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The role of different cues in the brain mechanism on visual spatial attention

Progress in Natural Science:Materials International 2006年第10期16卷 1045-1050页

作者： SONG Weiqun, LUO Yuejia, CHI Song, JI Xunming, LING Feng, ZHAO Lun, WANG Maobin and SHI Jiannong ( department of Rehabilitation, Xuanwu hospital, Capital university of medical Science, Beijing 100053, china State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal university, Beijing 100875, china School of Psychology, Southwest university, Chongqing 400715, china Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, china department of neurology, affiliated hospital of qingdao university, medical college, qingdao 266003, china department of neurology, Xuanwu hospital, Capital university of medical Science, Beijing 100053, china Institute of Linguistics, Xuzhou Normal university, Xuzhou 221116, china) department of Rehabilitation Xuanwu Hospital Capital University of Medical Science Beijing 100053 China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing 100875 China School of Psychology Southwest University Chongqing 400715 China Key Laboratory of Mental Health Institute of Psychology Chinese Academy of Sciences Beijing 100101 China department of neurology Affiliated Hospital of Qingdao University Medical College Qingdao 266003 China department of neurology Xuanwu Hospital Capital University of Medical Science Beijing 100053 China Institute of Linguistics Xuzhou Normal University Xuzhou 221116 China

The visual spatial attention mechanism in the brain was studied in 16 young subjects through the visual search paradigm of precue-target by the event-related potential (ERP) technique, with the attentive ranges cued by different scales of Chinese character and region cues. The results showed that the response time for Chinese character cues was much longer than that for region cues especially for small region cues. With the exterior interferences, the target stimuli recognition under region cues was much quicker than that under Chinese character cues. Compared with that under region cues, targets under Chinese character cues could lead to increase of the posterior P1, decrease of the N1 and increase of the P2. It should also be noted that the differences between region cues and Chinese character cues were affected by the interference types. Under exterior interferences, no significant difference was found between region cues and Chinese character cues; however, it was not the case under the interior interferences. Considering the difference between the exterior interferences and the interior interferences, we could conclude that with the increase of difficulty in target recognition there was obvious difference in the consumption of anterior frontal resources by target stimuli under the two kinds of cues.

关键词： visual spatial attention cue scale event-related potential (ERP) Chinese character cues region cues.

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加巴喷丁胶囊添加治疗癫痫的临床疗效和安全性

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中国新药与临床杂志 2004年第9期23卷 571-575页

作者：毓青王凤楼王景华程焱李洪钧迟兆富冷珍 王雁天津医科大学总医院神经内科天津300052 南京医科大学第一附属医院神经内科江苏南京210029 山东大学齐鲁医院神经内科山东济南250012 山东省立医院神经内科山东济南250021 青岛大学医学院附属医院神经内科山东青岛266003

目的 :评价国产加巴喷丁的临床疗效和安全性。方法 :采用多中心、双盲、安慰剂对照、平行试验方法观察加巴喷丁添加治疗癫痫部分性发作(PS)和泛化性全身强直阵挛发作 (SGTCS) 2 4wk。分 2组 :加巴喷丁组 (原基础抗癫痫药 +加巴喷丁胶... 详细信息

目的 :评价国产加巴喷丁的临床疗效和安全性。方法 :采用多中心、双盲、安慰剂对照、平行试验方法观察加巴喷丁添加治疗癫痫部分性发作(PS)和泛化性全身强直阵挛发作 (SGTCS) 2 4wk。分 2组 :加巴喷丁组 (原基础抗癫痫药 +加巴喷丁胶囊 90 0mg·d- 1) 110例 ,对照组 (原基础抗癫痫药 +安慰剂 ) 10 8例。结果 :加巴喷丁组总有效率5 2 .7% (5 8/ 110 ) ,对照组 31.5 % (34/ 10 8) ,2组比较 ,P 复杂部分性发作 (CPS) >简单部分性发作(SPS) (P 0 .0 5 )。结论 :国产加巴喷丁添加治疗对控制癫痫PS和SGTCS是有效而安全的。

关键词：癫痫药物评价安全多中心研究双盲法安慰剂加巴喷丁

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Transoesophageal emergency ventricular pacing with esophageal balloon electrode catheter

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Journal of Geriatric Cardiology 2008年第3期5卷 142-145页

作者： Fangsheng Zheng Rongqiang Yan Hairong Zhao Luxia Mao department of Cardiology, affiliated hospital of qingdao university medical college, qingdao Shandong 266003, china department of Cardiology Qingdao University Medical College Qingdao Shandong 266003 China

