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Effects of Salacia lehmbachii ethanol root bark extract on estrous cycle and sex hormones of female albino rats

Asian pacific Journal of Reproduction 2018年第6期7卷 274-279页

作者： Grace A.Essiet Godwin C.Akuodor Daniel oJ Aja Mathew o.Nwokike desmond o.eke Anuli N.Chukwumobi Department of Pharmacology Faculty of Basic Medical SciencesCollege of Medical SciencesUniversity of CalabarCalabarNigeria Department of Pharmacology and Therapeutics Faculty of MedicineEbonyi State UniversityAbakalikiNigeria Department of Internal Medicine Chukwuemeka Odumegwu Ojukwu University Teaching HospitalAwkaNigeria

objective:To evaluate the effect of Salacia lehmbachii (S. lehmbachii) ethanol root bark extract on estrous cycle and sex hormones in female rats. Methods: Forty-eight virgin rats with regular 4-day cycle were grouped into four and each group was further subdivided into 'a' and 'b' (n=6). Each group was orally treated for 28 days with 2 mL of distilled water (control), ethanol root bark extract ofS. lehmbachii in doses of 250, 500 and 750 mg/kg/body weight (groups 2, 3, 4, respectively). Estrous cycle was determined daily using the vaginal smear method. Rats in'a' subgroups were weighed and sacrificed on the 29th day, and blood was collected for serum generation which was used for hormonal assay and sex organs were removed and weighed. Rats in 'b' subgroups were discontinued from treatment for 2 weeks and the parameters above were ***:The mean length of estrous cycle and duration of diestrous of treated rats were prolonged dose dependently compared to control. The increase was significant (Pother estrous phases were shortened in the same pattern. Relative weights of sex organs were reduced significantly (Pose. Sex hormones levels were significantly (Pompared to control. The above changes reverted towards the control values two weeks post ***: Ethanol root bark extract ofS. lehmbachii (high doses) has antifertility effect in female rats as it prolongs the estrous and diestrous cycle, and reduces serum sex hormones levels. The observed alterations were reversible.

关键词： Salacia lehmbachii ovulation Estrous cycle Root bark Female sex hormones

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A risk assessment system for alien plant bio-invasion in Xiamen,China

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Journal of Environmental Sciences 2008年第8期20卷 989-997页

作者： desmond K.o'TooLE Department of Biology and Chemistry City University of Hong Kong83 Tat Chee AveKowloonHong Kong SAR 999077China

Bio-invasion has caused serious ecosystem damage and enormous economic losses in China,and it has been the greatest factor to island bio-diversity ***,as an important seaport with a relatively high conservation value,is particularly vulnerable to bio-invasion for its typical island ecosystem as well as frequent human-made *** a result of field surveys,literature review, and consultation with experts,a list of 67 alien plants identified as major invaders(12 species)and emerging invade...

关键词： bio-invasion invasive species alien plants risk assessment

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Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 126-129页

作者： Gavin o'Brien Conor J Shields desmond C Winter John P Dillon Department of Academic Surgery Cork University Hospital and National University of Ireland Cork Ireland William O Kirwan and H. Paul RedmondCork Ireland

BACKGRoUND: The exact mechanism by which cyclooxy- genase-2 (CoX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of CoX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHoDS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or CoX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine CoX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with CoX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P oX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the CoX-2 group (Pot analysis confirmed attenuated CoX-2 protein expression. CoNCLUSIoN: This study shows, for the first time in a rat model, that adjuvant CoX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.

关键词： cyclooxygenase-2 pancreatitis genesis lung injury

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Personalising pancreas cancer treatment:When tissue is the issue

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World Journal of Gastroenterology 2014年第24期20卷 7849-7863页

作者： Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie o'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin desmond Yip NHMRC Clinical Trials Centre University of SydneySydney NSW 1450Australia Cancer Care Centre St George HospitalKogarah NSW 2217Australia The Kinghorn Cancer Centre and the Cancer Research ProgramGarvan Institute of Medical ResearchSydney NSW 2010Australia Macarthur Cancer Therapy Centre Campbelltown HospitalCampbelltown NSW 2560Australia St Vincents Hospital Clinical School Sydney UNSW 2010Australia Cancer Therapy Centre Liverpool HospitalLiverpool NSW 2170Australia St John of God Pathology Subiaco WA 6904Australia Department of Surgery Bankstown HospitalEldridge RoadBankstownSydney NSW 2200Australia Faculty of Medicine South Western Sydney Clinical SchoolUniversity of NSWLiverpool NSW 2170Australia Wolfson Wohl Cancer Research Centre Institute of Cancer SciencesUniversity of GlasgowGlasgow G61 1BDUnited Kingdom Department of Anatomical Pathology St.Vincent’s HospitalDarlinghurstSydney NSW 2010Australia West of Scotland Pancreatic Unit Glasgow Royal InfirmaryGlasgow G4 0SFUnited Kingdom Department of Medical oncology The Canberra HospitalGarran ACT 2605Australia ANU Medical School Australian National UniversityActon ACT 2601Australia

