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diabetes Mellitus and COVID-19 at Abass Ndao Hospital Epidemic Treatment Center (ETC)

Open Journal of Endocrine and Metabolic diseases 2022年第4期12卷 91-102页

作者： diallo Ibrahima Mané diédhiou demba Ndour Michel Assane Sow Djiby diallo Adja Tacko Mané dieng Mouhamed Gadji Fatou Kiné Thioye El Hadji Mamadou Moussa Bassène Joseph Ndiaye Ndeye Fama Mody Sarr Anna Ndour Mbaye Maimouna Medical Clinic II Abass Ndao Hospital Center Cheikh Anta Diop University of Dakar Dakar Senegal

Introduction: SARS-COV2 infection is a major public health problem and diabetes mellitus is a serious factor. The objective was to determine the characteristics of COVID-19 in diabetics at the Epidemic Treatment Center (ETC) of the Abass Ndao Hospital Center. Observation: This was a retrospective, descriptive and analytical study carried out at Abass Ndao Hospital from March 01, 2021 to September 31, 2021. We evaluated the epidemiological, clinical and evolutionary characteristics. Results: Among 333 patients infected with COVID-19, 203 were diabetic (60.96%). The sex ratio was 0.70 and the mean age 60.18 years. diabetes was type 2 (84.2%) and inaugural (15.8%). Arterial hypertension was the main comorbidity (86.96% of cases). The RT-PCR test was positive in 86.21% of cases. The main clinical signs were: asthenia (90.14%), dyspnea (78.81%), cough (52.21%) and body aches (52.21%). Oxygen saturation was alanced in 71.43% with an average blood sugar of 2.02 ± 4 g/l. At the paraclinical, the D dimer was ≥1000 ng/l (71.52%) and the C-reactive protein ≥100 mg/l (32.01%). Chest CT scan found mild to moderate (55.17%), severe (21.67%) and critical (17.24%) lung lesions. Pulmonary embolism was found in 4 diabetics. The treatment of diabetes was represented by insulin therapy (85.82%) and oral antidiabetics (24.11%). Anti-COVID-19 treatment was dominated by azithromycin (89.11%), corticosteroid therapy (92.11%), anticoagulants (99%), hydroxychloroquine (21.29%). Mortality was found in 14.36% (n = 29) and significantly correlated with age ≥ 60 years (OR = 3.013 [1.266 - 7.173], P = 0.005), short duration of hospitalization (OR = 3.154 [1.149 - 8.663], P = 0.009), C-reactive protein > 100 mg/l (OR = 6.370 [2.704 - 15.006], P diabetes is one of the most important comorbidities linked to the severity of SARS-CoV-2 infection. The seriousness factors in this field remain age ≥ 60 years,

关键词： Abass Ndao diabetes Mellitus ETC SARS-CoV-2 Senegal

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Profile of Pituitary Adenomas in Senegal: Epidemiological, Clinical and Therapeutic Aspects about 241 Collected Cases

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Open Journal of Internal Medicine 2023年第3期13卷 144-154页

作者： diédhiou demba diallo Ibrahima Mané Mbaye Maguette Sow Djiby Ndiaye Fama Mody Ndour Michel Assane dieng Mouhamed Gadji Fatou Kiné Thioye Elhadj Mamadou Halim Charles Ndao Cheikh Matar Ndiaye Boun Khatab diouf Sarr Anna Ndour Mbaye Maimouna Medical Clinic II AbassNdao Hospital Center Cheikh Anta Diop University Dakar Senegal Department of Neurosurgery Fann Hospital Center Cheikh Anta Diop University Dakar Senegal

