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Use of a tissue clearing technique combined with retrograde trans-synaptic viral tracing to evaluate changes in mouse retinorecipient brain regions following optic nerve crush

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Neural Regeneration Research 2023年第4期18卷 913-921页

作者： Zong-Yi Zhan Yi-Ru Huang Lu-Wei Zhao Ya-Dan Quan Zi-Jing Li di-fang sun Ya-Li Wu Hao-Yuan Wu Zi-Tian Liu Kai-Li Wu Yu-Qing Lan Min-Bin Yu Department of Ophthalmology Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene RegulationSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Light Innovation Technology Ltd. Hong Kong Special Administrative RegionChina Department of Ophthalmology&Visual Science Shanghai Medical CollegeFudan UniversityShanghaiChina Department of Ophthalmology Eye&ENT HospitalFudan UniversityShanghaiChina Department of Ophthalmology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Successful establishment of reconnection between retinal ganglion cells and retinorecipient regions in the brain is critical to optic nerve ***,morphological assessments of retinorecipient regions are limited by the opacity of brain *** this study,we used an innovative tissue cleaning technique combined with retrograde trans-synaptic viral tracing to observe changes in retinorecipient regions connected to retinal ganglion cells in mice after optic nerve ***,we performed light-sheet imaging of whole brain tissue after a clearing *** found that pseudorabies virus 724(PRV724)mostly infected retinal ganglion cells,and that we could use it to retrogradely trace the retinorecipient regions in whole tissue-cleared ***,PRV724-traced neurons were more widely distributed compared with data from previous *** found that optic nerve injury could selectively modify projections from retinal ganglion cells in the hypothalamic paraventricular nucleus,intergeniculate leaflet,ventral lateral geniculate nucleus,central amygdala,basolateral amygdala,Edinger-Westphal nucleus,and oculomotor nucleus,but not the superior vestibular nucleus,red nucleus,locus coeruleus,gigantocellular reticular nucleus,or facial nerve *** findings demonstrate that the tissue clearing technique,combined with retrograde trans-synaptic viral tracing,can be used to objectively and comprehensively evaluate changes in mouse retinorecipient regions that receive projections from retinal ganglion cells after optic nerve ***,our approach may be useful for future estimations of optic nerve injury and regeneration.

关键词： histology image analysis light-sheet imaging optic nerve crush pseudorabies virus retinal ganglion cells three-dimensional imaging tissue clearing viral tracing whole brain study

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The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan sun Lingyun Nie Jing Zhang Xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

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Recent Advances in Fibrous Materials for Hydroelectricity Generation

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Nano-Micro Letters 2025年第2期17卷 109-133页

作者： Can Ge Duo Xu Xiao Feng Xing Yang Zheheng Song Yuhang Song Jingyu Chen Yingcun Liu Chong Gao Yong Du Zhe sun Weilin Xu Jian fang College of Textile and Clothing Engineering Soochow UniversitySuzhou 215123People’s Republic of China National Engineering Laboratory for Modern Silk Soochow UniversitySuzhou 215123People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123People’s Republic of China Department of Electrical and Computer Engineering University of MassachusettsAmherstMA 01003USA Department of Materials Imperial College LondonSouth Kensington CampusLondon SW72AZUK College of Textile Science and Engineering Zhejiang Sci-Tech UniversityHangzhou 310018People’s Republic of China School of Materials Science and Engineering Shanghai Institute of Technology100 Haiquan RoadShanghai 201418People’s Republic of China

Depleting fossil energy sources and conventional polluting power generation pose a threat to sustainable *** generation from ubiquitous and spontaneous phase transitions between liquid and gaseous water has been considered a promising strategy for mitigating the energy *** materials with unique flexibility,processability,multifunctionality,and practicability have been widely applied for fibrous materials-based hydroelectricity generation(FHG).In this review,the power generation mechanisms,design principles,and electricity enhancement factors of FHG are first ***,the fabrication strategies and characteristics of varied constructions including 1D fiber,1D yarn,2D fabric,2D membrane,3D fibrous framework,and 3D fibrous gel are ***,the advanced functions of FHG during water harvesting,proton dissociation,ion separation,and charge accumulation processes are analyzed in ***,the potential applications including power supply,energy storage,electrical sensor,and information expression are also ***,some existing challenges are considered and prospects for future development are sincerely proposed.

关键词： Hydroelectricity Fibrous material Streaming potential Ion diffusion

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Control strategy for wayside supercapacitor energy storage system in railway transit network

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Journal of Modern Power Systems and Clean Energy 2014年第2期2卷 181-190页

作者： Zongyu GAO Jianjun fang Yinong ZHANG di sun College of Automation of Beijing Union University Beijing 100101China School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

This paper discusses the control strategy for energy management in railway transit network with wayside(substation)supercapacitor(SC)energy storage system(ESS).Firstly,the structure of the wayside energy storage system is ***,the model of energy storage system is built and the control strategy is ***,in order to estimate the required energy storage system,a useful method is proposed to predict the instantaneous regenerative energy magnitude which is delivered to each ***,the ESS configuration for each substation is determined.A simplified mathematical model of the whole metro network is established and the main features of the control strategy are *** simulations show the efficacy of suggested control strategy and the energy saving obtained for railway transit network.

