检索结果-南通市图书馆

Neural Regeneration Research 2022年第9期17卷 2007-2013页

作者： Qiu-Yuan Gong Lin Cai Yao Jing Wei Wang dian-xu yang Shi-Wen Chen Heng-Li Tian Department of Neurosurgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghaiChina

Urolithin A(UA)is a natural metabolite produced from polyphenolics in foods such as pomegranates,berries,and *** is neuroprotective against Parkinson’s disease,Alzheimer’s disease,and cerebral ***,its effect against traumatic brain injury remains *** this study,we established adult C57BL/6J mouse models of traumatic brain injury by controlled cortical impact and then intraperitoneally administered *** found that UA greatly reduced brain edema;increased the expression of tight junction proteins in injured cortex;increased the immunopositivity of two neuronal autophagy markers,microtubule-associated protein 1A/B light chain 3A/B(LC3)and p62;downregulated protein kinase B(Akt)and mammalian target of rapamycin(mTOR),two regulators of the phosphatidylinositol 3-kinase(PI3K)/Akt/mTOR signaling pathway;decreased the phosphorylation levels of inhibitor of NFκB(IκB)kinase alpha(IKKα)and nuclear factor kappa B(NFκB),two regulators of the neuroinflammation-related Akt/IKK/NFκB signaling pathway;reduced blood-brain barrier permeability and neuronal apoptosis in injured cortex;and improved mouse neurological *** findings suggest that UA may be a candidate drug for the treatment of traumatic brain injury,and its neuroprotective effects may be mediated by inhibition of the PI3K/Akt/mTOR and Akt/IKK/NFκB signaling pathways,thus reducing neuroinflammation and enhancing autophagy.

关键词： autophagy blood-brain barrier cerebral edema controlled cortical impact model neuronal apoptosis neuropharmacology neuroprotection tight junction protein traumatic brain injury urolithin A

Aloin Protects Against Blood-Brain Barrier Damage After Traumatic Brain Injury in Mice

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2020年第6期36卷 625-638页

作者： Yao Jing dian-xu yang Wei Wang Fang Yuan Hao Chen Jun Ding Zhi Geng Heng-Li Tian Department of Neurosurgery Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Department of Neurology Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China

Aloin is a small-molecule drug well known for its protective actions in various models of *** brain injury(TBI)-induced cerebral edema from secondary damage caused by disruption of the blood-brain barrier(BBB) often leads to an adverse *** the role of aloin in maintaining the integrity of the BBB after TBI remains unclear,we explored the protective effects of aloin on the BBB using in vivo and in vitro TBI *** male C57 BL/6 mice underwent controlled cortical impact injury,and mouse brain capillary endothelial bEnd.3 cells underwent biaxial stretch injury,then both received aloin *** the animal experiments,we found 20 mg/kg aloin to be the optimum concentration to decrease cerebral edema,decrease disruption of the BBB,and improve neurobehavioral performance after cortical impact *** the cellular studies,the optimum concentration of 40 μg/mL aloin reduced apoptosis and reversed the loss of tight junctions by reducing the reactive oxygen species levels and changes in mitochondrial membrane potential after stretch *** mechanisms may be that aloin downregulates the phosphorylation of p38 mitogen-activated protein kinase,the activation of p65 nuclear factor-kappa B,and the ratios of B cell lymphoma(Bcl)-2-associated X protein/Bcl-2 and cleaved caspase-3/*** conclude that aloin exhibits these protective effects on the BBB after TBI through its anti-oxidative stress and anti-apoptotic properties in mouse brain capillary endothelial *** may thus be a promising therapeutic drug for TBI.

关键词： Aloin Blood-brain barrier Traumatic brain injury Oxidative stress Apoptosis

Knockout of Sirt2 alleviates traumatic brain injury in mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第2期18卷 350-356页

作者： Wei Wang Qiu-Yuan Gong Lin Cai Yao Jing dian-xu yang Fang Yuan Hao Chen Heng-Li Tian Department of Neurosurgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghaiChina

Sirtuin 2(SIRT2)inhibition or Sirt2 knocko ut in animal models protects against the development of neurodegenerative diseases and cerebral ***,the role of SIRT2 in traumatic brain injury(TBI)remains *** this study,we found that knockout of Sirt2 in a mouse model of TBI reduced brain edema,attenuated dis ruption of the blood-brain barrie r,decreased expression of the nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3)inflammasome,reduced the activity of the effector caspase-1,reduced neuroinflammation and neuronal pyroptosis,and improved neurological *** kout of Sirt2 in a mechanical stretch injury cell model in vitro also decreased expression of the NLRP3 inflammasome and *** findings suggest that knockout of Sirt2 is neuro protective against TBI;***2 could be a novel to rget for TBI treatment.

