The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease
作者机构:Institute of ImmunologyChristian-Albrechts University Kiel and University Hospital Schleswig-Holstein Campus KielKielGermany
出 版 物:《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗(英文))
年 卷 期:2023年第8卷第12期
页 面:5575-5577页
核心收录:
学科分类:0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:Open Access funding enabled and organized by Projekt DEAL
主 题:bowel inflammatory diseases
摘 要:In a recent article published in Science,Dart and colleagues reported that colonic T cells expressing the Vγ4 T-cell receptor(TCR)interact with epithelial butyrophilin-like(BTNL)proteins BTNL3 and BTNL8 in healthy individuals,and they observed a depletion of Vγ4 T cells in inflammatory bowel diseases with renormalization associated with disease remission.1 This paper identifies the BTNL/Vγ4 axis as a new disease modifier in IBD.