The Vγ4/butyrophilin conspiracy: novel role of intraepithelial γδ T cells in chronic inflammatory bowel disease

作     者：Dieter Kabelitz Dieter Kabelitz

作者机构：Institute of ImmunologyChristian-Albrechts University Kiel and University Hospital Schleswig-Holstein Campus KielKielGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2023年第8卷第12期

页      面：5575-5577页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Open Access funding enabled and organized by Projekt DEAL 

主　　题：bowel inflammatory diseases 

摘      要：In a recent article published in Science,Dart and colleagues reported that colonic T cells expressing the Vγ4 T-cell receptor(TCR)interact with epithelial butyrophilin-like(BTNL)proteins BTNL3 and BTNL8 in healthy individuals,and they observed a depletion of Vγ4 T cells in inflammatory bowel diseases with renormalization associated with disease remission.1 This paper identifies the BTNL/Vγ4 axis as a new disease modifier in IBD.