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Pharmaceutical interfaces: Drug development,performance, regulation and e-health

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Asian journal of Pharmaceutical Sciences 2016年第1期11卷 2-2页

作者： diane j.burgess School of Pharmacy University of Connecticut

Interfaces have always been of concern with respect to the delivery of *** within the delivery system that can affect stability are a concern;however,there are other interfaces of importance,such as the interface with the body tissue,the regulatory interface and the emerging interface when drug delivery is linked to e-health *** presentation will address all these interfaces covering basic science aspects as well as discussion of e-health *** are interfaces between different phases in formulations such as emulsions,foams,suspensions *** are interfaces between actives and excipients within a *** actives as well as excipients may be in different states.

关键词： Pharmaceutical interfaces Drug development E-health

采用同轴喷射流实现脂质体的连续生产（英文）

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采用同轴喷射流实现脂质体的连续生产（英文）

Histones, histone chaperones and nucleosome assembly

2018年第十二届中国药物制剂大会

作者： diane j.burgess Dept. of Pharmaceutical Sciences University of Connecticut

Our laboratory has developed a continuous manufacturing platform for liposomes using a co-axial jet in co-flow and incorporating online PAT（process analytical technology）. DOE（design-of-experiments） approaches have been applied in the system design. The platform development will be presented along with application to liposomal drug delivery systems. Our continuous manufacturing platform is capable of tuning liposome particle size with precise control of the polydispersity index（PDI） to achieve monodisperse product. Identifying key process parameters and material attributes of liposomal formulations, such as the z-average particle size, polydispersity index and zeta-potential, are extremely important since they may impact the formulation quality, drug loading and in vivo performance of the final liposomal drug product.

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Protein & Cell 2010年第7期1卷 607-612页

作者： Rebecca j.burgess Zhiguo Zhang Department of Biochemistry and Molecular Biology Mayo Clinic College of Medicine200 First Street SWRochesterMN 55905USA

Chromatin structure governs a number of cellular processes including DNA replication,transcription,and DNA *** DNA replication,chromatin structure including the basic repeating unit of chromatin,the nucleosome,is temporarily disrupted,and then reformed immediately after the passage of the replication *** coordinated process of nucleosome assembly during DNA replication is termed replication—coupled nucleosome *** of this process can lead to genome instability,a hallmark of cancer ***,addressing how replication-coupled nucleosome assembly is regulated has been of great ***,we review the current status of this growing field of interest,highlighting recent advances in understanding the regulation of this important process by the dynamic interplay of histone chaperones and histone modifications.

关键词： nucleosome chaperones assembly

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

A dahlia flower extract has antidiabetic properties by improving insulin function in the brain

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Life Metabolism 2023年第4期2卷 39-50页

作者： Dominik Pretz Philip M.Heyward jeremy Krebs joel Gruchot Charles Barter Pat Silcock Nerida Downes Mohammed Zubair Rizwan Alisa Boucsein julia Bender Elaine j.burgess Geke Aline Boer Pramuk Keerthisinghe Nigel B.Perry Alexander Tups Centre for Neuroendocrinology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Department of Physiology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Maurice Wilkins Centre for Molecular Biodiscovery University of AucklandAuckland 1010New Zealand Department of Medicine University of OtagoWellingtonWellington South 6242New Zealand Centre for Endocrine Diabetes and Obesity Research Wellington Regional HospitalNewtownWellington 6021New Zealand Product Development Research Centre University of OtagoDunedin 9054New Zealand Department of Chemistry The New Zealand Institute for Plant and Food ResearchUniversity of OtagoDunedin 9054New Zealand

Butein,a rare chalcone found in the toxic plant Toxicodendron vernicifluum,has been shown to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit beta(IKKβ)/nuclear factor kappa B(NF-κB)pathway in the ***,we investigated whether the nonpoisonous plant Dahlia pinnata could be a source of butein as a potential treatment for type 2 diabetes(T2D).In mice fed a high-fat diet(HFD)to induce glucose intolerance,an oral *** petal extract improved glucose tolerance at doses of 3.3 mg/kg body weight and 10 mg/kg body ***,this effect was not mediated by butein alone but by butein combined with the closely related flavonoids,sulfuretin and/or ***,the extract improved systemic insulin *** of phosphatidylinositol 3-kinase to block insulin signaling in the brain abrogated the glucoregulatory effect of the orally administered *** extract reinstated central insulin signaling and normalized astrogliosis in the hypothalamus of HFD-fed *** NF-κB reporter zebrafish to determine IKKβ/NF-κB activity,a potent anti-inflammatory action of the extract was found.A randomized controlled crossover clinical trial on participants with predia-betes or T2D confirmed the safety and efficacy of the extract in *** conclusion,we identified an extract from the flower petals of *** as a novel treatment option for T2D,potentially targeting the central regulation of glucose homeostasis as a root cause of the disease.

