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Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy

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Acta Pharmacologica Sinica 2004年第12期25卷 10-17页

作者： De-chun JIANG, Li WANG2.department of Pediatrics, peking university First Hospital, TherapeuticDrug Monitoring and Clinical Toxicology, Center of peking university, beijing 100034, China department of Pediatrics Peking University First Hospital Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University Beijing 100034 China

AIM: Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach. METHODS: Two hundred epileptic children, whose VPA serum concentrations were collected, were divided randomly into two groups (A and B, n=100 each). The PPK parameter values of group A were calculated to establish a PPK Model by using the NPEM Program of USC*PACK software. Based on it, VPA serum concentrations of group B were predicted with the Bayesian Fitting Program of the USC*PACK software. To assess the accuracy and precision of prediction, a paired-comparisons t-test was run between predicted and ob- served concentrations, and then the mean prediction error (MPE), mean square prediction error (MSPE), root mean square prediction error (RMSPE), and coincidence rates for different percentages of prediction error were all calculated. RESULTS: Optimum PPK parameters were: Ka, 2.52.±2.743 h-1; Vs, 0.32.±0.496 L/kg; and Kel, 0.0438±0.0384 h-1. For group B, there was no significant difference between predicted and observed concentrations. MPE was -0.43 mg/L, MSPE was 115.40 (mg/L)2. and RMSPE was 5.47 mg/L. The coincidence rates for percent- ages of prediction error, which were less than 5 %, 10 %, 15 %, 2. %, 2. %, and 30 %, were 62.%, 74 %, 82.%, 85 %, 89 %, and 93 %, respectively. CONCLUSION: A PPK model of VPA in epileptic children was successfully established. Based on it, VPA serum concentrations can be predicted accurately with a Bayesian approach.

关键词： pharmacokinetics valproic acid epilepsy Bayes theorem USC*PACK software

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THE FUNCTION d_k(n) AT CONSECUTIVE INTEGERS

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Chinese Annals of Mathematics,Series B 1999年第4期20卷 473-478页

作者： MENG ZAIZHAO(department of Mathematics, peking university,{2. 100871, China) peking Univ Dept Math Beijing 100871 Peoples R China

Let dk(n) denote the k-fold iterated divisor function (k ≥ 2.. It is proved that for sufficiently large x) dk(n) = dk(n + 1) holds for >> x(log log x)-3 integers n ≤x.

关键词： Divisor function Multiplicative function Congruence

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The geometrical structure, electronic structure and magnetism of bimetallic Au_nM_2.(n=1, 2. M=Y, Zr, Nb, Mo, Tc, Ru, Rh, Pd) clusters

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Science China(physics,Mechanics & Astronomy) 2009年第7期52卷 1011-1020页

作者： GU Juan1,2. WANG ShanYing2.& GOU BingCong1 1 department of physics, beijing Institute of Technology, beijing 100081, China 2.department of physics, Tsinghua university, beijing 100084, China department of physics Beijing Institute of Technology Beijing 100081 China department of physics Tsinghua University Beijing 100084 China

The geometrical structure, stability, magnetism, and electronic structure of bimetallic clusters AuM2.and Au2.2. where M are 4d transition metal elements, are investigated systematically by using the first-principles method based on density functional theory. The calculation results show that there is a large amount of low-energy isomers with the very similar structure. AuM2.and Au2.2.clusters display dramatic magnetism. The magnetic moment of the 4d element is either enhanced or weakened with respect to the bulk value, which is largely dependent on the orbital exchange-splitting.

关键词： density functional theory first-principles cluster electronic structure magnetism

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The kink-soliton and antikink-soliton in quasi-one-dimensional nonlinear monoatomic lattice

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Science China(physics,Mechanics & Astronomy) 2005年第2期48卷 150-157页

作者： XU Quan1 & TIAN Qiang2.1. Scientific and Technological Office, Daqing Teacher College, Daqing 163712. China 2. department of physics , beijing Normal {2., beijing 100875, China Scientific and Technological Office Daqing Teacher College Daqing 163712 China department of physics Beijing Normal University Beijing 100875 China

The quasi-one-dimensional nonlinear monoatomic lattice is analyzed. The kink-soliton and antikink-soliton are presented. When the interaction of the lattice is strong in the x-direction and weak in the y-direction, the two-dimensional (2.) lattice changes to a quasi-one-dimensional lattice. Taking nearest-neighbor interaction into account, the vibration equation can be transformed into the KPI, KPII and MKP equation. Considering the cubic nonlinear potential of the vibration in the lattice, the kink-soliton solution is presented. Considering the quartic nonlinear potential and the cubic interaction potential, the kink-soliton and antikink-soliton solutions are presented.

关键词： two-dimensional nonlinear lattice, quasi-one-dimensional nonlinear lattice, kink-soliton, antikink-soliton.

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Constraints on Cardassian universe from Gamma ray bursts

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Science China(physics,Mechanics & Astronomy) 2010年第9期53卷 1720-1725页

作者： WANG TaiShan1 & LIANG Nan2.1 department of physics & Center for Astrophysics,Tsinghua {2.,beijing 100084,China 2.department of Astronomy,beijing Normal {2.,beijing 100875,China 1. department of physics & Center for Astrophysics Tsinghua University Beijing 100084 China2. Department of Astronomy Beijing Normal University Beijing 100875 China

Constraints on the original Cardassian model and the modified polytropic Cardassian model are examined from the recently derived 42.gamma-ray bursts(GRBs) data calibrated with the method that can avoid the circularity *** results show that GRBs can be an optional observation to constrain the Cardassian *** the GRBs data with the newly de-rived size of baryonic acoustic oscillation peak from the Sloan Digital Sky Survey(SDSS),and the position of the first acoustic peak of the Cosmic Microwave Background radiation(CMB) from Wilkinson Microwave Anisotropy Probe(WMAP),we find Ωm0=0.2.+0.02.0.02.n=0.06+0.07-0.08(1σ) for the original Cardassian model,and Ωm0=0.2.+0.2.-0.02.n=-0.09+0.2.-1.91,β=0.82.2.10-0.62.1σ) for the modified polytropic Cardassian model.

