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MXene-Based Elastomer Mimetic StretchableSensors: Design, Properties, and Applications

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Nano-Micro Letters 2024年第7期16卷 295-342页

作者： Poushali Das Parham Khoshbakht Marvi Sayan ganguly Xiaowu(Shirley)Tang Bo Wang Seshasai Srinivasan Amin reza rajabzadeh Andreas rosenkranz School of Biomedical Engineering McMaster University1280 Main Street WestHamiltonON L8S 4L8Canada Department of Chemistry and Waterloo Institute for Nanotechnology(WIN) University of Waterloo200 University Ave WestWaterlooONCanada Centre for Eye and Vision research(CEVr) 17W Hong Kong Science ParkShatinHong KongPeople’s Republic of China Chair of Functional Materials Department of Materials Science and EngineeringSaarland UniversitySaarbruckenGermany W Booth School of Engineering Practice and Technology McMaster University1280 Main Street WestHamiltonON L8S 4L7Canada Department for Chemical Engineering Biotechnology and MaterialsUniversity of ChileSantiagoChile

Flexible sensors based on MXene-polymer composites are highly prospective for next-generation wearable electronics used in human-machine interfaces.One of the motivating factors behind the progress of flexible sensors is the steady arrival of new conductive materials.MXenes,a new family of 2D nanomaterials,have been draw-ing attention since the last decade due to their high electronic conduc-tivity,processability,mechanical robustness and chemical tunability.In this review,we encompass the fabrication of MXene-based polymeric nanocomposites,their structure-property relationship,and applications in the flexible sensor domain.Moreover,our discussion is not only lim-ited to sensor design,their mechanism,and various modes of sensing platform,but also their future perspective and market throughout the world.With our article,we intend to fortify the bond between flexible matrices and MXenes thus promoting the swift advancement of flexible MXene-sensors for wearable technologies.

关键词： Flexible sensor 2D nanomaterials MXene Wearable and conductive Applications

resistance and resilience of soil biological indicators:A case study with multi-walled carbon nanotube

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Pedosphere 2024年第3期34卷 664-675页

作者： Shagufta YASMEEN Nintu MANDAL Anupam DAS Pritam ganguly Sanjay KUMAr rajiv rAKSHIT Department of Soil Science and Agricultural Chemistry Bihar Agricultural UniversitySabourBhagalpur 813210(India) Department of Agronomy Bihar Agricultural UniversitySabourBhagalpur 813210(India)

Soil ecosystem is experiencing stresses due to climate change,and soil inhabitants try to demonstrate their inherent resistance and resilience against those stresses.Application of nanomaterials as agricultural inputs could bring shifts in resistance and resilience patterns of soil microbes and associated enzymes,especially under short-term heat stress.With this background,the impacts of multi-walled carbon nanotube(MWCNT)on the resistance and resilience of soil biological indicators were evaluated.An incubation experiment was conducted with varied MWCNT concentrations(0,50,100,250,and 500 mg kg-1soil)for 90 d after 24-h heat stress at 48±2?C to assess the impacts of MWCNT on soil enzyme activities and microbial populations vis-à-vis their resistance and resilience indices under short-term exposure to heat stress.Enzyme activities were reduced after exposure to heat stress.resistance indices of enzyme activities were enhanced by MWCNT application on day 1 after heat stress,whereas there was no recovery of enzyme activities after 90-d incubation.Like soil enzyme activities,resistance index values of soil microbial populations followed the similar trend and were improved by MWCNT application.Multi-walled carbon nanotube has the potential to improve resistance indices of soil enzyme activities and microbial populations under heat stress,although they could not recover to their original state during periodical incubation after heat stress.This study helps to understand the relative changes of biological indicators under MWCNT and their ability to withstand heat stress.

关键词： enzyme activity heat stress microbial population nanomaterial recovery

Monolithic metal-based/porous carbon nanocomposites made from dissolved cellulose for use in electrochemical capacitor

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Green Carbon 2024年第1期2卷 109-117页

作者： Madhav P.Chavhan Arjeta Kryeziu Somenath ganguly Julien Parmentier University of Ostrava Faculty of Science30.dubna 22Ostrava 70103Czech Republic Universitéde Strasbourg Universitéde Haute-AlsaceInstitut de Science des Matériaux de Mulhouse(IS2M)UMR 7361 CNRS-UHA15 rue Jean StarckyBP 248868057 Mulhouse CedexFrance Indian Institute of Technology Kharagpur Department of Chemical EngineeringKharagpurIndia