Objective To evaluate the safety and possibility of transesophageal emergency ventricular pacing with esophageal balloonelectrode *** Sixty four patients with critical bradyarrhythmias were divided randomly to receive either transesophagealventricular pacing with esophageal balloon electrode catheter(*** group,n=32),or transesophageai ventricular pacing withnormal esophageal electrode catheter(normal catheter group,n=32).Pulse width(ms),current output(mA),and the success rate werecompared between the 2 *** Success rate in the balloon catheter group was 87.5%,which was significantly higher thanthat in the nodal catheter group(18.7%,X2=27.7,P＜0.01).The success rate oftransesophageal ventricular pacing with esophagealballoon electrode catheter was 87.5%.The average current output(mA)was significantly lower in the balloon catheter group than thatin the normal catheter group (24.5+2.5 mA VS 53±3.4mA,P＜0.05).Conclusions Esophageal balloon electrode catheter pacing couldbecome an available teclmiqBe for transesophageal emergency ventricular pacing.

关键词： ventriculax pacing balloon elcctrode catheter emergency.

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Relationship between expressions of E-cadherin and alpha-catenin and biological behaviors of human pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2003年第2期2卷 471-477页

作者： Yu-Jun Li Yun-Xiao Meng Xiang-Rui Ji the department of Pathology. affiliated hospital of medical college, qingdao university, qingdao 266003, china department of Pathology Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China. yujun-li66@***

OBJECTIVES: To investigate the expressions of E-eadherin and alpha-catenin in pancreatic carcinoma and their relationship with biological behaviors, and clarify the mechanism of invasion and metastasis of pancreatic cancer. METHODS: The expressions of E-eadherin and alpha-catenin was examined in 47 patients with infiltrative ductal adenocarcinoma of the pancreas and 12 specimens of normal pancreatic tissues by immunohistochemical technique (PicTure^(TM) two-step method). Proliferation cell nuclear antigen (PCNA) was tested as an index of the proliferation degree of pancreatic cancer cells. RESULTS: The immunoreactivity of E-cadherin and alpha-catenin was expressed by normal ductal and acinar cells with strong membranous staining at the intercellular border in 12 specimens of normal pancreatic tissues. The abnormal rate of E-cadherin expression in pancreatic cancer was 53.2% (25/47), and it was significantly related to differentiation, high proliferation degree and lymph node and liver metastases (P0.05, all). There was a positive relationship between the expressions of E-cadherin and alpha-catenin in the 47 patients with pancreatic cancer (P

关键词： pancreatic neoplasms cadherin catenin metastases prognosis immunohistochemistry

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Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 303-307页

作者： department of General Surgery (Lu Y and Zhang BY),department of Bio-Information (Jia ZX),affiliated medical college hospital,qingdao university,qingdao 266003,china Shanghai Jiaotong university School of Medicine,Shanghai 200025,china (Wu WJ) department of Medicine,Heze medical college,Heze 274000,china (Lu ZQ) department of General Surgery Affiliated Medical College Hospital Qingdao University Qingdao 266003 China department of Bio-Information Affiliated Medical College Hospital Qingdao University Qingdao 266003 China Shanghai Jiaotong university School of Medicine Shanghai 200025 China department of Medicine Heze Medical College Heze 274000 China

BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent ***,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well *** this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (Semen coicis,SC),and monitored the expression of Bcl-2 and ***:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 ***:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and ***,it did not significantly influence the expression of ***:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8.

关键词： Semen coicis traditional Chinese medicine Bcl-2 caspase-8 HepG2 cells apoptosis

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Muscarinic acetylcholine receptor M3 in proliferation and perineural invasion of cholangiocarcinoma cells

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 418-423页

作者： Yu-Jie Feng,Bing-Yuan Zhang,Ru-Yong Yao and Yun LuSecond department of General Surgery and Central Laboratory of Molecular Biology,affiliated medical college hospital,qingdao university,qingdao 266003,china Second department of General Surgery Affiliated Medical College Hospital Qingdao University Qingdao 266003 China Second department of General Surgery and Central Laboratory of Molecular Biology Affiliated Medical College Hospital Qingdao University Qingdao 266003 China

