Identifi cation of targets and mechanisms for Eleutheroside E in the treatment of cancer
作者机构：School of Medicine and HealthHarbin Institute of TechnologyHarbin 150001China National and Local Joint Engineering Laboratory for SynthesisTransformation and Separation of Extreme Environmental NutrientsHarbin 150001China Chongqing Research InstituteHarbin Institute of TechnologyChongqing 401135China
出 版 物：《Journal of Future Foods》 (未来食品学报（英文）)
年 卷 期：2022年第2卷第1期
页 面：69-81页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Eleutheroside E Cancer Bioinformatics
摘 要：Eleutheroside E(EE)is a monomer compound isolated from Acanthopanax senticosus,which has functions of antifatigue,antioxidation,and immune ***,the function of EE in inhibiting cancer has rarely been *** this study,we used bioinformatics to determine the role and mechanisms of EE in inhibiting breast cancer(BRCA),prostate cancer(PRAD),lung cancer(LUAD),and bladder cancer(BLCA).Finally,the MTT method was used to evaluate the inhibitory effect of EE on breast cancer MDA-MB-231 cells,and the target genes were determined by *** results showed that the survival rate of MDA-MB-231 cells was reduced by 27.33%after 400μg/mL EE *** results of qRT-PCR showed that EE down-regulated target genes in breast cancer cells,which was consistent with our predicted ***,our results indicated that EE may have impact on the transcription and translation of BLCA cells by targeting ADCY2,ADCY5 and *** BRCA,we identified three targets for *** addition,EE affected DNA repair and the development of BRCA by affecting the expression of *** LUAD,we identified 9 targets for EE,8 of which were related to DNA *** inhibited PRAD by targeting *** research was the first report on the targets and mechanisms of EE for suppressing cancer combined with clinical *** research also provides theoretical support for using EE to suppress cancer.
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