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Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition:Harnessing the power of nanotheranostics

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 79-101页

作者： Sagnik Nag Oishi Mitra Bhanu Maturi Simran Preet Kaur Ankita Saini Muskan Nama Soumik roy Souvik Samanta Leena Chacko Rohan Dutta Suresh Babu Sayana Vetriselvan Subramaniyan Jasvinder Singh Bhatti Ramesh Kandimalla Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia Department of Bio-Sciences School of Bio-Sciences&Technology(SBST)Vellore Institute of Technology(VIT)Tiruvalam RoadVellore 632014Tamil NaduIndia Department of Internal Medicine University of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Delhi(South Campus)Benito Juarez RoadNew Delhi 110021India Department of Biotechnology Indian Institute of TechnologyHyderabad(IIT-H)SangareddyTelangana 502284India BioAnalytical Lab Meso Scale Discovery1601 Research BlvdRockvilleMDUSA Department of Pharmacology Government Medical CollegeSuryapetTelanganaIndia Laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathindaIndia Department of Biochemistry Kakatiya Medical CollegeWarangal 506007India

Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition(DHC),which encompasses a complex range of cardiovascular issues linked to diabetes and associated *** significant progress in reducing mortality rates from cardiovascular diseases(CVDs),heart failure remains a major cause of increased morbidity among diabetic *** cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components,and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and *** a variety of conventional diagnostic and therapeutic strategies are available,DHC continues to present a significant ***-of-care diagnostics,supported by nanobiosensing techniques,offer a promising alternative for these complex *** conventional medications have been widely used in DHC patients,they raise several concerns regarding various physiological *** medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DHC,offering a promising approach to deliver drugs beyond the limitations of traditional *** article aims to explore the potential connections between autophagy,mitophagy and DHC,while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.

关键词： Autophagy Diabetes Diabetic heart condition Mitophagy Nanotheranostics Nanomedicine

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Textile dyeing wastewater negatively influences the hematological profile and reproductive health of male Swiss albino mice

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Asian pacific Journal of Reproduction 2024年第4期13卷 169-177页

作者： Taimur Islam Nusrat Binte Rafique Mohosina Mou Dipu roy Robius Sani Sadi Ziban Chandra Das Anup kumar Talukder Minhaz Ahmed Mizanur Rahman Golam Haider Department of Pathobiology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Gynecology Obstetrics and Reproductive HealthBangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Agroforestry and Environment Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Department of Physiology and Pharmacology Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh

Objective:To determine the effects of textile dyeing industrial wastewater on the hematological parameters and reproductive health including histoarchitecture of male gonad(testes)of ***:Twenty-four Swiss albino mice at 4-weeks old were divided into four groups(n=6 per group).Mice of group 1 supplied with normal drinking water were served as the control *** of group 2,3 and 4 were supplied normal drinking water mixed with textile dyeing wastewater at 5%,10% and 20% concentration,*** completing 24 weeks of treatment,different hematological profile,weight of testes,gonadosomatic index(GSI),sperm concentration and morphology were ***,histopathological changes in testes were ***:Hematocrit value and hemoglobin concentrations were decreased in all groups of wastewater-treated mice compared to the control ***,weight of testes,GSI and sperm concentration were decreased significantly in wastewater-treated mice in comparison to the control *** percentage of morphologically healthy epididymal sperm was significantly reduced in wastewater-treated *** examination revealed degenerative changes in seminiferous tubules,a smaller number of spermatogenic cells,elongation of seminiferous tubules and degenerative changes of seminiferous tubules in wastewater-treated ***:Textile dyeing wastewater has harmful effects on hematological profile and reproductive health of male mice.

关键词： Textile dyeing wastewater Gonads Hematology Histopathology Mice

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以职业技术教育构建绿色可持续发展的未来——加拿大应用技术与职业学院协会(CICan)的实践与思考

教育国际交流

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教育国际交流 2024年第2期 25-29页

作者： Alain roy 刘媛(译) 加拿大应用技术与职业学院协会不详

在国际社会的共同努力下,联合国《2030年可持续发展议程》的进程已经过半,我们距离实现可持续发展目标只剩下6年时间。创新比以往任何时候都更加重要。人工智能(AI)等技术有可能彻底改变我们的商业模式以及培养未来劳动力的方式。在这... 详细信息