Porous metal-based carbon nanocomposites,with a monolithic shape,were prepared by a one-pot synthesis from dissolved cellulose and metallic salts using a simple,cheap,and environmentally friendly route.Their potential performances as electrochemical capacitors were tested with three metal precursors(M=Cu,Mn,and Fe)with two loadings and in an asymmetric cell for the Fe-based carbon material.Interestingly,here soluble metal precursors were not deposited on a hard cellulose template but mixed in a precooled concentrated NaOH solution where cellulose was previously dissolved,allowing for a good dispersion of the metallic species.After a freezing step where concomitant cellulose regeneration and pore ice-templating phenomena took place,followed by a carbonization step,the mixture led to a porous carbon monolith embedding well-dispersed metal-based nanoparticles having a diameter below 20 nm and present as metallic,oxide,or carbide phase(s)according to the element M.These materials were characterized by different physicochemical techniques and electrochemical tests.Their performances as supercapacitors are discussed in light of the specific behaviour of the metal-based phase and its influence on the carbon matrix properties such as mesopore formation and carbon graphitization.An asymmetric energy storage cell assembled with a Fe-based carbon electrode against a carbon xerogel electrode derived from a phenolic resin shows specific energy and power of 18.3 Wh kg^(−1)at 5 mA cm^(−2)and 1.6 kW kg^(−1)at 25 mA cm^(−2),respectively.

关键词： Cellulose Metal-based carbon nanocomposite Nanoparticles Monolith Supercapacitor

role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders:A review

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World Journal of Gastroenterology 2022年第26期28卷 3047-3062页

作者： risha ganguly Ashutosh Gupta Abhay K Pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002Uttar PradeshIndia

Baicalin is a natural bioactive compound derived from Scutellaria baicalensis,which is extensively used in traditional Chinese medicine.A literature survey demonstrated the broad spectrum of health benefits of baicalin such as antioxidant,anticancer,anti-inflammatory,antimicrobial,cardio-protective,hepatoprotective,renal protective,and neuroprotective properties.Baicalin is hydrolyzed to its metabolite baicalein by the action of gut microbiota,which is further reconverted to baicalin via phase 2 metabolism in the liver.Many studies have suggested that baicalin exhibits therapeutic potential against several types of hepatic disorders including hepatic fibrosis,xenobiotic-induced liver injury,fatty liver disease,viral hepatitis,cholestasis,ulcerative colitis,hepatocellular and colorectal cancer.During in vitro and in vivo examinations,it has been observed that baicalin showed a protective role against liver and gut-associated abnormalities by modifying several signaling pathways such as nuclear factor-kappa B,transforming growth factor beta 1/SMAD3,sirtuin 1,p38/mitogen-activated protein kinase/Janus kinase,and calcium/calmodulin-dependent protein kinase kinaseβ/adenosine monophosphate-activated protein kinase/acetyl-coenzyme A carboxylase pathways.Furthermore,baicalin also regulates the expression of fibrotic genes such as smooth muscle actin,connective tissue growth factor,β-catenin,and inflammatory cytokines such as interferon gamma,interleukin-6(IL-6),tumor necrosis factor-alpha,and IL-1β,and attenuates the production of apoptotic proteins such as caspase-3,caspase-9 and B-cell lymphoma 2.However,due to its low solubility and poor bioavailability,widespread therapeutic applications of baicalin still remain a challenge.This review summarized the hepatic and gastrointestinal protective attributes of baicalin with an emphasis on the molecular mechanisms that regulate the interaction of baicalin with the gut microbiota.

关键词： Baicalin Biotransformation Gut microbiota Hepatobiliary and gastrointestinal disorders Signaling pathways

Baicalin provides protection against fluoxetine-induced hepatotoxicity by modulation of oxidative stress and inflammation

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World Journal of Hepatology 2022年第4期14卷 729-743页

作者： risha ganguly ramesh Kumar Abhay K Pandey Department of Biochemistry University of AllahabadPrayagraj 211002India

