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Retinal capillary plexus in Parkinson’s disease using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 131-136页

作者： Ioannis Giachos spyridon Doumazos Anastasia Tsiogka Konstantina manoli George Tagaris Tryfon Rotsos Vassilios Kozobolis Ioannis Iliopoulos Marilita Moschos First Department of Ophthalmology National and Kapodistrian University of Athens Medical SchoolAthens 11527Greece Department of Neurology General Hospital of Athens“Georgios Gennimatas”Athens 11527Greece Department of Ophthalmology Faculty of MedicineSchool of Health SciencesUniversity of PatrasPatras 26504Greece Neurology Department Democritus University of ThraceAlexandroupolis 68100Greece

AIM:To evaluate the alterations of the retinal microvasculature and foveal avascular zone in patients with Parkinson’s disease(PD)using optical coherence tomography angiography(OCT-A).METHODs:A retrospective study of PD patients examined in the Ophthalmology Department of the General Hospital of Athens,“Georgios Gennimatas”from March 2021 to March 2022 was *** 44 patients with PD were included and 18 healthy controls were examined,hence a total of 124 eyes were enrolled in the *** foveal and parafoveal superficial and deep capillary plexus vascular density(fsCP-VD,fDCP-VD,psCP-VD,pDCP-CD)and foveal avascular zone(FAZ)were quantified with *** coherence tomography(OCT)was used to measure macular *** statistical analysis was conducted by using a mixed effect linear regression ***:After adjustment for age and gender,the mean parafoveal superficial capillary plexus vascular density(psCP-VD)and mean parafoveal deep capillary plexus vascular density(pDCP-VD)were significantly decreased in individuals with PD(Pstatistical *** FAZ area and perimeter were significantly decreased(Pstatistical *** retinal thickness(CRT)was significantly decreased in individuals with PD(Pss(TRT)was decreased(P=0.025)by-11μm(95%CI-22,-1.5)while nasal retinal thickness(NRT)only approached statistical significance(P=0.066).CONCLUsION:The mean psCP-VD,pDCP-VD,CRT and TRT are significantly decreased and FAZ is altered in individuals with *** findings can be potentially used as biomarkers for the diagnosis and evaluation of early PD.

关键词： Parkinson’s disease optical coherence tomography angiography retinal vascular density foveal avascular zone

Influence of immobilization and sensory re-education on the sensory recovery after reconstruction of digital nerves with direct suture or muscle-in-vein conduits

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Neural Regeneration Research 2016年第2期11卷 338-344页

作者： Theodora manoli Jennifer Lynn schiefer Lukas schulz Thomas Fuchsberger Hans-Eberhard schaller Department of Hand Plastic and Reconstructive Surgery Burn Unit BG Trauma Center University of Tuebingen

The influence of duration of immobilization and postoperative sensory re-education on the final outcome after reconstruction of digital nerves with direct suture or muscle-in-vein conduits was investigated. The final sensory outcome of 35 patients with 41 digital nerve injuries, who either underwent a direct suture（Ds） or a nerve reconstruction with muscle-in-vein conduits（MVC）, was assessed the earliest 12 months postoperatively using static and moving two-point discrimination as well as semmes-Weinstein monofilaments. There was no significant difference in sensory recovery in cases with an immobilization of 3–7 days versus 10 days in the Ds or MVC group. Moreover, no statistically significant difference in sensory recovery was found in cases receiving postoperative sensory re-education versus those not receiving in the Ds or MVC group. An early mobilization does not seem to have a negative impact on the final outcome after digital nerve reconstruction. The effect of sensory re-education after digital nerve reconstruction should be reconsidered.

关键词： nerve regeneration peripheral nerve digital nerve sensory re-education immobilization digital direct suture muscle-in-vein conduits

Chromium-Containing Organic Fertilizers from Tanned Hides and skins: A Review on Chemical, Environmental, Agronomical and Legislative Aspects

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Journal of Environmental Protection 2012年第11期3卷 1532-1541页

作者： Claudio Ciavatta Chiara manoli Luciano Cavani Clizia Franceschi Paolo sequi Agricultural Research Council Research Center for the Soil-Plant System Roma Italy Department of Agro-Environmental science and Technology University of Bologna Bologna Italy ILsA spA Arzignano Italy

