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Realization of flexible in-memory computing in a van der Waals ferroelectric heterostructure tri-gate transistor

Nano Research 2024年第3期17卷 1886-1892页

作者： Xinzhu Gao Quan chen Qinggang Qin Liang Li Meizhuang Liu derek Hao Junjie Li Jingbo Li Zhongchang Wang Zuxin chen School of Semiconductor Science and Technology South China Normal UniversityFoshan 528225China Guangdong Provincial Key Laboratory of chip and Integration Technology Guangzhou 510631China Institute of Solid State Physics Hefei Institutes of Physical Science Chinese Academy of SciencesHefei 230601China School of Science STEM CollegeRMIT UniversityMelbourne 3000Australia cAS Key Laboratory of Functional Materials and Devices for Special Environments Xinjiang Technical Institute of Physics&ChemistryChinese Academy of SciencesUrumqi 830011China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China college of Optical Science and Engineering Zhejiang UniversityHangzhou 310027China International Iberian Nanotechnology Laboratory(INL) Av.Mestre Jose Veiga s/nBraga 4715-330Portugal

combining logical function and memory characteristics of transistors is an ideal strategy for enhancing computational efficiency of transistor ***,we rationally design a tri-gate two-dimensional(2D)ferroelectric van der Waals heterostructures device based on copper indium thiophosphate(cuInP_(2)S_(6))and few layers tungsten disulfide(WS_(2)),and demonstrate its multi-functional applications in multi-valued state of data,non-volatile storage,and logic *** co-regulating the input signals across the tri-gate,we show that the device can switch functions flexibly at a low supply voltage of 6 V,giving rise to an ultra-high current switching ratio of 107 and a low subthreshold swing of 53.9 mV/*** findings offer perspectives in designing smart 2D devices with excellent functions based on ferroelectric van der Waals heterostructures.

关键词： two-dimensional(2D)ferroelectric heterostructure tri-gate polymorphic regulation in-memory computing

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Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

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Journal of chinese Pharmaceutical Sciences 2017年第12期26卷 858-871页

作者： Monisola Itohan Ikhile Marthe carine Djuidje Fotsing charmaine Ardeme Jane catherine Ngila derek Tantoh Ndinteh Department of Applied chemistry University of JohannesburgDoornfontein CampusPO 17011Johannesburg 2028South Africa Department of chemistry University of JohannesburgP O Box 524Auckland ParkJohannesburg 2006South Africa

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1–4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P2_1/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.

关键词： Schiff bases Biological activity Synthesis X-ray diffraction characterization

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cross-neutralization and cross-protection among SARS-coV-2 viruses bearing different variant spikes

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3202-3205页

作者： Yang Liu Jianying Liu Jing Zou Birte Kalveram Rafael R.G.Machado Ping Ren Sina Tureli derek J.Smith Scott c.Weaver Xuping Xie Pei-Yong Shi Department of Biochemistry and Molecular Biology University of Texas Medical BranchGalvestonTXUSA Institute of Infectious Diseases Shenzhen Bay LaboratoryShenzhenChina Department of Microbiology and Immunology University of Texas Medical BranchGalvestonTXUSA Department of Pathology University of Texas Medical BranchGalvestonTXUSA center for Pathogen Evolution Department of ZoologyUniversity of CambridgeCambridgeUK Sealy Institute for Drug Discovery University of Texas Medical BranchGalvestonTXUSA Sealy center for Structural Biology&Molecular Biophysics University of Texas Medical BranchGalvestonTXUSA

Dear Editor The rapid evolution of SARS-coV-2 mandates a better under-standing of cross-neutralization and cross-protection among *** information is essential to guide vaccine strategy and public *** examine the cross-protection among different variant spikes,we initially prepared four chimeric SARS-coV-2 viruses(Fig.1a),each bearing the spike gene from Alpha,Beta,Gamma,or Epsilon in the backbone of USA-WA1/2020[isolated in January 2020 and defned as wild-type(WT)].