BACKGrOUND Fluoxetine is one of the most widely prescribed anti-depressant drugs belonging to the category of selective serotonin reuptake inhibitors.Long-term fluoxetine treatment results in hepatotoxicity.Baicalin,a natural compound obtained from the Chinese herb Scutellaria baicalensis is known to have antioxidant,hepatoprotective and anti-inflammatory effects.However,the beneficial effects of baicalin against fluoxetine-induced hepatic damage have not previously been reported.AIM To evaluate the protective action of baicalin in fluoxetine-induced liver toxicity and inflammation.METHODS Male albino Wistar rats were divided into seven groups.Group 1 was the normal control.Oral fluoxetine was administered at 10 mg/kg body weight to groups 2,3,4 and 5.In addition,groups 3 and 4 were also co-administered oral baicalin(50 mg/kg and 100 mg/kg,respectively)while group 5 received silymarin(100 mg/kg),a standard hepatoprotective compound for comparison.Groups 6 and 7 were used as a positive control for baicalin(100 mg/kg)and silymarin(100 mg/kg),respectively.All treatments were carried out for 28 d.After sacrifice of the rats,biomarkers of oxidative stress[superoxide dismutase(SOD),catalase(CAT),reduced glutathione(GSH),glutathione-S-transferase(GST),advanced oxidation protein products(AOPP),malondialdehyde(MDA)],and liver injury[alanine transaminase(ALT),aspartate transaminase(AST),alkaline phosphatase(ALP),total protein,albumin,bilirubin]were studied in serum and tissue using standard protocols and diagnostic kits.Inflammatory markers[tumor necrosis factor(TNF-α),interleukin(IL)-6,IL-10 and interferon(IFN)-γ]in serum were evaluated using ELISA-based kits.The effect of baicalin on liver was also analyzed by histopathological examination of tissue sections.rESULTS Fluoxetine-treated rats showed elevated levels of the serum liver function markers(total bilirubin,ALT,AST,and ALP)and inflammatory markers(TNF-α,IL-6,IL-10 and IFN-γ),with a decline in total protein and albumin levels.Biochemical markers of oxidative stress

关键词： Fluoxetine Hepatotoxicity Oxidative stress Baicalin Anti-inflammatory Hepatoprotective and antioxidant

CrysXPP:An explainable property predictor for crystalline materials

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npj Computational Materials 2022年第1期8卷 424-434页

作者： Kishalay Das Bidisha Samanta Pawan Goyal Seung-Cheol Lee Satadeep Bhattacharjee Niloy ganguly Indian Institute of Technology Kharagpur KharagpurIndia Indo Korea Science and Technology Center BangaloreIndia Leibniz University of Hannover HannoverGermany

We present a deep-learning framework,CrysXPP,to allow rapid and accurate prediction of electronic,magnetic,and elastic properties of a wide range of materials.CrysXPP lowers the need for large property tagged datasets by intelligently designing an autoencoder,CrysAE.The important structural and chemical properties captured by CrysAE from a large amount of available crystal graphs data helped in achieving low prediction errors.Moreover,we design a feature selector that helps to interpret the model’s prediction.Most notably,when given a small amount of experimental data,CrysXPP is consistently able to outperform conventional DFT.A detailed ablation study establishes the importance of different design steps.We release the large pre-trained model CrysAE.We believe by fine-tuning the model with a small amount of property-tagged data,researchers can achieve superior performance on various applications with a restricted data source.

关键词： materials. property crystalline

Targeting PD-1/PD-L1 in cancer immunotherapy:An effective strategy for treatment of triple-negative breast cancer(TNBC)patients

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Genes & Diseases 2023年第4期10卷 1318-1350页

作者： Sunny Kumar Mouli Chatterjee Pratyasha Ghosh Kirat K.ganguly Malini Basu Mrinal K.Ghosh Cancer Biology and Inflammatory Disorder Division Council of Scientific and Industrial Research-Indian Institute of Chemical Biology(CSIR-IICB)TRUE CampusCN-6SectoreVSalt LakeKolkata 700091JadavpurKolkataPIN 700032India Department of Economics Bethune CollegeUniversity of CalcuttaKolkataPIN 700006India Department of Microbiology Michael Madhusudan Memorial CollegeDurgapurPIN 713216India Department of Microbiology Dhruba Chand Halder CollegeUniversity of CalcuttaKolkataPIN 743372India