关键词： Supercapacitor(SC) Energy storage system(ESS) Regeneration failure Control strategy Railway transit network

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Microstructure and hot ductility behavior of Ni-based superalloy U720Li with boron addition

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Rare Metals 2021年第5期40卷 1145-1154页

作者： Guang-di Zhao fang Liu Xi-Min Zang Wen-Ru sun School of Material and Metallurgy University of Science and Technology LiaoningAnshan 114051China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

High-alloyed superalloy U720 Li is difficult to be processed through the conventional cast and wrought *** is an important strengthening element for superalloys,but the role of boron in the hot ductility of U720 Li alloy is not *** study is focused on the effect of boron addition,in the range ofdition significantly increases the content of eutectic(γ+γ’)and greatly affects the degree of continuity of the grain boundary eutectic(γ+γ’)*** addition dramatically worsens the 1100℃ tensile ductility of conventional cast U720 Li alloy and causes a change in tensile fracture mode from transgranular to *** eutectic(γ+γ’)represents the most effective site for crack *** deteriorates the hot ductility mainly by promoting the continuous precipitation of eutectic(γ+γ’)along the grain boundary.

关键词： Boron U720Li Eutectic(γ+γ’) Hot ductility Fracture mechanism

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A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： Kun-Peng Yang Song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin sun Zhang-Chi Ling Huai-Bin Yang De-Han Li Qing-fang Guan Shu-Hong Yu Department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

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Hierarchical auditory perception for species discrimination and individual recognition in the music frog

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Current Zoology 2022年第5期68卷 581-591页

作者： Yanzhu Fan Ke fang Ruolei sun di Shen Jing Yang Yezhong Tang Guangzhan fang Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610041China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Life Science Anhui UniversityHefei 230601China

The ability to discriminate species and recognize individuals is crucial for reproductive success and/or survival in most ***,the temporal order and neural localization of these decision-making processes has remained *** this study,event-related potentials(ERPs)were measured in the telencephalon,diencephalon,and mesencephalon of the music frog Nidirana *** ERPs were elicited by calls from 1 group of heterospecifics(recorded from a sympatric anuran species)and 2 groups of conspecifics that differed in their fundamental *** terms of the polarity and position within the ERP waveform,auditory ERPs generally consist of 4 main components that link to selective attention(N1),stimulus evaluation(P2),identification(N2),and classification(P3).These occur around 100,200,250,and 300 ms after stimulus onset,*** results show that the N1 amplitudes differed significantly between the heterospecific and conspecific calls,but not between the 2 groups of conspecific calls that differed in fundamental *** the other hand,the N2 amplitudes were significantly different between the 2 groups of conspecific calls,suggesting that the music frogs discriminated the species first,followed by individual identification,since N1 and N2 relate to selective attention and stimuli identification,***,the P2 amplitudes evoked in females were significantly greater than those in males,indicating the existence of sexual dimorphism in auditory *** addition,both the N1 amplitudes in the left diencephalon and the P2 amplitudes in the left telencephalon were greater than in other brain areas,suggesting left hemispheric dominance in auditory *** together,our results support the hypothesis that species discrimination and identification of individual characteristics are accomplished sequentially,and that auditory perception exhibits differences between sexes and in spatial dominance.

关键词： event-related potentials(ERPs) individual identification music frog species discrimination temporal hierarchy

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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A glove-based system for object recognition via visual-tactile fusion

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Science China(Information Sciences) 2019年第5期62卷 11-13页

作者： Bin fang Fuchun sun Huaping LIU Chuanqi TAN di GUO Department of Computer Science and Technology Tsinghua University

Dear editor,In our daily life, information such as tactile and visual information is widely used to recognize objects when we manipulate them. Research has shown that the human brain makes use of multisensory models o... 详细信息

关键词： DTW

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Transformation Mechanism of (γ+γ') and the Effect of Cooling Rate on the Final Solidification of U720Li Alloy

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Acta Metallurgica Sinica(English Letters) 2017年第9期30卷 887-894页

作者： Guang-di Zhao Guo-Liang Yang fang Liu Xin Xin Wen-Ru sun Institute of Metal Research Chinese Academy of Sciences School of Materials Science and Engineering University of Science and Technology of China

The transformation mechanism of （γ ＋γ′） was studied by analyzing the microstructure and elemental distri- bution of the U720Li samples heated at 1250℃ and cooled at the rates in the range of 1-100℃/s. Although the （γ ＋γ′） is deemed to be formed by a eutectic reaction and has been called eutectic （γ ＋γ′）, it was found in the present study that the （γ ＋γ′） precipitation begins with a peritectic reaction of （L ＋ γ）γ′, and develops by the eutectic reaction of L （γ ＋γ′）. The energy for the γ′ nucleation is low because the interfacial energy for the γ /γ′ interface is about one-tenth of the solid/liquid interface, and hence, the nucleation rate is high and the fine structure of （γ ＋ γ′） is formed at the initial precipitation stage. The γ and γ′ in （γ ＋ γ′） tend to grow into a lamellar structure because it is difficult for them to nucleate directly from the residual liquids, and hence, the γ′ precipitates naturally tend to grow divergently direction of the regions rich in AI and Ti, forming a fan-like structure of the （γ ＋γ′）. As a result, the γ′ precipitates will coarsen finally because the space between them is enlarged. The solidification of the final residual liquids is a diffusion dependent process. When cooled at a higher rate, a higher degree of super cooling is reached and finally the solidification is finished by the pseudo- eutectic reaction of L → （γ ＋ boride） and L→ （γ ＋γ′）, which can absorb Zr and B. When cooled at a rate low enough, most of the residual liquids are consumed by the （γ ＋γ′） growth due to the sufficient diffusion, and the boride and Zr- bearing phase are precipitated at a quasi-equilibrium state. Under this condition, Ti is depleted at the （γ ＋γ′） growth front. However, the η-Ni3Ti phase is formed there occasionally due to the boride precipitation, because the compositions of the two phases are complementary.

关键词： U720Li (γ +γ′) formation mechanism Cooling rate Solidification

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