检索结果-南通市图书馆

Auxetics in Biomedical Applications: A Review

Journal of Minerals and Materials Characterization and Engineering 2023年第2期11卷 27-35页

作者： Sean Rose dexter siu JD Zhu Reem Roufail Department of Systems Design Engineering University of Waterloo Waterloo ON Canada

Materials exhibiting auxetic properties have a negative Poisson’s ratio, which intrigued researchers to understand the behavior of auxetic structure. Several researchers focused on the different auxetic cell designs, while others focused on the auxetic applications. With the advance of additive manufacturing methods, computer-aided design and finite element analysis in recent decades, auxetics have been explored. One of the interesting applications is in the field of biomedical devices or implants, especially for certain natural biomedical organs such as tissues, certain ligaments that have auxetic properties. This paper is an overview of auxetic design approaches and biomedical applications.

关键词： Auxetics Negative Poisson’s Ratio Biomaterials Biomedical Engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Recent advances in optical techniques for dynamically probing cellular mechanobiology

引用

Biomedical Engineering Communications 2024年第3期3卷 3-11页

作者： Fengqi Wang Qin Zhang Mo Yang Bohan Yin siu Hong dexter Wong School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts Qingdao Marine Science and Technology CenterQingdao 266237China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China.

Cellular mechanotransduction characterized by the transformation of mechanical stimuli into biochemical signals,represents a pivotal and complex process underpinning a multitude of cellular *** process is integral to diverse biological phenomena,including embryonic development,cell migration,tissue regeneration,and disease pathology,particularly in the context of cancer metastasis and cardiovascular *** the profound biological and clinical significance of mechanotransduction,our understanding of this complex process remains *** recent development of advanced optical techniques enables in-situ force measurement and subcellular manipulation from the outer cell membrane to the organelles inside a *** this review,we delved into the current state-of-the-art techniques utilized to probe cellular mechanobiology,their principles,applications,and *** mainly examined optical methodologies to quantitatively measure the mechanical properties of cells during intracellular transport,cell adhesion,and *** provided an introductory overview of various conventional and optical-based techniques for probing cellular *** techniques have provided into the dynamics of mechanobiology,their potential to unravel mechanistic intricacies and implications for therapeutic intervention.

关键词： mechanobiology cell adhesion optical techniques live cell imaging cell fates

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy

引用

Engineered Regeneration 2021年第1期2卷 70-81页

作者： Wai Ki Wong Bohan Yin Anel Rakhmatullina Jingying Zhou siu Hong dexter Wong Department of Bioengineering Imperial College LondonLondon SW72AZUnited Kingdom Department of Biomedical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina School of Biomedical Sciences The Chinese University of Hong KongShatinHong KongChina

Adoptive T-cell therapy(ACT)is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the *** outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells,which provides signals for generating different T-cell phenotypes with different roles in tumor ***,such interaction is often not optimal in vivo and results in low therapeutic *** reach the full potential of the T-cell response,current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell *** this perspective,we provide(1)an overview of ACT and general T-cells behaviors,(2)explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors,(3)and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy.

关键词： T-cell mechanobiology Dynamic nanobiomaterials Adoptive T-cell immunotherapy T-Ligand presentation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An AIEgen/graphene oxide nanocomposite(AIEgen@GO)-based two-stage“turn-on”nucleic acid biosensor for rapid detection of SARS-CoV-2 viral sequence

聚集体(英文)

引用

聚集体(英文) 2023年第1期4卷 219-230页

作者： Qin Zhang Bohan Yin Jianhua Hao Linjie Ma Yingying Huang Xueying Shao Chuanqi Li Zhiqin Chu Changqing Yi siu Hong dexter Wong Mo Yang Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Department of Electrical and Electronic Engineering Joint Appointment with School of Biomedical SciencesThe University of Hong KongHong KongChina Key Laboratory of Sensing Technology and Biomedical Instruments(Guangdong Province) School of Biomedical EngineeringSun Yat-Sen UniversityGuangzhouPR China

The ongoing outbreak of Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)pandemic has posed significant challenges in early viral ***,it is urgently desirable to develop a rapid,inexpensive,and sensitive method to aid point-of-care SARS-CoV-2 *** this work,we report a highly sequence-specific biosensor based on nanocomposites with aggregationinduced emission luminogens(AIEgen)-labeled oligonucleotide probes on graphene oxide nanosheets(AIEgen@GO)for one step-detection of SARS-CoV-2-specific nucleic acid sequences(Orf1ab or N genes).A dual“turn-on”mechanism based on AIEgen@GO was established for viral nucleic acids ***,the first-stage fluorescence recovery was due to dissociation of the AIEgen from GO surface in the presence of target viral nucleic acid,and the second-stage enhancement of AIEbased fluorescent signal was due to the formation of a nucleic acid duplex to restrict the intramolecular rotation of the ***,the feasibility of our platform for diagnostic application was demonstrated by detecting SARS-CoV-2 virus plasmids containing both Orf1ab and N genes with rapid detection around 1 h and good sensitivity at pM level without *** platform shows great promise in assisting the initial rapid detection of the SARS-CoV-2 nucleic acid sequence before utilizing quantitative reverse transcription-polymerase chain reaction for second confirmation.

关键词： aggregation-induced emission(AIE)luminogen graphene oxide SARS-CoV-2 detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：