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Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements

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Infectious Diseases of Poverty 2014年第1期3卷 1-14页

作者： Denis Zofou Raymond B Nyasa dickson s nsagha Fidele Ntie-Kang Henry D Meriki Jules Clement N Assob Victor Kuete Biotechnology Unit Faculty of ScienceUniversity of BueaP.O.Box 63BueaSouth West RegionCameroon Department of Public Health and Hygiene Faculty of Health SciencesUniversity of BueaBueaCameroon CEPAMOQ Faculty of ScienceUniversity of DoualaP.O.Box 8580DoualaCameroon Chemical and Bioactivity Information Centre Department of ChemistryUniversity of BueaP.O.Box 63BueaCameroon Department of Biomedical sciences Faculty of Health SciencesUniversity of BueaBueaCameroon Department of Biochemistry University of DschangP.O.Box 67DschangCameroon

Vector-borne protozoan diseases represent a serious public health challenge,especially in the tropics where poverty together with vector-favorable climates are the aggravating *** of the various strategies currently employed to face these scourges is seriously *** enormous efforts,vaccines-which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and *** and vector control are therefore the sole effective attempts to minimize the disease ***,both strategies are also highly challenged by the phenomenon of drug and insecticide resistance,which affects virtually all interventions currently *** recently growing support from international organizations and governments of some endemic countries is warmly welcome,and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases,especially malaria,leishmaniasis,Human African Trypanosomiasis(HAT),and Chagas disease.

关键词： Malaria Vector-borne protozoan diseases African trypanosomiasis Chagas disease Leishmaniasis Vector control Chemotherapy Vaccine development

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A study on the Transmission Dynamics of the Omicron Variant of COVID-19 Using Nonlinear Mathematical Models

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Computer Modeling in Engineering & sciences 2024年第6期139卷 2265-2287页

作者： s.dickson s.Padmasekaran Pushpendra Kumar Kottakkaran sooppy Nisar Hamidreza Marasi Department of Mathematics Periyar UniversitySalemTamilnadu636011India Faculty of Engineering and Natural sciences Istanbul Okan UniversityIstanbulTurkey Department of Mathematics College of Science and Humanities in AlkharjPrince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of Applied Mathematics Faculty of MathematicsStatistics and Computer ScienceUniversity of TabrizTabrizIran

This research examines the transmission dynamics of the Omicron variant of COVID-19 using sEIQIcRVW and sQIRV models,considering the delay in converting susceptible individuals into infected *** significant delays eventually resulted in the pandemic’s *** ensure the safety of the host population,this concept integrates quarantine and the COVID-19 *** investigate the stability of the proposed *** fundamental reproduction number influences stability *** to our findings,asymptomatic cases considerably impact the prevalence of Omicron infection in the *** real data of the Omicron variant from Chennai,Tamil Nadu,India,is used to validate the outputs.

关键词： Omicron local stability reproduction number steady states global stability

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Loss to specialized Cardiology Follow-Up in Adults Living with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 49-63页

作者： Cheryl dickson Danielle Osborn David Baker Judith Fethney David s.Celermajer Rachael Cordina Department of Cardiology Royal Prince Alfred HospitalSydneyAustralia Department of Cardiothoracic surgery Westmead HospitalSydneyAustralia susan Wakil school of Nursing and Midwifery The University of SydneySydneyAustralia sydney Medical school The University of SydneySydneyAustralia