BACKGROUND:Cholangiocarcinoma,a type of malignant tumor,originates from epithelial cells of the bile *** invasion is common path for cholangiocarcinoma metastasis,and it is highly correlated with postoperative recurrence and poor *** has been reported that muscarinic acetylcholine receptor M3(mAChR M3) is widely expressed in digestive tract cancer,and may play an important role in the proliferation,differentiation,transformation and carcinogenesis of *** study was to explore the effect of mAChR M3 on the growth of cholangiocarcinoma cells in vitro and provide a new approach to the pathogenesis and treatment of ***:Streptavidin-biotin complex immunohistochemistry was carried out to assess the expression of mAChR M3 in surgical specimens of cholangiocarcinomas(40 cases) and normal bile duct tissues(9),as well as to investigate nerve *** cholangiocarcinoma cells were treated with different concentrations of selective M-receptor agonist pilocarpine and M-receptor blocker atropine sulfate to induce changes in cell *** experimental data were analyzed by the Chi-square ***:The strongly-positive expression rate of mAChR M3 was much higher in poorly-differentiated(69%,9/13) than in well-and moderately-differentiated cholangiocarcinomas(30%,8/27)(χ 2 =5.631,P<0.05).The strongly-positive mAChR M3 expression rate in hilar cholangiocarcinoma(50%,14/28) was higher than that in cholangiocarcinomas from the middle and lower common bile duct(25%,3/12)(χ 2 =2.148,P<0.05).Cholangiocarcinomas with distant metastasis had a stronglypositive expression rate(75%,9/12),which was much higher than those without distant metastasis(29%,8/28)(χ 2 =7.410,P<0.01).The absorbance value in the pilocarpine+atropine group was significantly higher than the corresponding value in the pilocarpine ***:The expression of mAChR M3 is influenced by the extent of differentiation,distant metastasis and the site

关键词： cholangiocarcinoma mAChR M3 immunohistochemistry perineural invasion proliferation

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Spinal cord injury and cholelithiasis

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 595-598页

作者： Chang-Suo Xia, Ying-Qiu Han, Xuan-Ying Yang and Guang-Xiang Hong qingdao, china department of Orthopaedics, affiliated hospital of medical college , qingdao university, qingdao 266003 , china and department of Orthopaedics, Union hospital, Tongji medical college, Huazhong university of Science and Technology, Wuhan 430030 , china department of Orthopaedics Affiliated Hospital of Medical College Qingdao University Qingdao 266003 China. xcs_009@***

BACKGROUND: Spinal cord injury (SCI) is found to be related to increased prevalence of gallstones and acute acal- culous cholecystitis. In this study we assessed the prevalence of cholelithiasis in male patients with SCI and the correla- tion of cholelithiasis with age and weight of patients, level of injury, as well as severity and duration of SCI. METHODS: One hundred male SCI patients (58 patients rated ASIA A or B and 42 rated ASIA C or D) aged more than 20 years (average 46.5 years) suffered from a spinal cord injury for more than one year. One hundred male vo- lunteers served as controls without SCI and biliary diseases (age range 20-68 years; average 42.6 years). The two groups were subjected to ultrasonography of the gallbladder and biliary tract. RESULTS: The prevalence of cholelithiasis in the group of SCI patients and the control group was 26% and 10% re- spectively. Significant differences in the prevalence of cho- lelithiasis were found between the normal controls and SCI patients and between high- and low-level injury (P 0.05). CONCLUSIONS: SCI represents a major risk factor for the development of cholelithiasis, especially in patients with high-level injury. Cholelithiasis in SCI patients is not relat- ed to their age and weight, the severity of spinal lesion, and the duration of spinal cord injury.

关键词： spinal cord injury cholelithiasis gallstones risk factors

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Polypeptide from Chlamys farreri attenuates murine thymocytes damage induced by ultraviolet B

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Acta Pharmacologica Sinica 2007年第10期28卷 1665-1670页

作者： Hai-ying CHEN~(2,3),Xiao CHU~4,Chun-ling YAN~5,Xue-hong CHEN~5,Mi SUN~6,Yue-jun WANG~6,Chun-bo WANG~(3,7),Wen-gong YU~(2,7)~2 department of Pharmacochemistry,Ocean university of china,qingdao 266003,china ~3 department of Pharmacology,medical college,qingdaouniversity,qingdao 266021,china ~4 qingdao Municipal hospital,qingdao 266010,china ~5 department of Pathophysiology,medicalcollege,qingdao university,qingdao 266021,china ~6 Yellow Sea Fishery Research Institute,qingdao 266071,china department of Pharmacochemistry Ocean University of China Qingdao China department of Pharmacology Medical College Qingdao University Qingdao China qingdao Municipal hospital Qingdao China department of Pathophysiology Medical College Qingdao University Qingdao China Yellow Sea Fishery Research Institute Qingdao China