Maintaining the balance between eliciting immune responses against foreign pro-teins and tolerating self-proteins is crucial for maintenance of homeostasis.The functions of programmed death protein 1(PD-1)and its ligand programmed death ligand 1(PD-L1)are to inhibit immune responses so that over-reacting immune cells does not cause any damage to its own body cells.However,cancer cells hijack this mechanism to attenuate immune cells functions and create an immunosuppressive environment that fuel their continuous growth and proliferation.Over the past few years’rapid development in cancer immunotherapy has opened a new avenue in cancer treatment.Blockade of PD-1 and PD-L1 has become a potential strategy that rescue the functions of immune cells to fight against cancer with high efficacy.Initially,immune checkpoint monotherapies were not very successful,making breast cancer less immunogenic.Although,recent reports support the presence of tumor infiltrating lympho-cytes(TILs)in breast cancer that make it favorable for PD-1/PD-L1 mediated immunotherapy,which is effective in PD-L1 positive patients.recently,anti-PD-1(pembrolizumab)and anti-PD-L1(atezolizumab)gets FDA approval for breast cancer treatment and make PD-1/PD-L1 immunotherapy is meaningful for further research.Likewise,this article gathered understand-ing of PD-1 and PD-L1 in recent years,their signaling networks,interaction with other mole-cules,regulations of their expressions and functions in both normal and tumor tissue microenvironments are crucial to find and design therapeutic agents that block this pathway and improve the treatment efficacy.Additionally,authors collected and highlighted most of the important clinical trial reports on monotherapy and combination therapy.

关键词： Breast cancer Cancer Clinical trial Immunotherapy PD-1/PD-L1 TNBC

Modulatory effect of caffeic acid in alleviating diabetes and associated complications

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World Journal of Diabetes 2023年第2期14卷 62-75页

作者： risha ganguly Shiv Vardan Singh Kritika Jaiswal ramesh Kumar Abhay K Pandey Department of Biochemistry University of AllahabadAllahabad(Prayagraj)211002India

Diabetes mellitus(DM)is one of the most common metabolic disorders characterized by elevated blood glucose levels.Prolonged uncontrolled hyperglycemia often leads to multi-organ damage including diabetic neuropathy,nephropathy,retinopathy,cardiovascular disorders,and diabetic foot ulcers.Excess production of free radicals causing oxidative stress in tissues is often considered to be the primary cause of onset and progression of DM and associated complications.Natural polyphenols can be used to induce or inhibit the expression of antioxidant enzymes such as glutathione peroxidase,heme oxygenase-1,superoxide dismutase,and catalase that are essential in maintaining redox balance,and ameliorate oxidative stress.Caffeic acid(CA)is a polyphenolderived from hydroxycinnamic acid and possesses numerous physiological properties including antioxidant,anti-inflammatory,anti-atherosclerotic,immune-stimulatory,cardioprotective,antiproliferative,and hepatoprotective activities.CA acts as a regulatory compound affecting numerous biochemical pathways and multiple targets.These include various transcription factors such as nuclear factor-B,tumor necrosis factor-α,interleukin-6,cyclooxygenase-2,and nuclear factor erythroid 2-related factor 2.Therefore,this review summarizes the pharmacological properties,molecular mechanisms,and pharmacokinetic profile of CA in mitigating the adverse effects of DM and associated complications.The bioavailability,drug delivery,and clinical trials of CA have also been discussed.

关键词： Diabetes mellitus Caffeic acid Diabetic foot ulcer retinopathy Nephropathy

Influence of ionic radius of rare-earths on the structural and electrical properties of Ba_5rTi_3Nb_7O_(30)(r=rare-earth) ferroelectric ceramics

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Journal of rare Earths 2015年第12期33卷 1310-1315页

作者： Prasun ganguly Department of Physics National Defence Academy

In the present report, BasrTi3Nb7030 （r=La, Nd, Sm, Eu, Dy） compounds were synthesized by solid-state reaction method in order to know the effect of ionic radius of rare-earths on their structural, dielectric, ferroelectric, pyroelectric, piezoelectric and con- ductive properties. X-ray diffraction analysis revealed the formation of the compounds having orthorhombic structure. Scanning elec- tron micrographs showed the formation of fine granular microstructure in all the compounds with a decrease in the average grain size with increasing ionic radius of the substituted rare-earths. Detailed dielectric studies showed that the dielectric constant （er） increased while Curie temperature （To） decreased as the ionic radius of the rare-earths increased. With the decrease in the ionic radius of the rare-earths, remanent polarization （2Pr）, piezoelectric （d33） and pyroelectric coefficients were observed to increase in BasrTi3Nb7030 compounds. The temperature variation of dc conductivity suggested that the compounds had negative temperature coefficient of re- sistance （NTCr） behaviour.

关键词： ceramics ferroelectrics solid-state reaction dielectric response piezoelectricity rare earths