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Single Cellular Algae Digestive Supplement Designed by Yeast &Lactobacillus Rearranged Leukocyte Subsets through Activation of Complement Components

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Open Journal of Immunology 2015年第3期5卷 104-121页

作者： Hitoshi Kubota Nurmuhamamt Amat dilxat yimit Parida Hoxur Nobuo Yamaguchi Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Department of Fundament Research for CAM Kanazawa Medical University Ishikawa Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumqi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumqi China

A plant fermentation was carried out by Yeast and Lactobacilli against single cellular algae (f-Chlorella). These materials were proved by as safe in animal safety experiment. We sought to look into changes of immune-competent cells that commonly utilized f-Chlorella including after administration of immno-suppressed animals. The effects by f-Chlorella on the regurational effect to the host were measured. Our results showed that f-Chlorella regulated the level of lymphocytes, while conventional-Chlorella worked to adjust the level of granulocytes. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio was obtained as neutral in the peripheral blood. In rodents, immune-compromised host as well as normal animal were prepared with cancer chemotherapeutic agent (Mytomycin-C), and then tried to rescue the immune-competent rebel. Our observations showed that both Chlorella derivatives regulated in number and functions. The effect was more prominent in f-Chlorella than that of conventional one. We discussed the significance and mechanism of f-Chlorella on the level of leukocyte subsets in number and function. These effects were considered to bring the potential elevation of antibody secreting cell by the localized heamolysis in gel method. We also proposed an idea that exhibited tonic effects were brought via activating the complement components in the serum. Moreover, we tried to access further to the anti-oxidative activities of this f-Chlorella. This modification brought to the significant lifted up for immune competent cells and anti-oxidative activity for phagocytic cells.

关键词： Family Poaceae Chlorella pyrenoidosa Fermentation Yeast Lactobacillus Cancer Chemotherapeutic Agent Compromised Host Lipidosis Cardiovascular Disease Diabetes Meritus Immune Augmentation

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A New Activated Water Charged by Electrophoresis, Effect on the Experimentally Immuno-Suppressed Animal and Their Anti-Oxidative Activity

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Open Journal of Immunology 2015年第3期5卷 122-132页

作者： Yasuteru Eguchi Nobuo Yamaguchi Nurmuhamamt Amat dilxat yimit Parida Hoxur Kei Yokokawa Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Department of Fundament Research for CAM Kanazawa Medical University Ishikawa Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumqi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumqi China

Every individuals expose to the lisk of conventional immunodeficiency in daily life with both internal and externals. In a series of investigation, we have been assessed the various health promoting menu such as hot spring hydrotherapy, acupuncture & moxibution, light excurse, evidenced Control water western medicine technique. In this report, we try to investigate the regulatory effect of hydrotherapy by activated water molecule as our representative menu under the influence of hypothalamus system. We set up both animal and human model for assessment of hydrotherapy. Before starting experimental assessment, six males and females seven-week-old ddY mice, are used for the acute oral toxicity study. There is no sign for toxicity as judged by body weight, organ inspection by veterinary doctor. Next, young ddY mice are experimentally induced diabetes and immune-deficient status by administrating cancer chemotherapeutic agent, Streptzotosin. Charged Water was evident to control the blood sugar level compared to the Control Water group together with conventional control group. Both experimental group of mice wear statistically significant for recovery from blood sugar level and antibody secreting cell both IgM and IgG plaque-forming cell. We confirm also activated water group delivered the granulocyte that slow down the oxidative stress by super oxide.