关键词： vaccine cross backbone

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Next-Generation Sequencing-Based Diagnosis of Bacteremic Listeria monocytogenes Meningitis in a Patient with Anti-Interferon Gamma Autoantibodies:A case Report

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Infectious Microbes & Diseases 2022年第1期4卷 44-46页

作者： Fanfan Xing derek L.L.Hung Simon K.F.Lo Shuang chen Susanna K.P.Lau Patrick c.Y.Woo Department of clinical Microbiology and Infection control The University of Hong Kong–Shenzhen HospitalShenzhenGuangdongChina Department of Microbiology The University of Hong KongHong KongChina Department of Pathology The University of Hong Kong-Shenzhen HospitalShenzhenGuangdongChina

Although various opportunistic infections have been described in patients with anti-interferon gamma autoantibodies,so far there is no Listeria monocytogenes infection reported to be associated with this primary ***,we describe the first case of bacteremic *** meningitis in a 59-year-old chinese man with anti-interferon gamma autoantibodies,who presented with acute onset of fever and severe *** culture was positive but culture of the cerebrospinal fluid was negative,although it showed features suggestive of partially treated bacterial *** presence of *** in the cerebrospinal fluid was confirmed by next-generation *** of high-risk food items in these patients is important for the prevention of *** use of antibiotic regimens that cover Listeria is crucial for empirical treatment,particularly if such patients develop acute or subacute ***-generation sequencing is becoming an important diagnostic modality for culture-negative infections.

关键词： Listeria monocytogenes meningitis anti-interferon gamma autoantibody next-generation sequencing

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Levels and trends of current-use pesticides(cUPs)in the arctic:An updated review,2010-2018

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Emerging contaminants 2019年第1期5卷 70-88页

作者： Jennifer E.Balmer Adam D.Morris Hayley Hung Liisa Jantunen Katrin Vorkamp Frank Riget Marlene Evans Magali Houde derek c.G.Muir Arctic Monitoring and Assessment Programme Fram CentrePO Box 6606Langnes9296TromsøNorway Department of Biology The Citadel171 Moultrie StreetCharlestonSCUSA Environment and climate change canada National Wildlife Research CenterOttawaCanada Air Quality Processes Research Section Environment and Climate Change CanadaTorontoOntarioCanada Air Quality Processes Research Section Environment and Climate Change CanadaEgbertOntarioCanada Aarhus University Department of Environmental ScienceArctic Research CentreRoskildeDenmark Aarhus University Department of BioscienceRoskildeDenmark Aquatic Ecosystem Protection Research Division Environment Canada11 Innovation BlvdSaskatoonSKS7N 3H5Canada Environment and climate change canada St.Lawrence CenterMontrealQuebecCanada Environment and climate change canada Canada Centre for Inland WatersBurlingtonOntarioCanada

Global regulations and many regional and national controls restrict the use of substances that exhibit the potential for environmental persistence and long-range ***,many current-use pesticides(cUPs)continue to be newly discovered in remote regions,including the *** present review serves as an update,summarizing newly available information for cUPs in the Arctic environment and biota published from 2010 to *** 2010,at least seven new cUPs have been measured in Arctic media:2-methyl-4-chlorophenoxyacetic acid(McPA),metribuzin,pendimethalin,phosalone,quizalofop-ethyl,tefluthrin and *** the large number of pesticides in current use,the number measured in the Arctic is very limited,however,modelling studies have identified additional cUPs as potential Arctic contaminants that have yet to be investigated in the *** to their recent detection,reports of cUPs in the Arctic are limited,but *** have been reported in a wide range of abiotic Arctic matrices,including air,snow,ice,freshwater and seawater,indicating their capacity for long-range atmospheric transport,however,concentrations are generally low in comparison to legacy pesticides and other persistent organic pollutants(POPs).Recent food-web studies indicate cUPs can enter Arctic terrestrial and marine food chains,however,in contrast to POPs,the highest concentrations of many cUPs were found in lower trophic-level organisms,and the lowest concentrations detected in animals at the highest trophic levels(i.e,ringed seals,polar bear,caribou,and wolves)indicating significant trophic *** detection of cUPs in the remote Arctic ecosystem reinforces the need for continued monitoring of both known and potential Arctic pollutants to prevent impacts on human and environmental health as the global arsenal of pesticides used in agriculture continuously changes.

