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Effects of terlipressin on systolic pulmonary artery pressure of patients with liver cirrhosis: An echocardiographic assessment

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World Journal of Gastroenterology 2004年第15期10卷 2278-2280页

作者： Engin Altintas Necdet Akkus Ramazan Gen M.Rami Helvaci Orhan Sezgin dilek oguz Division of Gastroenterology Mersin UniversitySchool of MedicineMersinTurkey Cardioiogy Department Mersin UniversitySchool of MedicineMersinTurkey Internal Medicine Department Mersin UniversitySchool of MedicineMersinTurkey Gastroenterology

AIM:Portopulmonary hypertension is a serious complication of chronic liver *** aim was to search into the effect of terlipressin on systolic pulmonary artery pressure among cirrhotic patients. METHODS:Twelve patients(6 males and 6 females)with liver cirrhosis were recruited in the *** blood gas samples were obtained in sitting position at *** enhanced echocardiography and measurements of systolic pulmonary artery pressure were performed before and after the intravenous injection of 2 mg terlipressin. RESULTS:Of 12 patients studied,the contrast enhanced echocardiography was positive in 5,and the positive findings in contrast enhanced echocardiography were reversed to normal in two after terlipressin *** mean systolic pulmonary artery pressure was 25.5±3.6 mmHg before terlipressin injection,and was 22.5+2.5 mmHg after terlipressin(P=0.003).The systolic pulmonary artery pressure was above 25 mmHg in seven of these 12 patients. After the terlipressin injection,systolic pulmonary artery pressure was<25 mmHg in four of these cases(58.3% vs 25%,P=0.04). CONCLUSION:Terlipressin can decrease the systolic pulmonary artery pressure in patients with liver cirrhosis.

关键词： Blood Pressure Adult Antihypertensive Agents Echocardiography Female Humans Liver Cirrhosis Lypressin derivatives Male Middle Aged Pulmonary Artery

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Effect of interferon and ribavirin combined with amantadine in interferon and ribavirin non-responder patients with chronic hepatitis C (genotype 1)

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World Journal of Gastroenterology 2005年第4期11卷 580-583页

作者： dilek oguz Bahattin Cicek Levent Filik Bulent Odemis Mesut Kilic Engin Altintas Neslihan Zengin Emin Altiparmak Turkiye Yuksek Ihtisas Hospital Gastroenterology Clinic Mersin University Department of Gastroenterology Turkiye Yuksek Ihtisas Hospital Department of Pathology Turkiye Yuksek Ihtisas Hospital Gastroenterology Clinic

AIM: To evaluate the efficacy of amantadine plus interferonalpha and ribavirin in non-responder patients with chronic hepatitis ***: Twenty-six non-responder patients received the regimen of IFN-α-2a at a dose of 6 million units three times a week, 1 000-1 200 mg of ribavirin daily, and 200 mg of amantadine daily in divided doses over 48 wk. After the end of treatment, at the 72nd wk, a sustained viral response rate was ***: An early (after 12 wk of therapy) response was seen in 34.6% (9/26) of patients. Response rate at the 24th wk was 42.3% (11/26). End of treatment response (ETR) was 53.8% (14/26). Sustained viral response (SVR) was 42.3% (11/26). There was a statistically significant difference between 0 and 12 wk (P = 0.04), 0 and 24 wk (P = 0.01), 0 and 48 wk (P = 0.00), and 0 and 72 wk (P = 0.001). No patient had severe adverse effects during the ***: Combination regimen of interferon-α,ribavirin and amantadine can enhance sustained viral response on IFN-α and ribavirin non-responder patients with HCV. Triple therapy with amantadine should be evaluated in further studies.

关键词： Chronic hepatitis C IFN-α-2a Ribavirin

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