关键词： New Charged Water Hydrotherapy Peripheral Leukocyte Leukocyte Subsets Ratio Diabetes Meritesanti-Oxidative Activity CAM

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Plant Digestive Supplement Designed by Lactobacillus Regulated Leukocyte Subsets through Activation of Complement Components and Implication for Use against Tumor Bearing Host against Infection

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Open Journal of Immunology 2015年第3期5卷 133-146页

作者： Kohji Ohtubo Nobuo Yamaguchi Nurmuhamamt Amat dilxat yimit Parida Hoxur Hiroshi Ushijima Yousuke Watanabe Ishikawa Natural Medicinal Products Research Center Ishikawa Japan Department of Fundament Research for CAM Kanazawa Medical University Ishikawa Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumqi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumqi China

A plant material consisted by Family Poaceae was fermented by Yeast and Lactobaccilli (U-164). This material was proved by as safe in animal safety experiment for oral administration. In order to prove the effect of U-164 against physiological function, the animal and human trials were set up to look into mainly leukocyte functions. In animal experiment, anti-oxidative effect and antibody response in immune-compromised host and diabetes meritus were made up. For human use, peripheral lymphocyte in number and subset ratio were followed up to one month after administration. In order to understand its effect, human complement component analysis was made by immune-electrophoresis. Our results showed that U-164 augmented the level of lymphocytes, while U-164 down regulated the level of granulocytes. In our clinical study with 19 healthy volunteers, granulocyte and lymphocyte ratio was obtained as neutral in peripheral blood being increased significantly 30 days after the ingestion of U-164. In experimental animal study, the compromised host as well as normal animal was administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against antibody producing cell, this material recovered the antibody production in the host compromising the immure responsiveness. We also proposed an idea that U-164 exhibited tonic effects via activating complement components. Moreover, we tried to access further to the anti-oxidative activities of this U-164. This modification brought to the significant lifted up for anti-oxidative activity for phagocytic cell.

关键词： Family Poaceae Fermentation Yeast Lactobacillus Cancer Chemotherapeutic Agent Compromised Host Complement C3b Fragment Anti-Oxidant Diabetes Blood Sugar

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Hemopoietic Formulae Rearranged Leukocyte Subsets and Implication for Use against the Type of Constitution and Infectious Agent for Further Modification to Future

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Open Journal of Immunology 2015年第3期5卷 183-198页

作者： Nobuo Yamaguchi Wataru Hiruma Kohei Suruga Nurmuhamamt Amat dilxat yimit Parida Hoxur Daisuke Sakamoto Kazuhiro Okamoto Shan-Yu Su Department of Fundamental Research for CAM Kanazawa Medical University Ishikawa Japan Ishikawa Natural Medicinal Products Research Center Ishikawa Japan International Operation Department (FM Center for R & D) Kibun Foods Inc. Tokyo Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumchi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumchi China Department of Otolaryngology Kanazawa Medical University Ishikawa Japan Department of Chinese Medicine China Medical University Hospital Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medicinal University Taiwan

A hemopoietic formula (HF) in traditional Chinese medicine (TCM) usually consists of more than six single herbs. We seek to look into changes of immune-competent cells by two commonly utilized HF, including Shi-Quan-Da-Bu-Tang (SDT) and Bu-Zong-Ye-Qi-Tang (BYT). However, the effects of both formulae on levels of leukocyte subsets are not yet defied. After administration of immno-suppressant to animals, the effects by HFs on the augmentation for subsets of leukocytes, CD positive cell counts of lymphocytes, and the cytokine-producing cells are measured. Our results show that SDT augments the level of lymphocytes, while BYT increases the level of granulocytes. In our clinical study with 15 healthy volunteers, positive cells for CD2, CD11b, CD14, IL-4, IL-1β and IFN-γ in peripheral blood are increased significantly 15 days after the ingestion of HFs. In rodents, compromised host as well as normal animal is administered with cancer chemotherapeutic agent (Mytomycin-C). Our observations show that SDT regulates phagocyte activities of the immune system, introducing it against intracellular parasite, and that BYT augments intercellular pathogen through humoral immunity. We discuss the significance and mechanism of HFs on the level of leukocyte subsets in number and function that are considered to be potential indicators for the evaluation of TCM modalities. We also propose an idea that TCM exhibits tonic effects via enhancing the ability to fight against infection and bacteria, as well as turning the multi-drug resistant bacteria to the sensitive ones. Together with these evidences, we suggest an ideal remedy for the compromised to fight host against pathogens. Moreover, we try to modify these hemopoietic formulae to more digestive forms. This modification brings to the significant lifted up for antibody producing cells and anti-oxidative activity for phagocytic cells.

