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Palaeobotanical and biomarker evidence for Early Permian(Artinskian) wildfire in the Rajmahal Basin, India

Journal of Palaeogeography 2021年第1期10卷 55-75页

作者： Srikanta Murthy Vinod Atmaram Mendhe dieter Uhl Runcie Paul Mathews Vivek Kumar Mishra Saurabh Gautam Birbal Sahni Institute of Palaeosciences 53University RoadLucknow 226007India CSIR-Central Institute of Mining and Fuel Research Dhanbad 826015JharkhandIndia Senckenberg Forschungsinstitut und Naturmuseum Frankfurt Senckenberganlage 2560325 Frankfurt am MainGermany

This study provides a combined analysis on the palynology, fossil charcoal and biomarkers of the subsurface coal deposits from a borehole RMB #2 drilled at the Dhulia Coal Block, Rajmahal Basin, India, in attempts to establish the chronology of sedimentation and to propose palaeobotanical as well as geochemical evidence for the occurrence of wildfires in these sediments. The palynological investigation suggests a Scheuringipollenites barakarensis palynoassemblage from the lower Barakar Formation, dated as Artinskian(Early Permian) in age. This assemblage reveals the dominance of Glossopteridales and sub-dominance of taxa belonging to Cordaitales and *** charcoal in sediments is usually recognized as a direct indicator for the occurrence of palaeo-wildfires. More data involving the anatomical features of fossil charcoal analyzed by Field Emission Scanning Electronic Microscope broaden our knowledge on Early Permian wildfires from the peninsula of India. The studied macroscopic charcoal fragments exhibit anatomical details such as homogenized cell walls, uniseriate simple and biseriate alternate pitting on tracheid walls and rays of varying heights pointing to a gymnospermous wood affinitity. The excellent preservation of charcoal fragments, shown by their large sizes and almost unabraded edges, suggests a parautochthonous origin. The embedded biomarker study performed for charcoal sediments and its characterization demonstrate the presence of n-alkanes, isoprenoids, terpenoids and aromatic compounds. A bimodal distribution pattern of n-alkanes with a Cmaxat n-C25 is identified. Diterpenoids and pentacyclic terpenoids are identified, indicating the input of an early conifer vegetation and bacterial activity, respectively. The identified polyaromatic hydrocarbon(PAH) compounds, together with the charcoal fragments, clearly suggest that repeated wildfire events occurred during the deposition of these Artinskian sediments in the Rajmahal Basin.

关键词： Palaeo-wildfire Palynology Fossil charcoal Biomarker Barakar Formation Rajmahal Basin

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The virtual lover： variable and easily guided 3D fish animations as an innovative tool inmate-choice experiments with sailfinmollies-II. Validation

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Current Zoology 2017年第1期63卷 65-74页

作者： Stefanie GIERSZEWSKI Klaus MuLLER levgen SMIELIK Jan-Marco HUTWOHL Klaus-dieter KUHNERT Klaudia WITTE Research Group of Ecology and Behavioral Biology Institute of Biology University of Siegen Adolf-Reichwein- StraBe 2 Siegen 57068 Germany Institute of Real-Time Learning Systems Department of ElectricalEngineering & Computer Science University of Siegen HSIderlinstraBe 3 Siegen 57076 Germany

The use of computer animation in behavioral research is a state-of-the-art method for designing andpresenting animated animals to live test animals. The major advantages of computer animations are：（1） the creation of animated animal stimuli with high variability of morphology and even behavior; （2）animated stimuli provide highly standardized, controlled and repeatable testing procedures; and （3）they allow a reduction in the number of live test animals regarding the 3Rs principle. But the use of ani-mated animals should be attended by a thorough validation for each test species to verify that behaviormeasured with live animals toward virtual animals can also be expected with natural stimuli. Here wepresent results on the validation of a custom-made simulation for animated 3D sailfin mollies Poecilialatipinna and show that responses of live test females were as strong to an animated fish as to a videoor a live male fish. Movement of an animated stimulus was important but female response was stron-ger toward a swimming 3D fish stimulus than to a ＂swimming＂ box. Moreover, male test fish wereable to discriminate between animated male and female stimuli; hence, rendering the animated 3D fisha useful tool in mate-choice experiments with sailfin mollies.

关键词： computer animation, fish behavior, mate-choice experiment, validation, virtual fish model.

