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Critical role of butyrophilin 3A1 in presenting preny pyrophosphate antigens to human y~ T cells

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Cellular & Molecular Immunology 2014年第2期11卷 117-119页

作者： dieter kabelitz Institute of Immunology University of Kiel Kiel Germany

Tlymphocytes recognize antigen via the heterodimeric T-cell receptor（TCR） which is closely associated with the signal-transducing CD3 complex. αβ TCR-expressing T cells recognize peptides presented by MHC class II （for CD4＋ T cells） or MHC class I molecules （for CD8＋ T cells）. In striking contrast, the majority of human y8 T cells expres- sing the Vy9V82-encoded TCR recog- nize small non-peptidic phosphorylated ligands which have been identified as pyrophosphate intermediates of micro- bial and eukaryotic isoprenoid synthesis.

关键词： T细胞受体抗原焦磷酸脂蛋白人类细胞识别异源二聚体 T淋巴细胞

Multilayer epigenetic analysis reveals novel transcription factor networks in CD8 T cells

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Cellular & Molecular Immunology 2018年第3期15卷 199-202页

作者： Jaydeep Bhat dieter kabelitz Institute of Immunology University of KielKielD-24105Germany

A characteristic feature of the adaptive immune system is immunological memory,which is the more rapid and more potent response to antigenic challenge upon re-encountering the antigen–even years after the primary antigen ***8 T cells are essential players in the adaptive immune response to viruses and intracellular *** infection,antigen-responsive naive CD8 T cells are activated and they clonally expand to give rise to sufficient effector cell numbers to execute an adequate immune *** cells are deleted after the clearance of infection,but some T cells survive and are maintained as memory T cells in a non-proliferative state in secondary lymphoid tissues and bone marrow.1 Complex transcriptional programs regulate CD8 T-cell differentiation from antigen-inexperienced naive cells via the effector cell stage towards long-term memory cells.

关键词： infection maintained networks

Novel insights into regulation of butyrophilin molecules:critical components of cancer immunosurveillance by yo T cells

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Cellular & Molecular Immunology 2024年第4期21卷 409-411页

作者： dieter kabelitz Institute of Immunology University of KielKielGermany

Members of the butyrophilin(BTN)family of transmembrane molecules play an important role in the activation of humanγδT *** recent years,it has been discovered that BTN3A1 and BTN2A1 are indispensable in this process,but other members like BTN3A2 and BTN3A3 are also *** far,very little is known about the transcriptional and post-translational regulation of BTN expression.

关键词： expression. insight critical

Vitamin C and Vitamin D—friends or foes in modulating γδ T-cell differentiation?

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Cellular & Molecular Immunology 2022年第10期19卷 1198-1200页

作者： Christian Peters Katharina Klein dieter kabelitz Institute of Immunology Christian-Albrechts UniversityKielGermany

The differentiation and functional plasticity of T cells are transcriptionally and epigenetically regulated by signals imposed by the local cytokine milieu and a variety of additional factors,including *** C has pleiotropic functions in the immune *** exerts antioxidant activity,can directly kill selected tumor targets,promotes early T-cell differentiation,and enhances Th1 cytokine production in mature T cells[1,2].

关键词： vitamin cytokine Vitamin

3efining the nature of human yo T cells： a biographical ketch of the highly empathetic

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Cellular & Molecular Immunology 2013年第1期10卷 21-29页

作者： Shirin Kalyan dieter kabelitz Institute of Immunology Christian-Albrechts University K)el Kiel Germany

The elusive task of defining the character of 76 T cells has been an evolving process for immunologists since stumbling upon their existence during the molecular characterization of the a and p T cell receptor genes of their better understood brethren. Defying the categorical rules used to distinctly characterize lymphocytes as either innate or adaptive in nature, 76 T cells inhabit a hybrid world of their own. At opposing ends of the simplified spectrum of modes of antigen recognition used by lymphocytes, natural killer and ap T cells are particularly well equipped to respond to the ＇missing self＇ and the ＇dangerous non-self＇, respectively. However, between these two reductive extremes, we are chronically faced with the challenge of making peace with the ＇safe non-self＇ and dealing with the inevitable ＇distressed self＇, and it is within this more complex realm 76 T cells excel thanks to their highly empathetic nature. This review gives an overview of the latest insights revealing the unfolding story of human 76 T cells, providing a biographical sketch of these unique lymphocytes in an attempt to capture the essence of their fundamental nature and events that influence their life trajectory. What hangs in their balance is their nuanced ability to differentiate the friends from the foe and the pathological from the benign to help us adapt swiftly and efficiently to life＇s many stresses.

关键词： antigen recognition danger-associated molecular patterns gamma delta T cell subsets immune homeostasis innateimmunity stress response

γδT cells:origin and fate,subsets,diseases and immunotherapy

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5769-5806页

作者： Yi Hu Qinglin Hu Yongsheng Li Ligong Lu Zheng Xiang Zhinan Yin dieter kabelitz Yangzhe Wu Microbiology and Immunology Department School of MedicineFaculty of Medical ScienceJinan UniversityGuangzhouGuangdong 510632China Guangdong Provincial Key Laboratory of Tumour Interventional Diagnosis and Treatment Zhuhai Institute of Translational MedicineZhuhai People’s Hospital Affiliated with Jinan UniversityJinan UniversityZhuhaiGuangdong 519000China Department of Medical Oncology Chongqing University Cancer HospitalChongqing 400030China Biomedical Translational Research Institute Jinan UniversityGuangzhouGuangdong 510632China Institute of Immunology Christian-Albrechts-University KielKielGermany

