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柔性神经探针：当前的优点、缺点及未来需求（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期 153-168页

作者： Sara PIMENTA Jo?o R.freitas José H.CORREIA CMEMSUMinho 米尼奥大学 LABBELS联合实验室

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流... 详细信息

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流体相互作用）的研发不断增加，产生了更高时空分辨率的设备。增加神经探针的适用性以及集成元素，促进了柔性接口的需求，减少了探针植入期间对神经组织的损伤，并提高了神经采集数据的质量。本文综述了几种柔性神经探针的制备、表征和验证，探讨了这些器件的主要优缺点。最后，对其今后的发展及应用作了展望。总体而言，本综述旨在介绍目前可用的柔性神经探针设备及其未来可能的发展途径，为未来设备设计提供指导。

关键词：脑神经柔性接口多功能探针

Antimicrobial Activity, Structural, Crystallographic and Thermal Characteristics of Alpha-Titanium Phosphate Promoted by Silver Ions

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Materials Sciences and Applications 2024年第8期15卷 253-269页

作者： Enzo Erbisti Garcia Agnes Maria Cupertino Fernandes Araujo Gerson Alberto Valencia Albitres Daniela de França da Silva freitas Danielle Mattos Mariano Carlos Magno Fialho Soares Sibele Piedade Cestari Marco Antônio Lemos Miguel Luis Claudio Mendes Institute of Macromolecules Professora Eloisa Mano Federal University of Rio de Janeiro Avenida Horacio Macedo 2030 Centro de Tecnologia Bloco J Ilha do Fundo Rio de Janeiro Brazil Institute of Microbiology Paulo de Ges Federal University of Rio de Janeiro Centro de Ciencias da Saude Bloco I Ilha do Fundo Rio de Janeiro Brazil Innovation in Polymer Engineering (PIEP) University of Minho Guimares Portugal

The recent global spread of the pandemic underscores the necessity of seeking new materials effective against microorganisms. Nanotechnology offers avenues for developing multifunctional materials. In this study, alpha-titanium phosphate (α-TiP) nanoparticles were synthesized and treated with silver salt to enhance their antimicrobial properties. The physicochemical characteristics and antimicrobial activity were evaluated. It was revealed by X-ray diffraction analysis that the structural integrity of α-TiP was influenced by ethylenediamine and silver ions. Distinct degradation profiles for each chemical modification were shown by thermogravimetric analysis. Infrared spectroscopy detected shifts and new absorption peaks in the spectra depending on the type of modification. Energy dispersive spectroscopy confirmed the disaggregation of α-TiP galleries following the addition of silver salt, which increased their effectiveness against microorganisms. Notably, only the sample treated with silver ions exhibited antimicrobial action. Antimicrobial activity was tested against the bacteria of medical importance Escherichia coli, Salmonella Enteritidis, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Listeria momocytogenes and the yeast Candida albicans. All microorganisms were inhibited by sample containing silver. Minor inhibition was observed against the Gram-positive bacteria L. monocytogenes and Bacillus cereus, while the greatest inhibition occurred against the fungus (yeast) C. albicans. The results revealed a potential application of the nanoparticles for control of microorganisms in public health.

关键词： Titanium Phosphate Silver Nitrate Antimicrobial Action

Gravitational waves from compact objects

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Research in Astronomy and Astrophysics 2010年第11期10卷 1071-1099页

作者： José Antonio de freitas Pacheco University of Nice-Sophia Antipolis Observatoire de la Cote d'Azur Laboratoire Cassiopée-UMR 6202 BP 4229-F606304-Nice Cedex 4-France

Large ground-based laser beam interferometers are presently in operation both in the USA （LIGO） and in Europe （VIRGO） and potential sources that might be detected by these instruments are revisited. The present generation of detectors does not have a sensitivity high enough to probe a significant volume of the universe and, consequently, predicted event rates are very low. The planned advanced generation of interferometers will probably be able to detect, for the first time, a gravitational sig- nal. Advanced LIGO and EGO instruments are expected to detect few （some）： binary coalescences consisting of either two neutron stars, two black holes or a neutron star and a black hole. In space, the sensitivity of the planned LISA spacecraft constellation will allow the detection of the gravitational signals, even within a ＂pessimistic＂ range of possible signals, produced during the capture of compact objects by supermassive black holes, at a rate of a few tens per year.

