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A ROBUST DISCRETIZATION OF THE REISSNER-MINDLIN PLATE WITH ARBITRARY POLYNOMIAL DEGREE

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Journal of Computational Mathematics 2020年第1期38卷 1-13页

作者： dietmar Gallistl Mira Schedensack Friedrich-Schiller-Universitdt Jena 07737 JenaGermany Universitat Leipzig PF 10092004009 LeipzigGermany

A numerical scheme for the Reissner-Mindlin plate model is *** method is based on a discrete Helmholtz decomposition and can be viewed as a generalization of the nonconforming finite element scheme of Arnold and Falk[SIAM ***.,26(6):1276-1290,1989].The two unknowns in the discrete formulation are the in-plane rotations and the gradient of the vertical *** decomposition of the discrete shear variable leads to equivalence with the usual Stokes system with penalty term plus two Poisson equations and the proposed method is equivalent to a stabilized discretization of the Stokes system that generalizes the Mini *** method is proved to satisfy a best-approximation result which is robust with respect to the thickness parameter t.

关键词： Reissner-Mindlin plate Nonconforming finite element Discrete Helmholtz decomposition Robustness

Peripheral immune cell-derived matrix metalloprotease 8(MMP8):brain trafficking promotes depression-like behavior

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2357-2358页

作者： dietmar Spengler Theo Rein Max Planck Institute of Psychiatry Epigenomics of Early-Life Stress80804 MunichGermany Max Planck Institute of Psychiatry Molecular Pathways of Depression80804 MunichGermany

In a study recently published in Nature,Cathomas et al.1 report that social stress in mice increases the levels of matrix metalloprotease(MMP)8 in circulating immune cells,thereby altering extracellular space(ECS)and neuronal activity,and ultimately social behavior in susceptible *** deficits resembled those from major depressive disorder(MDD)raising the prospect of MMP8 as a new druggable target in tailored treatments.

关键词： MMP8 al. behavior

BRAIN INJURY BIOMECHANICS IN REAL WORLD VEHICLE ACCIDENT USING MATHEMATICAL MODELS

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Chinese Journal of Mechanical Engineering 2008年第4期21卷 81-86页

作者： YANG Jikuang XU Wei OTTE dietmar State Key Laboratory of Advanced Design and Manufacture for Vehicle Body Hunan University Changsha 410082 China Accident Research Unit Medical University HannoverHannover D-30623 Germany

This paper aims at investigating brain injury mechanisms and predicting head injuries in real world accidents. For this purpose, a 3D human head finite element model （HBM-head） was developed based on head-brain anatomy. The HBM head model was validated with two experimental tests. Then the head finite element（FE） model and a multi-body system （MBS） model were used to carry out reconstructions of real world vehicle-pedestrian accidents and brain injuries. The MBS models were used for calculating the head impact conditions in vehicle impacts. The HBM-head model was used for calculating the injury related physical parameters, such as intracranial pressure, stress, and strain. The calculated intracranial pressure and strain distribution were correlated with the injury outcomes observed from accidents. It is shown that this model can predict the intracranial biomechanical response and calculate the injury related physical parameters. The head FE model has good biofidelity and will be a valuable tool for the study of injury mechanisms and the tolerance level of the brain.

关键词： Skull-brain FE model Head injury Real-world vehicle accident

The Fingerprint of Global Warming in the Tropical Pacific

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Advances in Atmospheric Sciences 2016年第4期33卷 I0001-I0002页

作者： Noel KEENLYSIDE dietmar DOMMENGET Geophysical Institute University of Bergen/Bjerknes Center for Climate Research Bergen 5007 Norway Nansen Environmental and Remote Sensing Center/Bjerknes Center for Climate Research Bergen 5006 Norway ARC Centre of Excellence for Climate System Science School of Earth Atmosphere and Environment Monash University Clayton VIC Australia

The impacts of global warming will be felt most strongly at regional scales. However, great uncertainties exist in climate change projections at these scales, limiting our ability to provide useful information for the planning and implementation of appropriate adaptation measures. Thus, there is an urgent need to reduce these uncertainties.

关键词： EPSW The Fingerprint of Global Warming in the Tropical Pacific

Subsidence history and forming mechanism of anomalous tectonic subsidence in the Bozhong depression, Bohaiwan basin

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Science China Earth Sciences 2007年第9期50卷 1310-1318页

作者： MüLLER R. dietmar School of Geosciences University of Sydney Sydney NSW 2006 Australia

The Bozhong depression of the Bohaiwan basin belongs to a family of extensional basins in East China, but is quite different from other parts of the basin. The Cenozoic subsidence of the depression is controlled by a combination of lithospheric thinning and polycyclic strike-slip movements. Three episodic rifts have been identified, i.e. Paleocence-early Eocene, middle-late Eocene and Oligocene age. The depression underwent syn-rift and post-rift stages, but two episodic dextral movement events of the strike-slip faults modify the subsidence of the Bozhong depression since the Oligocene. The early dextral movement of the Tan-Lu fault associated with crustal extension resulted in accelerated subsidence during the time of deposition of the Dongying Formation with a maximum thickness of 4000 m. A late reactivation of dextral movement of the Tan-Lu fault began in late Miocene (about 12 Ma), which resulted in the intense subsidence of Minghuazhen Formation and Quaternary. In addition, dynamic mantle convection-driven topography also accelerated the post-rift anomalous subsidence since the Miocene (24.6 Ma). Our results indicate that the primary control on rapid subsidence both during the rift and post-rift stages in the Bozhong depression originates from a combination of multiple episodic crustal extension and polycyclic dextral movements of strike-slip faults, and dynamic topography.