The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FoLFIRINoX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved *** in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease *** has allowed identification of potentially actionable mutations that may be targeted by new biological *** heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the *** paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice.

关键词： Pancreatic neoplasms Molecular targeted therapy Genomics Tissue banks Chemotherapy

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老年驾驶员与痴呆

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中国社会医学杂志 1993年第4期10卷 179-180页

作者： desmond o'Neill 辜明铭

在西方国家,老年驾驶员的比例正在迅速上升。到2000年,55岁以上的驾驶员将超过驾驶员总数的1/4。虽然老年驾驶员尽量少开车或避免开夜车,然而,65岁以上驾驶员发生的汽车事故仍明显增多。医生如何识别有危险性的驾驶员呢?一旦作出鉴定,... 详细信息

在西方国家,老年驾驶员的比例正在迅速上升。到2000年,55岁以上的驾驶员将超过驾驶员总数的1/4。虽然老年驾驶员尽量少开车或避免开夜车,然而,65岁以上驾驶员发生的汽车事故仍明显增多。医生如何识别有危险性的驾驶员呢?一旦作出鉴定,病人拒绝自动放弃驾驶执照又将如何处置呢?对于容易发生意识丧失的患者,医学处理方案是明确的。而正常老化过程与早期痴呆的鉴别及评价却是十分困难的,在一些国家已经采取了相应的对策。

关键词：汽车事故驾驶执照西方国家正常老化家庭医生痴呆者撞车事故汽车司机事故率行车路线

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Secondary Plant Metabolites of Natural Product origin—<i>Strongylodon macrobotrys</i>as Pitting Corrosion Inhibitors of Steel around Heavy Salt Deposits in Gabu, Nigeria

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Journal of Materials Science and Chemical Engineering 2020年第5期8卷 38-60页

作者： Benedict U. Ugi Victoria M. Bassey Mbang E. obeten Stephen A. Adalikwu desmond o. Nandi Department of Pure & Applied Chemistry University of Calabar Calabar Nigeria Department of Chemistry Cross River State University of Technology Calabar Nigeria Department of Chemistry Cross River State College of Education Akamkpa Nigeria

Investigation into the Inhibition of pitting corrosion in mild steel around heavy salt deposits by some selected secondary plant metabolites—alkaloid extract (AESML), saponin extract (SESML and flavonoid extract (FESML) of natural product origin—Strongylodon macrobotrys was successfully completed with the aid of electrochemical impedance spectroscopy, potentiodynamic polarization, gravimetric and gasometric experimentation. The research proved that the selected secondary plant metabolites were excellent inhibitors of mild steel in the salt water environment as inhibition efficiency was recorded at 99.2%, 92.6% and 84.7% for AESML, SESML and FESML. The inhibitors showed higher inhibition at lower temperature due to frequent scale redeposition from agitation in temperature rise and loss in collision of the molecules. The potentiodynamic polarization result confirmed the reduction in the loss of electrons at the anode by the inhibitors that would have trigger oxidation reaction that causes the anode to corrode. Charge transfer resistance reflected the maximum inhibition efficiency obtained for mild steel at maximum concentration and the decrease in double layer capacitance is due to the decrease of the area where electrolyte is present due to the formation of inhibitor film. Thermodynamic investigation shows that the inhibitor has the potential of increasing the energy of the intermediate, reducing both the number of collisions, and number of particles that have enough energy to react and also number of corrosion reaction particles with the correct orientation. The adsorption isotherm consideration shows physical adsorption mechanism with binding constant increasing with increasing temperature.

