Peripheral immune cell-derived matrix metalloprotease 8(MMP8):brain trafficking promotes depression-like behavior

作     者：Dietmar Spengler Theo Rein Dietmar Spengler;Theo Rein

作者机构：Max Planck Institute of PsychiatryEpigenomics of Early-Life Stress80804 MunichGermany Max Planck Institute of PsychiatryMolecular Pathways of Depression80804 MunichGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2024年第9卷第6期

页      面：2357-2358页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by the Re-MEND project which has received funding from the European Union’s Horizon Europe research and innovation program under grant agreement no.101057604 

主　　题：MMP8 al. behavior 

摘      要：In a study recently published in Nature,Cathomas et al.1 report that social stress in mice increases the levels of matrix metalloprotease(MMP)8 in circulating immune cells,thereby altering extracellular space(ECS)and neuronal activity,and ultimately social behavior in susceptible *** deficits resembled those from major depressive disorder(MDD)raising the prospect of MMP8 as a new druggable target in tailored treatments.