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A vocabulary recommendation method for spatiotemporal data discovery based on Bayesian network and ontologies

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Big Earth Data 2019年第3期3卷 220-231页

作者： Kejin Cui Yongyao Jiang Yun Li dieter Pfoser Department of Geography and Geoinformation Science George Mason UniversityUniversity Dr.FairfaxVA 4400USA Environmental Systems Research Institute RedlandsCAUSA

In the research field of spatiotemporal data discovery,how to utilize the semantic characteristics of spatiotemporal datasets is an important *** paper presented a content-based recommendation method,and applied Bayesian networks and ontologies into the vocabulary recommendation process for spatiotemporal data *** source data of this research was from the MUDROD(Mining and Utilizing Dataset Relevancy from Oceanographic Datasets)search *** the historical search log,major keywords were extracted and organized according to ontologies in a hierarchical *** the search history,the posterior probability between each subclass and their super class in the ontologies was calculated,indicating a recommendation *** created a Bayesian network model for inference based on *** model can address the following two objectives:(1)Given one class in the ontology,the model can judge which class has the biggest likelihood to be selected for recommendation.(2)Based on the search history of a user,the Bayesian network model can judge which class has the biggest probability to be *** experimentation with existing system and evaluation experimentation with expert knowledge show that this method is specifically helpful for spatiotemporal data discovery.

关键词： Spatiotemporal big data spatiotemporal data infrastructure data discovery Bayesian network artificial intelligence search relevance ontologies

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The virtual lover： variable and easily guided 3D fish animations as an innovative tool inmate-choice experiments with sailfin mollies-I,Design and implementation

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Current Zoology 2017年第1期63卷 55-64页

作者： Klaus MuLLER Jevgen SMIELIK Jan-Marco HOTWOHL Stefanie GIERSZEWSKI Klaudia WITTE Klaus-dieter KUHNERT Department of Electrical Engineering & Computer Science Institute of Real-Time Learning Systems University of Siegen HSIderlinstraBe 3 Siegen 57076 Germany Research Group of Ecology and Behavioral Biology Institute of Biology University of Siegen Adolf-Reichwein-Stral~e 2 Siegen 57068 Germany

Animal behavior researchers often face problems regarding standardization and reproducibility oftheir experiments. This has led to the partial substitution of live animals with artificial virtual stim-uli. In addition to standardization and reproducibility, virtual stimuli open new options for re-searchers since they are easily changeable in morphology and appearance, and their behavior canbe defined. In this article, a novel toolchain to conduct behavior experiments with fish is presentedby a case study in sailfin mollies Poecilia latipinna. As the toolchain holds many different and novelfeatures, it offers new possibilities for studies in behavioral animal research and promotes thestandardization of experiments. The presented method includes options to design, animate, andpresent virtual stimuli to live fish. The designing tool offers an easy and user-friendly way to definesize, coloration, and morphology of stimuli and moreover it is able to configure virtual stimuli ran-domly without any user influence. Furthermore, the toolchain brings a novel method to animatestimuli in a semiautomatic way with the help of a game controller. These created swimming pathscan be applied to different stimuli in real time. A presentation tool combines models and swim-ming paths regarding formerly defined playlists, and presents the stimuli onto 2 *** with live sailfin mollies validated the usage of the created virtual 3D fish models inmate-choice experiments.

关键词： computer animation, fish behavior, mate-choice experiment, research tool, virtual fish model.

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Cryoablation of malignant liver tumors: results of a single center study

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Hepatobiliary & Pancreatic Diseases International 2005年第4期4卷 554-560页

作者： Wolfgang Jungraithmayr dieter Burger Manfred Olschewski Stefan Eggstein Department of General Surgery University Hospital of Freiburg Hugstetter Straβe 5579106 FreiburgGermany Department of Radiology University Hospital of Freiburg Hugstetter Straβe 5579106 FreiburgGermany Department of Medical Biometry and Medical Statistics University Hospital of FreiburgHugstetter Straβe 5579106 FreiburgGermany

BACKGROUND: Local ablative procedures such as cryo-surgery and thermo-ablation are increasingly employed as a supplement to liver resection for the therapy of primary and secondary liver tumors. It is still unclear if the survival time can be extended through local ablative procedures. This prospective study shows operative actions, complications and long-term follow-up of 19 patients undergoing cryotherapy. METHODS: Between 1997 and 1998, 19 patients underwent cryotherapy due to a non-resectable malignant liver tumor (17 patients with metastases of a colon carcinoma, 2 patients with a hepatocellular carcinoma). Twelve patients (63.2%) received cryotherapy only and seven patients (36.8%) received a combination of resection and cryotherapy. The median follow-up period was 23 months. RESULTS: In a total of 59 liver tumors (18 were resected and 41 received cryotherapy), 12 had cryotherapy only, and 7 had a combination of cryotherapy and resection. The 30-day lethality was 0%, and the rate of major complications was 21%. After one year, 27.3% of the patients were still recurrence- free. The recurrence rate for all tumors treated was 58.8%. The median survival time for all patients was 21 months. The one- and three-year survival rates were 62. 5% and 15.8%, respectively. CONCLUSIONS: The mortality for cryotherapy is low, but there is a high rate of complications and long-term tumor control is not sufficient. If local ablative procedures of hepatic lesions are to be performed, not laparotomy but percutaneous, percutaneous thermoablation should be discussed as an alternative therapeutic measure.

