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Journal of Environmental Sciences 2013年第7期25卷 1492-1499页

作者： dina tan Honghu Zeng Jie Liu Xiaozhang Yu Yanpeng Liang Lanjing Lu College of Environmental Science and Engineering Guilin University of Technology Guangxi Institute of Building Research & Design Guangxi Polytechnic of Construction

The kinetics of thedegradation of trace nitrobenzene （NB） by a granular activated carbon （GAC） enhanced microwave （MW）/hydrogen peroxide （H202 ） systemwas studied. Effects of pH, NB initial concentration and tert-butyl alcohol on the removal efficiencywere examined. Itwas found that the reaction rate fitswell to first-order reaction kinetics in the MW/GAC/H202 process. Moreover, GAC greatly enhanced thedegradation rate of NB inwater. Under a given condition （MW power300 W, H202dosage 10 mg/L, pH 6.85 and temperature （60 ± 5）°C）, thedegradation rate of NBwas 0.05214 min 1when4 g/L GACwas added. In general, alkaline pHwas better for NBdegradation; however, the optimum pHwas 8.0 in the tested pH value range of4.0-12.0. At H202dosage of 10 mg/L and GACdosage of4 g/L, the removal of NBwasdecreasedwith increasing initial concentrations of NB, indicating that a low initial concentrationwas beneficial for thedegradation of NB. These results indicated that the MW/GAC/H202 processwas effective for trace NBdegradation inwater. Gas chromatography-mass spectrometry analysis indicated that a hydroxyl radical addition reaction anddehydrogenation reaction enhanced NBdegradation.

关键词： microwave granular activated carbon hydrogen peroxide nitrobenzene hydroxyl radicals

MW-GAC-H_2O_2降解水中微量硝基苯的动力学研究

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水处理技术 2013年第6期39卷 83-86,93页

作者：谭荻娜曾鸿鹄梁延鹏雷昌文吴海兵陆兰晶桂林理工大学环境科学与工程学院广西桂林541004 广西建设职业技术学院设备工程系广西南宁530003

采用MW-GAC-H2O2工艺(微波-活性炭颗粒-过氧化氢)降解水中微量硝基苯,研究了硝基苯初始质量浓度、pH、HCO3-和腐植酸对MW/GAC/H2O2降解硝基苯的动力学行为的影响。结果表明,硝基苯初始质量浓度越大,硝基苯降解速率越小;初始溶液pH为8时... 详细信息

采用MW-GAC-H2O2工艺(微波-活性炭颗粒-过氧化氢)降解水中微量硝基苯,研究了硝基苯初始质量浓度、pH、HCO3-和腐植酸对MW/GAC/H2O2降解硝基苯的动力学行为的影响。结果表明,硝基苯初始质量浓度越大,硝基苯降解速率越小;初始溶液pH为8时,硝基苯的降解速率最高;投加适量HCO3(-100～200mg/L)、腐植酸均可促进系统降解硝基苯。在硝基苯初始质量浓度为200μg/L、微波功率为300W、GAC和H2O2投加量分别为4g/L和10mg/L的试验条件下反应21min,MW-GAC-H2O2工艺降解硝基苯的速率为0.052 1 min-1,反应过程遵循1级反应动力学方程。

关键词：微波活性炭颗粒过氧化氢硝基苯羟基自由基

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

New animal models for hepatitis C viral infection and pathogenesis studies

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World Journal of Gastroenterology 2007年第17期13卷 2427-2435页

作者： dina Kremsdorf Nicolas Brezillon INSERM U812 ParisFrance Pasteur Institute Paris France Université Paris Descartes Faculté de Médecine René Descartes CHU Necker Paris 75015France

Hepatitis C virus （HCV） is a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma （HCC）. In man, the pathobiological changes associated with HCV infection have been attributed to both the immune system and direct viral cytopathic effects. Until now, the lack of simple culture systems to infect and propagate the virus has hampered progress in understanding the viral life cycle and pathogenesis of HCV infection, including the molecular mechanisms implicated in HCV-induced HCC. This clearly demonstrates the need to develop small animal models for the study of HCV-associated pathogenesis. This review describes and discusses the development of new HCV animal models to study viral infection and investigate the direct effects of viral protein expression on liver disease.