在国际社会的共同努力下,联合国《2030年可持续发展议程》的进程已经过半,我们距离实现可持续发展目标只剩下6年时间。创新比以往任何时候都更加重要。人工智能(AI)等技术有可能彻底改变我们的商业模式以及培养未来劳动力的方式。在这样一个前所未有的全球化的世界里,各国的劳动力都需要具备全球竞争力。职业技术教育与培训(TVET)机构不仅可以支持国家经济发展,同时也能带领我们的社区实现可持续发展的理想未来,通过提供基于技能培训的终身学习机会,让每个人能各尽其能、各展其长。

关键词：职业技术教育可持续发展目标终身学习绿色可持续发展全球竞争力各尽其能未来劳动力技能培训

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Credit Card Fraud Detection Using Machine Learning Techniques

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Journal of Computer and Communications 2024年第6期12卷 1-11页

作者： Ananya Sarker Must. Asma Yasmin Md. Atikur Rahman Md. Harun Or Rashid Bristi Rani roy Department of Computer Science and Engineering Bangladesh Army University of Engineering & Technology (BAUET) Natore Bangladesh

Credit card companies must be able to identify fraudulent credit card transactions so that clients are not charged for items they did not purchase. Previously, many machine learning approaches and classifiers were used to detect fraudulent transactions. However, because fraud patterns are always changing, it is becoming increasingly vital to investigate new frauds and develop the model based on the new patterns. The purpose of this research is to create a machine learning classifier that not only detects fraud but also detects legitimate transactions. As a result, the model should have excellent accuracy, precision, recall, and f1-score. As a result, we began with a large dataset in this study and used four machine learning classifiers: Support Vector Machine (SVM), Decision Tree, Naïve Bayes, and Random Forest. The random forest classifier scored 99.96% overall accuracy with the best precision, recall, f1-score, and Matthews correlation coefficient in the experiments.

关键词： Support Vector Machine Decision Tree Nave Bayes Random Forest Matthews Correlation

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轴向双级氨/甲烷湍流预混火焰燃烧特性及NO生成

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化工学报 2024年

作者：张泽雨王平戴凯论钱伟佳 Subhajit roy 帅瑞洋 Antonio Ferrante 江苏大学能源研究院浙江大学清洁能源利用国家重点实验室能源与环境中心米兰Gioia del Colle(BA)

氨气燃烧面临着氮氧化物排放高、燃烧稳定性差等问题，而分级燃烧概念是解决上述问题的途径之一，但其中复杂的燃烧特性尚不明确。为此，对一个自主设计的轴向空气分级氨气-甲烷湍流燃烧装置开展了详细的实验测量和大涡模拟研究。以氨/... 详细信息

氨气燃烧面临着氮氧化物排放高、燃烧稳定性差等问题，而分级燃烧概念是解决上述问题的途径之一，但其中复杂的燃烧特性尚不明确。为此，对一个自主设计的轴向空气分级氨气-甲烷湍流燃烧装置开展了详细的实验测量和大涡模拟研究。以氨/甲烷的混合物为燃料，首级当量比保持为1.2，总当量比在0.4-0.9之间改变，通过实验测量获得了一氧化氮（NO）随总当量比的变化特性，采用大涡模拟结合动态火焰增厚模型对3个燃烧状态进行了计算分析，计算结果与实验数据吻合良好。研究表明：随着总当量比的减小，NO排放呈增加的趋势；燃烧室内存在两种燃烧模式，上游是金黄色的含氨燃气富燃预混火焰，下游则是淡蓝色的氢气-空气扩散火焰为主；一级燃烧室中，NO排放主要受OH影响，而二级燃烧室中NO生成受OH影响变小。

关键词：双级氨气燃烧湍流预混燃烧一氧化氮排放数值模拟燃烧实验测量

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The Prevalence of Overweight/Obesity and Related Comorbidities among HIV-Positive and HIV-Negative Patients Attending the Same Clinics in Gaborone, Botswana

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Advances in Infectious Diseases 2024年第3期14卷 523-540页

作者： Jose Gaby Tshikuka Matshwenyego Boitshwarelo Shimeles Genna Hamda roy Tapera Ngoyi Kashiba Zacharie Bukonda Marie Esako Onokoko Department of Family Medicine and Public Health Faculty of Medicine University of Botswana Gaborone Botswana Department of Nursing Science Faculty of Health Sciences National Pedagogical University Kinshasa I Congo Department of Public Health Faculty of Medicine University of Mbuji-Mayi Mbuji-Mayi Congo School of Public Health Faculty of Health Sciences University of Botswana Gaborone Botswana