关键词： Keywords Corrosion Electrochemistry Polarization Adsorption Strongylodon macrobotrys Gasometric

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中国和加纳房地产市场比较

中国和加纳房地产市场比较

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作者： desmond Senanu Loveridge Ahiahonu 中国矿业大学

学位级别：硕士

世界各地的房地产市场体系各不相同。由于不同地点的历史,文化和习俗而产生差异。一个国家的文化对房屋所有权产生重大影响,而住房所有权是人类生存的基础。在全球范围内,房地产帮助大多数经济体扩大GDP。低估房地产行业发展的影响及其... 详细信息

世界各地的房地产市场体系各不相同。由于不同地点的历史,文化和习俗而产生差异。一个国家的文化对房屋所有权产生重大影响,而住房所有权是人类生存的基础。在全球范围内,房地产帮助大多数经济体扩大GDP。低估房地产行业发展的影响及其对经济增长的贡献是复杂的。住房对经济增长和发展至关重要。因此,它对全世界许多社会的增长和发展产生了重大的积极影响,但在加纳却没有。多年来,该国一直在努力解决住房问题。另一方面,中国在住房领域取得了重大进展。该研究领域侧重于中国房地产市场的经验,作为精心规划的发达房地产市场的一个例子。因此,政府、私营部门、研究人员和学者有必要研究中国房地产业的发展模式,并吸取宝贵的经验教训,以满足加纳的住房需求。该论文介绍了有关中国和加纳房地产市场体系的信息,这两个国家截然不同。本研究的目的是使用SWoT分析来揭示在加纳获得经济适用房的威胁和弱点,分析优势和机会,讨论该行业的赤字,讨论信息不足对加纳住房部门的影响,解决市场上不专业和不稳定的住房定价的挑战,讨论政府无法彻底监管市场的问题,并提出从中国住房政策和管理经验中学习的解决方案和进一步建议。本研究将仅限于中国和加纳之间的房地产市场活动,其他国家,如美国,英国和欧洲在该领域的经验将不予考虑。论文研究分为三个主要步骤。首先,对中国和加纳的房地产市场进行了表征。进行了文献综述。接下来,对这两个国家的市场进行了比较分析。选择了一些描述房地产市场的共同特征。第三,研究人员进一步采用SWoT分析来从文献和调查中得出差异和相似性以及数据,以描绘使用SWoT分析进行研究的背景。SWoT分析是一种战略规划工具,用于评估加纳和中国住房行业的优势（S）,劣势（W）,机会（o）和威胁（T）。论文吸取了宝贵的教训和结论,新进入者必须熟悉优势、劣势、机遇和威胁（SWoT）,然后才能充分探索和成功。然而,这篇论文指出了加纳和中国内部的这些优势、劣势、机遇和威胁。新进入者和所有关键参与者必须注意所有这些,以帮助他们在房地产行业蓬勃发展。加纳的住房部门仍然不发达,面临许多问题,如土地征用,私营部门开发商的房屋价格过高,使普通工人无法拥有体面的房屋,建筑材料成本高昂,土地所有权登记过程延长,历届政府未能继续前几届政府发起的社会住房项目,以及缺乏获得信贷的机会。我们的调查显示,尽管房地产开发商在最大限度地减少加纳巨大的住房赤字方面发挥着重要作用,但由于低收入水平,大多数普通工人负担不起他们建造的房屋。此外,比较结果表明,在发展、政策实施和向公民提供社会住房方面,中国市场比加纳市场更重要,加纳市场面临许多住房挑战。通过学习加纳可以采取和实施的中国房地产市场发展战略,概述了宝贵的意见和建议,以满足其当地的住房需求。该研究还表明,中国政府通过启动定价机制和战略政策,如获得房地产交易的资金等,在住房部门发挥着关键作用。中国政府是主要住房保障者,这与加纳不同。在加纳,私营部门在提供社会住房方面发挥着重要作用,导致该行业的住房定价过高。总而言之,中国政府是房地产市场的管理者,其主要功能是规范和引导中国房地产市场,以保持其市场稳定。本研究还提供了一些见解,分析和建议,如通过借鉴中国的管理方式进行房地产开发和提高效率,以此改善加纳的房地产市场,减少住房赤字并使加纳的房地产市场有效。

关键词：房地产市场中国与加纳 SWoT分析比较分析房地产开发

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至尊——阿联酋迪拜酋长皇宫酒店，绵延1．3km的真正皇家体验

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照明设计 2006年第3期 60-67页

作者： David Robertson desmond o＇Donovan Peter Fordham Dorothea Schmid（摄影） Emirates Palace（摄影）马艳（译）

酋长皇宫酒店隶属于Kempinski旅店鞋号，并且被认为是世界上最大、最豪华的酒店之一。2005年2月酒店铺开了红地毯，欢迎客人入住。由于“五星级”显得远远不足以标榜这个华贵的处所，干脆就将“皇宫”一词冠在酒店名前。客人被带入一个... 详细信息