关键词： POPs contaminants Air Biota Long-range transport Persistence

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Ectopic Tcf1 expression instills a stem-like program in exhausted cD8^(+) T cells to enhance viral and tumor immunity

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cellular & Molecular Immunology 2021年第5期18卷 1262-1277页

作者： Qiang Shan Sheng’en Hu Xia chen derek B.Danahy Vladimir P.Badovinac chongzhi Zang Hai-Hui Xue center for Discovery and Innovation Hackensack Meridian HealthNutleyNJ07110USA Department of Microbiology and Immunology Carver College of MedicineUniversity of IowaIowa CityIA52242USA center for Public Health Genomics University of Virginia School of MedicineCharlottesvilleVA22908USA Department of Pathology Carver College of MedicineUniversity of IowaIowa CityIA52242USA Interdisciplinary Immunology Graduate Program Carver College of MedicineUniversity of IowaIowa CityIA52242USA Iowa city Veterans Affairs Health care System Iowa CityIA52246USA

Exhausted cD8^(+)T(Tex)cells are dysfunctional due to persistent antigen exposure in chronic viral infection and tumor contexts.A stem cell-like Tex(Tex-stem)subset can self-renew and differentiate into terminally exhausted(Tex-term)***,we show that ectopic Tcf1 expression potently promoted the generation of Tex-stem cells in both a chronic viral infection and preclinical tumor ***1 overexpression diminished coinhibitory receptor expression and enhanced polycytokine-producing capacity while retaining a heightened responses to checkpoint blockade,leading to enhanced viral and tumor ***,ectopically expressed Tcf1 exploited existing and novel chromatin accessible sites as transcriptional enhancers or repressors and modulated the transcriptome by enforcing pre-existing expression patterns in Tex-stem cells,such as enhanced suppression of Blimp1 and Bim and acquisition of new downstream genes,including Mx1,Tox2,and *** findings reveal a pronounced impact of ectopic Tcf1 expression on Tex functional restoration and highlight the therapeutic potential of harnessing Tcf1-enforced transcriptional programs.

关键词： T cell exhaustion Tcf1 Stem cell features

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In Situ Test on Dynamic Response of Single Surface Slope

In Situ Test on Dynamic Response of Single Surface Slope

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： Shengwen Qi c.derek Martin Shenglin Qi Yu Zou Key Laboratory of Engineering Geomechanics Institute of Geology and GeophysicsChinese Academy of Sciences Department of civil and Environmental Engineering University of Alberta University of chinese Academy of Sciences

An in situ explosion test on dynamic responses of one single surface slope(stepped slope) of open-pit iron mine in Miyun county,Beijing has been carried *** slope consists of gneiss and magnetite quartzite with blocky structure and its surface is strongly disturbed due to excavation and *** explosion recorders have been used as data acquisition instruments in the *** of the recorder has two channels and can record horizontal and vertical component at the same *** recorders have been placed at different elevation of the slope to monitor the dynamic responses of the slope during *** explosion point was located at the foot of the *** results indicate that peak ground velocity(PGV) and peak ground acceleration(PGA) varies with elevation *** can be seen that both PGV and PGA decrease gradually with elevation increasing,and then amplify at the near crest of the slope.

