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The Effects of Omega-3 Fatty Acids Supplementation in Bronchial Asthma

Journal of Biosciences and Medicines 2023年第4期11卷 208-219页

作者： Uttam kumar Barua Pranab Karmaker Arup kumar Saha Md. Merazul Mostofa dilip kumar ghosh Kamal Krishna Biswas Department of Respiratory Medicine Shaheed Suhrawardy Medical College Hospital Dhaka Bangladesh Bangladesh Reference Institute for Chemical Measurements (BRiCM) Dhaka Bangladesh Department of Dental Public Health City Dental College and Hospital Dhaka Bangladesh Department of Genetic Engineering and Biotechnology University of Rajshahi Rajshahi Bangladesh Department of Gastroenterology Shaheed Suhrawardy Medical College Hospital Dhaka Bangladesh Department of Biochemistry and Molecular Biology University of Rajshahi Rajshahi Bangladesh

Bronchial asthma is a chronic inflammatory disease. Allergies are intensely related to bronchial asthma and to other respiratory diseases such as chronic sinusitis, middle ear infections, and nasal polyps. Treatment can vary from inhalers to oral medications to drugs delivered in a nebulizer or breathing machine. Besides, dietary involvement was a significant tool to reduce the severity of many chronic inflammatory diseases including asthma. Randomly assigned, double blind, and placebo controlled 290 adults with mild to moderately persistent bronchial asthma concluded in this study, were subjected to alternating phases of supplementation with omega-3 fatty acids, vitamin C and Zn either singly or in combination. Subjective symptom improvement, pulmonary function, and biochemical tests were carried out at the beginning of the study and at the end of each therapeutic phase. The study findings showed that nearly half of the cases were in age between 18 years to 40 years followed by 29.6 of the cases that fall in age range between 40 years and 60 years. It was clear that all the four supplements (ogema-3 fatty acids, vitamin C and Zn, and combination) contributed more than placebo in reducing the severity of bronchial asthma. However, omega 3 fatty acids and combined supplement significantly contributed in symptomatic improvement (p < 0.05). There was a significant improvement of pulmonary function and sputum inflammatory markers with diet supplementation (p < 0.05). So, the subjects with mild and moderately persistent bronchial asthma may get benefit from their dietary supplementation with omega 3 fatty acids, Zinc and vitamin C. It is evident from this study that omega 3 fatty acids and combined supplementation significantly improved the severity of bronchial asthma.

关键词： Bronchial Asthma FEV1 FVC Omega 3 Fatty Acids

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Clinical Characteristics of COVID-19 Patients with Digestive Symptoms in a Tertiary Level Hospital

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Open Journal of Gastroenterology 2022年第9期12卷 232-248页

作者： dilip kumar ghosh Akhlak Ahmed Hafez Mohammad Nazmul Ahsan Parash Ullah Mukta Nath Syed Alamgir Safwath Department of Gastroenterology Shaheed Suhrawardy Medical College Hospital Sher-e-Bangla Nagar Dhaka Bangladesh Department of Medicine Shaheed Suhrawardy Medical College Hospital Sher-e-Bangla Nagar Dhaka Bangladesh Sir Salimullah Medical College Dhaka Bangladesh Department of Gastroenterology Jalalabad Ragib-Rabeya Medical College Sylhet Bangladesh