酋长皇宫酒店隶属于Kempinski旅店鞋号，并且被认为是世界上最大、最豪华的酒店之一。2005年2月酒店铺开了红地毯，欢迎客人入住。由于“五星级”显得远远不足以标榜这个华贵的处所，干脆就将“皇宫”一词冠在酒店名前。客人被带入一个不可思议的世界，那里洋溢着浪漫、妙想与奇遇，浸淫在国王般的奢华中。奢华常与黄金相伴，特别是在阿拉伯世界中。伦敦的DHA做的照明设计更为其平添了一份魅力。

关键词：酒店皇宫阿联酋迪拜照明设计世界五星级阿拉伯

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聆听人类的病痛:音乐演绎的痛风

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英国医学杂志中文版 2022年第10期25卷 602-603页

作者： desmond o'Neill 韦建辉(译) 唐施祺(译) 周红霞(校) Tallaght University Hospital Dublin 广西医科大学外国语学院

由于患者可能使用非典型的其他语言来描述自己的疾病,因此我们提醒临床医生应该更仔细地倾听患者的陈述。在此,desmond o'Neill解释了音乐如何帮助我们体验人类的病痛,尤其是对痛风的体验。一些研究发现,冬季是痛风发作风险上升的季节:... 详细信息

由于患者可能使用非典型的其他语言来描述自己的疾病,因此我们提醒临床医生应该更仔细地倾听患者的陈述。在此,desmond o'Neill解释了音乐如何帮助我们体验人类的病痛,尤其是对痛风的体验。一些研究发现,冬季是痛风发作风险上升的季节:对于饮食油腻、大量饮酒(两者都会引发痛风)的肥胖男士来说,冬季并非是个令人愉快的季节2-3。

关键词：临床医生痛风大量饮酒病痛非典型

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High-performance oxygen reduction and evolution carbon catalysis： From mechanistic studies to device integration

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Nano Research 2017年第4期10卷 1163-1177页

作者： John W. F. To Jia Wei desmond Ng Samira Siahrostami Ai Leen Koh Yangjin Lee Zhihua Chen Kara D. Fong Shucheng Chen Jiajun He Won-Gyu Bae Jennifer Wilcox Hu Young Jeong Kwanpyo Kim Felix Studt Jens K. Nфrskov Thomas F. Jaramillo Zhenan Bao Department of Chemical Engineering Stan ford University Stanford CA 94305 USA Institute of Chemical and Engineering Sciences Agency for Science Technology and Research Jurong Island 627833 Singapore Stanford Nano Shared Facilities Stanford University Stanford CA 94305 USA Department of Physics Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea Department of Chemical and Biological Engineering Colorado School of Mines Golden CO 80401 USA UNIST Central Research Facilities (UCRF) Ulsan National Institute of Science and Technology (UNIST) Ulsan 689-798 Republic of Korea SUNCAT Center for Interface Science and Catalysis SLAC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA Institute of Catalysis Research and Technology Karlsruhe Institute of Technology Hermann-von-Helmholtz Platz 1 76344 Eggenstein-Leopoldshafen Germany Institute for Chemical Technology and Polymer Chemistry Karlsruhe Institute of Technology Engesserstr. 18 76131 Karlsruhe Germany

The development of high-performance and low-cost oxygen reduction and evolution catalysts that can be easily integrated into existing devices is crucial for the wide deployment of energy storage systems that utilize o2-H2o chemistries, such as regenerative fuel cells and metal-air batteries. Herein, we report an NHB-activated N-doped hierarchical carbon （NHC） catalyst synthesized via a scalable route, and demonstrate its device integration. The NHC catalyst exhibited good performance for both the oxygen reduction reaction （oRR） and the oxygen evolution reaction （oER）, as demonstrated by means of electrochemical studies and evaluation when integrated into the oxygen electrode of a regenerative fuel cell. The activities observed for both the oRR and the oER were comparable to those achieved by state-of-the-art Pt and Ir catalysts in alkaline environments. We have further identified the critical role of carbon defects as active sites for electrochemical activity through density functional theory calculations and high-resolution TEM visualization. This work highlights the potential of NHC to replace commercial precious metals in regenerative fuel cells and possibly metal-air batteries for cost-effective storage of intermittent renewable energy.

关键词： electrocatalysis porous carbon density functional theory

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