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Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker

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World Journal of Gastroenterology 2015年第1期21卷 333-341页

作者： Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser Klaus-dieter Wernecke Ulrike Stein Charité Comprehensive Cancer Center Invali-denstra?e 8010117 BerlinGermany Experimental and Clinical Research Center Charité University Medicine Berlin and Max- Delbrück-Center for Molecular MedicineRobert-R?ssle-Stra?e 1013125 BerlinGermany Charité University Medicine Berlin Lindenberger Weg 8013125 BerlinGermany Institute of Medical Biometry Charité University Medicine BerlinLuisenstra?e 6510117 BerlinGermany

AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer ***: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient ***1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid *** conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up *** were controlled by using plasma samples from 54 tumor-free *** was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative ***: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),***,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Level

关键词： Gastric cancer Plasma Circulating transcripts MACC

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Vitamin C promotes the proliferation and effector functions of human γδ T cells

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Cellular & Molecular Immunology 2020年第5期17卷 462-473页

作者： Léonce Kouakanou Yan Xu Christian Peters Junyi He Yangzhe Wu Zhinan Yin dieter Kabelitz Institute of Immunology Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein Campus KielKielGermany The First Affiliated Hospital Biomedical Translational Research InstituteGuangdong Province Key Laboratory of Molecular Immunology and Antibody EngineeringJinan University510632 GuangzhouChina

γδT cells are of interest as effector cells for cellular immunotherapy due to their HLA-non-restricted lysis of many different tumor cell *** applications include the adoptive transfer of in vitro-expandedγδT ***,it is important to optimize the culture conditions to enable maximal proliferative and functional *** C(L-ascorbic acid)is an essential vitamin with multiple effects on immune *** is a cofactor for several enzymes,has antioxidant activity,and is an epigenetic ***,we investigated the effects of vitamin C(VC)and its more stable derivative,L-ascorbic acid 2-phosphate(pVC),on the proliferation and effector function of humanγδT cells stimulated with zoledronate(ZOL)or synthetic phosphoantigens(pAgs).VC and pVC did not increaseγδT-cell expansion within ZOL-or pAg-stimulated PBMCs,but increased the proliferation of purifiedγδT cells and 14-day-expandedγδT-cell lines in response toγδT-cell-specific *** reduced the apoptosis ofγδT cells during primary *** pVC did not prevent activation-induced death of pAg-restimulatedγδT cells,it enhanced the cell cycle progression and cellular ***,VC and pVC enhanced cytokine production during primary activation,as well as upon pAg restimulation of 14-day-expandedγδT *** and pVC also increased the oxidative respiration and glycolysis ofγδT cells,but stimulus-dependent differences were *** modulatory activity of VC and pVC might help to increase the efficacy ofγδT-cell expansion for adoptive immunotherapy.

关键词： γδT cells Vitamin C lymphocyte activation adoptive T-cell transfer

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Exploring the degradation behavior of MgXAg alloys by in vitro electrochemical methods

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Bioactive Materials 2022年第1期7卷 441-452页

作者： Yuqiuhan Zhang Tycho Zimmermann Wolf-dieter Mueller Frank Witte Florian Beuer Andreas Schwitalla Charit´e-Universit¨atsmedizin Berlin corporate member of Freie Universit¨at Berlin and Humboldt-Universit¨at zu BerlinDental Materials and Biomaterial ResearchDepartment of ProsthodonticsGeriatric Dentistry and Craniomandibular DisordersAßmannshauser Str.4-614197BerlinGermany

Magnesium as biodegradable biomaterial could serve as bone augmentation material in implant *** knowledge about the predictability of the biodegradation process is essential as this process needs to go hand in hand with the formation of new bone to gradually replace the augmentation ***,this work aimed to assess if the electrochemistry(EC)measurements of the corrosion process correlate with the surface features at various time points during the surface degradation,in order to describe the degradation process of Mg and Mg alloys more reliably,under the assumption that differences in EC behavior can be detected and related to specific patterns on the *** this test setup,a special optical chamber was used for electrochemical measurements on Mg and Mg-alloys(Mg2Ag,Mg4Ag,and Mg6Ag).Specimens were investigated using different circulating cell culture solutions as electrolytes,these were minimum essential medium(MEM),Hank’s Balanced Salt Solution(HBSS),and MEM+(MEM with added sodium hydrogen carbonate)at 37℃.Open circuit potential measurements(OCP)over 30 min followed by cyclic polarization were *** electrochemistry data,including OCP,exchange current density and corrosion potential,were compared with visible changes at the surface during these treatments over *** results show that the addition of silver(Ag)leads to a“standardization”of the degradation regardless of the selected test *** is currently difficult to correlate the visible microscopic changes with the data taken from the ***,further investigations are necessary.

