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Identifi cation of targets and mechanisms for Eleutheroside E in the treatment of cancer

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Journal of Future Foods 2022年第1期2卷 69-81页

作者： deyong zeng Yi Xiong Yishu Yin Shan Shan Fangyuan Duan Xin Gao Chen Song Mengyao Liu Yingchun Zhang Weihong Lu School of Medicine and Health Harbin Institute of TechnologyHarbin 150001China National and Local Joint Engineering Laboratory for Synthesis Transformation and Separation of Extreme Environmental NutrientsHarbin 150001China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401135China

Eleutheroside E(EE)is a monomer compound isolated from Acanthopanax senticosus,which has functions of antifatigue,antioxidation,and immune regulation.However,the function of EE in inhibiting cancer has rarely been reported.In this study,we used bioinformatics to determine the role and mechanisms of EE in inhibiting breast cancer(BRCA),prostate cancer(PRAD),lung cancer(LUAD),and bladder cancer(BLCA).Finally,the MTT method was used to evaluate the inhibitory effect of EE on breast cancer MDA-MB-231 cells,and the target genes were determined by qRT-PCR.The results showed that the survival rate of MDA-MB-231 cells was reduced by 27.33%after 400μg/mL EE treatment.The results of qRT-PCR showed that EE down-regulated target genes in breast cancer cells,which was consistent with our predicted results.Moreover,our results indicated that EE may have impact on the transcription and translation of BLCA cells by targeting ADCY2,ADCY5 and JUN.In BRCA,we identified three targets for EE.In addition,EE affected DNA repair and the development of BRCA by affecting the expression of RAD51.In LUAD,we identified 9 targets for EE,8 of which were related to DNA repair.EE inhibited PRAD by targeting ADCY8.Our research was the first report on the targets and mechanisms of EE for suppressing cancer combined with clinical data.Our research also provides theoretical support for using EE to suppress cancer.

关键词： Eleutheroside E Cancer Bioinformatics

Carotenoid isomerase regulates rice tillering and grain productivity by its biosynthesis pathway

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Journal of Integrative Plant Biology 2024年第2期66卷 172-175页

作者： Chaoqing Ding Zhengji Shao Yuping Yan Guangheng Zhang Dali zeng Li Zhu Jiang Hu Zhenyu Gao Guojun Dong Qian Qian deyong Ren State Key Laboratory of Rice Biology and Breeding ChinaNational Rice Research InstituteHangzhou 310006China

Tillers are unique inflorescence-like branches in grasses,and their number determines the panicle number,plant architecture,and yield(Shang et al.,2021).Tiller formation mainly undergoes axillary meristem(AM)initiation and tiller bud outgrowth(Wang et al.,2018;Yan et al.,2023).The rice(Oryza sativa)KNOX gene OSH1 is expressed in AMs,and an osh1 mutant produces fewer tillers(Tanaka et al.,2015).

关键词： sativa Oryza panicle

Effects of Space Flight on Expression of Key Proteins in Rice Leaves

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Rice science 2020年第5期27卷 423-433,I0026-I0033页

作者： zeng deyong Cui Jie Yin Yishu Zhang Meng Shan Shan Gao Xin Zhang Yingchun Sun Yeqing Lu Weihong School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150000China National and Local Joint Engineering Laboratory For Synthesis Transformation and Separation of Extreme Environmental NutrientsHarbin 150001China Dalian Maritime University Institute of Environmental Systems BiologyDalian 116026China

As a unique form of abiotic stress, the environmental conditions of outer space are expected to induce changes in plant genomes, proteomes and metabolic pathways. However, the effect of outer space conditions on the overall physiology of plants at the protein level has yet to be reported. To investigate the effects of outer space conditions on the growth-and development-related physiological processes and metabolic pathways of rice different stages, the seeds of rice variety DN423 were sent into orbit for 12.5 d aboard the SJ-10 Returning Satellite, and then the seedlings of both treated and control rice were compared at the three-leaf stage(TLS) and tillering stage(TS). In addition to comparing plant growth and reactive oxygen species(ROS) levels, seedling proteomes were also compared using isobaric tags for relative and absolute quantitation(i TRAQ). Space flight increased TLS plant height by 20%, reduced and increased ROS levels of the TLS and TS seedlings, respectively, and affected the expression of 36 and 323 proteins in TLS and TS leaves, respectively. Furthermore, the functions of the differentially abundant proteins were mainly associated with metabolism, energy, and protein synthesis and degradation. These results suggested that the exposure of seeds to outer space conditions affects the subsequent abundance of key signaling proteins, gene expression, and the processes of protein synthesis and degradation, thereby affecting metabolic processes and promoting adaptation to the abiotic stress of outer space. As such, the present study sheds light on the effects of space flight on plants and contributes to a more comprehensive understanding of extraterrestrial biology.

