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The Effect of Spironolactone Loading on the Properties of 3D-Printed Polycaprolactone/Gold Nanoparticles Composite Scaffolds for Myocardial Tissue Engineering

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Journal of Bionic Engineering 2024年第2期21卷 924-937页

作者： Sharareh Ghaziof Shahrokh Shojaei Mehdi Mehdikhani Mohammad khodaei Milad Jafari Nodoushan Department of Biomedical Engineering Central Tehran BranchIslamic Azad UniversityTehran***Iran Stem Cells Research Center Tissue Engineering and Regenerative Medicine InstituteCentral Tehran BranchIslamic Azad UniversityTehran***Iran Department of Biomedical Engineering Faculty of EngineeringUniversity of IsfahanIsfahan***Iran Materials Engineering Group Golpayegan College of EngineeringIsfahan University of TechnologyGolpayegan87717-67498Iran Hard Tissue Engineering Research Center Tissue Engineering and Regenerative Medicine InstituteCentral Tehran BranchIslamic Azad UniversityTehran***Iran

Engineered cardiac constructs(ECC)aid in the progression of regenerative medicine,disease modeling and targeted drug delivery to adjust and aim the release of remedial combination as well as decrease the side effects of *** this research,polycaprolactone/gold nanoparticles(PCL/GNPs)three-dimensional(3D)composite scaffolds were manufactured by 3D printing using the fused deposition modeling(FDM)method and then coated with gelatin/spironolactone(GEL/SPL).Scanning electron microscopy(SEM)and Fourier transform-infrared spectroscopy(FTIR–ATR)were applied to characterize the ***,drug release,biodegradation,behavior of the myoblasts(H9C2)cell line,and cytotoxicity of the 3D scaffolds were *** microstructural observation of the scaffolds reported interconnected pores with 150–300µm in *** 3D scaffolds were degraded significantly after 28 days of immersion in stimulated body fluid(SBF),with the maximum rate of GEL-coated 3D *** release from cross-linked GEL coating demonstrated the excess of drug release over time,and according to the control release systems,the drug delivery systems(DDS)went into balance after the 14th *** addition,cell culture study showed that with the addition of GNPs,the proliferation of(H9C2)was enhanced,and with GEL/SPL coating the cell attachment and viability were improved *** findings suggested that PCL/GNPs 3D scaffolds coated with GEL/SPL can be an appropriate choice for myocardial tissue engineering.

关键词： Polycaprolactone Gold nanoparticles Drug delivery systems Spironolactone Cell behavior Myoblasts

First Light Curve Analysis of NSVS 8294044,V1023 Her,and V1397 Her Contact Binary Systems

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Research in Astronomy and Astrophysics 2024年第5期24卷 1-12页

作者： Atila Poro Sabrina Baudart Mahshid Nourmohammad Zahra Sabaghpour Arani Fatemeh Farhadi Selda Ranjbar Salehian Ahmad Sarostad Saeideh Ranjbaryan Iri Olya Maryam Hadizadeh AmirHossein khodaei Astronomy Department of the Raderon AI Lab. BurnabyBCCanada Double Stars Committee SociétéAstronomique de FranceParisFrance Independent Astrophysics Researcher IsfahanIran Akhtaran Astronomical Society Isfahan ProvinceAran and BidgolIran Department of Physics Faculty of ScienceZanjan UniversityZanjanIran Astronomy Students'Scientific Association University of TabrizEast Azerbaijan ProvinceTabrizIran Yazd Desert Night Sky Astronomy Institute Yazd ProvinceYazdIran Ayaz Astronomical Association East Azerbaijan ProvinceTabrizIran Khayyam Astronomy Association FarsFasaIran