关键词： Traditional Chinese Medicine Cancer Chemotherapeutic Agent Compromised Host Intracellular Infectious Agent Intercellular Infectious agent

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Bi-Directional Regulation by Chinese Herbal Formulae to Host and Parasite for Multi-Drug Resistant <i>Staphylococcus aureus</i>in Humans and Rodents

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Open Journal of Immunology 2015年第1期5卷 18-32页

作者： Nobuo Yamaguchi Takanao Ueyama Nurmuhamamt Amat dilxat yimit Parida Hoxur Daisuke Sakamoto Yuma Katoh Ikkan Watanabe Shan-Yu Su Department of Fundamental Research for CAM Kanazawa Medical University Uchinada Japan Ishikawa Natural Medicinal Products Research Center Kanazawa Japan Department of Medicine II Kansai Medical University Osaka Japan Traditional Uighur Medicine Department Xinjiang Medical University Urumqi China Traditional Chinese Medicine Hospital Xinjiang Medical University Urumqi China Department of Chest Surgery Kanazawa Medical University Himi Citizen Hospital Himi Japan Department of Respiratory Medicine Tohkai Central Hospital Gifu Japan Department of Chinese Medicine China Medical University Hospital Taichung City Taiwan School of Post-Baccalaureate Chinese Medicine College of Chinese Medicine China Medical University Taichung City Taiwan

A decline in the immunopotential of the host plays acritical factor(s) in the occurrence of infections with methicillin-resistant Staphylococcus aureus (MRSA) or microorganisms by opportunistic infection. In such an infection, no way out for therapeutic concept, therefore bi-directional trial was the final choice. So we selected aformula, Dang Gui Liu Huang Tang (dLHT), which could both augmentimmune factorsin host and exert bacteriostatic effect. We sought to break through the epidemic by MRSA especially in elderly patient, by the fundamental and clinical trial by employing minor TCM, characterizing bidirectional ability of the decoction by western methods. Animal Experiment: Mitomycin-C (MMC)-treated mice with or without the infection of MRSA were made. The experimental design was made up to examine the bacteriostatic action as well as the immunopo-tentiating bias of the promising Chinese herbal medicine, dLHT, which was first proved for its immune potentiating activities as well as their sensitivity to antibiotics, but not direct aseptic effect was clear for MRSA. Both basic and clinical data showed that this formula was effective on repelling from the infectious focus after the treatment of MRSA infection. After the administration of dLHT, the number of white blood cells in MMC-treated mice recovered to 80% of the normal level. In addition, the phagocytic activity of macrophages increased to 70% in the dLHT-treated group, while that of the non-treated group was only 20%. The bactericidal activity also recovered to the level close to the normal value by dLHT. The ratio of neutrophils in the dLHT-administered group increased to 2.2% (normal mice, 2.6%), whereas that in the non-terated group was only 0.5%. The bacterial count in the liver of MRSA-challenged mice reached the peak at six hours after the challenge in both dLHT-treated and non-treated mice. However, the number of bacteria in dLHT group was much greater than that in the non-treated group. The bacterial

关键词： Drug Sensitivity Multiple Resistance Dang Gui Liu Huang Tang MRSA Nosocomical Infection Host Immunity

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Super-biderivations and Post-Lie Superalgebras on Some Lie Superalgebras

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Acta Mathematica Sinica,English Series 2023年第9期39卷 1736-1754页

作者： Munayim dilxat Shou Lan Gao Dong Liu College of Mathematics and System Sciences Xinjiang UniversityUrumqi830046P.R.China Department of Mathematics Huzhou UniversityHuzhou313000P.R.China

In this paper,all symmetric super-biderivations of some Lie superalgebras are *** an application,commutative post-Lie super algebra structures on these Lie super algebras are also obtained.