关键词： Biodegradable magnesium Magnesium silver alloys Electrochemistry Hydrogen evolution

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Immanuel Kant's groundwork for The metaphysics of morals

Immanuel Kant's groundwork for The metaphysics of morals

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作者： Scho虉necker dieter.

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Principle and Potential of Gradient Elution in Planar Chromatography

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分析测试学报 1989年第3期 6-14页

作者： dieter E. Jaenchen CAMAG, Muttenz Switzerland

It was the intention of this paper to show some recent developments in thin layer chroma-togrphy aiming at increasing the separation efficiency by instrumental means and techniquesusing existing separation layers. Gradient elution in the normal phase is a most efficient wayto achieve this goal. Multi-dimensional separations by coupling gradient elution column liquid chromatography inthe reversed phase with AMD gradient elution in normal phase is suitable to achieve newdimensions of separation numbers. Assuming that the N numbers reported for HPLC translateinto separation numbers near 100, by coupling the two kinds of chromatography, separationnumbers around 500 become practically usable.

关键词： Gradient elution in planar caromatography Automated Multiple Development (AMD) Direct coupling of HFLC and TLC(AMD) Multi-dimensional separation

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Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

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International Journal of Oral Science 2023年第4期15卷 701-717页

作者： Maria B.Asparuhova Xiaoqing Song Dominic Riedwyl Geert van Geest dieter D.Bosshardt Anton Sculean Laboratory of Oral Cell Biology School of Dental MedicineUniversity of BernBernSwitzerland Department of Periodontology School of Dental MedicineUniversity of BernBernSwitzerland Interfaculty Bioinformatics Unit University of BernBernSwitzerland Robert K.Schenk Laboratory of Oral Histology School of Dental MedicineUniversity of BernBernSwitzerland

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human ***-four CTGs belonging to anterior deep(AD),anterior superficial(AS),posterior deep(PD),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed *** correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was ***,endothelial,and monocytic cell migration was strongly(P<0.001)potentiated by AD-and ***,significantly increased expression of genes encoding C-C and C-X-C motif chemokine ligands as well as significantly(P<0.01)activated p38 signaling suggested immunomodulatory phenotype for AD-and *** growth factor gene expression and significantly activated(P<0.001)Erk and Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and *** collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(P<0.001)Smad1/5/8 signaling characterized HPFs originating from *** present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than *** findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.

关键词： selecting characterizing showing

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Transient elastography improves detection of liver cirrhosis compared to routine screening tests

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World Journal of Gastroenterology 2015年第3期21卷 953-960页

作者： Thomas Gobel Janine Schadewaldt-Tümmers Lucas Greiner Christopher Poremba dieter Haussinger Andreas Erhardt Klinik für Gastroenterologie Hepatologie und InfektiologieUniversitatsklinikum Düsseldorf40225 DüsseldorfGermany Klinik für Gastroenterologie Hepatologie und DiabetologiePetrus-Krankenhaus Wuppertal42283 WuppertalGermany Pathologie München-Nord Ernst-Platz-StraBe 280992 MünchenGermany

AIM:To investigate the diagnostic significance oftransient elastography(TE) in a daily routine clinical setting in comparison to clinical signs,laboratory parameters and ***:TE,ultrasound,laboratory parameters and cutaneous liver signs were assessed in 291 consecutive patients with chronic liver disease of various aetiologies who underwent liver biopsy in daily ***:Sensitivity of TE for the detection of liver cirrhosis was 90.4%,compared to 80.1% for ultrasound,58.0% for platelet count and 45.1% for cutaneous liver signs(P < 0.0001 for comparisons with histology).AUROC for TE was 0.760(95%CI:0.694-0.825).Combination of TE with ultrasound increased sensitivity to 96.1% and AUROC to 0.825(95%CI:0.768-0.882).TE correlated with laboratory parameters of cirrhosis progression like albumin(r =-0.43),prothrombin time(r =-0.44),and bilirubin(r = 0.34; P < 0.001 for each).Particularly,in patients with Child Pugh score A or normal platelet count TE improved sensitivity for the detection of liver cirrhosis compared to ultrasound by 14.1%(P < 0.04) and 16.3%(P < 0.02),***:Transient elastography is superior to routine diagnostic tests allowing detection of liver cirrhosis in additional 10%-16% of patients with chronic liver disease that would have been missed by clinical examinations.