Introduction: in adults, adenomas are the most frequent causes of pituitary tumours. The objective was to characterize its epidemiological and clinical aspects, as well as its therapeutic modalities in Senegal. Methodology: this was a multicenter, retrospective, descriptive and analytical study carried out from the Senegalese register of pituitary adenomas (2008-2022). Results: 242 patients were collected with an average age of 42.4 ± 13 years and a sex ratio (M/F) of 0.91. The mean consultation time was 19.7 ± 23 months. The circumstances of discovery were pituitary apoplexy (11 cases, 4.54%), tumor syndrome (176 cases, 72.72%), gonadal manifestations (103 cases, 42.56%), dysmorphic syndrome (21 cases, 8.68%), hypercorticism (15 cases, 6.19%). Morphologically, it was a macroadenoma (197 cases, 81.40%), an extensive adenoma (22 cases, 9.10%). The hormonal profile was lactotropic hypersecretion (80 cases, 33.05%), somatotropic (13 cases, 5.39%), corticotropic (14 cases, 5.78%), mixed (9 cases, 3.71%). The factors significantly associated with prolactinoma were young age (p = 0.000), female sex (p = 0.000), long consultation delay (p = 0.000) and microadenoma (p = 0.001). Only arterial hypertension was associated with acromegaly (p = 0.000). We found a significant correlation between Cushing’s disease and microadenomas (p = 0.000). Non-secreting adenomas were significantly associated with advanced age (p = 0.000), long delay in consultation (p = 0.000), male gender (p = 0.000), tumor syndrome (p = 0.001) and macroadenomas (p = 0.000). Pituitary surgery was effective in 173 patients (71.49%) including 166 cases (68.59%) by transphenoidal approach. Postoperative incidents were transient diabetes insipidus in 82 cases (47.39%), cerebrospinal fluid leak (20 cases, 11.56%). Death was observed in 18 patients in the entire series (7.44%). The latter had a tumor syndrome (88.88%), a macroadenoma (83.33%) and had undergone pituitary surgery (72.22%). Conclusion: pituitary path

关键词： Pituitary Adenoma Prognosis Management Senegal

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Profile of Extra-Pulmonary Tuberculosis in Internal Medicine

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Open Journal of Internal Medicine 2024年第1期14卷 64-73页

作者： Mouhamed dieng Djiby Sow demba diédhiou Michel Assane Ndour Boundia Djiba Mouhamed Almahy Niang Matar Ndiaye Oumar Boun Khattab diouf Fatou Kiné Gadji Anna Sar Maïmouna Ndour Mbaye Clinique Médicale II H&ocircpital Aristide Abass Ndao Université Cheikh Anta Diop Dakar Sénégal

Introduction: Tuberculosis is an infectious disease that mainly affects the lung. Extrapulmonary localizations are a reason for hospitalization in our health facilities. The objective of this study was to describe the epidemiological, clinical, paraclinical and evolutionary aspects of extra pulmonary tuberculosis (EPT) at the Abass Ndao Hospital Center. Patients and Methods: This was a descriptive cross-sectional study conducted over a period of 11 years (January 1, 2010 to December 30, 2021). All patients with extrapulmonary tuberculosis hospitalized in the department of internal medicine during the recruitment period were included. Results: Fifty-two (52) patients were collected. The year 2019 recorded the most cases 23.08% (n = 20). The mean age of the patients was 40.56 ± 18.24 years. The age group 20 - 34 years 42.31% (n = 22) was the most represented. Females were in the majority 61.54% (n = 32) with a sex ratio (M/F) was 0.63. Housewives were in the majority 40.38% (n = 21). 60.87% of the cases (n = 14) came from a health facility. 38.46% of the cases had been infected. 21.74% (n = 9) were smokers. The reasons for consultation were dominated by fever (67.44%), AEG (62.79%) and cough (41.86%). Eighteen patients (40.91%) had fever. The mean time to consultation was 77.37 ± 90.3 days with extremes of 3 and 365 days. The median was 45 days. More than half of the patients 61.90% (n = 26) had anemia. Positive retroviral serology was noted in 21.43% of cases. All patients had a CRP greater than 6. More than half of the patients 51.92% (n = 27) had multifocal tuberculosis. The peritoneum 44.23% (n = 23) was the main organ affected. The average hospital stay was 9.8 ± 4.9 days with extremes of 1 and 19 days. All patients had received the protocol in force at the national level. Death was noted in 4 patients (9.52%). Conclusion: EPT is characterized in our context by a notorious diagnostic difficulty due to the multiplicity of clinical presentations, the complexity of