Aim:Polypeptide from Chlamys farreri (PCF,molecular mass is 879) is a newmarine polypeptide compound isolated from Chlamys *** study investi-gates the possible protective roles and the mechanism of PCF against ultravioletB (UVB)-induced apoptosis in murine ***:The rate of apoptosisand caspase-3 activation was measured by flow *** expression ofstress-response genes c-fos and c-jun was observed by *** blotanalysis was performed to determine the release of cytochrome ***:It wasfound that UVB induced murine thymocyte *** cells treated with UVBshowed an increase in cytochrome c release,caspase-3 activity,as well as in theexpression of c-fos and *** addition,all were involved in UVB-induced ***:Our present observations pointed to the ability of PCF toavert UVB-induced apoptosis in thymocytes by modulating c-fos and c-junexpression,cytochrome c release,and the consequent activation of caspase-3,which were essential components of the UV-induced cell apoptotic *** suggested that PCF is a promising protective substance against UVradiation.

关键词： polypeptide from Chlamys farreri (PCF) ultraviolet B apoptosis cytochrome c caspase-3

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Pre-ligation of afflicted hepatic inflow and outflow blood vessels of lesioned liver lobe during hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2003年第3期2卷 358-361页

作者： Zhe-Fu Li Min Song the department of Hepatobiliary, qingdao Municipal hospital, qingdao university medical college, qingdao 266011, china department of Hepatobiliary Qingdao Municipal Hospital Qingdao University Medical College Qingdao 266011 China. lizhefu@***

OBJECTIVE: To compare the merits of hepatectomy after pre-ligation of the hepatic inflow and outflow blood vessels of the lesioned liver lobe with those of Pringle's maneuver. METHODS: A total of 68 patients were divided into two groups A and B. In the group A (n=38), Pringle's maneuver was employed, whereas in the group B (n=30), hepatectomy after pre-ligation of the hepatic inflow and outflow blood vessels of the lesioned side of the liver was used. Perioperative blood loss, postoperative bleeding and drainage, time of liver function recovery as well as incidence of postoperative complications were compared between the 2 groups. RESULTS: The mean perioperative blood loss, the mean amount of postoperative bleeding and drainage, the time of liver function recovery as well as incidence of postoperative complications were significantly higher in the group A than in the group B (P<0.01). CONCLUSION: Hepatectomy after pre-ligation of the hepatic inflow and outflow blood vessels of the lesioned side of the liver is superior to Pringle's maneuver.

关键词： hepatectomy blood flow clamping

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Relationship between expression of E-cadherin-catenin complex and clinicopathologic characteristics of pancreatic cancer

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World Journal of Gastroenterology 2003年第2期9卷 368-372页

作者： Yu-Jun Li Xiang-Rui Ji department of Pathology, the affiliated hospital of medical college, qingdao university, qingdao 266003, Shandong Province, china department of Pathology the Affiliated Hospital of Medical College Qingdao University 16 Jiangsu Rd Qingdao 266003 China. yunjun-Li66@***

AIM: To investigate the expression of E-cadherin and alpha-catenin and beta-catenin in pancreatic carcinoma and itsrelationship with the clinicopathologic characteristics, andclarify the mechanism of invasion and metastasis ofpancreatic ***: The expression of E-cadherin and alpha-, beta-catenin was examined in 47 cases of infiltrative ductaladenocarcinoma of pancreas and 12 adult normal pancreatictissues by immunohistochemical ***: The immunoreactivity of E-cadherin and alpha-,beta-catenin was expressed by normal ductal and acinarcells with strong membranous staining at the intercellularborder in 12 cases of adult normal pancreatic tissues. Abnormalexpression of E-cadherin and alpha-, beta-catenin in 47pancreatic carcinoma tissues was demonstrated in 53.2 %,61.7 % and 68.1%, respectively. Both abnormal expressionof E-cadherin and alpha-catenin significantly correlated withdifferentiation, lymph node and liver metastases (P＜0.05,respectively), whereas aberrant beta-catenin expression onlycorrelated with lymph node and liver metastases (P＜0.001).Abnormal E-cadherin and alpha-, beta-catenin expressionwas not associated with tumor size, invasion and survivaltime of patients (P＞0.05, all).CONCLUSION: Pancreatic cancer likely occurs in case ofE-cadherin-catenin complex genes mutations or deletionsand abnormal expression of proteins, which significantlycorrelate with the biologic character of the tumor and lymphnode and liver metastases. It is suggested that the abnormalE-cadherin-catenin complex expression plays an importantrole in the development and progression of tumor, and thusmay become a new marker in pancreatic cancer metastasis.

关键词： E-钙粘素连接素胰腺癌临床病理学肿瘤侵袭肿瘤转移免疫活性

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