The first photometric light curve investigation of the NSVS 8294044,V1023 Her,and V1397 Her binary systems is *** used ground-based observations for the NSVS 8294044 system and Transiting Exoplanet Survey Satellite data for V1023 Her and V1397 *** primary and secondary times of minima were extracted from al the data,and,by collecting the literature,a new ephemeris was computed for each *** fits for the O-C diagrams were conducted using the Markov Chain Monte Carlo (MCMC) *** curve solutions were performed using the PHysics Of Eclipsing BinariEs Python code and the MCMC *** systems were found to be contact binary stars based on the fillout factor and mass ratio.V1023 Her showed the O’Connell effect and a cold starspot on the secondary component was required for the light curve *** absolute parameters of the system were estimated based on an empirical relationship between orbital period and *** presented a new T–M equation based on a sample of 428 contact binary systems and found that our three target systems were in good agreement with the *** positions of the systems were also depicted on the M–L,M–R,q–L_(ratio),and M_(tot)–J_(0)diagrams in the logarithmic scales.

关键词： (stars:)binaries eclipsing-techniques photometric-stars individual(NSVS 8294044)

Evaluation the Properties of Polycaprolactone/Fluorapatite Nano-biocomposite

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Journal of Bionic Engineering 2022年第1期19卷 179-187页

作者： Mojtaba Momeni Kamran Amini Ali Heidari Mohammad khodaei Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahr84181-48499IsfahanIran Center for Advanced Engineering Research Majlesi BranchIslamic Azad University86316-56451IsfahanIran Materials Engineering Group Golpayegan College of EngineeringIsfahan University of Technology87717-67498GolpayeganIran

In this study,nano-biocomposites of polycaprolactone(PCL)as the matrix and different amounts of nanofluorapatite(nFA)(0,10,20 and 30 wt.%)as the reinforcement were prepared for possible scaffold fabrication using the fused filament fabrication(FFF)3D *** Emission Scanning Electron Microscopy(FE-SEM)and Energy Dispersive Spectroscopy(EDS)showed that nFA particles were well distributed in the PCL matrix.X-ray diffraction analysis(XRD)and Fourier Transform Infrared Spectroscopy(FTIR)depicted no chemical interaction between the elements of the *** Scanning Calorimetric(DSC)analysis was then used to assess the thermal properties of the composites,suggesting that this could be due to the amorphous phase formation of the intermolecular hydrogen bonds between PCL and nFA,resulting in the suppression of PCL *** results of mechanical characterization also showed that the addition of nFA up to 20 wt.%to the PCL increased the tensile and yield strength,as well as reducing the elongation at both yield and failure points and increasing the Young *** best mechanical properties were obtained for the PCL/20nFA *** strength and Young modulus were increased by 30%and 179%,respectively;meanwhile,elongation of PCL/20nFA was decreased by 70%,as compared to the naked *** changes could be attributed to the better distribution of the nFA filler in the PCL *** to the obtained results,PCL/20nFA could be regarded as a good composite in terms of the mechanical properties for the regeneration of the bone tissue.

关键词： Nano-biocomposite Polycaprolactone Fluorapatite Bone tissue engineering Mechanical properties

Detailed seismic risk analysis of electrical substation equipment using a reliability based approach

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 495-511页

作者： Amir Ghahremani Baghmisheh Milad khodaei Ali Zare Feiz Abadi Homayoon E.Estekanchi Department of Civil Engineering University of British ColumbiaVancouver V6T 2B8Canada Department of Civil Engineering University of TabrizTabriz 51666Iran Department of Civil Engineering Sharif University of TechnologyTehran 11155-9313Iran

This paper proposes a risk analysis framework for substation structures based on reliability *** though several risk assessment approaches have been developed for buildings,detailed risk analysis procedures for infrastructure components have been lacking in prior *** proposed framework is showcased by its application to a system of interconnected structures at a power substation in *** element models of structures are developed and validated in accordance with previous *** uncertainties in the material,mass,and geometric properties of structures are described by random variables that are input to the finite element *** artificial ground motion model is employed to comprehensively consider uncertainty in ground *** Carlo sampling is subsequently conducted on the library of probabilistic *** analysis resulted in the loss distribution in the life cycle of ***,the loss associated with six earthquake scenarios having specific magnitudes and return periods is *** application provides insight into the most vulnerable equipment in the considered ***,introduced risk measures can guide stakeholders to make risk-based decisions to optimize design or prioritize a retrofit of infrastructure components under conditions of uncertainty.