Background:Much has been written about the loss to follow-up in the transition between pediatric and adult Congenital Heart Disease(CHD)care *** less is understood about the loss to follow-up(LTF)after a successful *** is critical too,as patients lost to specialised care are more likely to experience mor-bidity and premature ***:To understand the prevalence and reasons for loss to follow-up(LTF)at a large Australian Adult Congenital Heart Disease(ACHD)***:Patients with moderate or highly complex CHD and gaps in care of>3 years(deﬁned as LTF)were identiﬁed from a comprehensive ACHD *** telephone interviews examined current care and barriers to clinic ***:Overall,407(22%)of ACHD patients(n=1842)were *** mean age at LTF was 31(sD 11.5)years and 54%were male;311(76%)were *** to adults seen regularly,lost patients were younger,with a greater socio-economic disadvantage,and had less complex CHD(ps(14%).The top 3 responses for care absences were“feeling well”(61%),losing track of time(36%),and not needing fol-low-up care(25%).Conclusions:A large proportion of the ACHD population becomes lost to specialised cardiac care,even after a successful *** Australian study reports younger age,moderate complexity defects,and socio-economic disadvantage as predictive of loss to *** study highlights the need for novel approaches to patient-centered service delivery even beyond the age of transition and resources to maintain patient engagement within the ACHD service.

关键词： Loss to follow-up follow-up adult congenital heart disease lapse in care gaps in care care gaps care continuity ACHD predictors

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Coinfection with malaria and intestinal parasites, and its association with anaemia in children in Cameroon

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Infectious Diseases of Poverty 2015年第1期4卷 382-388页

作者： Anna Longdoh Njunda shuri Ghasarah Fon Jules Clement Nguedia Assob dickson shey nsagha Tayong Dizzle Bita Kwenti Tebit Emmanuel Kwenti Department of Medical Laboratory sciences University of BueaP.B.63BueaCameroon Department of Public Health and Hygiene University of BueaP.B.63BueaCameroon Department of Microbiology and Parasitology University of BueaP.B.63BueaCameroon

Background:The purpose of this study was to determine the prevalence of coinfection with malaria and intestinal parasites,as well as to determine its association with anaemia in children aged 10 years and below in Muyuka,*** and methods:This was a cross-sectional *** were febrile children who were admitted to the Muyuka district hospital between April and October *** and stool samples were collected from those participants who gave consent to take part in the *** concentration(Hb)and complete blood count(CBC)were performed using an automated haematology analyser(Mindray®,BC-2800).Giemsa-stained blood film was examined to detect malaria parasites,while the formol-ether concentration technique was used to detect intestinal parasitic infections(IPIs).The Pearson’s chi-square,student’s T-test and correlation analysis were all performed as part of the statistical ***:Four hundred and eleven(411)children successfully took part in this *** prevalence of malaria,IPIs,malaria and IPI coinfection,and anaemia observed were 98.5%,11.9%,11.9%and 44.8%,*** and IPIs were significantly associated with age;anaemia was more prevalent in children under five years of age(p=0.000),whereas IPIs were more prevalent in children aged between five and 10 years(p=0.006).The parasite species isolated included Ascaris lumbricoides(36[73.5%]),Entamoeba histolytica/dispar(9[18.4%])and hookworm(4[8.2%]).The mean Hb observed was 10.64 g/dl(±1.82).A significant negative correlation was observed between malaria parasite density and *** was no significant difference in the prevalence of anaemia among children infected with malaria,IPIs,or malaria and IPI coinfection,or among non-infected ***,the mean Hb did not differ among infected and non-infected ***:This study showed that malaria and IPIs still constitute a major public health problem in the study area despite a lack of any si

关键词： Malaria Intestinal parasites Intestinal parasitic infections Coinfection Anaemia Children Prevalence Cameroon

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Comparative evaluation of a rapid diagnostic test,an antibody ELIsA,and a pLDH ELIsA in detecting asymptomatic malaria parasitaemia in blood donors in Buea,Cameroon

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Infectious Diseases of Poverty 2017年第1期6卷 931-939页

作者： Tebit Emmanuel Kwenti Longdoh Anna Njunda Beltine Tsamul shey dickson nsagha Nguedia Jules-Clement Assob Kukwah Anthony Tufon Dilonga Henry Meriki Enow George Orock Department of Medical Laboratory sciences Faculty of Health SciencesUniversity of BueaP.B.63BueaSouthwest RegionCameroon Department of Public Health and Hygiene Faculty of Health SciencesUniversity of BueaP.B.63BueaSouthwest RegionCameroon Blood Bank Regional Hospital BueaP.B.32BueaSouthwest RegionCameroon Programme in Medicine Faculty of Health SciencesUniversity of BueaBueaSouthwest RegionCameroon

