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Glyphosate as a direct or indirect activator of pro-inflammatory signaling and cognitive impairment

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Neural Regeneration Research 2024年第10期19卷 2212-2218页

作者： Yukitoshi Izumi Kazuko A.o'Dell Charles F.Zorumski Department of Psychiatry Washington University School of MedicineSt.LouisMOUSA Taylor Family Institute for Innovative Psychiatric Research Washington University School of MedicineSt.LouisMOUSA

Glyphosate-based herbicides are widely used around the world, making it likely that most humans have significant exposure. Because of habitual exposure, there are concerns about toxicity including neurotoxicity that could result in neurological, psychiatric, or cognitive impairment. We recently found that a single injection of glyphosate inhibits long-term potentiation, a cellular model of learning and memory, in rat hippocampal slices dissected 1 day after injection, indicating that glyphosate-based herbicides can alter cognitive function. Glyphosate-based herbicides could adversely affect cognitive function either indirectly and/or directly. Indirectly, glyphosate could affect gut microbiota, and if dysbiosis results in endotoxemia(leaky gut), infiltrated bacterial by-products such as lipopolysaccharides could activate pro-inflammatory cascades. Glyphosate can also directly trigger pro-inflammatory cascades. Indeed, we observed that acute glyphosate exposure inhibits long-term potentiation in rat hippocampal slices. Interestingly, direct inhibition of long-term potentiation by glyphosate appears to be similar to that of lipopolysaccharides. There are several possible measures to control dysbiosis and neuroinflammation caused by glyphosate. dietary intake of polyphenols, such as quercetin, which overcome the inhibitory effect of glyphosate on long-term potentiation, could be one effective strategy. The aim of this narrative review is to discuss possible mechanisms underlying neurotoxicity following glyphosate exposure as a means to identify potential treatments.

关键词： cognitive impairment glyphosate microglia neuroinflammation roundup toll-like receptor 4 zinc chelation

Perceived value of microfinance and SME performance: The role of exploratory innovation

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International Journal of Innovation Studies 2024年第2期8卷 172-185页

作者： Christian Sarfo Jing A.Zhang Conor o'Kane Paula o'Kane Department of Management University of LincolnBrayford PoolLincoln LN67TSUnited Kingdom Department of Management Otago Business SchoolUniversity of OtagoPO Box 56Dunedin9054New Zealand

This study examines how perceived value of microfinance and exploratory innovation affect small and medium-sized enterprises(SME)performance in the context of a developing *** on the strategic innovation and microfinance literature,we hypothesize that(1)perceived value of microfinance affects exploratory innovation and SME performance,and(2)exploratory innovation serves as an effective mechanism through which microfinance enhances SME *** employ partial least squares structural equation modeling(PLS-SEM)to test our *** a sample of 581 Ghanaian SMEs with microfinance,the results of the PLS SEM support our *** further conducted a qualitative analysis of comments provided by the SMEs(n=144)to gain a deeper understanding of exploratory innovation in developing *** findings show that SMEs purposefully attempt to strengthen their exploratory inno-vation in *** discuss the theoretical and practical implications of these findings as well as future research avenues.

关键词： Perceived value of microfinance Exploratory innovation SME performance

SIRS epidemic modeling using fractional-ordered differential equations:Role of fear effect

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International Journal of Biomathematics 2024年第5期17卷 79-100页

作者： Shiv Mangal o.P.Misra Joydip Dhar School of Mathematics and Allied Sciences Jiwaji University GwaliorMadhya PradeshIndia Department of Mathematics Post Graduate College BinaMadhya PradeshIndia Department of Applied Sciences Atal Bihari Vajpayee-Indian Institute of Information Technology and Management GwaliorMadhya PradeshIndia

In this paper,an SIRS epidemic model using Grunwald-Letnikov fractional-order derivative is formulated with the help of a nonlinear system of fractional differential equations to analyze the effects of fear in the population during the outbreak of deadly infectious *** criteria for the spread or extinction of the disease are derived and discussed on the basis of the basic reproduction *** condition for the existence of Hopf bifurcation is discussed considering fractional order as a bifurcation ***,using the Grunwald-Letnikov approximation,the simulation is carried out to confirm the validity of analytic results *** the real data of CoVID-19 in India recorded during the second wave from 15 May 2021 to 15 December 2021,we estimate the model parameters and find that the fractional-order model gives the closer forecast of the disease than the classical *** the analytical results and numerical simulations presented in this study suggest different policies for controlling or eradicating many infectious diseases.