关键词： seismic risk reliability analysis infrastructure components loss estimation uncertainty

Immune response differences in degradable and non-degradable alloy implants

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Bioactive Materials 2023年第6期24卷 153-170页

作者： Taravat khodaei Elizabeth Schmitzer Abhirami P.Suresh Abhinav P.Acharya Biomedical Engineering School of Biological and Health System EngineeringArizona StateUniversityTempeAZ85281USA Biological Design Arizona State UniversityTempeAZ85281USA Chemical Engineering School for the Engineering of MatterTransportand EnergyArizona StateUniversityTempeAZ85281USA Materials Science and Engineering School for the Engineering of MatterTransportand EnergyArizona State UniversityTempeAZ85281USA Center for Immunotherapy Vaccines and VirotherapyArizona State UniversityTempeAZ85281USA

Alloy based implants have made a great impact in the clinic and in preclinical *** responses are one of the major causes of failure of these implants in the *** the immune responses toward non-degradable alloy implants are well documented,there is a poor understanding of the immune responses against degradable alloy ***,there have been several reports suggesting that degradable implants may develop substantial immune *** phenomenon needs to be further studied in detail to make the case for the degradable implants to be utilized in ***,we review these new recent reports suggesting the role of innate and potentially adaptive immune cells in inducing immune responses against degradable ***,we discussed immune responses to allergen components of non-degradable implants to give a better overview on differences in the immune response between non-degradable and degradable ***,we also provide potential areas of research that can be undertaken that may shed light on the local and global immune responses that are generated in response to degradable implants.

关键词： alloy utilized implants

Effect of Different Titanium Surface Treatments on the Adhesion Test Result:Dental Application

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Journal of Wuhan University of Technology(Materials Science) 2023年第1期38卷 255-259页

作者： Alireza Valanezhad Masayoshi Suzue Sirus Safaee Mahdis Nesabi Mohammad khodaei Shigeaki Abe Ikuya Watanabe Department of Dental and Biomedical Materials Science Nagasaki UniversityNagasakiJapan Medical Education Development Center Nagasaki University HospitalNagasakiJapan Materials Engineering Group Golpayegan College of EngineeringIsfahan University of TechnologyGolpayegan 87717-67498Iran

The aim of the study was to investigate the effect of different surface treatment of titanium(Ti)on the adhesion test results for dental *** substrates roughened by 400 to 1500-grit SiC polish papers and alumina blasting,alkali treated by 5 molar(M)NaOH and KOH solutions and heat treated at the temperature range of 400-800℃were used in this *** treated samples were subjected to the adhesion *** to the results of the adhesion test,the adhesive strength showed the highest value for the blasted titanium among all polished and blasted *** Ti samples heated at 650℃showed the highest adhesive strength among all heat-treated ***,the adhesion test results indicated the higher adhesive strength of chemically treated samples treated by NaOH rather than that by *** polished and heated Ti samples showed the highest adhesive strength among all samples.

关键词： titanium implant surface treatment bonding strength anatase rutile

Probabilistic load curtailment estimation using posterior probability model and twin support vector machine

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Journal of Modern Power Systems and Clean Energy 2019年第4期7卷 665-675页

作者： Rozhin ESKANDARPOUR Amin khodaei Department of Electrical and Computer Engineering University of DenverDenverCO 80208USA

Estimating the potential load curtailments as a result of hurricane is of great significance in improving the paper proposes a three-step sequential method in identifying such load curtailments prior to *** the first step,a twin support vector machine(TWSVM)model is trained on path/intensity information of previous hurricanes to enable a deterministic outage state assessment of the grid components in response to upcoming *** TWSVM model is specifically used as it is suitable for handling imbalanced *** the second step,a posterior probability sigmoid model is trained on the obtained results to convert the deterministic results into probabilistic outage *** outage states enable the formation of probability-weighted contingency ***,the obtained component outages are integrated into a load curtailment estimation model to determine the expected results,tested on the standard IEEE 118-bus system and based on synthetic datasets,illustrate the high accuracy emergency response and the recovery of power *** potential load curtailments in power *** simulation of the proposed method.