关键词： cryotherapy complications liver tumor survival

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Vertical-cavity surface-emitting lasers with nanostructures for optical interconnects

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Frontiers of Optoelectronics 2016年第2期9卷 249-258页

作者： Anjin LIU dieter BIMBERG Laboratory of Solid-State Optoelectronics Information Technology Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China Institute of Solid State Physics Technische Universitat Berlin Hardenbergstrasse 36 10623 Berlin Germany King Abdulaziz University Jeddah Kingdom of Saudi Arabia (KSA)

Optical interconnects （OIs） are the only solution to fulfil both the requirements on large bandwidth and minimum power consumption of data centers and high-performance computers （HPCs）. Vertical-cavity surface-emitting lasers （VCSELs） are the ideal light sources for Ols and have been widely deployed. This paper will summarize the progress made on modulation speed, energy efficiency, and temperature stability of VCSELs. Espe- cially VCSELs with surface nanostructures will be reviewed in depth. Such lasers will provide new opportunities to further boost the performance of VCSELs and open a new door for energy-efficient OIs.

关键词： optical interconnects (OIs) vertical-cavitysurface-emitting laser (VCSEL) subwavelength grating,modulation speed energy efficiency

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Viral and cellular determinants involved in hepadnaviral entry

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World Journal of Gastroenterology 2007年第1期13卷 22-38页

作者： dieter Glebe Stephan Urban Institute of Medical Virology Justus-Liebig University of Giessen Frankfurter Str. 107 D-35392 Giessen Germany Department of Molecular Virology Otto Meyerhof Zentrum University of Heidelberg Im Neuenheimer Feld 350 D-69120 Heidelberg Germany

Hepadnaviridae is a family of hepatotropic DNA viruses that is divided into the genera orthohepadnavirus of mammals and avihepadnavirus of birds. All members of this family can cause acute and chronic hepatic infection, which in the case of human hepatitis B virus （HBV） constitutes a major global health problem. Although our knowledge about the molecular biology of these highly liver-specific viruses has profoundly increased in the last two decades, the mechanisms of attachment and productive entrance into the differentiated host hepatocytes are still enigmatic. The difficulties in studying hepadnaviral entry were primarily caused by the lack of easily accessible in vitro infection systems. Thus, for more than twenty years, differentiated primary hepatocytes from the respective species were the only in vitro models for both orthohepadnaviruses （e.g. HBV） and avihepadnaviruses （e.g. duck hepatitis B virus [DHBV]）. Two important discoveries have been made recently regarding HBV：（1） primary hepatoo/tes from tree-shrews; i.e., Tupaia belangeri, can be substituted for primary human hepatocytes, and （2） a human hepatoma cell line （HepaRG） was established that gains susceptibility for HBV infection upon induction of differentiation in vitro. A number of potential HBV receptor candidates have been described in the past, but none of them have been confirmed to function as a receptor. For DHBV and probably all other avian hepadnaviruses, carboxypeptidase D （CPD） has been shown to be indispensable for infection, although the exact role of this molecule is still under debate. While still restricted to the use of primary duck hepatocytes （PDH）, investigations performed with DHBV provided important general concepts on the first steps of hepadnaviral infection. However, with emerging data obtained from the new HBV infection systems, the hope that DHBV utilizes the same mechanism as HBV only partially held true. Nevertheless, both HBV and DHBV in vitro infection systems will help

关键词： Hepatitis B virus Duck hepatitis B virus Infection models Receptor Viral attachment Tupaia belangeri HepaRG Carboxypeptidase D

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Critical role of butyrophilin 3A1 in presenting preny pyrophosphate antigens to human y~ T cells

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Cellular & Molecular Immunology 2014年第2期11卷 117-119页

作者： dieter Kabelitz Institute of Immunology University of Kiel Kiel Germany (GRID:grid.9764.c) (ISNI:0000 0001 2153 9986)

Tlymphocytes recognize antigen via the heterodimeric T-cell receptor（TCR） which is closely associated with the signal-transducing CD3 complex. αβ TCR-expressing T cells recognize peptides presented by MHC class II （for CD4＋ T cells） or MHC class I molecules （for CD8＋ T cells）. In striking contrast, the majority of human y8 T cells expres- sing the Vy9V82-encoded TCR recog- nize small non-peptidic phosphorylated ligands which have been identified as pyrophosphate intermediates of micro- bial and eukaryotic isoprenoid synthesis.