Background: The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has greatly challenged public health worldwide. A growing number of studies have reported gastrointestinal (GI) symptoms. The study aimed to estimate the various digestive symptoms frequently reported in Covid-19 patients among the adult population of Bangladesh. Methods: In this descriptive, cross-sectional study, we enrolled confirmed patients with COVID-19 who were admitted to the COVID unit of Shaheed Suhrawardy Medical college hospital, Dhaka from July 2020 to December 2020. All patients were COVID confirmed by real-time polymerase chain reaction (RT-PCR) and were analyzed for clinical characteristics, laboratory findings and imaging study. Results: The study population consisted of 121 COVID-19-positive patients, among them, 57.85% were male and 42.15% female. The majority (43%) of the study population were in the age group of 31 - 40 years. The male to female ratio was 1.4:1. Nearly 94.2% of the sample population were married, among them 92.9% were male and 96.1% were female. Out of 121 Covid-19 patients, 30.65% had a contact history, 17.4% had a history of traveling or residing in an area reporting COVID-19 and 11.6% of family members were affected by Covid-19. Most of the patients had a fever (95%), cough (88.4%) and dyspnoea (43.8%), pneumonia (37.4%) and severe pneumonia (36.4%). In this study, 40% patients reported a digestive symptom including diarrhea 47.9%, vomiting 55.5%, loss of appetite 16.5%, abdominal pain 29.8%, abdominal bloating 24.8%, reflux 0%, jaundice 3.3%. Regarding co-morbidities, the majority had bronchial asthma (50%) followed by hypertension 46%, diabetes 38%, obesity 23%, and CKD 14% and heart disease 3%. Among 121 COVID-19 patients, 98% had recovered from the disease and 2% of patients expired. Conclusion: Gastrointestinal symptoms are common among patients with COVID-19 and this group of patients had a long time of hospital sta

关键词： COVID-19 Gastrointestinal Symptoms Diarrhoea Prognosis Fecal-Oral-Transmission

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三层流体中被淹没球体的波浪散射研究

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Journal of Marine Science and Application 2022年第1期21卷 37-50页

作者： Minakshi ghosh Manomita Sahu dilip Das Department of Mathematics Diamond HarbourWomen’s UniversitySarisha 743368India

Using linear water wave theory,three-dimensional problems concerning the interaction of waves with spherical structures in a fluid which contains a three-layer fluid consisting of a layer of finite depth bounded above by freshwater of finite depth with free surface and below by an infinite layer of water of greater density are *** such a situation timeharmonic waves with a given frequency can propagate with three *** sphere is submerged in either of the three *** problem is reduced to an infinite system of linear equations by employing the method of multipoles and the system of equations is solved numerically by standard *** hydrodynamic forces(vertical and horizontal forces)are obtained and depicted graphically against the *** the density ratio of the upper and middle layer is made to approximately one,curves for vertical and horizontal forces almost coincide with the corresponding curves for the case of a two-layer fluid with a free *** means that in the limit,the density ratio of the upper and middle layer goes to approximately one,the solution agrees with the solution for the case of a two-layer fluid with a free surface.

关键词： Three-layer fluid Wave scattering Submerged sphere Hydrodynamic forces Vertical and horizontal forces Linear water wave theory Density-stratified three-layer fluid Submerged spherical structure Underwater sphere

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Impeded Carbohydrate Metabolism in Rice Plants under Submergence Stress

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Rice science 2011年第2期18卷 116-126页

作者： Malay kumar ADAK Nirmalya ghosh dilip kumar DASGUPTA Sudha GUPTA Plant Physiology and Plant Molecular Biology Research Unit Department of Botany University of Kalyani Department of Crop Physiology University of Calcutta

The detrimental effects of submergence on physiological performances of some rice varieties with special references to carbohydrate metabolisms and their allied enzymes during post-flowering stages have been documented and clarified in the present investigation. It was found that photosynthetic rate and concomitant translocation of sugars into the panicles were both related to the yield. The detrimental effects of the complete submergence were recorded in generation of sucrose, starch, sucrose phosphate synthase and phosphorylase activity in the developing panicles of the plants as compared to those under normal or control （i.e. non-submerged） condition. The accumulation of starch was significantly lower in plants under submergence and that was correlated with ADP-glucose pyrophosphorylase activity. Photosynthetic rate was most affected under submergence in varying days of post-flowering and was also related to the down regulation of Ribulose bisphosphate carboxylase activity. However, under normal or control condition, there recorded a steady maintenance of photosynthetic rate at the post-flowering stages and significantly higher values of Ribulose bisphosphate carboxylase activity. Still, photosynthetic rate of the plants under both control and submerged conditions had hardly any significant correlation with sugar accumulation and other enzymes of carbohydrate metabolism like invertase with grain yield. Finally, plants under submergence suffered significant loss of yield by poor grain filling which was related to impeded carbohydrate metabolism in the tissues. It is evident that loss of yield under submergence is attributed both by lower sink size or sink capacity （number of panicles, in this case） as well as subdued carbohydrate metabolism in plants and its subsequent partitioning into the grains.

