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Neuroscience & Medicine 2024年第1期15卷 66-75页

作者： Jimmy Zúñiga-Márquez Lina Borda-Camargo diego buitrago-mora Lorely Guerra-Valdés Laura González Patricia Quintero-Cusgüen Nataly Gutierrez-Ávila Hospital Universitario de la Samaritana Bogotá Colombia Neuropsychological Assessment and Diagnosis Graduate Program School of Psychology Universidad San Buenaventura Bogotá Bogotá Colombia

Stroke is a physiological alteration associated with changes in blood flow that can result in sudden-onset cognitive impairment. It has a heterogenous clinical presentation with varying degrees of severity correlated with specific central nervous system zones or areas, and its prognosis is uncertain. This case study describes a 62-year-old male patient with acquired brain damage of the anterior cingulate cortex as a result of an ischemic event in the territory of the left anterior cerebral artery. Cognitive function was assessed using the neuropsychological executive function and frontal lobe test battery (BANFE-2) as well as other neuropsychological tests. The results show a profile of higher mental functions characterized by the presence of dysexecutive syndrome with marked behavioral alteration and diencephalic amnesia. .

关键词： Ischemic Stroke Anterior Cingulate Cortex Neuropsychology Acquired Brain Damage

In Silico Pipeline to Identify Tumor‑Specific Antigens for Cancer Immunotherapy Using Exome Sequencing Data

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Phenomics 2023年第2期3卷 130-137页

作者： diego morazán‑Fernández Javier mora Jose Arturo Molina‑mora Caja Costarricense de Seguro Social San José10104Costa Rica Centro de Investigación de Enfermedades Tropicales Centro de Investigación en Cirugía y Cáncerand Facultad de MicrobiologíaUniversidad de Costa RicaSan José2060Costa Rica

Tumor-specific antigens or neoantigens are peptides that are expressed only in cancer cells and not in healthy *** of these molecules can induce an immune response,and therefore,their use in immunotherapeutic strategies based on cancer vaccines has been extensively *** based on these approaches have been triggered by the current high-throughput DNA sequencing ***,there is no universal nor straightforward bioinformatic protocol to discover neoan-tigens using DNA sequencing ***,we propose a bioinformatic protocol to detect tumor-specific antigens associated with single nucleotide variants(SNVs)or“mutations”in tumoral *** this purpose,we used publicly available data to build our model,including exome sequencing data from colorectal cancer and healthy cells obtained from a single case,as well as frequent human leukocyte antigen(HLA)class I alleles in a specific *** data from Costa Rican Central Valley population was selected as an *** strategy included three main steps:(1)pre-processing of sequencing data;(2)variant calling analysis to detect tumor-specific SNVs in comparison with healthy tissue;and(3)prediction and characterization of peptides(protein fragments,the tumor-specific antigens)derived from the variants,in the context of their affinity with frequent alleles of the selected *** our model data,we found 28 non-silent SNVs,present in 17 genes in chromosome *** protocol yielded 23 strong binders peptides derived from the SNVs for frequent HLA class I alleles for the Costa Rican *** the analyses were performed as an example to implement the pipeline,to our knowledge,this is the first study of an in silico cancer vaccine using DNA sequencing data in the context of the HLA *** is concluded that the standardized protocol was not only able to identify neoantigens in a specific but also provides a complete pipeline for the eventual design of cancer vaccines using

关键词： Neopeptide Colorectal cancer Cancer vaccine Neoantigens Human leukocyte antigen Costa Rica

Development of Aircraft Maintenance Glossaries in Higher Education:Exploring Methodological Paths to Corpus-Driven Analysis of Key Keywords

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中国科技术语 2025年第1期27卷 83-93页

作者： Malila PRADO Daniela TERENZI diego BRITO BNU-HKBU United International College Zhuhai 519087 Federal Institute of Education Science and Technology of São PauloSão Carlos 13.565-820

This paper presents a project aimed at developing a trilingual visual dictionary for aircraft maintenance professionals and *** project addresses the growing demand for accurate communication and technical terminology in the aviation industry,particularly in Brazil and *** study employs a corpus-driven approach,analyzing a large corpus of aircraft maintenance manuals to extract key technical terms and their *** specialized subcorpora and a comparative analysis,this paper demonstrates challenges and solutions into the identification of high-frequency keywords and explores their contextual use in aviation documentation,emphasizing the need for clear and accurate technical *** incorporating these findings into a trilingual visual dictionary,the project aims to enhance the understanding and usage of aviation terminology.

