel Ochoa Rahim Rahimi Jiawei Zhou Hongjie Jiang Chang Keun Yoon dinesh maddipatla Binu Baby Narakathu Vaibhav Jain Mark Michael Oscai Thaddeus Joseph Morken Rebeca Hannah Oliveira Gonzalo L.Campana Oscar W.Cummings Michael A.Zieger Rajiv Sood Massood Z.Atashbar Babak Ziaie School of Electrical and Computer Engineering Purdue UniversityWest Lafayette 47907 INUSA Birck Nanotechnololgy Center 1205W State StreetWest Lafayette 47907 INUSA School of Material Science Engineering Purdue UniversityWest Lafayette 47907 INUSA Electrical and Computer Engineering Department Western Michigan University4601 Campus Drive B-236Kalamazoo 49008 MIUSA School of Mechanical Engineering Purdue UniversityWest Lafayette 47907 INUSA Indiana University School of Medicine 980 West Walnut StreetBuilding R3 Room C634Indianapolis 46202 INUSA Department of Pathology and Laboratory Medicine Indiana University School of MedicineIU Health Pathology Laboratory350W 11th StreetRoom 4054IndianapolisIN 46202USA Weldon School of Biomedical Engineering Purdue UniversityWest Lafayette 47907 INUSA Present address:Shenzhen MSU-BIT University ShenzhenChina

Chronic wounds affect over 6.5 million Americans and are notoriously difficult to *** oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable ***,we developed a low-cost alternative for continuous O 2 delivery and sensing comprising of an inexpensive,paper-based,biocompatible,flexible platform for locally generating and measuring oxygen in a wound *** platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology,inkjet ***,we demonstrate the functionality of the oxygenation patch,capable of increasing oxygen concentration in a gel substrate by 13%(5ppm)in *** platform is able to sense oxygen in a range of 5–26 *** vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.

关键词： patch smart printing

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