关键词： blood-brain barrier caspase-1 cerebral edema neuroinflammation neuroprotection NLRP3 pyroptosis Sirt2 tightjunction protein traumatic brain injury

Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after experimental traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 130-136页

作者： Ren Wang dian-xu yang Ying-Liang Liu Jun Ding Yan Guo Wan-Hai Ding Heng-Li Tian Fang Yuan Department of Neurosurgery Shanghai Jiao Tong University Affiliated Sixth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Shanghai Tenth People’s HospitalTongji UniversityShanghaiChina

Our previous study showed that cell cycle exit and neuronal differentiation 1(CEND1)may participate in neural stem cell cycle exit and oriented ***,whether CEND1-transfected neural stem cells can improve the prognosis of traumatic brain injury remained *** this study,we performed quantitative proteomic analysis and found that after traumatic brain injury,CEND1 expression was downregulated in mouse brain *** days after traumatic brain injury,we transplanted CEND1-transfected neural stem cells into the area surrounding the injury *** found that at 5 weeks after traumatic brain injury,transplantation of CEND1-transfected neural stem cells markedly alleviated brain atrophy and greatly improved neurological *** vivo and in vitro results indicate that CEND1 overexpression inhibited the proliferation of neural stem cells,but significantly promoted their neuronal ***,CEND1 overexpression reduced protein levels of Notch1 and cyclin D1,but increased levels of p21 in CEND1-transfected neural stem *** with CEND1-transfected neural stem cells was superior to similar treatment without CEND1 *** findings suggest that transplantation of CEND1-transfected neural stem cells is a promising cell therapy for traumatic brain *** study was approved by the Animal Ethics Committee of the School of Biomedical Engineering of Shanghai Jiao Tong University,China(approval No.2016034)on November 25,2016.

关键词： cell cycle exit and neuronal differentiation 1 cyclin D1 embryonic neural stem cells neuronal differentiation genetic engineering overexpression mice Notch1 p21 traumatic brain injury

Inhibiting phosphatase and actin regulator 1 expression is neuroprotective in the context of traumatic brain injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第7期18卷 1578-1583页

作者： Yao Jing Lin Zhang Shi-Wen Chen Yan Guo Shi-Ming Ju Fang Yuan Hao Chen dian-xu yang Heng-Li Tian Zhi-Ming xu Jun Ding Department of Neurosurgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina

Studies have found that the phosphatase actin regulatory factor 1 expression can be related to stroke,but it remains unclear whether changes in phosphatase actin regulatory factor 1 expression also play a role in traumatic brain *** this study we found that,in a mouse model of traumatic brain injury induced by controlled cortical impact,phosphatase actin regulatory factor 1 expression is increased in endothelial cells,neurons,astrocytes,and *** we overexpressed phosphatase actin regulatory factor 1 by injection an adeno-associated virus vector into the contused area in the traumatic brain injury mice,the water content of the brain tissue ***,when phosphatase actin regulatory factor 1 was knocked down,the water content *** also found that inhibiting phosphatase actin regulatory factor 1 expression regulated the nuclear factor kappa B signaling pathway,decreased blood-brain barrier permeability,reduced aquaporin 4 and intercellular adhesion molecule 1 expression,inhibited neuroinflammation,and neuronal apoptosis,thereby improving neurological *** findings from this study indicate that phosphatase actin regulatory factor 1 may be a potential therapeutic target for traumatic brain injury.

关键词： apoptosis aquaporin 4 blood brain barrier intercellular adhesion molecule 1 neuroinflammation nuclear factor kappa B occludin phosphatase and actin regulator-1 traumatic brain injury zonula occludens 1

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 917-935页

作者： dian Jiao Lai xu Zhen Gu Hua Yan Dingding Shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

基于多分支增强和融合注意力机制的水下图像增强算法

在线全文

学校读者我要写书评

暂无评论

陕西科技大学学报 2025年第1期43卷 193-202页

作者：姚斌韩典芝徐轩李婉陕西科技大学电子信息与人工智能学院陕西西安710021

由于水对光的折射和吸收,水下图像通常会出现严重的退化,如色偏、模糊、能见度低等.为了提高水下图像的可视性,提出了一种基于多分支增强和融合注意力机制的水下图像增强网络MBFA-GAN.首先,通过分析水下图像的色彩退化和模糊因素,设计... 详细信息