关键词： aircraft maintenance corpus keyword extraction

A spatial framework for detecting anthropogenic impacts on predator-prey interactions that sustain ecological integrity in Mexico

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Ecological Processes 2018年第1期7卷 408-424页

作者： Franz mora Coordinación del Sistema de Información Espacial para el Soporte de Decisiones sobre Impactos a la Biodiversidad.Comisión Nacional para el Conocimiento y Uso de la Biodiversidad(CONABIO) Liga Periférico-Insurgentes SurNúm.4903Col.Parques del Pedregal14010 Delegación TlalpanMexico

Background:This paper presents several spatial indicators developed to evaluate anthropogenic impacts on predator-prey interactions and their relationship with ecological integrity loss in *** integrity loss is defined as the inability to sustain viable populations,habitat functions,and species interactions of Nearctic and Neotropical apex predators as a result of anthropogenic *** direct impacts,the indicators evaluate habitat loss and the number of inhospitable *** indirect impacts,the indicators evaluate the avoidance of human features such as highways,roads,and human *** total impact level is described at 1 km^(2) resolution,and registered within the domain defined by the spatial habitat requirements of apex *** impact level is associated with ecological integrity loss,or the ecosystem capacity to reorganize habitat functions and sustain predator-prey interactions as the most visible elements of ecological *** integrity loss is evaluated for different groups of apex predators that are classified with different levels of anthropogenic ***:The framework presented here identifies the spatial information needed for the assessment of cumulative anthropogenic *** characterizing their distribution range,Nearctic predators have significantly larger intact habitats than neotropical predators but with higher ecological degradation,less landscape transformation,and overall less ecological *** observed within their distribution areas,indirect impacts have a generalized effect in the broad range of landscapes in *** integrity loss is the result of road,highway,and human settlement avoidance;but landscape transformation and human activity control the threshold for which ecological integrity loss becomes *** the other hand,there are no significant differences in impact levels among threat conservation categories for apex predators,which indicate that all predator

关键词： Anthropogenic impacts Ecological integrity Spatial indicators Apex predators Impact assessment

Multifocal G1-G2 gastric neuroendocrine tumors:Differentiating between Type Ⅰ, Ⅱ and Ⅲ, a clinicopathologic review

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World Journal of Clinical Cases 2019年第17期7卷 2413-2419页

作者： Khaled Algashaamy Monica Garcia-buitrago Department of Pathology and Laboratory Medicine Jackson Memorial Hospital University of Miami Miller School of Medicine

Gastric neuroendocrine tumors (gNETs) are a rare entity that is increasing in *** pathophysiological processes can lead to the development of these tumors,appropriate histological analysis is necessary to differentiate between grade 1 (G1) and grade 2 (G2) tumors as this will impact the management of these patients based on their increased risk of lymph node and distant *** provide a comprehensive clinicopathologic review of multifocal gastric neuroendocrine tumors,with particular emphasis on G1 and G2 tumors and differentiating between types I,II and II and risk stratification based upon immunohistochemical *** review is based on peer-reviewed literature and the authors’ *** are a heterogenous group of tumors that is rising in *** lesions while arise from the same cell type,they have different *** the type of gNETs is a collective effort of clinical and pathologic *** correct grading and staging of these lesions are of paramount significance,due its impact on patient management and prognosis.

关键词： Gastric neuroendocrine tumors Enterochromaffin like cells Histopathological features Immunohistochemistry Diagnosis Treatment

Calibration of discrete element modeling: Scaling laws and dimensionless analysis

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Particuology 2022年第3期20卷 55-62页

作者： Yucang Wang Peter mora Yunpei Liang State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400044China College of Petroleum Engineering and Geosciences King Fahd University of Petroleum and MineralsSaudi Arabia

In this paper,dynamic similarity conditions are derived for discrete element simulations by non-dimensionalising the governing *** conditions must be satisfied so that the numerical model is a good representation of the physical *** a pure mechanical system,if three independent ratios of the corresponding quantities between the two models are set,then the ratios of other quantities must be chosen according to the similarity *** scalability of linear and non-linear contact laws is also *** tests of 3D uni-axial compression are carried out to verify the theoretical *** example is presented to show how to calibrate the model according to laboratory data and similarity ***,it is impossible to reduce computer time by scaling up or down certain parameters and continue to uphold the similarity *** results in this paper provide guidelines to assist discrete element modelers in setting up the model parameters in a physically meaningful way.