The intricacy of diseases,shaped by intrinsic processes like immune system exhaustion and hyperactivation,highlights the potential of immune renormalization as a promising strategy in disease *** recent years,our primary focus has centered onγδT cell-based immunotherapy,particularly pioneering the use of allogeneic Vδ2+γδT cells for treating late-stage solid tumors and tuberculosis ***,we recognize untapped potential and optimization opportunities to fully harnessγδT cell effector functions in *** review aims to thoroughly examineγδT cell immunology and its role in ***,we elucidate functional differences betweenγδT cells and theirαβT cell *** also provide an overview of major milestones inγδT cell research since their discovery in ***,we delve into the intricate biological processes governing their origin,development,fate decisions,and T cell receptor(TCR)rearrangement within the *** examining the mechanisms underlying the anti-tumor functions of distinctγδT cell subtypes based onγδTCR structure or cytokine release,we emphasize the importance of accurate subtyping in understandingγδT cell *** also explore the microenvironment-dependent functions ofγδT cell subsets,particularly in infectious diseases,autoimmune conditions,hematological malignancies,and solid ***,we propose future strategies for utilizing allogeneicγδT cells in tumor *** this comprehensive review,we aim to provide readers with a holistic understanding of the molecular fundamentals and translational research frontiers ofγδT cells,ultimately contributing to further advancements in harnessing the therapeutic potential ofγδT cells.

关键词： γδT immunotherapy diseases

Vitamin C promotes the proliferation and effector functions of human γδ T cells

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Cellular & Molecular Immunology 2020年第5期17卷 462-473页

作者： Léonce Kouakanou Yan Xu Christian Peters Junyi He Yangzhe Wu Zhinan Yin dieter kabelitz Institute of Immunology Christian-Albrechts-University Kiel and University Hospital Schleswig-Holstein Campus KielKielGermany The First Affiliated Hospital Biomedical Translational Research InstituteGuangdong Province Key Laboratory of Molecular Immunology and Antibody EngineeringJinan University510632 GuangzhouChina

γδT cells are of interest as effector cells for cellular immunotherapy due to their HLA-non-restricted lysis of many different tumor cell *** applications include the adoptive transfer of in vitro-expandedγδT ***,it is important to optimize the culture conditions to enable maximal proliferative and functional *** C(L-ascorbic acid)is an essential vitamin with multiple effects on immune *** is a cofactor for several enzymes,has antioxidant activity,and is an epigenetic ***,we investigated the effects of vitamin C(VC)and its more stable derivative,L-ascorbic acid 2-phosphate(pVC),on the proliferation and effector function of humanγδT cells stimulated with zoledronate(ZOL)or synthetic phosphoantigens(pAgs).VC and pVC did not increaseγδT-cell expansion within ZOL-or pAg-stimulated PBMCs,but increased the proliferation of purifiedγδT cells and 14-day-expandedγδT-cell lines in response toγδT-cell-specific *** reduced the apoptosis ofγδT cells during primary *** pVC did not prevent activation-induced death of pAg-restimulatedγδT cells,it enhanced the cell cycle progression and cellular ***,VC and pVC enhanced cytokine production during primary activation,as well as upon pAg restimulation of 14-day-expandedγδT *** and pVC also increased the oxidative respiration and glycolysis ofγδT cells,but stimulus-dependent differences were *** modulatory activity of VC and pVC might help to increase the efficacy ofγδT-cell expansion for adoptive immunotherapy.

关键词： γδT cells Vitamin C lymphocyte activation adoptive T-cell transfer

DNA methylation profile of a hepatosplenic gamma/delta T-cell lymphoma patient associated with response to interferon-α therapy

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Cellular & Molecular Immunology 2021年第5期18卷 1332-1335页

作者： Jaydeep Bhat Anke KBergmann Silvio Waschina Christoph Nerl Christoph Kaleta Reiner Siebert Ole Ammerpohl dieter kabelitz Institute of Immunology Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Metabolic Programming School of Life Sciences WeihenstephanTechnical University Munich(TUM)85354FreisingGermany Institute of Human Genetics Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Institute of Human Genetics Medical School HannoverHannoverGermany Institute of Experimental Medicine Christian-Albrechts-University Kiel&University Hospital Schleswig-HolsteinCampus KielKielGermany Institute of Human Nutrition and Food Science Christian-Albrechts-University KielKielGermany Städtisches Krankenhaus München-Schwabing MunichGermany Institute of Human Genetics Ulm University&Ulm University Medical Center89081UlmGermany

The 2–5%γδT cells in healthy human peripheral blood recognize nonpeptide antigens,in contrast toαβT cells.1 DistinctγδT-cell malignancies have been identified,with hepatosplenic T-cell lymphoma(γδ-HSTL)being a rare but aggressive(median survival 13 months)subset.2γδ-HSTL usually presents with hepatosplenomegaly without lymphadenopathy,anemia,and *** is histologically characterized by the involvement of the hepatic sinusoids,splenic red pulp and bone marrow interstitium,with or without leukemic presentation in peripheral blood.3 A standard treatment regimen is not well established,but therapy mostly includes various chemotherapeutic ***,interferon-α(IFN-α)has been proven to be effective in some patients withγδ-HSTL,but other patients require allogeneic or autologous stem cell transplantation.

关键词： hepato splenic interferon

Towards improving the anti-tumor effcacy of human gamma/delta T cells

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Towards improving the anti-tumor effcacy of human gamma/delt...