Context: Antiretroviral therapy (ART) helps restore the health status of people living with HIV (PLHIV). Likewise, it increases the risk of overweight/obesity and related comorbidities among the recipients. In countries like Botswana where ±84% of PLHIV is on ART, the paucity of data comparing overweight/obesity between HIV-positive on ART and HIV-negative patients may impede clinical and policy decision-making. This study sought to estimate and compare: i) the prevalence of overweight/obesity between HIV-positive on ART and HIV-negative patients;ii) the prevalence of hypertension (HTN), diabetes mellitus (DM)/coronary heart disease (CHD) between HIV-positive patients on ART and HIV-negative patients attending same outpatient departments of general clinics in Gaborone, Botswana. Patients and Methods: Five hundred eighty-one (581) outpatients were recruited in four major clinics of Gaborone, Botswana, between June and July 2019;294 or 51% of them were HIV-negative and 287 or 49% were HIV-positive on ART. The prevalence of overweight/obesity and of HTN and DM/CHD were calculated and examined using stratified analysis. Subgroups were compared using Chi-square analysis with Yates correction or Fisher exact test and t-student test for continuous data. Results: Major findings after stratification of the study population by HIV status were: i) the prevalence of all categories of (BMI), including overweight/obesity, were comparable between HIV-negative-patients and HIV-positive. In fact, there were 24 (8.0%) cases of underweight among HIV-negative-Patients and 15(5%) cases among HIV-positive patients, p = 0.2;145 (49%) HIV-negative-patients and 128 (45%) HIV-positive, p = 0.07 cases of normal weight;72 (25%) HIV-negative-patients and 87 (30%) HIV-positive, p = 0.08, were overweight;53 (18%) HIV-negative-patients and 57 (20%) HIV-positive, p = 0.12, were obese;125 (43%) HIV-negative patients and 144 (50%) HIV-positive, p=0.06 were overweight/obese;ii) the prevalence of HTN a

关键词： Overweight/Obesity Related Comorbidities HIV-Positive HIV-Negative

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Recharge and vulnerability assessment of groundwater resources in North west India:Insights from isotope-geospatial modelling approach

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Geoscience Frontiers 2024年第1期15卷 247-262页

作者： Annadasankar roy Sitangshu Chatterjee Uday kumar Sinha Anil kumar Jain Hemant Mohokar Ajay Jaryal Tirumalesh Keesari Harish Jagat Pant Isotope and Radiation Application Division Bhabha Atomic Research CentreTrombayMumbai–400085India Homi Bhabha National Institute Mumbai 400094India Central Ground Water Board AhmedabadGujaratIndia

Recent studies indicate dwindling groundwater quantity and quality of the largest regional aquifer system in North West India,raising concern over freshwater availability to about 182 million population residing in this *** agricultural activities have resulted severe groundwater pollution in this area,demanding a systematic vulnerability assessment for proactive *** vulnerability assessment models encounter drawbacks due to subjectivity,complexity,data-prerequisites,and spatial-temporal *** study incorporates isotopic information into a weighted-overlay framework to overcome the above-mentioned limitations and proposes a novel vulnerability assessment *** isotope methodology provides crucial insights on groundwater recharge mechanisms(18O and 2H)and dynamics(3H)-often ignored in vulnerability *** characterisation of precipitation helped in establishing Local Meteoric Water Line(LMWL)as well as inferring contrasting recharge mechanisms operating in different *** aquifer(depth<60 m)showed significant evaporative signature with evaporation loss accounting up to 18.04%based on Rayleigh distillation ***-aquifer connections were apparent from Kernel Density Estimate(KDE)and isotope correlations.A weighted overlay isotope-geospatial model was developed combining 18O,3H,aquifer permeability,and water level *** central and northern parts of study area fall under least(0.29%)and extremely(1.79%)vulnerable zones respectively,while majority of the study area fall under moderate(42.71%)and highly vulnerable zones(55.20%).Model validation was performed using groundwater NO3-concentration,which showed an overall accuracy up to 82%.Monte Carlo Simulation(MCS)was performed for sensitivity analysis and permeability was found to be the most sensitive input parameter,followed by 3H,18O,and water *** the vulnerability map with Land Use Land Cover(LULC)and population density maps