关键词： SIRS epidemic model fear effect Mittag-Leffler function Hopf bifurcation parameter estimation

Numerical Simulation of Thermocapillary Convection with Evaporation Induced by Boundary Heating

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Fluid Dynamics & Materials Processing 2024年第7期20卷 1667-1686页

作者： o.N.Goncharova V.B.Bekezhanova Altai State University Institute of Mathematics and Information TechnologiesBarnaul656049Russia Institute of Computational Modelling SB RAS Department of Differential Equations of MechanicsKrasnoyarsk660036Russia

The dynamics of a bilayer system filling a rectangular cuvette subjected to external heating is *** influence of two types of thermal exposure on the flow pattern and on the dynamic contact angle is *** particular,the cases of local heating from below and distributed thermal load from the lateral walls are *** simulation is carried out within the frame of a two-sided evaporative convection model based on the Boussinesq approximation.A benzine–air system is considered as reference *** variation in time of the contact angle is described for both heating *** lateral heating,near-wall boundary layers emerge together with strong convection,whereas the local thermal load from the lower wall results in the formation of multicellular motion in the entire volume of the fluids and the appearance of transition regimes followed by a steady-state *** results of the present study can aid the design of equipment for thermal coating or drying and the development of methods for the formation of patterns with required structure and morphology.

关键词： Thermocapillary convection two-phase system numerical modeling contact angle

Alkali and Plasma-Treated Guadua angustifolia Bamboo Fibers:A Study on Reinforcement Potential for Polymeric Matrices

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Journal of Renewable Materials 2024年第8期12卷 1399-1416页

作者： Patricia Luna Juan Lizarazo-Marriaga Alvaro Mariño Facultad de Ingeniería Universidad Nacional de ColombiaBogotá11001Colombia Facultad de Ciencias Universidad Nacional de ColombiaBogotá11001Colombia

This study focuses on treating Guadua angustifolia bamboo fibers to enhance their properties for reinforcement applications in composite ***(alkali)and physical(dry etching plasma)treatments were used separately to augment compatibility of Guadua angustifolia fibers with various composite *** influence of these treatments on the fibers’performance,chemical composition,and surface morphology were *** analysis indicated that alkali treatments reduced the tensile modulus of elasticity and strength of fibers by up to 40%and 20%,respectively,whereas plasma treatments maintain the fibers’mechanical *** spectroscopy revealed significant alterations in chemical composition due to alkali treatments,while plasma-treated fibers showed minimal *** examination through Scanning Electron Microscopy(SEM)revealed post-treatment modifications in both cases;alkali treatments served as a cleanser,eliminating lignin and hemicellulose from the fiber surface,whereas plasma treatments also produce rough *** results validate the impact of the treatments on the fiber mechanical performance,which opens up possibilities for using Guadua angustifolia fibers as an alternative reinforcement in composite manufacturing.

关键词： Bamboo fibers Guadua angustifolia alkali treatment dry etching plasma treatment composite reinforcement

Efficacy of acupuncture on cancer pain:A systematic review and meta-analysis

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Journal of Integrative Medicine 2024年第3期22卷 235-244页

作者： Miguel Faria Mónica Teixeira Maria João Pinto Paulo Sargento Núcleo de Investigação em Ciências e Tecnologias da Saúde Instituto Politécnico da Lusofonia1950-396 LisboaPortugal Clínica São João de Deus 1700-048 LisboaPortugal REQUIMTE/LAQV(Rede de Química e Tecnologia/Laboratório Associado para a Química Verde) Instituto Superior de EngenhariaInstituto Politécnico do Porto4051-401 PortoPortugal Hospital SoERAD 2560-312 Torres VedrasPortugal Centro de Estudos Avançados em Direito“Francisco Suarez ”1749-024 LisboaPortugal