关键词： Lie superalgebra super-biderivation post-Lie superalgebra

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Puncturable ciphertext-policy attribute-based encryption scheme for efficient and flexible user revocation

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Science China(Information Sciences) 2023年第7期66卷 130-146页

作者： dilxat GHOPUR Jianfeng MA Xindi MA Yinbin MIAO Jialu HAO Tao JIANG School of Cyber Engineering Xidian University Guangxi Key Laboratory of Trusted Software Guilin University of Electronic Technology Xi'an Satellite Control Center

With the rapid deployment of storage services, secure and efficient user authorization and revocation data shared through the cloud have become a grand challenge hindering cloud data *** previous direct and indirect user revocation schemes implemented large-scale user revocation, they faced heavy communication and computational costs. To address these challenges, this study presents a new encryption scheme that combines ciphertext-policy attribute-based encryption(CP-ABE) with puncturable encryption to achieve efficient and flexible user revocation. We design a proxy server to reduce the computational overhead in the decryption phase. Because the puncture process is performed on a semi-honest cloud, we use the digital signature method to verify the correctness of its operation. Furthermore, we prove the security of our scheme under the chosen-plaintext attack(CPA), and compare it with other schemes to highlight its advantages. Numerical analysis and experimental simulation results reveal that our scheme is more suitable than other schemes for use in a cloud environment for user revocation.

关键词： ciphertext-policy attribute-based encryption puncturable encryption user revocation outsource decryption digital signature

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Combined Effects of Blood Pressure and Aldosterone on Cardiac Left Ventricular Mass Index—Ethnic Differences between Kazakh, Uygur and Han Subjects

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World Journal of Cardiovascular Diseases 2014年第3期4卷 99-105页

作者： Masakatsu Ohta Yuji Kasamaki Yukio Ozawa Atsushi Hirayama Tomohiro Nakayama Hiroshi Kawamura dilxat Himit Masayoshi Soma Yoichi Izumi Department of Cardiology Kanazawa Medical University Himi Municipal Hospital Himi Japan Department of Internal Medicine Nippon Dental University Tokyo Japan Department of Science and Research Xinjiang Medical University Urumqi China Division of Cardiology Department of Medicine Nihon University School of Medicine Tokyo Japan Division of General Medicine Department of Medicine Nihon University School of Medicine Tokyo Japan Division of Laboratory Medicine Department of Pathology and Microbiology Nihon University School of Medicine Tokyo Japan

Previous Background: Hemodynamic factors, like blood pressure, have been established to be major determinants of cardiac left ventricular structure. However, several factors other than blood pressure to influence cardiac mass have been implicated. When we did medical survey, cardiac left ventricular mass index (LVMI) of one ethnic group that had higher blood pressure was found to be smaller than that of the other ethnic groups with a lower blood pressure. Such contradicted data from the present study were analyzed combining blood pressure, LVMI and chemical parameters obtained from blood and urine. Methods: In a medical survey conducted in Xinjiang, China, 279 people (65 - 70 years old) from three ethnic groups (Kazakh, Uygur and Han) from two separated regions provided blood and urine samples and underwent echocardiography and 24-h ambulatory blood pressure monitoring (ABPM). Results: Systolic and diastolic blood pressure obtained from ABPM and urinary sodium excretion values were significantly higher in Kazakh than that in Uygur and Han. However, LVMI in Kazakh was lower than that in other 2 groups. Plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were significantly lowest in Kazakh. The values of LVMI in all ethnic groups were positively related to both blood pressure and PAC. An inverse correlation was identified between PAC and urinary sodium excretion value. Conclusion: Although higher blood pressure in Kazakh subjects, their LVMI was lower than those of Uygur and Han, whose blood pressure was lower than that in Kazakh. These results suggest that blood pressure is not always a determinant for LVMI value. There is a possibility that relatively lower PAC resulted from higher sodium intake suppressed the rise in LVMI caused by higher blood pressure in Kazakh.

关键词： Left Ventricular Mass Aldosterone Blood Pressure Salt Intake

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SMO基因siRNA慢病毒表达载体的构建及其对胰腺癌细胞SMO基因表达的影响

SMO基因siRNA慢病毒表达载体的构建及其对胰腺癌细胞SMO基因表达...