关键词： Extrapulmonary Tuberculosis Epidemiology diagnosis Senegal

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Epidemiological Aspects of Obesity, Overweight and Cardiovascular Risk Factors at Associes in Semi-Urban Areas (Case of Sébikotane)

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Food and Nutrition Sciences 2024年第5期15卷 390-400页

作者： Djiby Sow Nafy Ndiaye Mouhamed Yakham Leye Maty diagne Camara Michel Assane Ndour Mouhamed dieng Houleye Saou Ndiouga Fall Boundia Djiba demba diédhiou Im diallo Anna Sarr Mbaye Maimouna Ndour Abdoulaye Leye Clinique Mé dicale II Centre Hospitalier Abass Ndao Universit&#233 Cheikh Anta Diop de Dakar Dakar Senegal Pikine Department of Internal Medicine and Endocrinology Cheikh Anta Diop University Dakar Senegal Department of Public Health Cheikh Anta Diop University Dakar Senegal

Introduction: Obesity and overweight are a public health problem. The general objective was to determine the epidemiological aspects of obesity, overweight and associated risk factors in a semi-urban environment. Patients and Methods: This was a cross-sectional, descriptive study conducted on November 28 and 29, 2023 in Sébikotane. It focused on volunteers for screening for chronic non-communicable diseases. Epidemiological and clinical data were evaluated. Results: One hundred and twenty-nine cases of obesity were recorded (28%). Two hundred and eighty-two cases were overweight or obese (61.3%). The mean age was 49.55 years, with a standard deviation of 12.41 years. The age group [40 - 49 years] was the most representative, with 85 cases (30.1%), and the majority were female, with 264 cases (93.6%). Primary education was the most common, with 75 cases (46.3%). Grade 1 obesity concerned ninety-seven cases (75.2%), and diabetes was present in thirty cases (23%). Hypertension was present in ninety-five cases (33.7%). Obesity was more marked in the age group [40 - 49 years] with 45 cases (36%). Conclusion: Obesity and overweight are a major cause of morbidity and mortality. The development and implementation of a prevention and management program is essential.

关键词： Obesity Overweight Risk Factors Sébikotane Senegal

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Prevalence of Microalbuminury and Associated Risk Factors in a Population of diabetics Followed at the Marc Sankale Center of Dakar

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Open Journal of Internal Medicine 2018年第1期8卷 24-32页

作者： Sow Djiby diédhiou demba Ndour Michel Assane diallo Ibrahima Mané diouf Mahecor Ka-Cissé Marie Sarr Anna Ndour Mbaye Maimouna Clinique Médicale II Centre Hospitalier Abass Ndao UCAD Dakar Senegal

Introduction: To describe the epidemiologic profile, clinical and paraclinical of diabetics presenting microalbuminuria at Marc Sankale center. Patients and methods: We have done cross-sectional and retrospective study in a descriptive and analytic view or way. It happened within 6 months. diabetic patients who performed the nycthemeral urinary albumin dose and mentioned in the file were included. The last study is considered as a positive one from 30 to 299mg/24h: Microalbuminuria. The creatinine has been noted and the clearing of the creatinine is calculated through the formula of Cockcroft and Gault. The statistical analysis of data has been done thanks to software such as excel 2013 and SPSS VER 18.0. Results: 221 patients have been noted with 70% women and 30% men. The age varied between 30 years and 85 years with an average of 56, 62 against 9.97 years. Sixty three (63) patients have microalbuminuria (29%);creatinine has been regularized to 25 patients with 14.8% of cases. Among the microalbuminuria patients having completed the creatinine, 32 patients (42.7%) and 16 (21.3%) are respectively in a state of chronical renal failure, light and moderated. Conclusion: The microalbuminuria is frequent to diabetics. But in our series a starting renal insufficiency could precede that microalbuminuria.