关键词： Agricultural pollution Data scarcity Recharge mechanism Rayleigh distillation Isotope-geospatial model Vulnerability assessment

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In Vitro Antioxidant and Radio Protective Activities of Lycopene from Tomato Extract against Radiation—Induced DNA Aberration

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Journal of Biosciences and Medicines 2024年第2期12卷 202-213页

作者： Safaiatul Islam Abu Hena Mostofa Kamal Md. Ziaur Rahman Protul kumar roy A.Y.K. Md. Masud Rana Molecular Radiobiology and Biodosimetry Division Institute of Food and Radiation Biology Bangladesh Atomic Energy Commission Savar Bangladesh

Background: The accumulation of free radicals is linked to a number of diseases. Free radicals can be scavenged by antioxidants and reduce their harmful effects. It is therefore essential to look for naturally occurring antioxidants that come from plants, as synthetic antioxidants are toxic, carcinogenic and problematic for the environment. Lycopene is one of the carotenoids, a pigment that dissolves in fat and has antioxidant properties. Materials and Methods: The antioxidant and free radical scavenging activity were assessed using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The impact of lycopene on bacteria (E. coli) susceptibility to γ-radiation was examined by radio sensitivity assay. The study also examined the induction of strand breaks in plasmid pUC19 DNA and how lycopene extract protected the DNA from γ-radiation in vitro. Results: At varying concentrations, lycopene demonstrated its ability to scavenge free radicals such as 2, 2-diphenyl-1-picrylhydrazyl (DPPH). IC50 for lycopene was determined at 112 μg/mL which was almost partial to IC50 of standard antioxidant L-ascorbic acid. The D10 value 180 Gy of E. coli was found to be >2-fold higher in the extract-containing lycopene sample than in the extract-free controls. The lycopene extracts inhibited the radiation-induced deterioration of the plasmid pUC19 DNA. At an IC50 concentration, lycopene provided the highest level of protection. Conclusion: Lycopene functions as an efficient free radical scavenger and possible natural antioxidant source. For cancer patients and others who frequently expose themselves to radiation, lycopene may be a useful plant-based pharmaceutical product for treating a variety of diseases caused by free radicals.

关键词： Radio Protective Antioxidants Free Radical DNA Damage pUC19 Plasmid Gamma Irradiation DPPH

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Battery health management-a perspective of design,optimization,manufacturing,fault detection,and recycling

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Energy Storage and Saving 2024年第3期3卷 190-208页

作者： Pavel M.roy Harsh H.Sawant Pratik P.Shelar Prashil U.Sarode S.H.Gawande Industrial Tribology Laboratory Department of Mechanical EngineeringM.E.S.College of EngineeringSavitribai Phule Pune UniversityPune411007India

This paper explores the key aspects of battery technology,focusing on lithium-ion,lead-acid,and nickel metal hydride(NiMH)*** delves into manufacturing processes and highlighting their significance in optimizing battery *** addition,the study investigates battery fault detection,emphasizing the importance of early diagnosis using artificial intellignece(AI)and machine learning(ML)*** paper also addresses battery recycling techniques,discussing methods such as pyrometallurgy,hydrometallurgy,mechanical separation,and electrodialysis,considering their environmental *** comprehensive analysis sheds light on the evolution of battery technology and its role in sustainable energy systems.

关键词： Battery health Manufacturing Fault detection Recycling

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莫迪着眼“发达印度”愿景

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商业周刊（中文版） 2024年第7期 22-24页

作者： Ruchi Bhatia Anup roy 易语(译) 不详

印度经济的发展速度真能快到使之可以实现总理莫迪的2047愿景?经济学家对此深表怀疑。2022年8月,印度总理纳伦德拉·莫迪(Narendra Modi)在新德里历史悠久的红堡(Red Fort)发表演讲时作出了一个大胆承诺:到2047年,印度将身发达国家之列... 详细信息

印度经济的发展速度真能快到使之可以实现总理莫迪的2047愿景?经济学家对此深表怀疑。2022年8月,印度总理纳伦德拉·莫迪(Narendra Modi)在新德里历史悠久的红堡(Red Fort)发表演讲时作出了一个大胆承诺:到2047年,印度将身发达国家之列。这种一年一度的独立日演讲通常都不乏空头承诺和宏伟愿景,因此当时也并无人多加在意。

关键词：莫迪空头愿景伦德拉印度经济的发展发达国家承诺

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