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作者：迪力夏提·吐尼牙孜（dilxat Tuniyaz）新疆医科大学

学位级别：硕士

目的:构建携带SMO靶向siRNA慢病毒表达载体,并证实其对胰腺癌细胞中SMO基因表达的抑制作用。方法:设计并合成3条SMO基因靶向siRNA片段,利用基因重组技术构建携带此3条片段的慢病毒表达载体并测定其滴度,构建好的慢病毒表达载体转染人胰... 详细信息

目的:构建携带SMO靶向siRNA慢病毒表达载体,并证实其对胰腺癌细胞中SMO基因表达的抑制作用。方法:设计并合成3条SMO基因靶向siRNA片段,利用基因重组技术构建携带此3条片段的慢病毒表达载体并测定其滴度,构建好的慢病毒表达载体转染人胰腺癌细胞株SW1990后,采用RT-PCR法检测SMO基因的表达以筛选出效果最佳的干扰表达载体,并以此载体转染SW1990细胞后采用Western blot法检测SMO蛋白表达。结果:基因测序与酶切电泳结果提示成功合成SMO靶向siRNA片段且其正确插入慢病毒表达载体,无碱基缺失错排与突变,测定病毒滴度分别为5.31×108TU/ML,1.49×109TU/ML及8.50×108TU/ML,经转染SW1990细胞后,测定对SMO基因表达的抑制率分别为86.00%,74.85%及19.22%,效果最优的干扰表达载体转染SW1990细胞后对SMO蛋白表达的抑制率>80%。结论:成功构建携带SMO基因靶向siRNA的慢病毒表达载体,且该载体可有效抑制胰腺癌细胞中SMO基因的表达,为进一步的研究提供了良好的实验工具。

关键词：胰腺癌 SMO基因 siRNA 慢病毒表达载体

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Serological Prevalence Survey Among the High-Risk Populations of Brucellosis-Endemic Areas-China,2019−2020

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China CDC weekly 2021年第6期3卷 101-105页

作者： Shenghong Lin Zhe Wang Xinrong Liu Aizhi Yu Muhtar·Hasan Jiensi·Bayidawulieti Haitan·Aximujiang Ruiqing Li Guoxing Zheng Xinwang Liang Xiaoling Fan Biqiao Hou Xiaolong Fan dilxat·Abuliti Lusha Shi Cuihong Zhang Yifei Wang Pengjing Ning Caixiong Liu Zhongjie Li Liping Wang Division of Infectious Disease Key Laboratory of Surveillance and Early Warning on Infectious DiseaseChina Center for Disease Control and PreventionBeijingChina Hangzhou Center for Disease Control and Prevention HangzhouZhejiangChina Datong Center for Disease Control and Prevention DatongShanxiChina Huocheng Center for Disease Control and Prevention YiliXinjiangChina Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention UrumqiXinjiangChina Yili Kazakh Autonomous Prefecture Center for Disease Control and Prevention YiliXinjiangChina Yanggao Center for Disease Control and Prevention DatongShanxiChina Zuoyun Center for Disease Control and Prevention DatongShanxiChina Hunyuan Center for Disease Control and Prevention DatongShanxiChina

What is already known about this topic?Timely screening of high-risk population is important to improve the early detection of brucellosis among the endemic areas during the high incidence seasons,which is also required by the National Brucellosis Prevention and Control Plan(2016–2020)(NBPCP).What is added by this report?Seroepidemiological characteristics of brucellosis in high-risk populations were obtained and special occupational populations were *** seroprevalence of brucellosis has been decreasing compared with that reported in the recent years due to the ongoing implementation of control measures in endemic *** are the implications for public health practice?Special occupational populations could be promptly detected using routine screening,which makes it possible to initiate standardized treatment for infected patients as early as *** also reminds us to pay attention to special occupational populations to improve their knowledge of brucellosis and reduce the risk of infection.

关键词： Population Brucellosis incidence

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