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Endoscopic scoring of late gastrointestinal mucosal damage after adjuvant radiochemotherapy

World Journal of Gastroenterology 2006年第27期12卷 4411-4415页

作者： Resat Dabak Oya Uygur-Bayramicli Cengiz Gemici dilek yavuzer Mehmet Sargin Mehmet Yildirim Department of Family Medicine Kartal State HospitalKartalstanbulTurkey Department of Gastroenterology Kartal State HospitalKartalstanbulTurkey Department of Radiation Oncology Kartal State HospitalKartalstanbulTurkey Department of Pathology Kartal State HospitalKartalstanbulTurkey Department of General Surgery Kartal State HospitalKartalstanbulTurkey

AIM： To evaluate late effects of chemoradiation on gastrointestinal mucosa with an endoscopic scoring system and compare it to a clinical scoring system. METHODS： Twenty-four patients going to receive chemoradiation after gastric surgery underwent endoscopy four wk after surgery and one year after the chemoradiation finished. Upper gastrointestinal findings were recorded according to a system proposed by World Organisation for Digestive Endoscopy （OMED） and clinical scoring was done with RTOG-EORTC radiation morbidity scoring systems. RESULTS： There was no significant endoscopic difference in gastric and intestinal mucosa after chemoradiation （P 〉 0.05） and there was no association between endoscopic scores and clinical scores. Endoscopic changes were minimal. CONCLUSION： Late effects after chemoradiation in operated patients with gastric cancers can be evaluated with an endoscopic scoring system objectively and this system is superior to clinical scoring systems.

关键词： Radiochemotherapy Gastric cancer Endoscopy Gastrointestinal rnucositis

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Type 2 diabetes mellitus affects eradication rate of Helicobacter pylori

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World Journal of Gastroenterology 2003年第5期9卷 1126-1128页

作者： Mehmet Sarg■n OyaUygur-Bayramili Haluk Sarg■n Ekrem Orbay dilek yavuzer Ali Yayla Departments of Endocrinology and Diabetes GastroenterologyFamily MedicinePathology and Internal Medicine Kartal Education and Research Hospital IstanbulTurkey

AIM: To study the eradication rate of Helicobacter pylori (Hp) in a group of type 2 diabetes and compared it with an age and sex matched non-diabetic ***: 40 diabetic patients (21 females, 19 males;56±7 years) and 40 non-diabetic dyspeptic patients (20females, 20 males; 54±9 years) were evaluated. Diabetic patients with dyspeptic complaints were referred for upper gastrointestinal endoscopies; 2 corpus and 2 antral gastric biopsy specimens were performed on each patient. Patients with positive Hp results on histopathological examination comprised the study group. Non-diabetic dyspeptic patients seen at the Gastroenterology Outpatient Clinic and with the same biopsy and treatment protocol formed the control group.A triple therapy with amoxycillin (1 g b.i.d), clarithromycin (500 mg b.i.d) and omeprazole (20 mg b.i.d.) was given to both groups for 10 days. Cure was defined as the absence of Hp infection assessed by corpus and antrum biopsies in control upper gastrointestinal endoscopies performed 6weeks after completing the antimicrobial ***: The eradication rate was 50 % in the diabetic group versus 85 % in the non-diabetic control group (P＜0.001).CONCLUSION: Type 2 diabetic patients showed a significantly lower eradication rate than controls which may be due to changes in microvasculature of the stomach and to frequent antibiotic usage because of recurrent bacterial infections with the development of resistant strains.

关键词： Helicobacter pylori Amoxicillin Anti-Ulcer Agents Case-Control Studies Clarithromycin Diabetes Mellitus, Type 2 Drug Therapy, Combination Female Helicobacter Infections Humans Male Middle Aged Omeprazole Prospective Studies

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