关键词： Hepatitis C virus Viral infection Transgenicmice Pathogenesis

Assessing the lifetime performance index of weighted Lomax distribution based on progressive type-Ⅱ censoring scheme for bladder cancer

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International Journal of Biomathematics 2021年第4期14卷 49-66页

作者： dina A.Ramadan Department of Mathematics Faculty of Science Mansoura UniversityMansouraEgypt

In this paper,Health-related quality of life has not been adequately measured in bladder cancer.A recently developed reliable and disease-specific quality of life instrument(Bladder Cancer Index,RCI)was used to *** type Ⅱ censoring schemes have potential usefulness in practice where budget constraints in place or there is a necessity for the speedy *** test the process capability,the lifetime performance index Cl is widely recommended for evaluating the performance of the producfs lifetime and evaluating the lifetime performance index GL for the three-parameter Weighted-Lomax distribution(WLx)under progressive type-II censoring sample for a lower specification limit(L).The statistical inference concerning CL is conducted via obtaining the maximum likelihood of Cl on the base of progressive type-II *** asymptotic normal distribution of the MLE of CL and the confidence interval is ***,the hypothesis testing of CL for evaluating the lifetime performance of WLx data is ***,assuming the conjugate prior distribution and squared error loss function,this study constructs a Bayes estimator of *** Bayes estimator of CL is then utilized to develop a credible interval in the condition of known ***,we propose a Bayesian test to assess the lifetime performance of *** also propose a Bayesian test to assess the lifetime performance of ***,two examples are given,one of them is considering a real life data of the remission times of bladder cancer patients in endurance lifetime test and the other is a simulated example to illustrate the usage of the proposed procedure.

关键词： Lifetime performance index Weighted-Lomax distribution progressively type-II right censoring

Nucleon Form Factors and N-△ Transitions in a Hypercentral Constituent Quark Model with Meson Cloud

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Communications in Theoretical Physics 2007年第3期47卷 539-546页

作者： CHEN dina-Yong DONG Yu-Bing Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Gradtuate School of the Chinese Academy of Sciences Beijing 100049 China

We study the nucleon form factors and the nucleon-△（1232） transitions in a framework of hypercentral constituent quark model. The pion meson cloud effect is taken into account explicitly. Our results show that the pion cloud contributes substantially to the nucleon form factors as well as to the helicity amplitudes of △（1232）, and it gives an improved agreement compared to the experimental.

关键词： electromagnetic form factor nucleon and △(1232) hypercentral constituent quark model meson cloud

Histopathology of nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2010年第42期16卷 5286-5296页

作者： Elizabeth M Brunt dina G Tiniakos Department of Pathology and Immunology Washington University School of MedicineSt.LouisMO 63110United States Laboratory of Histology and Embryology Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Histological analysis of liver biopsies remains a standard against which other methods of assessment for the presence and amount of hepatic injury due to nonalcoholic fatty liver disease(NAFLD) are *** evaluation remains the sole method of distinguishing steatosis from advanced forms of NAFLD,*** steatohepatitis(NASH) and *** in the lesions of NAFLD are steatosis,lobular and portal inflammation,hepatocyte injury in the forms of ballooning and apoptosis,and ***,patterns of these lesions are as distinguishing as the lesions *** injury in adults and children due to NAFLD may have different histological *** this review,the rationale for liver biopsy,as well as the histopathological lesions,the microscopically observable patterns of injury,and the differential diagnoses of NAFLD and NASH are discussed.

关键词： Fatty liver Steatosis Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis Fibrosis

E2F transcription factors and digestive system malignancies: How much do we know?

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World Journal of Gastroenterology 2013年第21期19卷 3189-3198页

作者： Athanasios Xanthoulis dina G Tiniakos Department of Surgery Section of Gastroenterological SurgeryLevanger HospitalNord-Tr ndelag Hospital Trust7600 LevangerNorway Laboratory of Histology-Embryology Medical SchoolNational and Kapodistrian University of Athens11527 AthensGreece