关键词： photosynthesis sucrose starch phosphorylase grain yield rice submergence

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Condensed Matrix Descriptor for Protein Sequence Comparison

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International Journal of Analytical Mass Spectrometry and Chromatography 2016年第1期4卷 1-13页

作者： Soumen ghosh Jayanta Pal Bansibadan Maji dilip kumar Bhattacharya Department of Information Technology Narula Institute of Technology Kolkata India Department of Computer Science & Engineering Narula Institute of Technology Kolkata India Department of Electronics & Communication Engineering National Institute of Technology Durgapur India Department of Pure Mathematics Calcutta University Kolkata India

The present paper develops a novel way of reducing a protein sequence of any length to a real symmetric condensed 20 × 20 matrix. This condensed matrix can be nicely applied as a protein sequence descriptor. In fact, with such a condensed representation, comparison of two protein sequences is reduced to a comparison of two such 20 × 20 matrices. As each square matrix has a unique Alley Index/normalized Alley Index, such index is conveniently used in getting distance matrix to construct Phylogenetic trees of different protein sequences. Finally protein sequence comparison is made based on these Phylogenetic trees. In this paper three types viz., NADH dehydrogenase subunit 3 (ND3), subunit 4 (ND4) and subunit 5 (ND5) of protein sequences of nine species, Human, Gorilla, Common Chimpanzee, Pygmy Chimpanzee, Fin Whale, Blue Whale, Rat, Mouse and Opossum are used for comparison.

关键词： Amino Acids Condensed Matrix Eigen Values Matrix Invariants ALE Index

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Use of FFT in Protein Sequence Comparison under Their Binary Representations

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Computational Molecular Bioscience 2016年第2期6卷 33-40页

作者： Jayanta Pal Soumen ghosh Bansibadan Maji dilip kumar Bhattacharya Department of Computer Science & Engineering Narula Institute of Technology Kolkata India Department of Information Technology Narula Institute of Technology Kolkata India Department of Electronics & Communication Engineering National Institute of Technology Durgapur India Department of Pure Mathematics Calcutta University Kolkata India

The paper considers Voss type representation of amino acids and uses FFT on the represented binary sequences to get the spectrum in the frequency domain. Based on the analysis of this spectrum by using the method of inter coefficient difference (ICD), it compares protein sequences of ND5 and ND6 category. Results obtained agree with the standard ones. The purpose of the paper is to extend the ICD method of comparison of DNA sequences to comparison of protein sequences. The topic of discussion is to develop a novel method of comparing protein sequences. The main achievements of the work are that the method applied is completely new of its kind, so far as protein sequence comparison is concerned and moreover the results of comparison agree with the previous results obtained by other methods for the same category of protein sequences.

关键词： Voss Type Representation Inter-Coefficient Difference (ICD) Method Distance Matrix Phylogenetic Tree Fast Fourier Transform (FFT) ND5 and ND6 Category of Protein

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Comparative Study of Sublingual and Vaginal Misoprostol in Second Trimester Induced Abortion

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Open Journal of Obstetrics and Gynecology 2014年第13期4卷 751-756页

作者： Rupali Modak dilip kumar Biswas Arindam ghosh Amitava Pal Tapan kumar Mandal Department of Obstetrics and Gynecology Burdwan Medical College Burdwan India Department of Obstetrics and Gynecology R. G. Kar Medical College Kolkata India