Background:In malaria endemic areas,infected blood donors serve as a source of infection to blood recipients,which may adversely affect their *** necessitates the proper screening of blood to be used for transfusion in these *** purpose of this study was to determine the prevalence of malaria parasitaemia in blood donors in Buea,Cameroon,and to evaluate the performance of a rapid diagnostic test(RDT),a malaria antibody enzyme-linked immunosorbent assay(ELIsA),and a Plasmodium lactate dehydrogenase(pLDH)ELIsA in the detection of asymptomatic malaria parasitaemia in the target ***:In a prospective study conducted between september 2015 and June 2016,1240 potential blood donors were *** donors were screened for malaria parasites using Giemsa microscopy(GM)and a RDT.A sub-sample of 184 samples,comprising 88 positive and 96 negative samples,were selected for the evaluation of the pLDH ELIsA and the antibody *** chi-square test and correlation analysis were performed as part of the statistical *** statistical significance cut-off was set at Psitaemia in this study was found to be 8.1%(95%CI:6.6-9.7).The prevalence was not observed to be dependent on the age or sex of the *** RDT had a sensitivity(88.0%),specificity(99.1%),and negative predictive value(99.0%)higher than the *** performance of the pLDH ELIsA,which demonstrated the highest positive predictive value(91.6%),was generally comparable to the *** sensitivity was lowest with the antibody ELIsA(69.9%),which also demonstrated the highest false positive and false negative *** detection threshold for the pLDH(three parasites/μl)was lower compared to the RDT(50-60 parasites/μl).Non-significant positive correlations were observed between the parasite density and the pLDH titers and malaria antibody ***:Overall,the RDT and the pLDH ELIsA demonstrated a perfectly correlated agreem

关键词： Blood transfusion Malaria RDT pLDH ELIsA Malaria antibody ELIsA Comparative evaluation sensitivity specificity Buea Cameroon

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Degradation of chemical and mechanical properties of cements with different formulations in CO_(2)-containing HTHP downhole environment

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Petroleum science 2023年第2期20卷 1119-1128页

作者： Wei Yan Hao-Guang Wei Nguu dickson Muchiri Fu-Li Li Jing-Ru Zhang Zheng-Xian Xu state Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China sinopec Petroleum Engineering Technology Research Institute Co. Ltd.Beijing102206China

The increasing energy demand has pushed oil and gas exploration and development limits to extremely challenging and harsher HTHP (High Temperature and High Pressure) environments. Maintaining wellbore integrity in these environments, particularly in HPHT reservoirs with corrosive gases, presents a significant challenge. Robust risk evaluation and mitigation strategies are required to address these reservoirs' safety, economic, and environmental uncertainties. This study investigates chemo-mechanical properties degradations of class G oil well cement blended with silica fume, liquid silica, and latex when exposed to high temperature (150 °C) and high partial pressure of CO_(2) saturated brine. The result shows that these admixtures surround the cement grains and fill the interstitial spaces between the cement particles to form a dense crystal system of C–s–H. Consequently, the cement's percentage of pore voids, permeability, and the content of alkali compounds reduce, resulting in increased resistance to CO_(2) corrosion. Liquid silica, a specially prepared silica suspension, is a more effective alternative to silica fume in protecting oil well cement against CO_(2) chemical degradation. Micro-indentation analysis shows a significant deterioration in the mechanical properties of the cement, including average elastic modulus and hardness, particularly in the outer zones in direct contact with corrosive fluids. This study highlights the significance of incorporating admixtures to mitigate the effects of CO_(2) corrosion in HPHT environments and provides a valuable technique for quantitatively evaluating the mechanical-chemical degradation of cement sheath.