关键词： differentially abundant protein rice proteomics space flight isobaric tags for relative and absolute quantitation

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采用钠型混床进行发电机冷却水的碱性调节

华北电力技术 1999年第11期 16-20页

作者：曾德勇华能北京热电厂北京100023

水—氢—氢冷型发电机组，发电机冷却水进行碱性调节一般采用补充含氨凝结水来调节ｐＨ，为此介绍了采用钠型混床进行碱性调节处理的原理、标准和运行方式，分析了ｐＨ对发电机冷却水的电导率、铜、铁以及对线棒导热能力的影响等。

关键词：钠型混床发电机冷却水碱性调节

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澄清剂对蓝靛果果汁活性成分和特性的影响

食品科学 2018年第4期39卷 43-48页

作者：曾德永张立钢赵玉红东北林业大学林学院黑龙江哈尔滨150040 哈尔滨工业大学化工与化学学院黑龙江哈尔滨150001 东北农业大学食品学院黑龙江哈尔滨150030

采用8种澄清剂对果汁进行澄清处理,以自然澄清汁和原果汁为对照,比较8种澄清剂对果汁活性成分和特性的影响。结果表明:8种澄清剂对果汁的特性和活性成分含量的影响不同。与其他澄清剂相比,采用聚乙烯聚吡咯烷酮(polyvinylpyrrolidone,PV... 详细信息

采用8种澄清剂对果汁进行澄清处理,以自然澄清汁和原果汁为对照,比较8种澄清剂对果汁活性成分和特性的影响。结果表明:8种澄清剂对果汁的特性和活性成分含量的影响不同。与其他澄清剂相比,采用聚乙烯聚吡咯烷酮(polyvinylpyrrolidone,PVPP)处理的果汁透光率最大,为74.3%(P0.05)。8种澄清剂处理后果汁的p H值差异不显著(P>0.05)。经PVPP处理后果汁的L*值最大,为31.50,L*值最小的为原汁12.50(P0.05)。不同澄清剂对果汁的澄清效果、活性成分和特性影响不同,因此澄清剂的选择应综合各种因素进行考虑。

关键词：蓝靛果果汁澄清剂活性成分特性

上扬子地区下三叠统飞仙关组一段:大灭绝后从停滞海洋到动荡海洋的沉积记录

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地质论评 2010年第6期56卷 769-780页

作者：时志强伊海生曾德勇张华成都理工大学沉积地质研究院成都610059

在P—T界线生物大灭绝事件以后的早三叠世早期,上扬子地区广泛沉积了低能环境纹层状微晶灰岩、灰质页岩或条带状灰岩沉积,代表了P—T事件之后早三叠世最早期上扬子地区所处的古特提斯海海洋循环的近乎停滞;该套低能环境静水沉积广泛见... 详细信息

在P—T界线生物大灭绝事件以后的早三叠世早期,上扬子地区广泛沉积了低能环境纹层状微晶灰岩、灰质页岩或条带状灰岩沉积,代表了P—T事件之后早三叠世最早期上扬子地区所处的古特提斯海海洋循环的近乎停滞;该套低能环境静水沉积广泛见于江油、广元、旺苍、重庆等地剖面中。上覆于停滞海洋沉积之上的是角砾状灰岩、扁平砾石灰岩、丘状交错层理颗粒灰岩、沙纹层理粉砂岩等和风暴作用有关的动荡海水沉积;低能环境沉积与动荡海水沉积之间常见冲刷、侵蚀界面,这都反映了上扬子地区从停滞海洋到动荡海洋的地质记录。川西北地区角砾状灰岩分布面积大、成因特殊,而扁平砾石灰岩是早三叠世典型的与风暴作用有关的错时相灰岩。沉积岩石显示的从静水条件到与风暴有关的动荡水条件的环境变化,预示着早三叠世早期生物大灭绝以后不同寻常的古海洋和古气候变化。P—T生物大灭绝可能对早三叠世早期古气候和大气循环起到了显著作用,P—T事件后生物对整个地球系统的调节作用减弱,地球系统向极端情况发展的趋势将得不到有效制约,全球古环境与古气候可能因此变得极端恶劣。

关键词：早三叠世飞仙关组一段错时相上扬子地区沉积相演变

LSL1 controls cell death and grain production by stabilizing chloroplast in rice

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Science China(Life Sciences) 2022年第11期65卷 2148-2161页

作者： deyong Ren Wei Xie Qiankun Xu Jiang Hu Li Zhu Guangheng Zhang Dali zeng Qian Qian State Key Lab of Rice Biology China National Rice Research InstituteHangzhou 310006China College of Modern Agriculure Zhejiang A&F UniversityHangzhou 31006China National Nanfan Research Institute Chinese Academy of Agricultural SciencesSanya 572024China