Background:Pain associated with cancer is one of the greatest causes of reduced quality of life in *** is one of the treatments used to address this issue,with the great advantage of having little or no side effects,especially when compared with pharmacological ***:The aim of this systematic review and meta-analysis was to evaluate the current evidence regarding the efficacy of acupuncture for cancer *** strategy:Six electronic databases(PubMed,EBSCo,Cochrane Library,Scielo,b-on and Scopus)were searched for relevant articles about pain relief in cancer patients from their beginning until 2022using MeSH terms such as“acupuncture,”“electroacupuncture,”“ear acupuncture,”“acupuncture analgesia,”“oncological pain,”and“cancer pain.”Inclusion criteria:Studies included were randomized controlled trials(RCTs)where acupuncture was compared with no treatment,placebo acupuncture or usual *** extraction and analysis:Three independent reviewers participated in data extraction and evaluation of risk of bias,and a meta-analysis was *** primary outcome was pain intensity,measured with the visual analog scale,numeric rating scale,or brief pain *** outcomes also assessed were quality of life,functionality,xerostomia,pain interference,and analgesic *** were expressed as standardized mean difference(SMD)with 95%confidence interval(CI).Results:Sixteen RCTs with a total of 1124 participants were included in the meta-analysis,with the majority of the studies presenting a low or unclear risk of *** was more effective in reducing pain than no treatment(SMD=–0.90,95%CI[–1.68,–0.12]),sham acupuncture(SMD=–1.10,95%CI[–1.59,–0.61])or usual care(SMD=–1.16,95%CI[–1.38,–0.93]).Conclusion:The results of this study suggest that acupuncture may be an effective intervention to reduce pain associated with *** some limitations due to the low quality and small sample size of some included st

关键词： Acupuncture Cancer pain Meta-analysis Systematic review

Disentangling the effects of management and climate change on habitat suitability for saproxylic species in boreal forests

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Journal of Forestry Research 2024年第2期35卷 121-133页

作者： Ellinoora Ekman María Triviño Clemens Blattert Adriano Mazziotta Maria Potterf Kyle Eyvindson Department of Biological and Environmental Science University of JyvaskylaP.O.Box 3540014 JyvaskylaFinland Institute for Atmospheric and Earth System Research(INAR)/Physics Faculty of ScienceUniversity of HelsinkiP.O.Box 6800014 HelsinkiFinland School of Resource Wisdom University of JyvaskylaP.O.Box 3540014 JyvaskylaFinland Natural Resources Institute Finland(LUKE) Latokartanonkaari 900790 HelsinkiFinland Ecosystem Dynamics and Forest Management Group Technical University of MunichHans‑Carl‑Von‑Carlowitz‑Platz 285354 FreisingGermany Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesP.O.Box 50031433ÅsNorway

Forest degradation induced by intensive forest management and temperature increase by climate change are resulting in biodiversity decline in boreal *** forest management and high-end climate emission scenarios can further reduce the amount and diversity of deadwood,the limiting factor for habitats for saproxylic species in European boreal *** magnitude of their combined effects and how changes in forest management can affect deadwood diversity under a range of climate change scenarios are poorly *** used forest growth simulations to evaluate how forest management and climate change will individually and jointly affect habitats of red-listed saproxylic species in *** simulated seven forest management regimes and three climate scenarios(reference,RCP4.5 and RCP8.5)over 100 *** regimes included set aside,continuous cover forestry,business-as-usual(BAU)and four modifications of *** suitability was assessed using a speciesspecific habitat suitability index,including 21 fungal and invertebrate species groups.“Winner”and“loser”species were identified based on the modelled impacts of forest management and climate change on their habitat *** found that forest management had a major impact on habitat suitability of saproxylic species compared to climate *** suitability index varied by over 250%among management regimes,while overall change in habitat suitability index caused by climate change was on average only 2%.More species groups were identified as winners than losers from impacts of climate change(52%–95%were winners,depending on the climate change scenario and management regime).The largest increase in habitat suitability index was achieved under set aside(254%)and the climate scenario RCP8.5(>2%),while continuous cover forestry was the most suitable regime to increase habitat suitability of saproxylic species(up to+11%)across all climate change *** results show that close-to-na

关键词： Biodiversity Simulations Finland Forest planning Habitat suitability Deadwood

Is it possible to run after positive affective experiences instead of health benefits without tackling social inequalities?