关键词： HPHT reservoirs Oil well cement CO_(2)corrosion Chemo-mechanical Mechanical properties Micro-indentation

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Emerging role of protein modification in inflammatory bowel disease

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2022年第3期23卷 173-188页

作者： Gaoying WANG Jintao YUAN Ji LUO dickson Kofi Wiredu OCANsEY Xu ZHANG Hui QIAN Wenrong XU Fei MAO Key Laboratory of Medical science and Laboratory Medicine of Jiangsu Province School of MedicineJiangsu UniversityZhenjiang212013China Clinical Laboratory Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical UniversityWuxi214002China Clinical Laboratory the People’s Hospital of DanyangAffiliated Danyang Hospital of Nantong UniversityZhenjiang212300China Directorate of University Health services University of Cape CoastCape Coast02630Ghana

The onset of inflammatory bowel disease(IBD)involves many factors,including environmental parameters,microorganisms,and the immune *** research on IBD continues to expand,the specific pathogenesis mechanism is still *** modification refers to chemical modification after protein biosynthesis,also known as post-translational modification(PTM),which causes changes in the properties and functions of *** proteins can be modified in different ways,such as acetylation,methylation,and phosphorylation,the functions of proteins in different modified states will also be *** between different states of protein or changes in modification sites can regulate protein properties and *** modifications like neddylation,sumoylation,glycosylation,and acetylation can activate or inhibit various signaling pathways(e.g.,nuclear factor-κB(NF-κB),extracellular signal-regulated kinase(ERK),and protein kinase B(AKT))by changing the intestinal flora,regulating immune cells,modulating the release of cytokines such as interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and interferon-γ(IFN-γ),and ultimately leading to the maintenance of the stability of the intestinal epithelial *** this review,we focus on the current understanding of PTM and describe its regulatory role in the pathogenesis of IBD.

关键词： Inflammatory bowel disease(IBD) Protein modification Neddylation sumoylation Glycosylation Acetylation

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A Public Health Model and Framework to Mitigate the Impact of Orphans and Vulnerable Children Due to HIV/AIDs in Cameroon

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World Journal of AIDs 2014年第1期4卷 27-37页

作者： dickson shey nsagha Ngowe Ngowe Marcelin Jules Clement Nguedia Assob Anna Longdoh Njundah Department of Biomedical sciences Faculty of Health Sciences University of Buea Buea Cameroon Department of Medical Laboratory sciences Faculty of Health Sciences University of Buea Buea Cameroon Department of Public Health and Hygiene Faculty of Health Sciences University of Buea Buea Cameroon Department of surgery Obstetrics and Gynecology Faculty of Health Sciences University of Buea Buea Cameroon

UNICEF, UNAIDs and UsAID developed a global strategic framework to guide responses to care and protect orphans and other vulnerable children in the context of HIV/AIDs. In the developing world, about 132 million people have lost one or both parents due to the AIDs pandemic and 25 million children have been orphaned by HIV/AIDs in 2010. The HIV prevalence in Cameroon is estimated at 5.1%. As of 2010, there were 304,000 deaths due to AIDs in Cameroon. Out of 1,200,000 orphans and vulnerable children in Cameroon in 2010, 300,000 were AIDs orphans. The HIV/AIDs burden impacts child survival, growth and development in the traditional African setting. With so many orphans in the population, along with many vulnerable children, strategies must be developed to respond more effectively to their critical needs. This study provides a model for OVC care and support in Cameroon. The model was developed out of extensive work using a participatory approach involving traditional, administrative and health stakeholders on OVC in Yaounde I and Yaounde VI Councils, Nanga Eboko Health District, Isangelle, Ekondo Titi, and Bafaka-Balue communities in Cameroon. Consultancy services with PLAN Cameroon, the Pan African Institute for Development-West Africa coupled with facilitation of many training workshops on OVC with save the orphans Foundation, the Ministry of social Affairs, and the Ministry of Public Health and working with the National AIDs Control Committee. The essential components of a holistic framework for the care of OVC have been identified. A public health model for the care of OVC and a mechanism for their identification and a referral system for testing OVC for HIV are proposed. Through this model, a mechanism for the effective holistic care of OVC and collaboration is enhanced.