Lesion mutants can be valuable tools to reveal the interactions between genetic factors and environmental signals and to improve grain production.Here we identified a rice(Oryza sativa)mutant,lesion spotleaf1(lsl1),which produces necrotic leaf lesions throughout its life cycle.LSL1 encodes a protein of unknown function and belongs to a grass-specific clade.The lesion phenotype of the lsl1 mutant was sharply induced by shading,and its detached leaves incubated in 6-benzylamino purine similarly formed lesions in the dark.In addition,the lsl1 mutant exhibited reactive oxygen species accumulation and cell death.The terminal deoxynucleotidyl transferase d UTP nick end-labeling(TUNEL)and comet assays revealed that the lsl1 mutant contained severe DNA damage,resulting in reduced grain yield and quality.RNA sequencing,gene expression,and protein activity analyses indicate that LSL1 is required for chloroplast function.Furthermore,LSL1 interacts with Psa D and PAP10 to form a regulatory module that functions in chlorophyll synthesis and chloroplast development to maintain redox balance.Our results reveal that LSL1 maintains chloroplast structure,redox homeostasis,and DNA stability,and plays important roles in the interaction between genetic factors and environmental signals and in regulating grain size and quality.

关键词： lesion formation chloroplast function redox homeostasis grain size and quality LSL1 rice

晚三叠世卡尼期碳酸盐生产危机在东特提斯地区的地质记录

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地质论评 2010年第3期56卷 321-328页

作者：时志强钱利军曾德勇欧莉华成都理工大学沉积地质研究院成都610059

欧洲学者基于阿尔卑斯地区上三叠统卡尼阶地质研究提出卡尼期碳酸盐生产危机(carbonate productivity crisis)或者卡尼期洪水事件(Carnian Pluvial Event)的概念,其主要表现为黑色页岩(或绿色页岩、放射虫硅质岩)覆盖于特提斯范围的碳... 详细信息

欧洲学者基于阿尔卑斯地区上三叠统卡尼阶地质研究提出卡尼期碳酸盐生产危机(carbonate productivity crisis)或者卡尼期洪水事件(Carnian Pluvial Event)的概念,其主要表现为黑色页岩(或绿色页岩、放射虫硅质岩)覆盖于特提斯范围的碳酸盐岩之上,反映了早、晚卡尼期界面处一次明显的碳酸盐沉积中止事件,之上沉积有厚度逐步增加的硅质碎屑岩;这一地质现象在东特提斯地区(中国)卡尼阶中亦有显现,但远未引起重视。实际野外地质调查与前人文献显示,与古特提斯西部、喜马拉雅等地卡尼阶类似,在中国西南部古特提斯范围内的四川盆地西缘、黔中、滇西北、金沙江沿岸等地,卡尼期碳酸盐岩沉积多被一套灰黑色、深灰色页岩(或深色板岩)及之上的陆源碎屑岩覆盖,显示该时期碳酸盐生产的突然中止和生物礁的突然死亡。卡尼期特提斯范围的构造变动很可能对晚三叠世巨型季风气候造成巨大影响,古太平洋暖流向特提斯地区水汽输入增强,相对干旱的气候向相对潮湿的气候转换,大陆风化速率增加,陆源硅质碎屑输入增多,造成了这一显著的地质事件。

关键词：卡尼期巨型季风碳酸盐岩特提斯古气候

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石莼属绿藻多糖的生物活性研究进展

食品工业科技 2021年第2期42卷 364-369页

作者：高鑫山珊曾德永熊毅刘梦瑶卢卫红哈尔滨工业大学化工与化学学院哈尔滨工业大学极端环境营养与防护研究所哈尔滨工业大学极端环境营养分子合成转化与分离技术国家地方联合实验室黑龙江哈尔滨150001

石莼属绿藻中含有多种生物活性物质,其中最主要的生物活性成分为石莼属绿藻多糖(ulvan)。石莼属绿藻多糖是位于绿藻细胞壁上的一类酸性多糖,具有特殊的分子结构,主要由硫酸化的鼠李糖、糖醛酸和木糖组成;其可通过调节细胞信号传导功能... 详细信息

石莼属绿藻中含有多种生物活性物质,其中最主要的生物活性成分为石莼属绿藻多糖(ulvan)。石莼属绿藻多糖是位于绿藻细胞壁上的一类酸性多糖,具有特殊的分子结构,主要由硫酸化的鼠李糖、糖醛酸和木糖组成;其可通过调节细胞信号传导功能而发挥多种生物功能。因此,石莼属绿藻多糖已逐渐成为功能食品和医药等领域的研究热点。本文首先概述了石莼属绿藻多糖的理化性质、平均分子量、单糖组成以及化学结构;其次,详细介绍了石莼属绿藻多糖抗氧化、免疫调节、抗肿瘤、抗凝血、抗病毒和降血脂等生物活性的研究进展;最后介绍了石莼属绿藻多糖结构对活性的影响,以期为石莼属绿藻资源的深入开发和石莼属绿藻多糖的进一步利用提供参考依据。

关键词：石莼属绿藻多糖化学结构生物活性