关键词： Single surface slope Peak ground velocity Peak ground acceleration Explosion Dynamic response

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Streptococcus agalactiae Anterior cervical Space and Superior Mediastinum Abscess in a Liver Transplant Recipient

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Infectious Microbes & Diseases 2019年第2期1卷 75-77页

作者： derek L.L.Hung Man-Fai Leung Jade L.L.Teng Herman Tse Susanna K.P.Lau Patrick c.Y.Woo Department of Microbiology The University of Hong KongHong KongChina State Key Laboratory of Emerging Infectious Diseases The University of Hong KongHong KongChina carol Yu centre for Infection The University of Hong KongHong KongChina Public Health Laboratory Services Branch Centre for Health ProtectionHong Kong Department of HealthThe University of Hong KongHong KongChina collaborative Innovation center for Diagnosis and Treatment of Infectious Diseases The University of Hong KongHong KongChina

Introduction Streptococcus agalactiae is most commonly associated with pregnancy-related infections,neonatal sepsis,and infections in patients with immunocompromised states,such as diabetes mellitus and malignancies.1 Although abscesses caused by *** are sometimes encountered in immunocompromised patients,*** abscess in transplant recipients is extremely *** abscesses have never been reported in liver transplant *** this article,we report a case of *** abscess in the anterior cervical space extending to the superior mediastinum in a liver transplant recipient.

关键词： Streptococcus agalactiae liver transplant abscess

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In Situ Test on Dynamic Response of Single Surface Slope

In Situ Test on Dynamic Response of Single Surface Slope

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中国科学院地质与地球物理研究所2015年度（第15届）学术年会

An in situ explosion test on dynamic responses of one single surface slope(stepped slope)of open-pit iron mine in Miyun county,Beijing has been carried *** slope consists of gneiss and magnetite quartzite with blocky structure and its surface is strongly disturbed due to excavation and *** explosion recorders have been used as data acquisition instruments in the *** of the recorder has two channels and can record horizontal and vertical component at the same *** recorders have been placed at different elevation of the slope to monitor the dynamic responses of the slope during *** explosion point was located at the foot of the *** results indicate that peak ground velocity(PGV)and peak ground acceleration(PGA)varies with elevation *** can be seen that both PGV and PGA decrease gradually with elevation increasing,and then amplify at the near crest of the slope.

关键词： Single surface slope Peak ground velocity Peak ground acceleration Explosion Dynamic response

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Electrobiocorrosion by microbes without outer-surface cytochromes

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mLife 2024年第1期3卷 110-118页

作者： Dawn E.Holmes Trevor L.Woodard Jessica A.Smith Florin Musat derek R.Lovley Department of Microbiology University of Massachusetts AmherstAmherstMassachusettsUSA Department of Physical and Biological Science Western New England UniversitySpringfieldMassachusettsUSA Department of Biomolecular Sciences Central Connecticut State UniversityNew BritainConnecticutUSA Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molecular Biology and Biotechnology Facuity of Biology and GeologyBabes-Bolyai UniversityCluj-NapocaRomania

Anaerobic microbial corrosion of iron-containing metals causes extensive economic *** microbes are capable of direct metal-to-microbe electron transfer(electrobiocorrosion),but the prevalence of electrobiocorrosion among diverse methanogens and acetogens is poorly understood because of a lack of tools for their genetic *** studies have suggested that respiration with 316L stainless steel as the electron donor is indicative of electrobiocorrosion,because,unlike pure Fe^(0),316L stainless steel does not abiotically generate H_(2) as an intermediary electron ***,we report that all of the methanogens(Methanosarcina vacuolata,Methanothrix soehngenii,and Methanobacterium strain IM1)and acetogens(Sporomusa ovata and clostridium ljungdahli)evaluated respired with pure Fe^(0)as the electron donor,but only ***,***,and *** were capable of stainless steel *** electrobiocorrosive methanogens re-quired acetate as an additional energy source in order to produce methane from stainless *** of *** and *** demonstrated how acetogens can provide acetate to methanogens during *** only was Meth-anobacterium strain IM1 not capable of electrobiocorrosion,but it also did not accept electrons from Geobacter metal-lireducens,an effective electron-donating partner for direct interspecies electron transfer to all methanogens that can directly accept electrons from Fe^(0).The finding that ***,***,and *** are capable of electrobiocorrosion,despite a lack of the outer-surface c-type cytochromes previously found to be important in other electrobiocorrosive microbes,demonstrates that there are multiple microbial strategies for making electrical contact with Fe^(0).

关键词： acetogen corrosion Fe^(0) methanogen stainless steel

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