关键词： inflammation hypothalamus signal transduction neuroendocrine arcuate nucleus

Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Metal-organic framework(MOF)-derived catalysts for Fischer-Tropsch synthesis: Recent progress and future perspectives

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journal of Energy Chemistry 2020年第12期29卷 230-245页

作者： Kabir Opeyemi Otun Xinying Liu diane Hildebrandt Institute for the Development of Energy fo r African Sustainability College of ScienceEngineering and TechnologyUniversity of South AfricaJohannesburgSouth Africa Department of Chemistry Kwara State UniversityPMB 1530llorinKwara StateNigeria International joint Laboratory of New Energy Hebei University of Science and TechnologyShijiazhuang 050018HebeiChina

Fischer-Tropsch Synthesis(FTS) is an important catalytic chemical reaction that converts a mixture of CO and H2(syngas) derived from biomass, coal or natural gas into ultra-clean fuels or value-added chemicals. However, most traditional catalysts used in the Fischer-Tropsch process are faced with the problems of high deactivation rate triggered by sintering, phase changes and oxidation which hamper their catalytic performance. Metal-organic frameworks(MOFs)-derived materials have been a promising alternative in addressing the catalyst deactivation problems in FTS because of the encapsulation of their metal nanoparticles in carbon matrix and absence of large particle size, among other reasons. Therefore, this review emphasizes the most recent research headway in the investigation of MOFs as precursors to achieve high-performance FTS catalysts. Precisely, the design of iron and cobalt-based FTS catalysts from parent MOFs via MOF-mediated synthesis, the catalytic activity of the MOF-derived materials and the promoter effects under FTS operation were outlined and discussed. We have also evaluated the influence of MOF structures on the FTS performance and compared them with traditional/commercially available catalysts to show the importance of this approach. Finally, the challenges and opportunities to further expedite the extensive research efforts and promote their applications in material design and FT technology were mentioned.

关键词： Metal-organic frameworks Fischer-Tropsch synthesis Catalyst MOFMS Deactivation

P2X7 receptor antagonism in amyotrophic lateral sclerosis

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Neural Regeneration Research 2017年第5期12卷 749-750页

作者： Ronald Sluyter Rachael Bartlett diane Ly justin j.Yerbury School of Biological Sciences and Center for Medical and Molecular Bioscience University of Wollongong Wollongong NSW Australia Illawarra Health and Medical Research Institute NSW Wollongong Australia

Amyotrophic lateral sclerosis（ALS）is a rapidly progressive disorder characterized by the degeneration and subsequent loss of upper and lower motor neurons,resulting in reduced muscle function and paralysis（Mathis et al.,2017）.Current therapies are limited to the oral administration of riluzole,which improves survival by only 3 months（Mathis et al.,2017）.Thus,

关键词： BBG SOD

Tree community composition,structure and diversity along an elevational gradient in an Andean forest of Northern Ecuador

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journal of Mountain Science 2021年第9期18卷 2315-2327页

作者： jIMÉNEZ-PAZ Rosa WORTHY Samantha j VALENCIA Renato PÉREZÁlvaro j REYNOLDS Alex BARONE john A burgess Kevin S Laboratorio de Ecología de Plantas Escuela de Ciencias BiológicasFacultad de Ciencias Exactas y NaturalesPontificia Universidad Católica del EcuadorQuito 17-01-2184Ecuador Department of Biology College of Letters&SciencesColumbus State UniversityColumbusGeorgia 31907USA Herbario QCA Escuela de Ciencias BiológicasFacultad de Ciencias Exactas y NaturalesPontificia Universidad Católica del EcuadorQuito 17-01-2184Ecuador The Lovett School AtlantaGeorgia 30327USA

The Andean forests of northern Ecuador are known for their high levels of plant diversity relative to the area they ***,these forests grow on steep slopes that lead to dramatic habitat gradients across short *** extreme habitat gradients make the Andean forest ecosystem an excellent natural laboratory for understanding the effect of elevation on forest community diversity,structure and *** established 31 plots(50 m×5 m)which are divided between two elevational transects in the cloud forest of the Siempre Verde Reserve in the western foothills of the Andes Mountains of northern *** trees and tree ferns with a diameter at breast height(dbh)≥5 cm were measured and *** examined changes in community composition,structure,and diversity along and between the elevational transects and three elevational zones:low(2437–2700 m),middle(2756–3052 m),and high(3163–3334 m).We found four main trends associated with the elevational gradients at this site:(1)community composition differed between the two transects and among the three elevational zones according to N-MDS,ANOSIM,and percentage of shared species,with some species having limited distributions,(2)metrics of community structure showed opposite relationships with elevation,depending on the transect,with the only significant relationship(negative)found between basal area and elevation in the open trail transect,(3)alpha diversity,in general,peaked at mid-elevations,and(4)beta diversity consistently increased with distance between plots along *** complexity of changes in community composition,structure,and alpha diversity along elevation may be related to the heterogeneity of the environment on a local scale,such as topography,soil composition,and even human impact,or to dispersal limitation and should be investigated *** changes in community composition and the relatively high beta diversity found at this site exemplify the biological complexity of mon

关键词： Elevational gradient Cloud forest Andes Structure Composition Diversity