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文献详情 >采用同轴喷射流实现脂质体的连续生产(英文) 收藏
采用同轴喷射流实现脂质体的连续生产(英文)

采用同轴喷射流实现脂质体的连续生产(英文)

作     者:Diane J.Burgess 

作者单位:Dept. of Pharmaceutical Sciences University of Connecticut 

会议名称:《2018年第十二届中国药物制剂大会》

会议日期:2018年

学科分类:1007[医学-药学(可授医学、理学学位)] 10[医学] 

摘      要:Our laboratory has developed a continuous manufacturing platform for liposomes using a co-axial jet in co-flow and incorporating online PAT(process analytical technology). DOE(design-of-experiments) approaches have been applied in the system design. The platform development will be presented along with application to liposomal drug delivery systems. Our continuous manufacturing platform is capable of tuning liposome particle size with precise control of the polydispersity index(PDI) to achieve monodisperse product. Identifying key process parameters and material attributes of liposomal formulations, such as the z-average particle size, polydispersity index and zeta-potential, are extremely important since they may impact the formulation quality, drug loading and in vivo performance of the final liposomal drug product.

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