关键词： diabetics Microalbuminuria Renal Insufficiency Senegal

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Factors Associated with Death in Subjects Admitted for a diabetological Emergency: Experience of the Medical Clinic II of the Abass Ndao Hospital Center in Dakar (Senegal) —Death in diabetic Emergencies

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Open Journal of Endocrine and Metabolic diseases 2018年第1期8卷 38-48页

作者： diédhiou demba Sow Djiby diallo Ibrahima Mané diallo Abdou Karim Ndour Michel Assane Sarr Anna Ndour-Mbaye Maimouna diop Said Norou Department of Internal Medicine II University Hospital Center of Dakar Cheikh Anta Diop University Dakar Senegal Department of Preventive Medicine and Public Health University Hospital Center of Dakar Cheikh Anta Diop University Dakar Senegal

Introduction: Metabolic and vascular emergencies constitute a risk of lethality in diabetic subjects admitted to hospital. The objective was to evaluate the factors associated with death in subjects admitted for a diabetological emergency to improve management. Materials and Methods: It was a 12-month retrospective, descriptive and analytical study at Dakar’s Marc Sankale diabetes Center. The study concerned any type of diabetics subjects admitted for a diabetological emergency. We evaluated the profile of diabetes, the pathologies found and factors associated with death. Results: We identified 697 cases of diabetic emergencies with a prevalence of 13.8%. The sex ratio (M/F) was 0.82, the mean age was 49.6 years, and the mean duration of diabetes was 7.1 years. The metabolic profile was hypoglycemia (11.3%), ketoacidosis (34.6%), and hyperosmolar hyperglycemia syndrome (5%). The associated pathologies were vascular (51.1%), infectious (65.3%), kidney function impairment (7.6%), anaemia (13.8%). During the follow-up, 94 patients died, as an annual frequency of 13.5% among diabetological emergencies. In univariate analysis, the factors significantly associated with death were age > 60 years [OR = 4.09 (2.6 - 6.41)], hyperglycemia [OR = 2.58 (1.50 - 4.4)], hyperosmolar hyperglycemia syndrome [OR = 10.5 (5.19 - 21.5)], septic diabetic foot [OR = 3.57 (2.24 - 5.66)]. Vascular pathologies that significantly associated with death were stroke [OR = 4.06 (2.10 - 7.81)], lower limb arteriopathy [OR = 3.25 (1.84 - 5.73)], cardiovascular collapse [OR = 6.85 (2.34 - 20)]. In addition to diabetes, the deceased patients had one (18%), two (34%) and at least three (45.7%) known factors of poor prognosis. Conclusion: Emergencies in diabetology remain frequent in our practice. The comorbidity (vascular and infectious) constitutes a risk of abnormally high death rate. A particular attention must concern on old diabetics subjects with several pathologies.

关键词： diabetological Emergencies Mortality Risk Factors Senegal

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Contribution of High Sensible C-Reactive Protein (hsCRP) in the Assessment of the Risk of Onset of Type 2 diabetes and Its Cardiovascular Complications

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Journal of diabetes Mellitus 2024年第2期14卷 95-107页

作者： Maïmouna Touré Léopold Ngor Sène Jean Pierre diagne demba diédhiou Souleymane Thiam Abdou Khadir Sow Mor diaw Aïssatou Seck Salimata diagne Houndjo Abdoulaye Ba Abdoulaye Samb Fatou diallo-Agne Modou Oumy Kane Laboratoire de Physiologie et d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal IRL3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire Privé de Biologie General Kaolack S&#233n&#233gal Centre Hospitalier Universitaire (CHU) Abasse Ndao Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Biochimie et de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Physiologie Pharmaceutique Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