关键词： Transient elastography Fibroscan Liver cirrhosis Liver disease Chronic hepatitis

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基于自适应交互进化的设计意图驱动造型

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中国机械工程 2006年第4期17卷 350-353,375页

作者：张文莉左洪福 dieter Roller 南京航空航天大学斯图加特大学

基于先进的设计认知模型,即工业产品造型设计是问题空间和解决方案空间的协同进化过程,提出了在交互进化计算中引入自适应机制来捕捉并跟踪设计意图的思想,旨在使造型进化过程能够主动迎合设计意图,设计过程中的搜索能够沿着设计师希望... 详细信息

基于先进的设计认知模型,即工业产品造型设计是问题空间和解决方案空间的协同进化过程,提出了在交互进化计算中引入自适应机制来捕捉并跟踪设计意图的思想,旨在使造型进化过程能够主动迎合设计意图,设计过程中的搜索能够沿着设计师希望的方向自动调整。为验证该思想,基于自适应交互进化策略开发了简单的曲线修改器,并将其用于船体设计作为试验。初步的结果显示了这一概念的可行性和应用潜力。

关键词：造型设计交互进化计算自适应意图计算机辅助工业设计

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二氮双环阳离子游离基中N，N′—三电子键

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有机化学 2001年第8期21卷 618-621页

作者：邓克俭韩世刚 dieter Klapsteinc 中南民族学院化学系分析化学综合实验室西安交通大学化学化工学院 Deptment of Chemistry St. Francis Xavier University Antigonish N. S.

用从头算HF/3-21+G*优化了二氮双环[m,n,l]游离基阳离子(m,n,l≥2～5).分子[4,4,4]和[2,2,2]+,[3,3,3]+,[4,4,4]+游离基阳离子的优势构型有D3对称性,而其它游离基阳离子的优势构型为非对称性.通过比较这些阳离子几何构型,HOMO和NHOMO(即... 详细信息

用从头算HF/3-21+G*优化了二氮双环[m,n,l]游离基阳离子(m,n,l≥2～5).分子[4,4,4]和[2,2,2]+,[3,3,3]+,[4,4,4]+游离基阳离子的优势构型有D3对称性,而其它游离基阳离子的优势构型为非对称性.通过比较这些阳离子几何构型,HOMO和NHOMO(即Next HOMO和HOMO-1),和由MNDO计算确定的原子对作用能,表明当二氮双环游离基阳离子的桥链(CH2)n的n≥3时,桥头氮原子通过空间相互作用形成了一个弱的N,N＇-三电子σ-键.形成的三电子键强度不随环的扩大而增强.而三电子键强度被两个因素影响:一个是桥头氮原子间的p轨道重叠的取向;另一个是它们相应p轨道成分.

关键词：二氮双环游离基阳离子环张力效应从头算方法原子对作用能取代效应 N,N′-三电子键量子化学

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Evaluation of the ＂Harmony/Balance Value＂ on the Development of the Sensorial Quality of EVOOmExperiences in Germany and Europe

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Journal of Food Science and Engineering 2017年第9期7卷 423-434页

作者： dieter Oberg Deputy PSV German Olive Oil Panel (DOP) and Leader of Ass. for Care and Support of the Value of EVO0 (IGO) - D-82234Wessling/Germany

Since 2015 the methodology of the harmony value in the framework of the official organoleptic assessment has been accredited by the German authorities. It initiated additional background for this parameter which is set on top of the Official Paneltest （Standard IOC/T15/Reg. （EWG） 2568/91 in its actual version） which classifies Olive oil in the relevant classifications ＂extra virgin＂, ＂virgin＂ or ＂virgin lampante＂. This study will proof the possible accuracy of this additional parameter ＂harmony/balance＂ and the benefits which arise with this additional parameter for all stakeholders. The German Olive Oil Panel （DOP） is practicing this extended methodology for the sensory evaluation of extra virgin olive oil since 2003. In addition to the verification of the category ＂extra virgin＂ the Panel is continuously training for additional descriptors used to appraise the quality-discrimination for this category. But in case the panel decides for a valid median of a defect the panel supervisor （PSV） will set the harmony level to zero. In the focus is the additional attribute called ＂harmony＂（in some world areas called ＂balance＂--both mean a quantification of the specific overall quality with one single parameter） which is responsible for this advancement in the methodological approach. Using ＂harmony/balance＂（H/B） as a quality-factor, the discrimination between bad, average, good, very good and premium quality within the category of EVOO became possible. ＂Harmony＂ includes olfactory, tactile and kinesthetic stimuli and is evaluated on a bipolar 100 mm scale, which leads to this parameter from ＂average＂ in the center to ＂complex/harmonious＂ on one side or to ＂totally disharmonious＂ on the other side. In the study at hand we are able to prove the development of qualities in the framework of the accredited Panel in German speaking countries over more than 10 years. In this study the development of the increasing quality can be proved in yearly figures of the DOP. The trend cou

关键词： Extra virgin olive oil sensory quality extension of panel test complexity harmony/balance quantification private label Europe.

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