E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively studied member and the only one with prognostic value, exhibits a tumor-suppressing activity in esophageal, gastric and colorectal adenocarcinoma, and in hepatocellular carcinoma (HCC), whereas in pancreatic ductal adenocarcinoma and esophageal squamous cell carcinoma may function as a tumorpromoter. In the latter malignancies, E2F1 immunohistochemical expression has been correlated with higher tumor grade and worse patient survival, whereas in esophageal, gastric and colorectal adenocarcinomas is a marker of increased patient survival. E2F2 has only been studied in colorectal cancer, where its role is not considered significant. E2F4's role in colorectal, gastric and hepatic carcinogenesis is tumor-promoting. E2F8 is strongly upregulated in human HCC, thus possibly contributing to hepatocarcinogenesis. Adenoviral transfer of E2F as gene therapy to sensitize pancreatic cancer cells for chemotherapeutic agents has been used in experimental studies. Other therapeutic strategies are yet to be developed, but it appears that targeted approaches using E2F-agonists or antagonists should take into account the tissue-dependent function of each E2F member. Further understanding of E2Fs' contribution in cellular functions in vivo would help clarify their role in carcinogenesis.

关键词： E2F Colorectal cancer Gastric cancer Esophageal cancer Pancreatic cancer Hepatocellular carcinoma Digestive system malignancies

Warming induced changes in wood matter accumulation in tracheid walls of spruce

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Journal of Mountain Science 2020年第1期17卷 16-30页

作者： Elena BABUSHKINA dina ZHIRNOVA Liliana BELOKOPYTOVA Eugene VAGANOV Khakass Technical Institute Siberian Federal UniversityAbakan655017Russia Siberian Federal University Krasnoyarsk 660041Russia Sukachevlnstitute of Forest Siberian Branch of Russian Academy of SciencesKrasnoyarsk 660036Russia

The warming-driven increase of the vegetation season length impacts both net productivity and phenology of plants, changing an annual carbon cycle of terrestrial ecosystems. To evaluate this influence, tree growth along the temperature gradients can be investigated on various organization levels, beginning from detailed climatic records in xylem cells’ number and morphometric parameters. In this study, the Borus Ridge of the Western Sayan Mountains(South Siberia) was considered as a forest area under rapid climate change caused by massive Sayano-Shushenskoe reservoir. Several parameters of the xylem anatomical structure in Siberian spruce(Picea obovata Ledeb.)were derived from normalized tracheidograms of cell radial diameter and cell wall thickness and analyzed during 50 years across elevational gradient(at 520,960, and 1320 m a.s.l.). On the regional scale, the main warming by 0.42°C per decade occurs during cold period(November–March). Construction of the reservoir accelerated local warming substantially since 1980, when abrupt shift of the cold season temperature by 2.6°C occurred. It led to the vegetation season beginning 3-6 days earlier and ending 4-10 day later with more stable summer heat supply. Two spatial patterns were found in climatic response of maximal cell wall thickness:(1)temperature has maximal impact during 21-day period, and its seasonality shifts with elevation in tune with temperature gradient;(2) response to the date of temperature passing +9.5°C threshold is observed at two higher sites. Climate change yielded significantly bigger early wood spruce tracheids at all sites, but its impact on cell wall deposition process had elevational gradient: maximal wall thickness increased by 7.9% at the treeline, by 18.2% mid-range,and decreased by 4.9% at the lower boundary of spruce growth;normalized total cell wall area increased by 6.2%-6.8% at two higher sites but remained stable at the lowest one. We believe that these patterns are caused by two m

关键词： Climate change Sayano-Shushenskoe Reservoir Elevational gradient Picea obovata Quantitative wood anatomy Climate–growth relationship

Constrained Fractional Variational Problems of Variable Order

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IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 80-88页

作者： dina Tavares Ricardo Almeida Delfim F.M.Torres Department of Mathematics Polytechnic Institute of Leiria Department of Mathematics University of Aveiro

Isoperimetric problems consist in minimizing or maximizing a cost functional subject to an integral *** this work, we present two fractional isoperimetric problems where the Lagrangian depends on a combined Caputo derivative of variable fractional order and we present a new variational problem subject to a holonomic constraint. We establish necessary optimality conditions in order to determine the minimizers of the fractional problems. The terminal point in the cost integral,as well as the terminal state, are considered to be free, and we obtain corresponding natural boundary conditions.

关键词： Fractional calculus fractional calculus of variations holonomic constraints isoperimetric constraints optimization variable fractional order