关键词： T细胞受体抗原焦磷酸脂蛋白人类细胞识别异源二聚体 T淋巴细胞

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γδT cells:origin and fate,subsets,diseases and immunotherapy

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5769-5806页

作者： Yi Hu Qinglin Hu Yongsheng Li Ligong Lu Zheng Xiang Zhinan Yin dieter Kabelitz Yangzhe Wu Microbiology and Immunology Department School of MedicineFaculty of Medical ScienceJinan UniversityGuangzhouGuangdong 510632China Guangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment Zhuhai Institute of Translational MedicineZhuhai People’s Hospital Affiliated with Jinan UniversityJinan UniversityZhuhaiGuangdong 519000China Department of Medical Oncology Chongqing University Cancer HospitalChongqing 400030China Biomedical Translational Research Institute Jinan UniversityGuangzhouGuangdong 510632China Institute of Immunology Christian-Albrechts-University KielKielGermany

The intricacy of diseases,shaped by intrinsic processes like immune system exhaustion and hyperactivation,highlights the potential of immune renormalization as a promising strategy in disease *** recent years,our primary focus has centered onγδT cell-based immunotherapy,particularly pioneering the use of allogeneic Vδ2+γδT cells for treating late-stage solid tumors and tuberculosis ***,we recognize untapped potential and optimization opportunities to fully harnessγδT cell effector functions in *** review aims to thoroughly examineγδT cell immunology and its role in ***,we elucidate functional differences betweenγδT cells and theirαβT cell *** also provide an overview of major milestones inγδT cell research since their discovery in ***,we delve into the intricate biological processes governing their origin,development,fate decisions,and T cell receptor(TCR)rearrangement within the *** examining the mechanisms underlying the anti-tumor functions of distinctγδT cell subtypes based onγδTCR structure or cytokine release,we emphasize the importance of accurate subtyping in understandingγδT cell *** also explore the microenvironment-dependent functions ofγδT cell subsets,particularly in infectious diseases,autoimmune conditions,hematological malignancies,and solid ***,we propose future strategies for utilizing allogeneicγδT cells in tumor *** this comprehensive review,we aim to provide readers with a holistic understanding of the molecular fundamentals and translational research frontiers ofγδT cells,ultimately contributing to further advancements in harnessing the therapeutic potential ofγδT cells.

关键词： γδT immunotherapy diseases

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Predominant mucosal expression of 5-HT_(4(+h)) receptor splice variants in pig stomach and colon

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World Journal of Gastroenterology 2013年第24期19卷 3747-3760页

作者： Evelien KV Priem Joris H De Maeyer Mado Vandewoestyne dieter Deforce Romain A Lefebvre Heymans Institute of Pharmacology Ghent UniversityB-9000 Ghent Belgium Shire-Movetis NV B-2300 Turnhout Belgium Laboratory for Pharmaceutical Biotechnology Ghent UniversityB-9000 Ghent Belgium

AIM: To investigate cellular 5-HT4(-h/+h) receptor distribution, particularly in the epithelial layer, by laser mi-crodissection and polymerase chain reaction (PCR) in porcine gastrointestinal (GI) tissues. METHODS: A stepwise approach was used to evaluate RNA quality and to study cell-specific 5-HT4 receptor mRNA expression in the porcine gastric fundus and colon descendens. After freezing, staining and laser microdissection and pressure catapulting (LMPC), RNA quality was evaluated by the Experion automated electrophoresis system. 5-HT4 receptor and glyceral-dehyde-3-phosphate dehydrogenase (GAPDH) expressions were examined by endpoint reverse transcription (RT)-PCR in mucosal and muscle-myenteric plexus (MMP) tissue fractions, in mucosal and MMP parts of hematoxylin and eosin (HE) stained tissue sections andin microdissected patches of the epithelial and circular smooth muscle cell layer in these sections. Pig gastric fundus tissue sections were also stained immunohisto-chemically (IHC) for enterochromaffin cells (EC cells; MAB352); these cells were isolated by LMPC and examined by endpoint RT-PCR. RESULTS: After HE staining, the epithelial and circular smooth muscle cell layer of pig colon descendens and the epithelial cell layer of gastric fundus were identified morphologically and isolated by LMPC. EC cells of pig gastric fundus were successfully stained by IHC and isolated by LMPC. Freezing, HE and IHC staining, and LMPC had no influence on RNA quality. 5-HT4 recep-tor and GAPDH mRNA expressions were detected in mucosa and MMP tissue fractions, and in mucosal and MMP parts of HE stained tissue sections of pig colon descendens and gastric fundus. In the mucosa tissue fractions of both GI regions, the expression of h-exon containing receptor [5-HT4(+h) receptor] mRNA was significantly higher (P<0.01) compared to 5-HT4(-h) re-ceptor expression, and a similar trend was obtained in the mucosal part of HE stained tissue sections. Large microdissected patches of the

关键词： 5-hydroxytryptamine 4 receptors Pig Gastric fundus Colon descendens Epithelium Smooth muscle Laser microdissection and pressure catapulting

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