关键词： Orphans Vulnerable Children HIV AIDs Public Health Model Cameroon

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sexual Risk Behaviours among People Living with HIV and Implications for Control in the North West Region of Cameroon

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World Journal of AIDs 2014年第2期4卷 198-205页

作者： Tebit Emmanuel Kwenti dickson shey nsagha Bita Dizzle Tayong Kwenti Anna Longdoh Njunda Department of Medical Laboratory sciences Faculty of Health Sciences University of Buea Buea Cameroon Department of Microbiology and Parasitology Faculty of Science University of Buea Buea Cameroon Department of Public Health and Hygiene University of Buea Buea Cameroon Regional Hospital Buea Buea Cameroon

In Cameroon, despite extensive control efforts against HIV/AIDs, the number of new HIV infections is still on the rise. The factors contributing to this are not clearly understood. We hypothesized that it may lie on people living with HIV (PLHIV). In a case-control descriptive study, we studied the characteristics and sexual risky behaviour of PLHIV in the North West Region of Cameroon which has the highest HIV prevalence. Participants were screened for HIV and a structured questionnaire was used in data collection. An equivalent number (350) of PLHIV and controls who did not differ with respect to age and sex participated. Relative to the control, PLHIV were generally less educated (P ss privileged (P stable source of income. Among participants that were once married, a greater proportion of PLHIV were divorced (OR = 5.23, P = 0.007), and widows (OR = 2.73, P = 0.001). Among participants that were single, a relatively greater proportion of PLHIV practiced multi-partner sex (OR = 4.55, Pstory of sTDs was higher in PLHIV than the control (OR = 1.88, P = 0.001). Out of 350 PLHIV, 280 (80%) admitted to having had sexual intercourse after being diagnosed of which only 127 (41.78%) admitted to using condoms and 132 (47.14%) admitted to concealing their HIV status from their sexual partner(s). These findings have implications in HIV control programs which should target the poor and the less educated, as well as the sexual behaviour of PLHIV, so as to reverse the current rising trend of new infections in the country.

关键词： HIV/AIDs sTDs Risk Factors HIV Control North West Region Cameroon

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HucMsC-Ex alleviates inflammatory bowel disease via the lnc78583-mediated miR3202/HOXB13 pathway

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2022年第5期23卷 423-431页

作者： Yuting XU Li ZHANG dickson Kofi Wiredu OCANsEY Bo WANG Yilin HOU Rong MEI Yongmin YAN Xu ZHANG Zhaoyang ZHANG Fei MAO Key Laboratory of Medical science and Laboratory Medicine ofJiangsu Province School of MedicineJiangsu UniversityZhenjiang 212013China Nanjing Lishui People's Hospital Zhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200China Directorate of University Health services University of Cape CoastCape CoastGhana Department of Gastroenterology the Second People's Hospital of ZhenjiangZhenjiang 212000China Clinical Lab Taicang Hospital of Traditional Chinese MedicineSuzhou 215400China

As a group of nonspecific inflammatory diseases affecting the intestine,inflammatory bowel disease(IBD)exhibits the characteristics of chronic recurring inflammation,and was proven to be increasing in incidence(Kaplan,2015).IBD induced by genetic background,environmental changes,immune functions,microbial composition,and toxin exposures(sasson et al.,2021)primarily includes ulcerative colitis(UC)and Crohn's disease(CD)with complicated clinical symptoms featured by abdominal pain,diarrhea,and even blood in stools(Fan et al.,2021;Huang et al.,2021).

关键词： inflammatory intestine diarrhea

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