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IgA nephropathy: Causes, prognosis and treatment

肾脏病与透析肾移植杂志 2005年第6期14卷 584-587页

作者： Francesco Paolo Schena diletta domenica torres Giuseppina Cerrullo Renal Unit Department of Emergency and Organ Trans-plant University of Bari Bari Italy

IgA nephropathy (IgAN) or Berger's disease is the most common form of primary glomerulonephritis in many renal biopsy registries and it is very frequent in the Eastern regions of the world, such as China (32,1%), Hong... 详细信息

关键词： IgA肾病治疗病理机制免疫疾病

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Indications and results of renal biopsy in children:a 36-year experience

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World Journal of Pediatrics 2018年第2期14卷 127-133页

作者： Luisa Santangelo Giuseppe Stefano Netti Paolo Giordano Vincenza Carbone Marida Martino diletta domenica torres Michele Rossini Anna Maria Di Palma Loreto Gesualdo Mario Giordano Unit of Pediatric Nephrology and Dialysis Pediatric Hospital"GiovanniⅩⅩⅢ"BariItaly Clinical Pathology Department of Medical and Surgical SciencesUniversity of FoggiaFoggiaItaly Unit of Nephrology Dialysis and TransplantationDepartment of Emergency and OrganTransplantationUniversity"Aldo Moro"BariItaly

Background This study was conducted to investigate retrospectively the indications for renal biopsy(RB)in native kidneys and to analyze pathological findings in a single tertiary pediatric hospital in Southern Italy for the last 36 *** All patients who underwent RB at our hospital from 1979 to 2014 were *** renal tissue specimens were studied under light and immunofluorescent microscopy,while electron microscopy was performed only for specific clinical *** The study group included 213 patients(female 43.2%)who underwent 225 percutaneous native kidney *** age was 10.4 years(range 0.6-24 years).The most frequent indication for RB was nephrotic syndrome(44.4%),fol-lowed by proteinuria(27.6%),asymptomatic hematuria(17.3%)and acute kidney injury(9.8%).Gross hematuria appeared after biopsy in less than 5%of the patients,but none of them needed blood *** renal tissue sample was obtained in 95.5%of the renal *** glomerulonephritis(GN)was the most common finding(61.4%),followed by secondary GN(21.4%),tubulointerstitial diseases(3.7%)and hereditary nephropathy(2.8%),while in 10.7%of the cases,normal renal tissues were *** to histopathological diagnosis,the most common causes of primary GN were IgA nephropathy(20.9%),followed by minimal change disease(18.1%)and focal segmental glomerulosclerosis(11.6%).Conclusions The epidemiology of glomerular disease in our single-center cohort is similar to that shown in other national and international ***,our study shows that percutaneous ultrasound-guided RB is a safe,reliable and effec-tive technique in children.

关键词： Epidemiology Glomerular diseases Nephropathy Pediatric patients Renal biopsy

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