Background: To identify an effective misoprostol-only regime for the termination of second trimester pregnancy. Objectives: To compare the efficacy, safety and acceptability of sublingual and vaginal misoprostol for second trimester pregnancy termination. Methods: In a prospective randomized comparative study, over 138 pregnant women at 13 - 20 weeks (91 - 140 days) of gestation requiring medical abortion were randomly assigned to the sublingual or vaginal route for misoprostol administration with dose schedule of 400 mcg every 3 hours up to 5 doses within 24 hours. The course of misoprostol was repeated if the woman did not abort within 24 hours. Primary outcome was the efficacy of the treatment to terminate pregnancy completely at 24 and 48 hours. Secondary outcomes measured were induction-abortion interval, side effects, failure rate, and women’s perception to these treatments. Results: At 24 h, the complete abortion rate was?87.88% in the vaginal administration group and 79.41% in sublingual group (difference 8.5%, 95%?CI: 3.8 to 13.2). No significant difference in the complete abortion rates was observed at 48 h(90.91% versus 88.24% difference: 2.7%, 95% CI: ?0.04 to 5.4) when vaginal and sublingual?groups were compared. Mean induction-abortion interval in sublingual and vaginal groups was 12.28 h (95% CI of mean 11.019 - 13.541 h) and 13.11 h (95% CI of mean 12.0301 - 14.1899 h) respectively;p = 0.485. The rates of side effects were similar in both groups except for fever, which was more common in vaginal group. Significantly more women in the sublingual group preferred the route as compared to vaginal administration (RR 1.618. 95% CI: 1.277 - 2.050;p < 0.0001). Conclusion: Both sublingual and vaginal routes of misoprostol are equally effective in medical termination of pregnancy in second trimester but sublingual route was preferred by the women.

关键词： Misoprostol Sublingual Vaginal Route Mid Trimester Abortion

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Effect of Hydro-ethanolic (1:1) Extract of Stephania Hernandifolia and Achyranthes Aspera in Composite Manner on Testicular Activity in Male Albino Rat:A Dose Dependent Analysis

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Journal of Reproduction and Contraception 2012年第4期23卷 209-221页

作者： Daniel Paul Kazi Monjur Ali Debidas ghosh dilip K.Nandi Hanéne Chenni Mohamed M.Trabelsi Department of Bio-Medical Laboratory Science & Management (UGC Innovative Programme Funded Department under Xth-5 years plan) Vidyasagar University Department of Physiology Raja N.L. Khan Women's College Laboratory of Histology and Embryology Faculty of Medicine

Objective To investigate the effect of hydro-ethanolic extraet of Stephania hernandifolia leaves and Aehyranthes aspera roots in composite manner at the ratio of 1：3 on testicular activity in male rats. Methods Rats were divided into 4 groups with 8 animals in each group. The control （group A） received 0. 5 ml of olive oil/100 g body weight orally, other three groups were treated with said extract orally at a dose of 0.4 mg/g （group B） or 0.8 mg/g （group C） or 1.6 mg/g body weight （group D） respectively for 28 d. On 29th day of experiment, the animals were sacrificed. Sperm concentrations in cauda epididymis and biochemical markers like testicular cholesterol, androgenic key enzyme activity, plasma testosterone level seminal fructose level, glutamate oxaloacetate transaminase （GOT） and glutamate pyruvate transaminase （GPT） activities and serum triglyceride levels were measured following standard methods. ResuIts Extract treated animals in all doses resulted in a significant （P〈O. 05）decrease in sperm concentration, testicular androgenic key enzyme activity, plasma testosterone and seminal vesicle fructose levels along with an increase in testieular cholesterol level Animals treated at a dose of O. 8 mg/g body weight showed more promising result without causing any metabolic toxicity compared with other doses. Histological study also supported the biochemical results. The minimum but most effective dose i.e. 0.8 mg/g body weight had an inhibitory effect on implantation focused here by mating *** The composite efficacy as male contraceptive extract of S. hernandifolia and A. aspera has a potent that may provide clues to the pharmaceutical industries for male contraceptive development

关键词： Achyranthes aspera Stephania hernandifolia testosterone seminiferous tubule

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