关键词： Cardassian Gamma ray burst Cosmic Microwave Background baryonic acoustic oscillation

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Frontal genesis of moisture atmosphere during the early 2.08 persistent freezing-rain event in southern China

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Science China Earth Sciences 2010年第3期53卷 454-464页

作者： QIAN WeiHong1 & FU JiaoLan1,2.1 department of Atmospheric Sciences, School of physics,{2., beijing 100871, China 2.National Meteorological Center of CMA, beijing, 100081, China 1. department of Atmospheric Sciences School of Physics Peking University Beijing 100871 China2. National Meteorological Center of CMA Beijing 100081 China

From January 10 to February 2. 2.08, a severe and persistent freezing-rain event occurred in southern and southwestern China. Here we use an observational analysis to compare the persistent freezing-rain event in the early 2.08 with the winter precipita- tion in the late 2.07 over south of the Yangtze River (Jiangnan). The persistent freezing-rain event was directly linked to the activity of quasi-stationary front. The gradient of equivalent temperature (ET) can well indicate the frontal genesis of moist atmosphere (moisture front) and its activity as well as its relationship with precipitation belt. The precipitation types (snow and freezing rains) are related to the vertical structure of moisture front. The inversion profile of ET vertical distribution is a typical synoptic condition that caused the freezing-rain event. The horizontal gradient of ET with a criterion of 10℃ / 100 km, which reflects the accumulation and release of atmospheric energy, can be applied to predict the precipitation 5-10 days in advance.

关键词： freezing-rain event frontal genesis extended-range weather forecast winter Jiangnan

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Palaeogeographic Position of the South China Plate During the Early-Middle Devonian

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Acta Geologica Sinica(English Edition) 1991年第1期65卷 19-26页

作者： Bai Zhiqiang Bai Shunliang department of Geology, peking university,{2. department of Geology Peking University Beijing

In Guangxi, the Lower-Middle Devonian boundary beds yield abundant corals, brachiopods,stromatoporoids and conodonts. The former three were common in tropical and subtropical zones, while thelast occurred only round the equator. This reveals that the South China Plate in the Early-Middle Devonianwas at or near the equator, which was also supported by palaeomagnetic study giving the palaeolatitude of theGuangxi Region at the time to be 0°36′N.

关键词： Palaeogeographic Position of the South China Plate During the Early-Middle Devonian

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The General Characteristics and Distribution of the Glaucophane-Schist Belts of China

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Acta Geologica Sinica(English Edition) 1990年第1期64卷 101-114页

作者： Dong Shenbao Dong Shenbao department of Geology, peking university,{2. department of Geology Peking University Beijing

On the basis of the temperature variation, the glaucophane-schist facies Gan be classified into two faciesgroups, the glaucophane-lawsonite facies group and the glaucophane-greenschist facies group, and forms vari-ous facies series with other metamorphic facies. Glaucophane-schist belts of China are of different types withregard to their average T-P gradients and tectonic environments. They are: (1) Proterozoic intracratonicglaucophane-schist belts, (2. Caledonian intracratonic glaucophane-schist belts, (3) Palaeozoic pericratonicglaucophane-schist belts along the northern margin of the Chinese Platform, and (4) Meso-Cenozoicglaucophane-schist belts related to subduction. The initiation and evolution of glaucophane-schist metamorphism are related to their tectonic environ-ments. Most glaucophane-schist belts of China were formed in sialic environments. First the crust began tobreak up and eventually oceanic crust was formed. It seems that a non-uniformitarian mechanism may be in-volved as this evolution is related to the change of the configuration of the heat flow within the crust.

关键词： meta ab The General Characteristics and Distribution of the Glaucophane-Schist Belts of China

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A SMALLEST SINGULAR VALUE METHOD FOR SOLVING INVERSE EIGENVALUE PROBLEMS

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Journal of Computational Mathematics 1996年第1期14卷 23-31页

作者： S.F. Xu(department of Mathematics, peking university,{2.) beijing UNIV DEPT MATHBEIJING 100871PEOPLES R CHINA

Utilizing the properties of the smallest singular value of a matrix, we propose a new, efficient and reliable algorithm for solving nonsymmetric matrix inverse eigenvalue problems, and compare it with a known method. ... 详细信息

关键词： Math A SMALLEST SINGULAR VALUE METHOD FOR SOLVING INVERSE EIGENVALUE PROBLEMS

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Neuroimaging studies of self-reflection

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Progress in Natural Science:Materials International 2004年第4期14卷 10-16页

作者： ZHU Ying(department of Psychology, peking university,{2. 100871, China) peking Univ Dept Psychol Beijing 100871 Peoples R China

This paper reviews some basic findings and methodological issues in neuroimaging studies of self-referential processing. As a general rule, making judgments about one’s self, inclusive of personality trait adjectives or current mental states (person’ s preferences, norms, aesthetic values and feeling) uniformly generates medial prefrontal activations, regardless of stimulus materials (words or pictures) and modality (visual or auditory). Cingulate activations are also observed in association with most self-referential processing. Methodological issues include treating self-referential processing as either representing one’s own personality traits or representing one’s own current mental states. Finally, self-referential processing could be considered as implement of "I think therefore I am" approach to neuroimaging the self.

关键词： self self-referential processing medial prefrontal cortex cingulate brain image.

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