关键词： tectonic subsidence strike-slip dynamic topography Bozhong depression Bohaiwan basin

Melatonin, circadian rhythms and glaucoma: current perspective

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Neural Regeneration Research 2022年第8期17卷 1759-1760页

作者： Denis Gubin dietmar Weinert Chronobiology&Chronomedicine Laboratory Medical UniversityTyumen/Department of BiologyMedical UniversityTyumen/Tyumen Cardiology Research CenterTomsk National Research Medical CenterRussian Academy of ScienceTomskRussia Institute of Biology/Zoology Martin Luther UniversityHalle-WittenbergGermany

Primary open-angle glaucoma as a causal factor for circadian disruption:Living by the clock,in alignment with external time cues is an important condition for human health and *** changes in the ambient light serve as a key factor to synchronize the endogenously generated circadian *** retina perceives the photic signals and transmits them to the central body clock,the suprachiasmatic nuclei(SCN),via the retinohypothalamic tract.

关键词： ambient alignment Periodic

SATURATION AND RELIABLE HIERARCHICAL A POSTERIORI MORLEY FINITE ELEMENT ERROR CONTROL

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Journal of Computational Mathematics 2018年第6期36卷 833-844页

作者： Carsten Carstensen dietmar Gallistl Yunqing Huang Humboldt-Universitat zu Berlin Institut fiir Mathematik Unter den Linden 6 10099 Berlin Germany Department of Applied Mathematics University of Twente P.O. Box 217 7500 AE Enschede Institute for Computational and Applied Mathematics and Hunan Key Laboratory for Computation & Simulation in Science & Engineering Xiangtan University Xiangtan 411105 China

This paper proves the saturation assumption for the nonconforming Morley finite ele- ment discretization of the biharmonic equation. This asserts that the error of the Morley approximation under uniform refinement is strictly reduced by a contraction factor smaller than one up to explicit higher-order data approximation terms. The refinement has at least to bisect any edge such as red refinement or 3-bisections on any triangle. This justifies a hierarchical error estimator for the Morley finite element method, which simply compares the discrete solutions of one mesh and its red-refinement. The related adaptive mesh-refining strategy performs optimally in numerical experiments. A remark for Crouzeix-Raviart nonconforming finite element error control is included.

关键词： Saturation Hierarchical error estimation Finite element Nonconforming Biharmonie Morley Kirchhoff plate Crouzeix-Raviart

Inhibition of tubulin detyrosination:a novel strategy to promote central nervous system regeneration

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Neural Regeneration Research 2024年第12期19卷 2557-2558页

作者： Charlotte Zeitler Marco Leibinger dietmar Fischer Center of Pharmacology Institute for PharmacologyMedical Faculty and University of CologneCologneGermany

The adult mammalian central nervous system(CNS) coordinates essential functions such as sensation,movement,autonomic control,thought processes,and ***,injuries or diseases of the CNS are often associated with devastating and permanent functional impairments because damaged axons normally fail to *** insufficient neuron-intrinsic growth capacity and an inhibitory environment at the injury site are the leading causes of this regenerative failure.

关键词： injuries sensation diseases

Single-port versus multi-port cholecystectomy for patients with acute cholecystitis: a retrospective comparative analysis

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 521-525页

作者： dietmar Jacob Roland Raakow Department of Surgery Center for Minimally Invasive Surgery Vivantes Hospital Spandau Neue Bergstrasse 6 13585 Berlin Germany Department of Surgery Vivantes Klinikum Am Urban Dieffenbachstrasse 1 10967 Berlin Germany

BACKGROUND: Trans-umbilical single-port laparoscopic cholecystectomy for chronic gallbladder disease is becoming increasingly accepted worldwide. But so far, no reports exist about the challenging single-port surgery for acute cholecystitis. The objective of this study was to describe our experience with single-port cholecystectomy in comparison to the conventional laparoscopic technique. METHODS: Between August 2008 and March 2010, 73 patients with symptomatic gallbladder disease and histopathological signs of acute cholecystitis underwent laparoscopic cholecystec- tomy at our institution. Thirty-six patients were operated on with the single-port technique (SP group) and the data were compared with a control group of 37 patients who were treated with the multi-port technique (MP group). RESULTS: The mean age in the SP group was 61.5 (range 21-81) years and in the MP group was 60 (range 21-94) (P=0.712). Gender, ASA status and BMI were not significantly different. The number of white blood cells was different before [SP: 9.2 (range 2.8-78.4); MP: 13.2 (range 4.4-28.6); P=0.001] and after the operation [SP: 7.8 (range 3.5-184.8); MP: 11.1 (range 5-20.8); P=0.002]. Mean operating time was 88 (range 34-174) minutes in the SP group vs 94 (range 39-209) minutes in the MP group (P=0.147). Four patients (5%) required conversion to an open procedure (SP: 1; MP: 3; P=0.320). During the follow- up period of 332 (range 29-570) days in the SP group and 428 (range 111-619) days in the MP group (P=0.044), eleven (15%) patients developed postoperative complications (P=0.745) and two patients in the SP group required reoperation (P=0.154). CONCLUSIONS: Trans-umbilical single-port cholecystectomy for beginning acute cholecystitis is feasible and the complicationrate is comparable with the standard multi-port operation. In spite of our good results, these operations are difficult to perform and should only be done in high-volume centers for laparoscopic surgery with experience in sin

关键词： laparoscopic surgery single-port cholecystectomy acute cholecystitis