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Melatonin, circadian rhythms and glaucoma: current perspective

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Neural Regeneration Research 2022年第8期17卷 1759-1760页

作者： Denis Gubin dietmar Weinert Chronobiology&Chronomedicine Laboratory Medical UniversityTyumen/Department of BiologyMedical UniversityTyumen/Tyumen Cardiology Research CenterTomsk National Research Medical CenterRussian Academy of ScienceTomskRussia Institute of Biology/Zoology Martin Luther UniversityHalle-WittenbergGermany

Primary open-angle glaucoma as a causal factor for circadian disruption:Living by the clock,in alignment with external time cues is an important condition for human health and *** changes in the ambient light serve as a key factor to synchronize the endogenously generated circadian *** retina perceives the photic signals and transmits them to the central body clock,the suprachiasmatic nuclei(SCN),via the retinohypothalamic tract.

关键词： ambient alignment Periodic

SATURATION AND RELIABLE HIERARCHICAL A POSTERIORI MORLEY FINITE ELEMENT ERROR CONTROL

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Journal of Computational Mathematics 2018年第6期36卷 833-844页

作者： Carsten Carstensen dietmar Gallistl Yunqing Huang Humboldt-Universitat zu Berlin Institut fiir Mathematik Unter den Linden 6 10099 Berlin Germany Department of Applied Mathematics University of Twente P.O. Box 217 7500 AE Enschede Institute for Computational and Applied Mathematics and Hunan Key Laboratory for Computation & Simulation in Science & Engineering Xiangtan University Xiangtan 411105 China

This paper proves the saturation assumption for the nonconforming Morley finite ele- ment discretization of the biharmonic equation. This asserts that the error of the Morley approximation under uniform refinement is strictly reduced by a contraction factor smaller than one up to explicit higher-order data approximation terms. The refinement has at least to bisect any edge such as red refinement or 3-bisections on any triangle. This justifies a hierarchical error estimator for the Morley finite element method, which simply compares the discrete solutions of one mesh and its red-refinement. The related adaptive mesh-refining strategy performs optimally in numerical experiments. A remark for Crouzeix-Raviart nonconforming finite element error control is included.

关键词： Saturation Hierarchical error estimation Finite element Nonconforming Biharmonie Morley Kirchhoff plate Crouzeix-Raviart

Treatment of critical bone defects using calcium phosphate cement and mesoporous bioactive glass providing spatiotemporal drug delivery

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Bioactive Materials 2023年第10期28卷 402-419页

作者： Richard Frank Richter Corina Vater Margarete korn Tilman Ahlfeld Martina Rauner Winnie Pradel Bernd Stadlinger Michael Gelinsky Anja Lode Paula korn Centre for Translational Bone Joint and Soft Tissue ResearchUniversity Hospital Carl Gustav Carus and Faculty of MedicineTechnische Universitat DresdenDresdenGermany Department of Oral and Maxillofacial Surgery University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Department of Medicine III and Center for Healthy Aging University Hospital Carl Gustav CarusTechnische Universitat DresdenGermany Clinic of Cranio-Maxillofacial and Oral Surgery Center of Dental MedicineUniversity of ZurichSwitzerland

Calcium phosphate cements (CPC) are currently widely used bone replacement materials with excellent bioactivity, but have considerable disadvantages like slow degradation. For critical-sized defects, however, an improved degradation is essential to match the tissue regeneration, especially in younger patients who are still growing. We demonstrate that a combination of CPC with mesoporous bioactive glass (MBG) particles led to an enhanced degradation in vitro and in a critical alveolar cleft defect in rats. Additionally, to support new bone formation the MBG was functionalized with hypoxia conditioned medium (HCM) derived from rat bone marrow stromal cells. HCM-functionalized scaffolds showed an improved cell proliferation and the highest formation of new bone volume. This highly flexible material system together with the drug delivery capacity is adaptable to patient specific needs and has great potential for clinical translation.

关键词： Drug delivery 3D plotting Alveolar cleft defect Calcium phosphate cement Mesoporous bioactive glass

Role of GSK3 in peripheral nerve regeneration

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Neural Regeneration Research 2015年第10期10卷 1602-1603页

作者： Heike Diekmann dietmar Fischer Division of Experimental Neurology Department of Neurology Heinrich-Heine-University of Düsseldorf

In recent years,GSK3 has emerged as a key regulatory kinase in the nervous system,which is involved in diverse processes ranging from neural development to mood stabilization to *** addition,it has been described as a regulator of several aspects of neural morphology such as polarization,axon growth and branching （Seira and Del Rio, 2014）.

关键词： GSK gene

Single-port versus multi-port cholecystectomy for patients with acute cholecystitis: a retrospective comparative analysis

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 521-525页

作者： dietmar Jacob Roland Raakow Department of Surgery Center for Minimally Invasive Surgery Vivantes Hospital Spandau Neue Bergstrasse 6 13585 Berlin Germany Department of Surgery Vivantes Klinikum Am Urban Dieffenbachstrasse 1 10967 Berlin Germany