A category of chromium (Cr)-containing fertilizers is represented by the fertilizers deriving from byproducts of tanning process. Their use is widespread because of their good agronomic response due to the high content of slow release or- ganic nitrogen (N) and carbon (C). They do not represent an environmental hazard because only the non-toxic form of Cr(III) is present. Productive processes may involve chemical, enzymatic or thermal hydrolysis. The final product is characterized by different contents of peptides and free amino acids depending on the type of hydrolysis. Legislation concerning Cr-containing fertilizers is controversial because often do not consider any scientific evidences;nevertheless, the European Union, the United states and countries as Italy, do not set the restriction to Cr(III) and generally only the presence of the toxic form, Cr(VI), is limited. Depending on its two main oxidation forms, Cr issue has been studied for many years. several authors confirmed that Cr(VI) is carcinogenic, while Cr(III) is an essential trace element in human and animal diet. In soil Cr(III) has low mobility, whereas Cr(VI) is highly water soluble. However Cr(VI) in soil is quickly reduced to Cr(III);on the contrary oxidation of Cr(III) to Cr(VI) is rarely possible because particular conditions must occur. Only a very small fraction of Cr in soil is available to plant uptake and its translocation in edible parts is limited because it is immobilized in roots as Cr(III). Therefore risks of environmental pollution using these fertilizers are negligible;on the contrary they have positive environmental and agronomical effects. The aim of this review is to deal with the category of the organic fertilizers containing Cr derived from tannery processes focusing on its chemical, productive, legislative, environmental and agronomical aspects. special attention is given to the ambiguous issue of Cr briefly summarizing the most important studies of the last forty years.

关键词： Organic Fertilizers Tanned Hides and skins Hydrolyzed Leather Trivalent Chromium Hexavalent Chromium soil

DNA extraction from archived hematoxylin and eosin-stained tissue slides for downstream molecular analysis

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World Journal of Methodology 2019年第3期9卷 32-43页

作者： Pushkal sinduvadi Ramesh Venkatesh Madegowda suprith Kumar shailashree Narasimha Parichay s R Nandini Nandish manoli devananda Devegowda Center of Excellence in Molecular Biology and Regenerative Medicine Department of BiochemistryJSS Medical CollegeJSS Academy of Higher Education and ResearchMysuru 570015India CIPHER Healthcare Pvt Ltd. Hyderabad 500034India Department of Pathology JSS Medical CollegeJSS Academy of Higher Education and ResearchMysuru 570015India

BACKGROUND Histopathologically stained archived tissue slides are stored in hospital archives for years to *** are the largest available source of biological materials and are a potentially useful resource that can be used for retrospective epidemiological *** recovered from the slides can be used for several downstream molecular processes including polymerase chain reaction,single nucleotide polymorphism analysis,and whole genome *** DNA from these slides can be utilized to compare gene signatures of normal and diseased ***,extraction of high-quality DNA from archived stained hematoxylin and eosin(H&E)slides remains *** To standardize a new protocol for extracting DNA from archived H&E-stained tissue slides for further molecular *** A total of 100 archived H&E-stained cancer slides were subjected to a total of five methods of DNA *** were varied in the deparaffinization step,tissue rehydration,duration of lysis,and presence or absence of proteinase *** extracted DNA was quantified using a NanoDrop spectrophometer and the quality was analyzed by agarose gel *** each sample was subjected to polymerase chain reaction(PCR)to amplify the internal control gene GAPDH,thereby confirming the DNA intactness,which could be further utilized for other downstream *** Of the five different methods tested,the third method wherein xylene was used for tissue deparaffinization followed by 72 h of digestion and without proteinase K inactivation yielded the highest amount of DNA with good *** yield was significantly higher when compared to other *** addition,90%of the extracted DNA showed amplifiable GAPDH *** Here we present a step-by-step,cost-effective,and reproducible protocol for the extraction of PCR-friendly DNA from archived H&E-stained cancer tissue slides that can be used for further downstream molecular applications.

关键词： DNA extraction Hematoxylin and eosin tissue slides Molecular analysis Polymerase chain reaction Deparaffinization

Comparison of short- with long-term regeneration results after digital nerve reconstruction with musclein-vein conduits

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Neural Regeneration Research 2015年第10期10卷 1674-1677页

作者： Jennifer Lynn schiefer Lukas schulz Rebekka Rath stéphane stahl Hans-Eberhard schaller Theodora manoli Department of Hand Plastic and Reconstructive Surgery with Burn Center BG Trauma Center University of Tuebingen

Muscle-in-vein conduits are used alternatively to nerve grafts for bridging nerve defects. The purpose of this study was to examine short- and long-term regeneration results after digital nerve reconstruction with muscle-in-vein conduits. static and moving two-point discriminations and semmes-Weinstein Monofilaments were used to evaluate sensory recovery 6–12 months and 14–35 months after repair of digital nerves with muscle-in-vein in 7 cases. Both follow-ups were performed after clinical signs of progressing regeneration disappeared. In 4 of 7 cases, a further recovery of both two-point discriminations and in another case of only the static two-point discrimination of 1–3 mm could be found between the short-term and long-term follow-up examination. Moreover, a late recovery of both two-point discriminations was demonstrated in another case. Four of 7 cases showed a sensory improvement by one semmes-Weinstein Monofilaments. This pilot study suggests that sensory recovery still takes place even when clinical signs of progressing regeneration disappear.