关键词： gravitational waves -- neutron stars -- black holes

Arbuscular mycorrhizal fungal community assembly in the Brazilian tropical seasonal dry forest

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Ecological Processes 2017年第1期6卷 9-18页

作者： Tancredo Augusto Feitosa de Souza Helena freitas Centre for Functional Ecology Department of Life SciencesUniversity of Coimbra3000-456 CoimbraPortugal

Introduction:Here,we compare the arbuscular mycorrhizal fungal(AMF)community composition in soils from the root zone of the exotic invasive species Prosopis juliflora(EXO soils)and soils from the root zone of the native species Mimosa tenuiflora(NAT soils)from five locations in the Brazilian tropical seasonal dry forest,Paraíba,Brazil,using morphological ***:AMF community composition in EXO and NAT soils were *** phosphorus,diversity index,spore abundance,and species richness were the main factors differing between the EXO and NAT *** general,the most dominant order present in the soils were Glomerales(44.8%)and Gigasporales(41.4%).The most abundant AMF genus in all studied soils was ***:Differences in AMF community composition were associated with(1)differences in the dominant plant species(*** ***)and(2)changes in soil chemical factors(soil,pH,total organic carbon,total nitrogen,and available P)in EXO *** results contribute to a deeper view of the AMF communities in exotic soils and open new perspectives for ecological processes involving AMF species and exotic plant species in the Brazilian tropical seasonal dry forest.

关键词： Glomeromycota AMF community AMF diversity Native plant species Exotic plant species Caatinga

Biosurfactant Production by Pseudomonas aeruginosa and Yarrowia lipolytica and Its Use for detergent Formulations

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Journal of Chemistry and Chemical Engineering 2013年第8期7卷 767-773页

作者： Silvanito Alves barbosa diego de freitas Coelho Edgar Silveira Elias Basile Tambourgi Roberto Rodrigues de Souza departamento de Engenharia Quimica Universidade Federal e Sergipe S6o Crist6v~o 49100-000 Brazil departamento de Engenharia de Sistemas Qulmicos e Informftica Universidade Estadual de Campinas Campinas 13083-852Brazil Instituto de Gendtica e Bioquimica Universidade Federal de Uberldndia Uberldndia 38700-128 Brazil

This work reports detergents production using biological surfactants, microbiologically synthesized, and compares its foaming power and emulsification capacity to those presented by a petroleum based surfactant. Both used microorganisms were capable to produce surfactants, been able to emulsify oil/water mixtures and cause decrease of surface tension of water. The biosurfactant produced from Yarrowia lipolytica has a critical micelle concentration lower than that obtained from Pseudomonas aeruginosa （10 and 30 mg·Lt, respectively）, but the later showed better results in foaming power and emulsification experiments, similar to the synthetic detergent.

关键词： Biodetergent biosurfactant Pseudomonas aeruginosa Yarrowia lipolytica.

Melting behavior and globular microstructure formation in semi-solid CoCrCuxFeNi high-entropy alloys

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Journal of Materials Science & Technology 2020年第17期52卷 207-217页

作者： Kaio Niitsu Campo Caio Chaussêde freitas Leonardo Fanton Rubens Caram University of Campinas School of Mechanical EngineeringSPBrazil

High-entropy alloys can be compelling raw materials for semi-solid *** the present study,the influence of the Cu content on the melting behavior and semi-solid microstructure of CoCrCuxFeNi(x=0,1,2,3)alloys was ***-melted samples were cross-rolled at room temperature and then isothermally treated at 1175℃in the semi-solid state for 300 *** characterization showed that the alloys containing Cu were formed by two fcc ***,the increase in Cu content also led to an increase in the volumetric fraction of the Cu-rich *** solidification,this phase,which is the last to form,nucleates and epitaxially grows on the Cu-lean *** the studied CoCrCuFeNi alloys exhibited the same melting *** Cu-rich phase melts at approximately 1120℃,whereas the Culean phase melts at approximately 1350℃,providing a suitable processing temperature range of more than 200℃.The semi-solid microstructures were considerably refined and globular regardless of the alloy composition,being suitable for semi-solid ***,each fcc phase exhibited roughly the same composition under the different processing *** Cu content in the Cu-lean phase was approximately 10 at.%,while Co,Cr,Fe,and Ni were in an approximately equiatomic ***,the Cu content was between 80 at.%and 86 at.%in the Cu-rich *** isothermal treatment of the CoCrCu3FeNi alloy at a higher temperature(1300℃)only caused the globules to *** conclusion,this work showed that these alloys can be potential candidates for semi-solid processing.

