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Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer

World Journal of Gastroenterology 2021年第30期27卷 5076-5087页

作者： Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg dick Wågsäter Department of Medical Cell Biology Uppsala UniversityUppsala 75123Sweden Department of Laboratory Medicine and Pathology Region Jönköping CountyJönköping 55305Sweden Department of Surgery Region Jönköping CountyJönköping 55305Sweden Department of Biomedical and Clinical Science Linköping UniversityLinköping 58185Sweden Department of Natural Science and Biomedicine School of Health and WelfareJönköping UniversityJönköping 55111Sweden

BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in *** chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various *** To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic *** Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,*** transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy *** The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated *** CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC *** analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized ***,the rate of the A allele was higher among CRC patients with mucinous cancer than among th

关键词： CC chemokine ligand 4 Gene polymorphism Gene and protein expression Chemokine Survival rate Colorectal cancer

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Quanti?cation of Tyrosine Hydroxylase and Erb B4 in the Locus Coeruleus of Mood Disorder Patients Using a Multispectral Method to Prevent Interference with Immunocytochemical Signals by Neuromelanin

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Neuroscience Bulletin 2019年第2期35卷 205-215页

作者： Lei Guo Jochem StormmesaND Zheng Fang Qingbin Zhu Rawien Balesar Joop van Heerikhuize Arja Sluiter dick Swaab Ai-Min Bao Department of Neurobiology and Department of Neurology of the Second Affiliated Hospital Institute of NeuroscienceNHC and CAMS Key Laboratory of Medical NeurobiologyZhejiang University School of Medicine Netherlands Institute for Neuroscience Institute of the Royal Netherlands Academy of Arts and Sciences Department of Neurology Sir Run Run Shaw HospitalZhejiang University School of Medicine

The locus coeruleus(LC) has been studied in major depressive disorder(MDD) and bipolar disorder(BD). A major problem of immunocytochemical studies in the human LC is interference with the staining of the immunocytochemical end-product by the omnipresent natural brown pigment neuromelanin. Here, we used a multispectral method to untangle the two colors: blue immunocytochemical staining and brown *** found significantly increased tyrosine hydroxylase(TH) in the LC of MDD patients—thus validating the method—but not in BD patients, and we did not find significant changes in the receptor tyrosine-protein kinase ErbB4 in the LC in MDD or BD patients. We observed clear co-localization of ErbB4, TH, and neuromelanin in the LC neurons. The different stress-related molecular changes in the LC may contribute to the different clinical symptoms in MDD and BD.

关键词： Major depressive disorder Bipolar disorder Tyrosine hydroxylase ErbB4 Locus coeruleus

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DOUBLE BALLOON ANGIOPLASTY FOR TREATING RESTENOTIC VEIN GRAFT

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Chinese Medical Journal 1994年第6期 52-56页

作者：陈传荣 YeanL.Lim RonaldJ.dick

A 53-year-old man with a restenotic large right coronary vein graft was successfully treated by double balloon angioplasty. The technique and clinical application of double balloon angioplasty were discussed.

关键词： LAO DOUBLE BALLOON ANGIOPLASTY FOR TREATING RESTENOTIC VEIN GRAFT

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The Guard Dog （Ⅰ）

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考试与评价（英语高二专刊） 2009年第9期 38-39页

作者： dick King-Smith

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DDB Greater China Group

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中国广告 2011年第3期 25-26页

作者： dick Van Motman DDBGreaterChinaGroup总裁兼首席执行官

在2010年中，你们得到了哪些收获，做成了哪些值得您记忆和书写的事情？

关键词：企业文化人才培养业务增长创意

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Still Haunted噩梦犹存

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英语辅导（初三年级） 2005年第1期 54-55页

作者： dick

我是在一个上层家庭中长大的。生活一帆风顺，我有辛勤工作的父母，我很聪明，有很多朋友，而且拥有任何我想要的东西。

关键词：东西聪明朋友生活父母家庭

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The Guard Dog（Ⅲ）

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考试与评价（英语高二专刊） 2017年第12期 45-46页

作者： dick King-Smith

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The Guard Dog （ I ）

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考试与评价（英语高二专刊） 2017年第10期 43-44页

作者： dick King-Smith

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The Guard Dog（II）

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考试与评价（英语高二专刊） 2017年第11期 44-45页

作者： dick King-Smith

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Spatially distributed modelling and mapping of soil organic carbon and total nitrogen stocks in the Eastern Mau Forest Reserve,Kenya

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Journal of Geographical Sciences 2016年第1期26卷 102-124页

作者： Kennedy WERE Bal Ram SINGH ?ystein Bjarne dick Department of Mathematical Sciences and Technology Norwegian University of Life Sciences Kenya Agricultural and Livestock Research Organisation Kenya Soil Survey Department of Environmental Sciences Norwegian University of Life Sciences

Detailed knowledge about the estimates and spatial patterns of soil organic carbon(SOC) and total nitrogen(TN) stocks is fundamental for sustainable land management and climate change *** study aimed at:(1) mapping the spatial patterns,and(2) quantifying SOC and TN stocks to 30 cm depth in the Eastern Mau Forest Reserve using field,remote sensing,geographical information systems(GIS),and statistical modelling *** is a critical ecosystem offering essential services,but its sustainability is threatened by deforestation and *** revealed that elevation,silt content,TN concentration,and Landsat 8 Operational Land Imager band 11 explained 72% of the variability in SOC stocks,while the same factors(except silt content) explained 71% of the variability in TN *** results further showed that soil properties,particularly TN and SOC concentrations,were more important than that other environmental factors in controlling the observed patterns of SOC and TN stocks,*** stored the highest amounts of SOC and TN(3.78 Tg C and 0.38 Tg N) followed by croplands(2.46 Tg C and 0.25 Tg N) and grasslands(0.57 Tg C and 0.06 Tg N).Overall,the Eastern Mau Forest Reserve stored approximately 6.81 Tg C and 0.69 Tg *** highest estimates of SOC and TN stocks(hotspots) occurred on the western and northwestern parts where forests dominated,while the lowest estimates(coldspots) occurred on the eastern side where croplands had been ***,the hotspots need policies that promote conservation,while the coldspots need those that support accumulation of SOC and TN stocks.

关键词： soil organic carbon total nitrogen carbon sequestration climate change digital soil mapping East-ern Mau

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