关键词： peripheral nerve regeneration muscle-in-vein conduits digital nerves sensory recovery semmes-Weinstein two-point discrimination outcome short-term long-term

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两段式低温真空烹饪对牛肉品质的影响

食品与发酵工业 2021年第18期47卷 231-236页

作者：闫寒崔震昆李阳阳 manoli Tatiana 赵岩岩周威张浩李岚轩河南科技学院食品学院河南新乡453003 苏梅国立农业大学食品技术系乌克兰苏梅40021 敖德萨国立食品技术研究院乌克兰敖德萨65039

真空低温烹饪具有改善肉类品质、减少营养素损失和延长保质期等优势,然而该技术能否替代传统煎制牛排还未见报道。该文通过对牛排的烹饪损失、剪切力、色泽、挥发性风味物质以及电子鼻的风味分析,对比了传统煎制与两段式真空低温烹饪牛... 详细信息

真空低温烹饪具有改善肉类品质、减少营养素损失和延长保质期等优势,然而该技术能否替代传统煎制牛排还未见报道。该文通过对牛排的烹饪损失、剪切力、色泽、挥发性风味物质以及电子鼻的风味分析,对比了传统煎制与两段式真空低温烹饪牛肉的品质。结果表明,经两段式真空低温烹饪的牛肉在烹饪损失、剪切力和红度等方面均优于传统煎制牛排,而传统油煎牛排亮度较好。传统煎制牛肉有43种挥发性风味物质,真空低温烹饪后油煎的牛肉有28种,油煎后真空低温烹饪牛肉有37种。经电子鼻分析,3种烹饪方式的牛肉中2种真空低温烹饪方式的牛肉风味接近,但与传统油煎牛肉风味有差异。该研究可为牛排工业化生产提供参考。

关键词：牛肉真空低温烹饪烹饪方式挥发性风味成分两段式

一种适用于快速高分辨率A/D和D/A转换器的自校准方法

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微电子学 1989年第6期19卷 74-78,95页

作者： Yiannos manoli 曾平英

单片A/D和D/A转换器存在着受现有电路元件的有限精度限制的缺点。一种新的自校准方法使得对广泛用于高速转换器的二元加权电流源阵列的线性误差进行校正成为可能。为了得到高的校准精度,使用了一种改进的双斜率法(modified dual-slope m... 详细信息

单片A/D和D/A转换器存在着受现有电路元件的有限精度限制的缺点。一种新的自校准方法使得对广泛用于高速转换器的二元加权电流源阵列的线性误差进行校正成为可能。为了得到高的校准精度,使用了一种改进的双斜率法(modified dual-slope method)。这就使得制造具有14位或更高分辨率、转换时间小于15μs的A/D和D/A转换器成为可能。

关键词： A/D D/A 转换器自校准高分辨率

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爱的生理学

环球科学 2023年第5期 32-37页

作者：史蒂文·费尔普斯佐薇·唐纳森德夫·马诺利姜海伦(翻译) 不详

体型只有网球大小的草原田鼠是自然界中少有的、实行一夫一妻制的动物,它们的行为能为亲密关系以及社会纽带如何形成,提供了一些出人意料的新见解。

关键词：生理学亲密关系一夫一妻制新见解出人意料自然界

家庭语言政策为探索进城农民工社会融合问题提供新视角

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语言战略研究 2019年第2期4卷 60-60页

作者：杨红燕王晓梅李佳许静荣弗朗西斯·瓦尔斯凯瑟琳·布伦南凡妮莎·马诺利中国地质大学武汉不详

据国家统计局数据,2017年中国外出农民工17185万人,其中进城农民工13710万人,这是一个庞大的社会群体。迁入城市的农民工及其家庭成员首先要解决语言沟通问题,语言融合从而成为其社会融合的基础。国内学者付义荣、俞玮奇等对农民工及其... 详细信息

据国家统计局数据,2017年中国外出农民工17185万人,其中进城农民工13710万人,这是一个庞大的社会群体。迁入城市的农民工及其家庭成员首先要解决语言沟通问题,语言融合从而成为其社会融合的基础。国内学者付义荣、俞玮奇等对农民工及其子女语言生活的调查反映出其家庭领域语言使用的变化,但其过程和动因还有待进一步深入探讨。家庭语言政策是家庭成员对家庭领域语言使用和习得的规划,不仅体现家庭语言实践的过程和动因,还能折射家庭内外多重因素的互动,为深入探索以下问题提供了视角。

关键词：进城农民工家庭成员语言政策社会融合语言使用国家统计局社会群体沟通问题