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Journal of Sport and Health Science 2024年第6期13卷 756-758页

作者： Raphael H.o.Araujo Andre o.Werneck Gilmar M.de Jesus Danilo R.P.Silva Graduation Program in Health Sciences Londrina State UniversityLondrina 86057-970Brazil School of Public Health The University of QueenslandBrisbane QLD 4006Australia Center for Epidemiological Research in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil Department of Psychological Medicine Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondon SE58AFUK Public Health Post-Graduate Program State University of Feira de SantanaFeira de Santana 44036-900Brazil Department of Physical Education Federal University of SergipeSao Cristovao 490100-000Brazil

We recently read the opinion piece titled“Why people should run after positive affective experiences instead of health benefits”,which was carried out by Maltagliati et al.^(1)and published in the Journal of Sport and Health *** article started an important discussion about a physical activity(PA)promotion approach that encourages the use of affective experience to PA *** we agree with the authors’point of view and believe that its message can generate an important insight for PA promotion,the authors presented a scenario where behavior change seems to be exclusively dependent on the *** the existence of other barriers to an active lifestyle(e.g.,social inequalities)could enhance the authors’suggested approach because many people live in conditions that reduce their opportunities to engage in affective experiences related to PA;furthermore,affective experiences can vary depending on individual context.

关键词： promotion inequalities furthermore

Highly Defective Dark Tio_(2) Modified with Pt: Effects of Precursor Nature and Preparation Method on Photocatalytic Properties

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Transactions of Tianjin University 2024年第2期30卷 198-209页

作者： E.D.Fakhrutdinova o.A.Reutova T.A.Bugrova I.Yu.ovsyuk L.S.Kibis o.A.Stonkus D.B.Vasilchenko o.V.Vodyankina V.A.Svetlychnyi National Research Tomsk State University TomskRussia 634050 Novosibirsk State University NovosibirskRussia 630090 Boreskov Institute of Catalysis NovosibirskRussia 630090 Nikolaev Institute of Inorganic Chemistry NovosibirskRussia 630090

The study focused on the modification with platinum of dark defective titania obtained via pulsed laser ablation. Both the method of Pt introduction and the nature of the Pt precursor were varied. All samples exhibited similar phase compositions, specific surface areas, and Pt contents. High-resolution transmission electron microscopy coupled with pulsed Co adsorption revealed increased dispersity when photoreduction and the hydroxonitrate complex (Me _(4) N) _(2) [Pt _(2) (oH) _(2) (No _(3) ) _(8) ] were used. The sample featured a high content of single-atom species and subnano-sized Pt clusters. The X-ray photoelectron spectroscopy results showed that the photoreduction method facilitated the appearance of a larger number of Pt ^(2+) states, which appeared owing to the strong metal-support interaction (SMSI) eff ect of the transfer of electron density from the electron-saturated defects on the Tio _(2) surface to Pt ^(4+) . In the hydrogen evolution reaction, samples with a significant fraction of the Pt ^(2+) ionic component, capable of generating short-lived Pt^(0) single-atom sites under irradiation due to the SMSI eff ect, exhibited the highest photocatalytic activity. The 0.5Pt(C)/Tio_(2) -Ph sample exhibited the highest hydrogen yield with a quantum efficiency of 0.53, retaining its activity even after 8 h of operation.

关键词： Dark(black)Tio_(2) Pulsed laser ablation Platinum reduction method Precursor type Photocatalysis Hydrogen evolution reaction