BACKGROUND: Trans-umbilical single-port laparoscopic cholecystectomy for chronic gallbladder disease is becoming increasingly accepted worldwide. But so far, no reports exist about the challenging single-port surgery for acute cholecystitis. The objective of this study was to describe our experience with single-port cholecystectomy in comparison to the conventional laparoscopic technique. METHODS: Between August 2008 and March 2010, 73 patients with symptomatic gallbladder disease and histopathological signs of acute cholecystitis underwent laparoscopic cholecystec- tomy at our institution. Thirty-six patients were operated on with the single-port technique (SP group) and the data were compared with a control group of 37 patients who were treated with the multi-port technique (MP group). RESULTS: The mean age in the SP group was 61.5 (range 21-81) years and in the MP group was 60 (range 21-94) (P=0.712). Gender, ASA status and BMI were not significantly different. The number of white blood cells was different before [SP: 9.2 (range 2.8-78.4); MP: 13.2 (range 4.4-28.6); P=0.001] and after the operation [SP: 7.8 (range 3.5-184.8); MP: 11.1 (range 5-20.8); P=0.002]. Mean operating time was 88 (range 34-174) minutes in the SP group vs 94 (range 39-209) minutes in the MP group (P=0.147). Four patients (5%) required conversion to an open procedure (SP: 1; MP: 3; P=0.320). During the follow- up period of 332 (range 29-570) days in the SP group and 428 (range 111-619) days in the MP group (P=0.044), eleven (15%) patients developed postoperative complications (P=0.745) and two patients in the SP group required reoperation (P=0.154). CONCLUSIONS: Trans-umbilical single-port cholecystectomy for beginning acute cholecystitis is feasible and the complicationrate is comparable with the standard multi-port operation. In spite of our good results, these operations are difficult to perform and should only be done in high-volume centers for laparoscopic surgery with experience in sin

关键词： laparoscopic surgery single-port cholecystectomy acute cholecystitis

Improvement of thickness deposition uniformity in nickel electroforming for micro mold inserts

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Journal of Central South University 2016年第10期23卷 2536-2541页

作者：蒋炳炎翁灿周明勇吕辉 DRUMMER dietmar State Key Laboratory of High Performance Complex Manufacturing(Central South University) Changsha 410083China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Institute of Polymer Technology(Friedrich-Alexander-Universitat Erlangen-Numberg) Am weichselgarten 991058 ErlangenTennenloheGermany

Thickness deposition is a crucial issue on the application of electroformed micro mold inserts. Edge concentration effect is the main source of the non-uniformity. The techniques of adopting a non-conducting shield, a secondary electrode and a movable cathode were explored to improve the thickness deposition uniformity during the nickel electroforming process. Regarding these techniques, a micro electroforming system with a movable cathode was particularly developed. The thickness variation of a 16 mm×16 mm electroformed sample decreased respectively from 150% to 35%, 12% and 18% by these three techniques. Combining these validated methods, anickelmold insert for microlens array was electroformed with satisfactory mechanical properties and high replication precision. It could be applied to the following injection molding process.

关键词： deposition uniformity nickel electroforming secondary electrode non-conducting shield movable cathode micro mold insert

Transneuronal delivery of designer cytokines: perspectives for spinal cord injury

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Neural Regeneration Research 2022年第2期17卷 338-340页

作者： Daniel Terheyden-Keighley Marco Leibinger dietmar Fischer Department of Cell Physiology Ruhr University of BochumBochumGermany

We recently achieved significant functional recovery after a complete spinal cord injury,allowing previously paralyzed mice to walk *** was accomplished by a single,unilateral application of an adeno-associated virus(AAV) carrying the cDNA for the designer cytokine hyper-interleukin-6 (hIL-6) into the sensorimotor cortex after spinal cord injury.

关键词： cortex cytokines injury

Alloying effect of silver in magnesium on the development of microstructure and mechanical properties by indirect extrusion

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Journal of Magnesium and Alloys 2021年第1期9卷 112-122页

作者： Bjorn Wiese Regine Willumeit-Römer dietmar Letzig Jan Bohlen Division Metallic Biomaterials Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany Magnesium Innovation Center(MagIC) Institute of Materials ResearchHelmholtz-Zentrum GeesthachtMax-Planck-Str.1Geesthacht 21502Germany

The effect of Ag in solid solution on the microstructure,texture and the deformation behaviour of indirectly extruded Mg was *** as a solid solution strengthener affects the behaviour during extrusion,resulting in enhanced deformation related heating and corresponding coarser grained *** substantial effect on the texture development is *** mechanical properties simultaneously increase in stress and strain levels with increasing Ag content,especially in tension as a result of the changing impact of the slip modes which can be associated with a decrease of the lattice parameters as well as the c/a ratio of the hcp lattice *** compression tests with twin dominated flow,the impact is much smaller on the compressive yield stress but higher with respect to the twinning related strain hardening *** solution strength functions for Fleischer and Labusch were determined,also confirming the anisotropic behaviour of the extruded Mg alloys.

关键词： Mg-Ag-alloys Lattice parameters Indirect extrusion Microstructure Mechanical properties

The role of muscle LIM protein in the nervous system

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Neural Regeneration Research 2019年第11期14卷 1907-1908页

作者： Daniel Terheyden-Keighley dietmar Fischer Department of Cell Physiology Faculty of Biology and Biotechnology Ruhr University Bochum

Unlike the peripheral nervous system (PNS), the central nervous system (CNS) has a low intrinsic regenerative capacity and has mechanisms that actively suppress axon regrowth, for example, glial scarring and myelin inhibition (Fischer, 2012). Even in the PNS, which has the principle ability to regenerate injured axons, functional recovery remains limited, particularly in cases where the nerve target has become unreceptive to re-innervation over time due to an insufficient axonal growth rate (Diekmann and Fischer, 2015). Progress towards robust neuroregenerative therapies depends upon an understanding of the relevant signaling and cytoskeletal proteins that drive and control axon extension. Muscle LIM protein (MLP), also known as cysteine and glycine-rich protein 3, was recently discovered to be one such protein that is expressed in regenerating rat neurons and whose overexpression can promote the axon regeneration of adult central, and peripheral neurons of different species (Levin et al., 2019).

关键词： LIM nervous system peripheral nervous system(PNS) central nervous system(CNS)