由于水对光的折射和吸收,水下图像通常会出现严重的退化,如色偏、模糊、能见度低等.为了提高水下图像的可视性,提出了一种基于多分支增强和融合注意力机制的水下图像增强网络MBFA-GAN.首先,通过分析水下图像的色彩退化和模糊因素,设计了青品色温修复模块和模糊恢复模块对水下图像进行色彩矫正和模糊恢复.然后,基于对多个分支特征的互补性考虑,采用循环合并策略将多个分支增强的特征利用自适应融合模块进行融合,逐步增强图像细节.最后,设计了融合注意力模块,用于深度挖掘图像在通道维度和像素维度的相关性矩阵,以提高增强图像的真实性.实验结果表明,与现有算法相比,提出的水下图像增强算法去模糊效果较好且颜色更真实,可以有效改善水下图像色偏和模糊的问题.

关键词：水下图像增强多分支增强融合注意力生成对抗网络

Improving dispersion and delamination of graphite in biodegradable starch materials via constructing cation-π interaction: Towards microwave shielding enhancement

在线全文

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第34期129卷 196-205页

作者： Yi yang Jun-Ru Tao dian yang Qian-Ming He xu-Dong Chen Ming Wang Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China Key Laboratory of Polymer Composite and Function Materials of Ministry of Education Key Laboratory for Designed Synthesis and Applied Polymer MaterialsSchool of Chemistry and Chemical EngineeringSun Yat-sen UniversityGuangzhou 510275China

Herein, a low-cost, biodegradable, and high-performance microwave shielding graphite/starch material was fabricated via constructing a cation-π interaction between ammonium ions and graphite. The graphite flakes and starch were firstly mixed with distilled water containing ammonium hydroxide to form graphite/starch slurry under an ultrasonic assistant. The cation-π interaction could improve delamination degree and dispersion of graphite in starch matrix. The slurry was first used as a coating material on the surface of wood and paper to develop shielding packages. The effect of coating thickness and coating layers on EM shielding property of the materials was investigated. Second, the composites with a high orientation of graphite were fabricated by compression at high pressures. The electrical conductivity and EM shielding effectiveness(SET) of the materials were greatly enhanced by construction of cation-πinteraction and orientation of graphite. Specifically, the EM SETvalues increased from 56.9 to 66.8 d B for the composites with 50 wt.% graphite and 2.0 mm in thickness by constructing cation-π interaction. The EM SETvalues raised from 17.4 to 66.8 d B via the graphite orientation in the materials with the same components and thickness. The shielding mechanism of the compressed composites with orientation dispersion of graphite was also discussed in comparison to the coating layer with random dispersion of graphite.

关键词： Electromagnetic shielding Graphite Starch Bio-degradable Cation-πinteraction

Total Quantum Statistical Entropy of Reissner-Nordstrom Black Holes: Scalar Field Case

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2001年第10期18卷 1312-1315页

作者： xu dian-Yan Institute of Microelectronics and Department of Computer Science and Technology Peking UniversityBeijing 100871

The total quantum statistical entropy of Reissner-Nordstrom (RN) black holes is evaluated. The spacetime of the black holes is divided into three regions-region 1, (r > ro);region 2, (ro > r > ri);andregion 3, (ri > r > 0)-where ro is the radius of the outer event horizon, and ri is the radius of the inner event horizon. The total quantum statistical entropy of RN black holes is S = S1 + S2 + Ss, where Si (i = 1, 2, 3) is the entropy, contributed by region Si (i = 1, 2, 3). The detailed calculation shows that S2 ≈ 0. S1 = (π^(2)/45)[kbAo/∈^(2)β^(3)], S3 = -(r2/45)[kbAi/∈^(2)β^(3)], where Ao and Ai are, respectively, the area of the outer and inner event horizons. Thus, as ri approaches ro, in the extreme case the total quantum statistical entropy of RN black holes approaches zero.

关键词： entropy Reissner radius

Quantum Statistical Entropy of Spherical Black Holes in Higher Dimensions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 2000年第10期17卷 705-707页

作者： xu dian-Yan Institute of Microeletronics and Department of Computer Science and TechnologyPeking UniversityBeijing 100871

The free energy and entropy of a general spherically symmetry black hole are calculated by quantum statistic method with brick wall model Two different kinds of approximation are used to calculate the number of states in transverse spatial space. The final results are approximately equal except a rational numerical constant. The formulas of free energy and entropy, evaluated by each one of the two different kinds of approximation, are the same except some numerical constants. The free energy and entropy are dependent on the spacetime dimensionsD. When D = 4, they reduce to the usual well known results.

关键词： space. entropy dimensions