关键词： Hurricanes Machine learning Power system resilience Predictive analytics

Microorganism-derived biological macromolecules for tissue engineering

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Frontiers of Medicine 2022年第3期16卷 358-377页

作者： Naser Amini Peiman Brouki Milan Vahid Hosseinpour Sarmadi Bahareh Derakhshanmehr Ahmad Hivechi Fateme khodaei Masoud Hamidi Sara Ashraf Ghazaleh Larijani Alireza Rezapour Cellular and Molecular Research Center Iran University of Medical SciencesTehran ***Iran Institutes of Regenerative Medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Tissue Engineering and Regenerative Medicine Faculty of Advanced Technologies in MedicineIran University of Medical SciencesTehran ***Iran Department of Pharmaceutics University of MinnesotaMN 55455USA Burn Research Center Department of Plastic and Reconstructive SurgeryIran University of Medical SciencesTehran ***Iran Department of Medical Biotechnology Faculty of ParamedicineGuilan University of Medical SciencesRasht ***Iran Department of Biology Science and Research BranchIslamic Azad UniversityTehran ***Iran Cellular and Molecular Research Centre Qom University of Medical SciencesQom ***Iran Department of Tissue Engineering and Regenerative Medicine School of MedicineQom University of Medical SciencesQom ***Iran

According to literature,certain microorganism productions mediate biological ***,their beneficial characteristics remain ***,scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative *** present review aims to introduce microorganism-derived biological macromolecules,such as pullulan,alginate,dextran,curdlan,and hyaluronic acid,and their available sources for tissue *** evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological *** natural-based materials are attractive in pharmaceutical,regenerative medicine,and biomedical *** study provides a detailed overview of natural-based biomaterials,their chemical and physical properties,and new directions for future research and therapeutic applications.

关键词： biological macromolecules regenerative medicine tissue engineering exopolysaccharide carbohydrate

Surface treatment of titanium dental implant with H2O2 solution

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1281-1286页

作者： Mohammad khodaei Kamran Amini Alireza Valanezhad Ikuya Watanabe Department of Materials Science and Engineering Golpayegan University of TechnologyGolpayegan ***Iran Center for Advanced Engineering Research Majlesi BranchIslamic Azad UniversityIsfahan 196151194Iran Department of Dental and Biomedical Materials Science Graduate School of Biomedical SciencesNagasaki University1-7-1 SakamotoNagasaki 852-8588Japan

The surface treatment is important for titanium and its alloys as promising candidates for dental implantation due to their bioinert *** surface samples were modified using H2O2 solution at different times up to 72 h to boost their *** to the results of the field emission scanning electron microscopy test,some nanostructures are formed on the surface of treated titanium samples and increased in size by increasing the time of treatment up to 24 *** 24 h of application,the sharpness of nanostructures decreased and the micro-cracks and discontinuity in the coating surface *** results of the X-ray diffraction study and Raman spectroscopy revealed that anatase(TiO2)was formed on the surface of treated titanium *** peak intensity of Raman spectroscopy increased with an improvement in treatment time of up to 24 h and then decreased due to the discontinuity of the *** wettability and ability to form apatite were reached at 6 h of *** is clear that the treatment time has a significant effect on the surface treatment of titanium using the H2O2 solution.

关键词： titanium implant surface treatment hydrogen peroxide anatase dental implant