Background: Type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia. The latter plays an essential role in inflammation by stimulating the production of pro-inflammatory cytokines or by increasing their secretion by an oxidative mechanism. These cytokines control the hepatic synthesis of an inflammatory protein called C-Reactive Protein (CRP). High or average values of CRP would have a predictive value of cardiovascular diseases and type 2 diabetes. The relationship between low CRP values and the risk of developing type 2 diabetes and its cardiovascular complications is not sufficiently studied. The hsCRP could serve as a predictive biomarker of risk of onset, follow-up and prognosis for type 2 diabetes and its cardiovascular complications. To answer this problem, we conducted this study, the aim of which was to study the predictive role of hsCRP in the risk of occurrence of type 2 diabetes and its cardiovascular complications. Materials and Methods: This is a prospective and cross-sectional case-control study involving 200 participants including 100 control women and 100 women with type 2 diabetes (mean age was respectively 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). The interviews were conducted on the basis of a questionnaire. Physical examination collected biometric data and cardiovascular constants. The biochemical parameters such as hsCRP were analyzed by an automated Abbott device. Results: We noted that hsCRP was significantly higher in type 2 diabetic subjects compared to control subjects (p (rho = 0.40, p systolic blood pressure (rho = 0.30, p = 0.003), diastolic blood pressure (rho = 0.28, p = 0.006), total body fat (rho = 0.48, p Conclusion: hsCRP has a prognostic value in the evaluation of cardiovascular risk. It seems to play an important role in the pathogenesis of type 2 diabetes mellitus and its cardiovascular complications. It could thus be considered as a biomarker for the screening, monitoring and prognosis of type 2

关键词： hsCRP Biomarker Inflammation Type 2 diabetes

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The Knowledge, Attitudes and Practices of diabetics on Physical Activity at the Marc Sankale Center of Dakar

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Open Journal of Internal Medicine 2018年第1期8卷 33-41页

Introduction: The objective of that study was to evaluate diabetics knowledge, attitudes and practices on physical activity. Patients and Methods: That study has concerned 200 diabetics at Marc Sankale antidiabetic Center of Abass Ndao Hospital in Dakar. Women represent 76% with a sex ratio M: F0.13. The average age is 54 years with extremes of 4 to 84 years. The housewives are 29% and among them 15% haven’t any professional activity. 45.07% of the population is illiterate. In our study, 63.13% of patients have low socio economic level. In our series, the majority of patients is type 2 diabetes (89.5%). The diabetes evolution time is about 8 years inferior to 7% in 84 patients. In our study obesity is noted in 17.20% of cases. The HTA is present in 56% of cases. 54% of the studied population presents a dyslipidemia. Physical activity is practiced in 81% of patients. In our study the doctor’ advice motivates the half of our patients to practice physical activity (62.26%). The lack of time (43.2%) and volution (8.1%), the useless character of physical activity (2.7%) and the patients’ health state 45.9% are the obstacles to the practice of physical activity. The average frequency of physical activity practiced by patients is about 4 times a week with extremes ranging from 1 to 7 stages a week. The average time of activity practiced by patients is 39.72% with extremes ranging from 10 to 150 mn. 87% of patients practice physical activity at least 3 times a week. The main risks noted from intense physical activity in diabetics are hypertension 39.0%, ortestic hypertension 3.0%. In the contrary 58.8% of patients ignore the answer. Conclusion: Our study demonstrates the ignorance of diabetics on physical activity. Therefore it would be necessary to reinforce the training mainly therapeutic education in the patients taken into account.

关键词： diabetes Mellitus Risk Factor Knowledge Physical Activity Senegal

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Survey on Knowledge of Cardiovascular disease Risk Factors in the Dakar Region

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Journal of diabetes Mellitus 2024年第2期14卷 122-132页

作者： Djiby Sow Nafy Ndiaye Mouhamed Yakham Leye Fulgence A. Faye Michel Assane Ndour Marie Joseph Gomis Fall Ndiouga Mouhamed dieng Boundia Djiba Houleye Saou Ibrahima M. diallo demba diédhiou Anna Sarr Mbaye Maimouna Ndour Abdoulaye Leye Clinique Mé dicale II Centre Hospitalier Abass Ndao UCAD Dakar Senegal Department of Internal Medicine and Endocrinology Centre Hospitalier Pikine Dakar Senegal Department of Medicine Faculty of Health and Sustainable Development Alioune Diop University of Bambey Bambey Senegal