关键词： Discrete element method Dimensionless analysis Dynamic similarity Parameter calibration ESyS_Particle

A two-stage approach for managing actuators redundancy and its application to fault tolerant flight control

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Chinese Journal of Aeronautics 2015年第2期28卷 469-477页

作者： Zhong Lunlong Félix mora-Camino Tianjin Key Laboratory for Advanced Signal and Image Processing Civil Aviation University of China Automation Research Group of MAIAA ENAC Toulouse University

In safety-critical systems such as transportation aircraft, redundancy of actuators is introduced to improve fault tolerance. How to make the best use of remaining actuators to allow the system to continue achieving a desired operation in the presence of some actuators failures is the main subject of this paper. Considering that many dynamical systems, including flight dynamics of a transportation aircraft, can be expressed as an input affine nonlinear system, a new state repre- sentation is adopted here where the output dynamics are related with virtual inputs associated with the intended operation. This representation, as well as the distribution matrix associated with the effectiveness of the remaining operational actuators, allows us to define different levels of fault tol- erant governability with respect to actuators＇ failures. Then, a two-stage control approach is devel- oped, leading frst to the inversion of the output dynamics to get nominal values for the virtual inputs and then to the solution of a linear quadratic （LQ） problem to compute the solicitation of each operational actuator. The proposed approach is applied to the control of a transportation air- craft which performs a stabilized roll maneuver while a partial failure appears. Two fault scenarios are considered and the resulting performance of the proposed approach is displayed and discussed.

关键词： Actuator allocation Fault tolerant control Flight control Linear quadratic (LQ)problem Nonlinear control

Effect of Heat Loss on Laminar Flamelet Species Concentration

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Journal of Thermal Science 2016年第5期25卷 418-423页

作者： Marco Boccanera diego Lentini Dipartimento di Ingegneria Meccanica e Aerospaziale Sapienza Università di Roma

The effects of heat loss on the structure of laminar flamelets,which are the constitutive elements of turbulent flames under the most common operating conditions,are investigated for typical aeronautical gas-turbine operating conditions at *** magnitude of heat loss is quantified via the "enthalpy defect" measured with respect to an adiabatic flame.A procedure to generate laminar flamelets with an assigned enthalpy defect at the boundaries is devised and applied to nonpremixed propane/air flames,as propane reproduces the essential features of higher hydrocarbon *** is found,contrary to commonly held beliefs,that the enthalpy defect has a significant effect on the concentration not only of minor species,but also of main reaction *** effects are found in general to be more pronounced for fuel-rich *** impact is anticipated on the formation rate of nitric *** effects of scalar dissipation rate are also discussed.

关键词： Turbulent Combustion Heat Transfer Laminar Flamelets Hydrocarbon Combustion Aeroengines Gas Turbines

Nerve growth factor catches copper in neuronal inning

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Neural Regeneration Research 2020年第4期15卷 665-666页

作者： diego La Mendola Department of Pharmacy University of Pisa

The physiological effect of neurotrophic factors and their role in Alzheimer’s disease(AD):Neurotrophins(NTs)are a family of homologues proteins that play an essential role in neuronal cells growth,survival and *** proteins include the nerve growth factor(NGF),the brain derived neurotrophic factor(BDNF),NT-3 and NT-3,also known as NT-4/5.

关键词： Alzheimer copper differentiation.

Two methodological approaches to assess the seismic vulnerability of masonry bridges

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Journal of Traffic and Transportation Engineering(English Edition) 2019年第1期6卷 49-64页

作者： diego Maria Barbieri Department of Civil and Environmental Engineering Norwegian University of Science and Technology Department of Civil Constructional and Environmental Engineering Sapienza University of Rome

This work describes the seismic vulnerability assessment of a railway masonry arch *** conservation state is initially investigated by means of a thorough field and laboratory test campaign, comprising destructive and non-destructive tests. Two different methods are used to evaluate the bridge seismic vulnerability. The first method adopts a deterministic approach and corresponds to a single non-linear static analysis, performed as described in the Eurocodes. The second method employs a probabilistic approach and considers the variability of the involved mechanical parameters(structure geometry and properties of the building materials) and seismic parameters(intensity of the action and site conditions). This method associates the probabilistic values of ground acceleration exceedance to the estimated seismic vulnerability. This is shown by means of fragility curves, which allow to take into consideration the uncertainty of the various components involved in the definition of the seismic vulnerability and display the seismic damage scenarios. Currently no code requires to perform this calculation procedure. In addition,this work compares the values of masonry mechanical properties specified in the Eurocodes with those obtained in an extensive investigation campaign involving more than one hundred masonry bridges. Compressive strength and longitudinal elasticity modulus are the relevant mechanical parameters investigated. The outcomes of this research can contribute to the development of a more efficient maintenance system of the masonry bridges belonging to the railway network. This has an important role when it comes to establishing the priority order of assets intervention.

关键词： Railway masonry arch bridge Bridge maintenance and conservation Masonry mechanical parameters Non-linear static analysis Seismic fragility Finite element analysis