关键词： Semi-solid processing Thixoforming High-entropy alloys Microstructure

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机器人加速入侵肉类加工业

商业周刊（中文版） 2024年第7期 10-12页

作者： Gerson freitas Jr. Isis Almeida 永年(译) 不详

机器学习和人工智能意味着精通高精度工作的不再只有人类了。在美国大平原上,遥控机器人在为农业巨头嘉吉公司(Cargill)放牛。在美国各地的肉类加工厂里,机器人在准备货物、堆放托盘。在家禽业巨头韦恩-桑德森农场(Wayne-Sanderson Farm... 详细信息

机器学习和人工智能意味着精通高精度工作的不再只有人类了。在美国大平原上,遥控机器人在为农业巨头嘉吉公司(Cargill)放牛。在美国各地的肉类加工厂里,机器人在准备货物、堆放托盘。在家禽业巨头韦恩-桑德森农场(Wayne-Sanderson Farms),一套机器设备在雏鸡出生时给它们接种疫苗,几周后则有另套机器将它们开肠破肚,取出内脏。乍一看,在这个世界上劳动密集程度最高的行业之一,美国肉类加工商似乎已经成功地从人工转向了机器。

关键词：肉类加工业肉类加工厂遥控机器人机器设备机器学习劳动密集家禽业人工智能

Responses of Rice Mini-Core Collection Accessions to Damage by Diatraea saccharalis(Fabricius)Stem Borer

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Agricultural Sciences 2014年第9期5卷 776-784页

作者： Jacqueline barbosa Nascimento Jose Alexandre de freitas Barrigossi department of Entomology Faculty of AgronomyFederal University of GoiasGoianiaBrazil Embrapa Rice and Beans Santo Antonio de GoiásBrazil

This study aimed to observe the response of 32 rice accessions to attack of sugarcane borer (Diatraea saccharalis Fabr., 1794). Twenty larvae were placed on the leaf sheaths of rice plants. At 30 days after infestation, the rice plants were cut at ground level and taken to the laboratory to analyse the signs of borer attack, external and internal diameter of the stem and weight of surviving larvae. The results of the morphological traits of the rice plant, response of the plant to insect attack and development of the sugarcane borer larvae indicated a genotypic variation. The accessions that most favored larval survivals were IRAT 124 and MEARIN. Larvae with highest weight (0.0643 g) were found in IAPAR L 99-98 and the largest internal diameters of the rice stem (5.65 mm) were found in LAC 12. These accessions (IRAT 124, MEARIN, IAPAR L 99-98 and LAC 12) remained morphologically grouped with IAC 47, cultivar susceptible to sugarcane borer. The most tolerant materials based on the ability to produce new tillers after larval infestation were BR IRGA 417 and MTU 15. The results of this study indicate that all the morphological traits were able to separate the accessions of rice into different groups in relation to resistance to the sugarcane borer D. saccharalis. These materials can be used as donor sources in pre-breeding for genetic resistance to sugarcane borers.

关键词： Rice Sugarcane Borer Morphological Traits Resistance

Heart failure in the elderly

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Journal of Geriatric Cardiology 2012年第2期9卷 101-107页

作者： Elizabete Viana de freitas Michel Batlouni Roberto Gamarsky department of Cardiology Pedro Ernesto University HospitalState University of Rio de JaneiroBoulevard 28 Setembro77 Vila IsabelBrazil department of Geriatrics Pro-Cardiaeo HospitalRua General Polidoro 182Brazil department of Cardiology Avenida Doutor Arnaldo455ConsolaqaoSao Paulo.CEP:01246-000Brazil department of lnternal Medicine Federal University of GoiasAv.Contorno s/n°.Estado:GO Cidade:Gioidnia Bairro:Central CEP:74055-140Brazil department of Cardiology Dante Pazzanese InstituteAv.Doutor Dante Pazzanesen o 500.Bairro:IbirapuerafVila Mariana Cidade:Sao PauloBrazil department of Geriatrics Federal University of Rio de JaneiroRJ20551-030Brazil

The aging of the population is, currently, a major phenomenon, drawing the attention of a number of investigators. The significant increase of life expectancies over the past few decades, in addition to social and economic consequences, has lead to a major change in the morbidity and mortality profile of elders. Heart failure （HF） is a condition in which the heart can not pump enough blood to meet the body＇s needs. HF is predominantly a disorder of the elderly with rates increasing exponentially. The prevalence of HF approximately doubles with each decade of life. As people live longer, the occurrence of HF rises, as well as other conditions that complicate its treatment. Impaired heart function implies a reduced duration of survival. Fortunately, many factors that can prevent HF and improve outcome are known and can be applied at any stage. This review emphasizes the importance of factors inherent in aging itself, focusing on heart disease, particularly as a disease of aging, can help critically refine management of this acute and chronic disease, as well as foster preventive strategies to reduce the incidence of this common malady.

关键词： Elderly people Geriatric problems Heart failure Hypertension