Introduction: Non-communicable diseases constitute a major public health problem, due to their morbi-mortality. The aim was to study knowledge of cardiovascular risk factors among residents of Dakar. Patients and Methods: This was a descriptive cross-sectional study. Our investigations were recruited over a six-month period (October 17, 2021 to March 21, 2022). Results: Two hundred and twenty-six (226) patients were enrolled. The mean age was 45.9 years. The under-40 age group was the most represented with 37.2%. There were 129 men (57.1%), giving a male/female sex ratio of 1.33. The highest level was represented by 159 people (70.4%). Those who responded (heart disease) were in the majority (38.1%). Hypertension was the most common CVD for 101 people (44.7%). One hundred and ninety (190) people (84%) knew the risk factors for CVD. Good knowledge of risk factors concerned 103 people (54.2%). Obesity was the best-known risk factor in 156 cases (69%). The media was the most important source of information for 121 people (53.5%). Hypertensives were the most represented with 8.4%. One hundred and thirty (130) people (57.5%) had previously paid attention to these FDRCVs. Awareness campaigns were the most effective means of communication for 170 cases (75.2%). Sixteen (16) people (35.6%) were taking antihypertensive medication. Walking was the most popular physical activity for 102 people (45%). People with a balanced diet were in the majority, with 174 respondents (77.0%). Conclusion: NCDs are a major cause of morbidity and mortality. It is essential to develop and implement a prevention and management program.

关键词： Hypertension diabetes Risk Factors Senegal

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Knowledge, Attitudes and Practices (K.A.P) of Pharmacy Pharmacists of the Department of Dakar in the Care of diabetics

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Journal of diabetes Mellitus 2019年第3期9卷 113-125页

作者： diallo Ibrahima Mane diédhiou demba Sow Djiby Ndour Michel Assane Aissatou Camara Ahmet Limane Barrage M. Ka-Cissé Sarr Anna Ndour-Mbaye Maimouna Clinique Médicale II Centre Hospitalier Abass Ndao UCAD Dakar Senegal

Aim: To evaluate the attitude practice and knowledge of pharmacists in the management of diabetes in the department of Dakar. Methodology: Cross-sectional study, conducted from 01 March to 30 September 2017 including all pharmacists in the Dakar region who agreed to participate in the survey. Data was collected through a pre-established questionnaire. Results: A total of 144 pharmacists were included in the study, representing a participation rate of 87.58%. The average age was 33.90 years, with a sex ratio of 1.69. Pharmacists were single in 50.88% of cases, and a minimum experience of 5 years was found in 64.03% of cases. Pharmacist assistants accounted for 57.9% of our study population. The assessment of knowledge based on 16 items shows an average score of 9.02. The level of knowledge was low to insufficient in 37.21% of cases, average in (50%) half of cases and good for (13.16%). Less than half (34.21%) of pharmacists had received training and the average date of last training was 33.76 ± 24.6 months. Training was provided by medical representatives and academics in 66.66% and 26.67% respectively. The most felt positive feelings were respectively the need for help, the compassion in respectively 98.42%, 42.11%. Feelings felt and simultaneously cited were: need for help and compassion in more than 40% of respondents. Only 29% of pharmacists did not have a lot of difficulty with patient questions and the only reason was the lack of awareness (84.68%) of patients about their disease. Screening for diabetes by capillary blood glucose was performed by 57% of pharmacists. dietary advice (76.15%) and referral to the hospital (94.41%) were the most common practices in case of blood sugar disruption. The dialogue with patients was impossible in 22.81% of pharmacists and the main reasons given were lack of time (53.85%) and lack of knowledge (34.62%). The method of delivery of insulin was done on: medical prescription (98.25%), presentation of the box (69.30%), on reques

关键词： Management Pharmacist diabetes Dakar

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